Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review

International Journal of Pharmaceutics

Volumn 417, Issue 1-2, 2011, Pages 48-60

  Shen, Yao Chun ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Coating; Imaging; Polymorph; Spectroscopy; Tablet; Terahertz

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA LACTOSE; AMPICILLIN; BENZOIC ACID; CARBAMAZEPINE; CEFTAZIDIME; CITRIC ACID; ENALAPRIL MALEATE; EXCIPIENT; FENOPROFEN CALCIUM; FRUCTOSE; FUROSEMIDE; GLUCOSE; INDOMETACIN; LACTOSE; MEFENAMIC ACID; OFLOXACIN; PARACETAMOL; PIROXICAM; PYRIDOXINE; RANITIDINE; RIBOFLAVIN; SALICYLIC ACID; SULFATHIAZOLE; THEOPHYLLINE; THIAMINE; THYMINE; TOLBUTAMIDE; URIC ACID; VITAMIN;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MAPPING; DENSITY; DRUG ABSORPTION; DRUG COATING; DRUG SOLUBILITY; ELECTROMAGNETIC FIELD; HARDNESS; INFRARED SPECTROSCOPY; INSTRUMENT; NEAR INFRARED SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAMAN SPECTROMETRY; TERAHERTZ IMAGING; TERAHERTZ PULSED IMAGING; TERAHERTZ PULSED SPECTROSCOPY; TERAHERTZ SPECTROSCOPY;

EID: 80052262860     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.01.012     Document Type: Review

References (94)

1. J. Aaltonen, K.C. Gordon, C.J. Strachan, and T. Rades Perspectives in the use of spectroscopy to characterise pharmaceutical solids Int. J. Pharm. 364 2008 159 169
2. D.G. Allis, D.A. Prokhorova, and T.M. Korter Solid-state modeling of the terahertz spectrum of the high explosive HMX J. Phys. Chem. A 110 2006 1951 1959 (Pubitemid 43343013)
3. D.H. Auston Picosecond optoelectronic switching and gating in silicon Appl. Phys. Lett. 26 1975 101 103
4. P.B. Balbuena, W. Blocker, R.M. Dudek, F.A. Cabrales-Navarro, and P. Hirunsit Vibrational spectra of anhydrous and monohydrated caffeine and theophylline molecules and crystals J. Phys. Chem. A. 112 2008 10210 10219
5. H.G. Brittain Polymorphism and solvatomorphism 2005 J. Pharm. Sci. 96 2007 705 728 (Pubitemid 46657863)
6. R. Chakkittakandy, J.A. Corver, and P.C. Planken Terahertz spectroscopy to identify the polymorphs in freeze-dried mannitol J. Pharm. Sci. 99 2010 932 940
7. W.L. Chan, J. Deibel, and D.M. Mittleman Imaging with terahertz radiation Rep. Prog. Phys. 70 2007 1325 1379
8. G.W. Chantry Submillimetre spectroscopy: a guide to the theoretical and experimental physics of the far infrared Acad. Pr. Lon. 1971 1325 1379
9. R.A. Cheville, and D. Grischkowsky Far-infrared terahertz time-domain spectroscopy of flames Opt. Lett. 20 1995 1646 1648
10. F.C. Clarke, M.J. Jamieson, D.A. Clark, S.V. Hammond, R.D. Jee, and A.C. Moffat Chemical image fusion the synergy of ft-nir and raman mapping microscopy to enable a more complete visualisation of pharmaceutical formulations Anal. Chem. 73 2001 2213 2220 (Pubitemid 32880685)
11. R.P. Cogdill, S.M. Short, R. Forcht, Z. Shi, Y.C. Shen, P.F. Taday, C.A. Anderson, and J.K. Drennen An efficient method-development strategy for quantitative chemical imaging using terahertz pulse spectroscopy J. Pharm. Innov. 1 2006 63 75 (Pubitemid 46804300)
12. R.P. Cogdill, R.N. Forcht, Y.C. Shen, P.F. Taday, J.R. Creekmore, C.A. Anderson, and J.K. Drennen III Comparison of terahertz pulse imaging and near-infrared spectroscopy for rapid non-destructive analysis of tablet coating thickness and uniformity J. Pharm. Innov. 2 2007 29 36 (Pubitemid 350054206)
