Design and syntheses of gramicidin S analogs, cyclo(-X-Leu-X-D-Phe-Pro-) 2 (X=His, Lys, Orn, Dab and Dap)

Journal of Antibiotics

Volumn 64, Issue 8, 2011, Pages 583-585

  Tamaki, Makoto ^a   Fujinuma, Kenta ^a   Harada, Takuji ^a   Takanashi, Kazumasa ^a   Shindo, Mitsuno ^b   Kimura, Masahiro ^b   Uchida, Yoshiki ^b  

^a TOHO UNIVERSITY   (Japan)

^b OSAKA SHOIN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Gramicidin S; polycationic analog; structure activity relationship; synthesis

Indexed keywords

GRAMICIDIN DERIVATIVE; GRAMICIDIN S DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BETA SHEET; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; HEMOLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SHEEP ERYTHROCYTE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GRAMICIDIN; HEMOLYSIS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052257745     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2011.43     Document Type: Article

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