Polycythaemia in infants of diabetic mothers: β-hydroxybutyrate stimulates erythropoietic activity

Journal of International Medical Research

Volumn 39, Issue 3, 2011, Pages 815-821

  Cetin, H ^a   Yalaz, M ^a   Akisu, M ^a   Kultursay, N ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Erythropoiesis; Fetal haemoglobin; Infants of diabetic mothers; Polycythaemia; Hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRIC ACID; ERYTHROPOIETIN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN F; INSULIN;

ADULT; ARTICLE; BIRTH WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROPOIESIS; FEMALE; GESTATIONAL AGE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN SYNTHESIS; HORMONE BLOOD LEVEL; HUMAN; INFANT; INSULIN BLOOD LEVEL; MATERNAL BLOOD; MATERNAL DIABETES MELLITUS; PATHOGENESIS; POLYCYTHEMIA; PREGNANT WOMAN; UMBILICAL CORD BLOOD;

EID: 80052216694     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001103900314     Document Type: Article

References (35)

1. Cunningham FG, Gant NF, Leveno KJ, et al (eds): Diabetes. In: Williams Obstetrics, 21st edn. New York: McGraw-Hill, 2001; pp 1359-1382.
2. Di Cianni G, Miccoli R, Volpe L, et al: Intermediate metabolism in normal pregnancy and in gestational diabetes. Diabetes Metab Res Rev 2003; 19: 259-270.
3. Tyrala EE: The infant of the diabetic mother. Obstet Gynecol Clin North Am 1996; 23: 221-241.
4. Schwartz R, Teramo KA: Effects of diabetic pregnancy on the fetus and newborn. Semin Perinatol 2000; 24: 120-135.
5. Mimouni F, Tsang RC, Hertzberg VS, et al: Polycythemia, hypomagnesemia, and hypocalcemia in infants of diabetic mothers. Am J Dis Child 1986; 140: 798-800.
6. Weintrob N, Karp M, Hod M: Short-and longrange complications in offspring of diabetic mothers. J Diabetes Complications 1996; 10: 294-301.
7. Perrine SP, Greene MF, Lee PD, et al: Insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia. Br J Haematol 1986; 64: 503-511.
8. Shannon K, Davis JC, Kitzmiller JL, et al: Erythropoiesis in infants of diabetic mothers. Pediatr Res 1986; 20: 161-165.
9. Miodovnik M, Skillman CA, Hertzberg V, et al: Effect of maternal hyperketonemia in hyperglycemic pregnant ewes and their fetuses. Am J Obstet Gynecol 1986; 154: 394-401.
10. Philips AF, Dubin JW, Matty PJ, et al: Arterial hypoxemia and hyperinsulinemia in the chronically hyperglycemic fetal lamb. Pediatr Res 1982; 16: 653-658.
11. Widness JA, Susa JB, Garcia JF, et al: Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers in hyperinsulinemic rhesus fetuses. J Clin Invest 1981; 67: 637-642.
12. Salvesen DR, Brudenell JM, Snijders RJ, et al: Fetal plasma erythropoietin in pregnancies complicated by maternal diabetes mellitus. Am J Obstet Gynecol 1993; 168: 88-94.
13. Akisü M, Darcan S, Oral R, et al: Serum lipid and lipoprotein composition in infants of diabetic mothers. Indian J Pediatr 1999; 66: 381-386.
14. Laffel L: Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 1999; 15: 412-426.
15. Paterson P, Sheath J, Taft P, et al: Maternal and foetal ketone concentrations in plasma and urine. Lancet 1967; 289: 862-865.
16. Jovanovic L, Metzger BE, Knopp RH, et al: The diabetes in early pregnancy study: β-hydroxybutyrate levels in type 1 diabetic pregnancy compared with normal pregnancy. NICHD-Diabetes in Early Pregnancy Study Group (DIEP). National Institute of Child Health and Development. Diabetes Care 1998; 21: 1978-1984.
17. Pappa KI, Anagnou NP, Salamalekis E, et al: Gestational diabetes exhibits lack of carnitine deficiency despite relatively low carnitine levels and alterations in ketogenesis. J Matern Fetal Neonatal Med 2005; 17: 63-68.
18. Bard H, Prosmanne J: Relative rates of fetal hemoglobin and adult hemoglobin synthesis in cord blood of infants of insulin-dependent diabetic mothers. Pediatrics 1985; 75: 1143-1147.
19. Bagby GC: Hematopoiesis. In: The Molecular Basis of Blood Disorders, 2nd edn. (Stamatoyannopulos G, Nienhuis AW, Majerus P, et al, eds). Philadelphia: WB Saunders, 1994; pp 321-378.
20. Zitnik G, Peterson K, Stamatoyannopoulos G, et al: Effects of butyrate and glucocorticoids on γ-to β-globin gene switching in somatic cell hybrids. Mol Cell Biol 1995; 19: 790-795.
21. Atweh GF, Sutton M, Nassif I, et al: Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood 1999; 93: 1790-1797.
22. Perrine SP, Grene MF, Faller DV: Delay in the fetal globin switch in infants of diabetic mothers. N Engl J Med 1985; 312: 334-338.
23. Stonestreet BS, Goldstein M, Oh W, et al: Effects of prolonged hyperinsulinemia on erythropoiesis in fetal sheep. Am J Physiol 1989; 257: R1199-R1204.
24. Cappellini MD, Graziadei G, Ciceri L et al: Butyrate trials. Ann N Y Acad Sci 1998; 850: 110-119.
25. McDonagh KT, Dover GJ, Donahue RE, et al: Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Exp Hematol 1992; 20: 1156-1164.
26. Reinhardt D, Ridder R, Kugler W, et al: Posttranscriptional effects of interleukin-3, interferon-γ, erythropoietin and butyrate on in vitro hemoglobin chain synthesis in congenital hemolytic anemia. Haematologica 2001; 86: 791-800.
27. Pace BS, White GL, Dover GJ, et al: Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood 2002; 100: 4640-4648.
28. Tsakalakos N, Macfarlane CM, Taljaard JJF: Evidence of hypoxemia and distribution of minor haemoglobin components in the cord blood of neonates born to diabetic mothers. S Afr Med J 1985; 67: 628-632.
29. Bard H, Gagnon C, Peri KG: HbF synthesis during stress erythropoiesis as determined by γ-mRNA/non-α-mRNA quantification. Pediatr Res 1999; 45: 684-686.
30. Perrine SP, Rudolph A, Faller DV, et al: Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching. Proc Natl Acad Sci USA 1988; 85: 8540-8542.
31. Perrine SP, Miller BA, Greene MF, et al: Butryic acid analogues augment gamma globin gene expression in neonatal erythroid progenitors. Biochem Biophys Res Commun 1987; 29: 694-700.
32. Perrine SP, Olivieri NF, Faller DV, et al: Butyrate derivates: new agents for stimulating fetal globin production in the β-globin disorders. Am J Pediatr Hematol Oncol 1994; 16: 67-71.
33. Yang YM, Pace B: Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms. Pediatr Pathol Mol Med 2001; 20: 87-106.
34. Stamatoyannopoulos G, Blau CA, Nakamoto B, et al: Fetal hemoglobin induction by acetate, a product of butyrate catabolism. Blood 1994; 84: 3198-3204.
35. Bhatia H, Hallock JL, Dutta A, et al: Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood 2009; 113: 6440-6448.