13. G.C. Cole Introduction and overview of pharmaceutical coating G. Cole, J. Hogan, A. Michael, Pharmaceutical Coating Technology 1 1995 1 5
14. G.M. Day, J.A. Zeitler, W. Jones, T. Rades, and P.F. Taday Understanding the influence of polymorphism on phonon spectra: lattice dynamics calculations and terahertz spectroscopy of carbamazepine J. Phys. Chem. B 110 2006 447 456 (Pubitemid 43133567)
15. B. Ferguson, and X.C. Zhang Materials for terahertz science and technology Rev. Art. Nat. Mater. 1 2002 26 33
16. B. Fischer, M. Hoffmann, H. Helm, G. Modjesch, and P.U. Jepsen Chemical recognition in terahertz time-domain spectroscopy and imaging Semicond. Sci. Technol. 20 2005 S246 S253
17. A.J. Fitzgerald, B.E. Cole, and P.F. Taday Nondestructive analysis of tablet coating thicknesses usign terahertz pulsed imaging J. Pharm. Sci. 94 2005 177 183 (Pubitemid 40116381)
18. M. Ge, G.F. Liu, S.H. Ma, and W.F. Wang Polymorphic forms of furosemide characterized by thz time domain spectroscopy Bull. Kor. Chem. Soc. 30 2009 2265 2268
19. K.C. Gordon, C.M. McGoverin, C.J. Strachan, and T. Rades The use of quantum chemistry in pharmaceutical research as illustrated by case studies of indometacin and carbarnazepine J. Pharm. Pharmacol. 59 2007 271 277 (Pubitemid 46203065)
20. A. Grunenberg, J.-O. Henk, and H.W. Siesler Theoretical derivation and practical application of energy/temperature diagrams as an instrument in preformulation studies of polymorphic drug substances Int. J. Pharm. 129 1996 147 158 (Pubitemid 26097982)
21. P.M. Hakey, D.G. Allis, M.R. Hudson, W. Ouellette, and T.M. Korter Investigation of (1R,2S)-(-)-ephedrine by cryogenic terahertz spectroscopy and solid-state density functional theory ChemPhysChem. 10 2009 2434 2444
22. P.Y. Han, M. Tani, M. Usami, S. Kono, R. Kersting, and X.C. Zhang A direct comparison between terahertz time-domain spectroscopy and far-infrared Fourier transform spectroscopy J. Appl. Phys. 89 2001 2357 2359 (Pubitemid 33662019)
23. A. Heinz, K.C. Gordon, C.M. McGoverin, T. Rades, and C.J. Strachan Understanding the solid-state forms of fenofibrate - a spectroscopic and computational study Eur. J. Pharm. Biopharm. 71 2009 100 108
24. A. Heinz, C.J. Strachan, K.C. Gordon, and T. Rades Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy J. Pharm. Pharmacol. 61 2009 971 988
25. L. Ho, R. Muller, M. Romer, K.C. Gordon, J. Heinamaki, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, C.J. Strachan, P.F. Taday, and J.A. Zeitler Analysis of sustained-release tablet film coats using terahertz pulsed imaging J. Controlled Release 119 2007 253 261 (Pubitemid 46770883)
26. L. Ho, R. Mueller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday, and J.A. Zeitler Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance J. Controlled Release 127 2008 79 87
27. L. Ho, R. Muller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday, and J.A. Zeitler Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating Eur. J. Pharm. Biopharm. 71 2009 117 123
28. L. Ho, R. Muller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday, and J.A. Zeitler Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging J. Pharm. Sci. 98 2009 4866 4876
29. L. Ho, Y. Cuppok, S. Muschert, K.C. Gordon, M. Pepper, Y. Shen, F. Siepmann, J. Siepmann, P.F. Taday, and T. Rades Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: A case study using terahertz pulsed imaging Int. J. Pharm. 382 2009 151 159
30. L. Ho, R. Mueller, C. Krueger, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P.F. Taday, and J.A. Zeitler Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging J. Pharm. Sci. 99 2010 392 402
31. S.W. Hoag, V.S. Dave, and V. Moolchandani Compression and compaction, in pharmaceutical dosage forms: tablets L.L. Augsburger, S.W. Hoag, Unit Operations and Mechanical Properties vol. 1 2008 Information Heathcare 555 630
32. J. Hooper, E. Mitchell, C. Konek, and J. Wilkinson Terahertz optical properties of the high explosive beta-HMX J. Wilkinson, Chem. Phys. Lett. 467 2009 309 312
33. Y. Ikeda, Y. Ishihara, T. Moriwaki, E. Kato, and K. Terada A novel analytical method for pharmaceutical polymorphs by terahertz spectroscopy and the optimization of crystal form at the discovery stage Chem. Pharm. Bull. 58 2010 76 81
34. C. Jansen, S. Wietzke, O. Peters, M. Scheller, N. Vieweg, M. Salhi, N. Krumbholz, C. Jordens, T. Hochrein, and M. Koch Terahertz imaging: applications and perspectives Appl. Optics. 49 2010 E48 E57
35. P.U. Jepsen, and S.J. Clark Precise ab-initio prediction of terahertz vibrational modes in crystalline systems Chem. Phys. Lett. 442 2007 275 280 (Pubitemid 47016381)
36. P.U. Jepsen, R.H. Jacobsen, and S.R. Keiding Generation and detection of terahertz pulses from biased semiconductor antennas J. Opt. Soc. Am. B 13 1996 2424 2436 (Pubitemid 126628627)
37. M. Juuti, H. Tuononen, T. Prykari, V. Kontturi, M. Kuosmanen, E. Alarousu, J. Ketolainen, R. Myllyla, and K.E. Peiponen Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: a case study of gloss, surface roughness and bulk properties of starch acetate tablets Meas. Sci. Tech. 20 2009 015301
38. M. Kawase, T. Saito, M. Ogawa, H. Uejma, Y. Hatsuda, S. Kawanishi, Y. Hirotani, M. Myotoku, K. Ikeda, K. Takano, M. Hangyo, K. Yamamoto, and M. Tani Terahertz absorption spectra of original and generic ceftazidime Anal. Sci. 25 2009 1483 1485
39. J.L. Koening, S.Q. Wang, and R. Bhargava FTIR images: a new technique produces images worth a thousand spectra Anal. Chem. 73 2001 360A 369A
40. N. Laman, S.S. Harsha, and D. Grischkowsky Narrow-line waveguide terahertz time-domain spectroscopy of aspirin and aspirin precursors Appl. Spectrosc. 62 2008 319 326 (Pubitemid 351450043)
41. E.N. Lewis, P.J. Treado, R.C. Reeder, G.M. Story, A.E. Dowrey, C. Marcott, and I.W. Levin Fourier transform spectroscopic imaging using an infrared focal-plane array detector Anal. Chem. 67 1995 3377 3381
42. R. Li, J.A. Zeitler, D. Tomerini, E.P.J. Parrott, L.F. Gladden, and G.M. Day A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid Phys. Chem. Chem. Phys. 12 2010 5329 5340
43. W. Limwikrant, K. Higashi, K. Yamamoto, and K. Moribe Characterization of ofloxacin-oxalic acid complex by PXRD NMR, and THz spectroscopy Int. J. Pharm. 382 2009 50 55
44. H.B. Liu, and X.C. Zhang Dehydration kinetics of d-glucose monohydrate studied using THz time-domain spectroscopy Chem. Phys. Lett. 429 2006 229 233
45. H.B. Liu, Y.Q. Chen, and X.C. Zhang Characterization of anhydrous and hydrated pharmaceutical materials with THz time-domain spectroscopy J. Pharm. Sci. 96 2007 927 934
46. V. Malaterre, M. Pedersen, J. Ogorka, R. Gurny, N. Loggia, and P.F. Taday Terahertz pulsed imaging, a novel process analytical tool to investigate the coating characteristics of push-pull osmotic systems Eur. J. Pharm. Biopharm. 74 2009 21 25
47. L. Maurer, and H. Leuenberger Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets Int. J. Pharm. 370 2009 8 16
48. J.M.A. Mauritz, R.S. Morrisby, R.S. Hutton, C.H. Legge, and C.F. Kaminski Imaging pharmaceutical tablets with optical coherence tomography J. Pharm. Sci. 99 2010 385 391
49. R.K. May, L. Han, J. Alton, S. Zhong, J.A. Elliott, C. Byers, L.F. Gladden, M.J. Evans, Y.C. Shen, and J.A. Zeitler Pharmaceutical tablet hardness measurements with THz pulsed imaging IEEE Int. Conf. IR. MMW. THz Waves 2009 (Busan, South Korea, 2009)
50. R.K. May, M.J. Evans, S. Zhong, I. Warr, L.F. Gladden, Y.C. Shen, and J.A. Zeitler Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time J. Pharm. Sci. 2010 (accepted)
51. C.M McGoverin, T. Rades, and K.C. Gordon Recent pharmaceutical applications of Raman and terahertz spectroscopies J. Pharm. Sci. 97 2008 4598 4621
52. D.A. Newnham, and P.F. Taday Pulsed terahertz attenuated total reflection spectroscopy Appl. Spectro. 62 2008 394 398 (Pubitemid 351529454)
53. K.L. Nguyen, T. Friscic, G.M. Day, L.F. Gladden, and W. Jones Terahertz time-domain spectroscopy and the quantitative monitoring of mechanochemical cocrystal formation Nat. Mater. 6 2007 206 209 (Pubitemid 46353768)
54. R. Nishikiori, M. Yamaguchi, K. Takano, T. Enatsu, M. Tani, U.C. de Silva, N. Kawashita, T. Taragi, S. Morimoto, M. Hangyo, and M. Kawase Application of partial least square on quantitative analysis of l-, d-, and dl-tartaric acid by terahertz absorption spectra Chem. Pharm. Bull. 56 2008 305 307 (Pubitemid 351463241)
55. J. Obradovic, J.H.P. Collins, O. Hirsch, M.D. Mantle, M.L. Johns, and L.F. Gladden The use of THz time-domain reflection measurements to investigate solvent diffusion in polymers Polymer 48 2007 3494 3503 (Pubitemid 46802660)
56. M. Otsuka, J.I. Nishizawa, J. Shibata, and M. Ito Quantitative evaluation of mefenamic acid polymorphs by terahertz-chemometrics J. Pharm. Sci. 99 2010 4048 4053
57. R. Palermo, R.P. Cogdill, S.M. Short, J.K. Drennen, and P.F. Taday Density mapping and chemical component calibration development of four-component compacts via terahertz pulsed imaging J. Pharm. Biomed. Anal. 46 2008 36 44 (Pubitemid 350225648)
58. E. Pickwell, and V.P. Wallace Biomedical applications of terahertz technology J. Phys. D-Appl. Phys. 39 2006 R301 R310
59. A. Portieri, P. Taday, and Y.C. Shen Terahertz pulsed imaging for non-invasive and non-destructive analysis of the hydration dynamics of HPMC matrix 58th PGH. Conf. Anal. Appl. Spectro. PITTCON 2007, Chicago, USA 2007
60. S. Saito, T.M. Inerbaev, H. Mizuseki, N. Igarashi, R. Note, and Y. Kawazoe Terahertz phonon modes of an intermolecular network of hydrogen bonds in an anhydrous beta-d-gluco- pyranose crystal Chem. Phys. Lett. 423 2006 439 444 (Pubitemid 43729628)
61. C.A. Schmuttenmaer Exploring dynamics in the far-infrared with terahertz spectroscopy Chem. Rev. 104 2004 1759 1779
62. J. Shen, G. Wang, D. Jiang, L. Liang, and X. Xu Terahertz spectroscopic investigations of caffeine and 3-acetylmorphine Int. J. Light Electron Opt. 121 2010 1712 1716
63. Y.C. Shen, P.C. Upadhya, E.H. Linfield, and A.G. Davies Temperature-dependent low-frequency vibrational spectra of purine and adenine Appl. Phys. Lett. 82 2003 2350 2352
64. Y.C. Shen, P.F. Taday, D.A. Newnham, and M. Pepper Chemical mapping using reflection terahertz pulsed imaging Semicond. Sci. Technol. 20 2005 S254 S257
65. Y.C. Shen, P.F. Taday, D.A. Newnham, M.C. Kemp, and M. Pepper 3D chemical mapping using terahertz pulsed imaging SPIE Proceedings 5727 2005 24 31 (Pubitemid 40953265)
66. Y.C. Shen, P.F. Taday, and M. Pepper Elimination of scattering effects in spectral measurement of granulated materials using terahertz pulsed spectroscopy Appl. Phys. Lett. 92 2008 051103
67. Y.C. Shen, and P.F. Taday Development and application of terahertz pulsed imaging for nondestructive inspection of pharmaceutical tablet IEEE. J. Sel. Top. Quant. Electro. 14 2008 407 415 (Pubitemid 351506304)
68. I.C. Sinka, S.F. Burch, J.H. Tweed, and J.C. Cunningham Measurement of density variations in tablets using X-ray computed tomography Int. J. Pharm. 271 2004 215 224 (Pubitemid 38210099)
69. J.A. Spencer, Z.M. Gao, T. Moore, L.F. Buhse, P.F. Taday, D.A. Newnham, Y.C. Shen, A. Portieri, and A. Husain Delayed release tablet dissolution related to coating thickness by terahertz pulsed image mapping J. Pharm. Sci. 97 2008 1543 1550
70. C.J. Strachan, T. Rades, D.A. Newnham, K.C. Gordon, M. Pepper, and P.F. Taday Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials Chem. Pharm. Lett. 390 2004 20 24
71. C.J. Strachan, P.F. Taday, D.A. Newnham, K.C. Gordon, J.A. Zeitler, M. Pepper, and T. Rades Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity J. Pharm. Sci. 94 2005 837 846 (Pubitemid 40577316)
72. P.F. Taday, I.V. Bradley, D.D. Arnone, and M. Pepper Using terahertz pulse spectroscopy to study the crystalline structure of a drug: A case study of the polymorphs of ranitidine hydrochloride J. Pharm. Sci. 92 2003 831 838 (Pubitemid 36396998)
73. P.F. Taday Applications of terahertz spectroscopy to pharmaceutical sciences Philos. Trans. R. Soc. London, Ser. A. Math. Phys. Eng. Sci. 362 2004 351 363
74. P.F. Taday Terahertz pulsed imaging for nondestructive testing of pharmaceutical products Spectroscopy 24 2009 28 36
75. H. Tuononen, E. Gornov, J.A. Zeitler, J. Aaltonen, and K.E. Peiponen Using modified Kramers-Kronig relations to test transmission spectra of porous media in THz-TDS Opt. Lett. 35 2010 631 633
76. P.C. Upadhya, Y.C. Shen, A.G. Davies, and E.H. Linfield Terahertz time-domain spectroscopy of glucose and uric acid J. Bio. Phys. 29 2003 117 121 (Pubitemid 36876509)
77. P.C. Upadhya, K.L. Nguyen, Y.C. Shen, J. Obradovic, K. Fukushige, R. Griffiths, L.F. Gladden, A.G. Davies, and E.H. Linfield Characterization of crystalline phase-transformations in theophylline by time-domain terahertz spectroscopy Spectr. Lett. 39 2006 215 224
78. M.P. Wagh, Y.H. Sonawane, and O.U. Joshi Terahertz technology: a boon to tablet analysis Ind. J. Pharm. Sci. 71 2009 235 241
79. V.P. Wallace, P.F. Taday, A.J. Fitzgerald, R.M. Woodward, J. Cluff, R.J. Pye, and D.D. Arnone Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications Faraday Discuss. 126 2004 255 263 (Pubitemid 38365598)
80. V.P. Wallace, E. MacPherson, J.A. Zeitler, and C. Reid Three-dimensional imaging of optically opaque materials using nonionizing terahertz radiation J. Opti. Soc. Am. Aopti. Img. Sci. Vis. 25 2008 3120 3133
81. M. Walther, B.M. Fischer, and P.U. Jepsen Noncovalent intermolecular forces in polycrystalline and amorphous saccharides in the far infrared Chem. Phys. 288 2003 261 268
82. M. Walther, B.M. Fischer, A. Ortner, A. Bitzer, A. Thoman, and H. Helm Chemical sensing and imaging with pulsed terahertz radiation Anal. Bioanal. Chem. 397 2010 1009 1017
83. H.Q. Wu, E.J. Heilweil, A.S. Hussain, and M.A. Khan Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets Int. J. Pharm. 343 2007 148 158 (Pubitemid 47334868)
84. H.Q. Wu, E.J. Heilweil, A.S. Hussain, and M.A. Khan Process analytical technology (PAT): quantification approaches in Terahertz spectroscopy for pharmaceutical application J. Pharm. Sci. 97 2008 970 984 (Pubitemid 351293896)
85. P. Zannikosm, W. Li, J. Drennen, and R. Lodder Spectrophotometric prediction of the dissolution rate of carbamazepine tablets Pharm. Res. 8 1991 974 978
86. J.A. Zeitler, D.A. Newnham, P.F. Taday, C.J. Strachan, M. Pepper, K.C. Gordon, and T. Rades Temperature dependent terahertz pulsed spectroscopy of carbamazepine Thermo. Acta 436 2005 71 77 (Pubitemid 41260402)
87. J.A. Zeitler, D.A. Newnham, P.F. Taday, T.L. Threlfall, R.W. Lancaster, R.W. Berg, C.J. Strachan, M. Pepper, K.C. Gordon, and T. Rades Characterization of temperature induced phase transitions in the five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry J. Pharm. Sci. 95 2006 2486 2498 (Pubitemid 44726388)
88. J.A. Zeitler, K. Kogermann, J. Rantanen, T. Rades, P.F. Taday, M. Pepper, J. Aaltonen, and C.J. Strachan Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy Int. J. Pharm. 334 2006 78 84 (Pubitemid 46400317)
89. J.A. Zeitler, Y.C. Shen, C. Baker, P.F. Taday, M. Pepper, and T. Rades Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging J. Pharm. Sci. 96 2007 330 340 (Pubitemid 46363564)
90. J.A. Zeitler, P.F. Taday, D.A. Newnham, M. Pepper, K.C. Gordon, and T. Rades Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting - a review J. Pharm. Pharmacol. 59 2007 209 223 (Pubitemid 46203060)
91. J.A. Zeitler, P.F. Taday, M. Pepper, and T. Rades Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy J. Pharm. Sci. 96 2007 2703 2709 (Pubitemid 47597819)
92. J.A. Zeitler, and L.F. Gladden In vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms Eur. J. Pharm. Biopharm. 71 2009 2 22
93. S. Zhong, H. Shen, Y.C. Shen, J.A. Zeitler, L. Ho, M. Evans, P.T. Taday, M. Pepper, T. Rades, K.C. Gordon, R. Muller, and P. Kleinebudde Noninvasive 3D characterization of layered samples using terahertz pulsed imaging and infrared optical coherence tomography IEEE Int. Conf. IR. MMW. THz Waves. (Busan, South Korea, 2009) 2009
94. S. Zhong, Y.C. Shen, L. Ho, R. May, J.A. Zeitler, M. Evans, P.T. Taday, M. Pepper, T. Rades, K.C. Gordon, R. Muller, and P. Kleinebudde Nondestructive Testing of Pharmaceutical Coatings by Terahertz Pulsed Imaging and Optical Coherency tomography Opt. Laser Eng. 49 2011 361 365