Endogenous brain-derived neurotrophic factor in the nucleus tractus solitarius tonically regulates synaptic and autonomic function

Journal of Neuroscience

Volumn 31, Issue 34, 2011, Pages 12318-12329

  Clark, Catharine G ^a,b   Hasser, Eileen M ^a,b,c   Kunze, Diana L ^d,e   Katz, David M ^e   Kline, David D ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c University of Missouri   (United States)

^d The MetroHealth System   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; IONOTROPIC RECEPTOR; K 252A;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN NERVE CELL; BRAIN STEM; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DEPOLARIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC SYSTEM; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NERVE EXCITABILITY; NEUROMODULATION; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; SYMPATHETIC TONE; SYNAPTIC TRANSMISSION;

ACTION POTENTIALS; ANIMALS; AUTONOMIC PATHWAYS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARDIOVASCULAR PHYSIOLOGICAL PROCESSES; MALE; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SOLITARY NUCLEUS; SYNAPTIC TRANSMISSION;

EID: 80052180712     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0746-11.2011     Document Type: Article

References (34)

1. Alonso M, Vianna M, Izquierdo I, Medina J (2002) Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cell Mol Neurobiol 22:663-674.
2. Andresen MC, Kunze DL (1994) Nucleus tractus solitarius- gateway to neural circulatory control. Annu Rev Physiol 56:93-116.
3. Andresen MC, Yang M (1990) Non-NMDA receptors mediate sensory afferent synaptic transmission in medial nucleus tractus solitarius. Am J Physiol 259:H1307-H1311.
4. Aylwin ML, Horowitz JM, Bonham AC (1998) Non-NMDA and NMDA receptors in the synaptic pathway between area postrema and nucleus tractus solitarius. Am J Physiol 275:H1236-H1246.
5. Bailey T, Hermes S, Andresen M, Aicher S (2006) Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns. J Neurosci 26:11893-11902.
6. Balkowiec A, Katz DM (2000) Activity-dependent release of endogenousbrain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci 22:10399-10407.
7. Balkowiec A, Kunze DL, Katz DM (2000) Brain-derived neurotrophic fact acutely inhibits AMPA-mediated currents in developing sensory relay neurons. J Neurosci 20:1904-1911.
8. Brady R, Zaidi S, Mayer C, Katz DM (1999) BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 19:2131-2142.
9. Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S (1997) Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence of anterograde axonal transport. J Neurosci 17:2295-2313.
10. Doyle MW, Andresen MC (2001) Reliability of monosynaptic sensory transmission in brain stem neurons in vitro. J Neurophysiol 85:2213-2223.
11. Eckberg DL, Drabinsky M, Braunwald E (1971) Defective cardiac parasympathetic control in patients with heart disease. New Engl J Med 877-883.
12. Faraguna U, Vyazovkiy W, Nelson A, Tononi G, Cirelli C (2008) A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci 28:4088-4095.
13. Foley CM, Moffitt JA, Hay M, Hasser EM (1998) Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors. Am J Physiol 275:R1858-R1866.
14. Gordon FJ, Leone C (1989) Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius? J Pharmacol Exp Ther 250:953-962.
15. Husson I, Rangon C, Lelievre V, Bemelmans A, Sachs P, Mallet J, Kosofsky B, Gressens P (2005) BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cereb Cortex 15:250-261.
16. Jenkins V, Pricher M, O'Donaughty T, Hsieh HY, Brooks V, Balkowiec A (2007) Activity-dependent regulation of BDNF expression in nodose ganglia of DOCA-salt hypertensive rats. Soc Neurosci Abstr 33:139.11.
17. Jovanovic JN, Thomas P, Kittler JT, Smart TG, Moss SJ (2004) Brainderived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability. J Neurosci 24:522-530.
18. Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662.
19. Katz D, Dutschmann M, Ramirez J, Hilaire G (2009) Breathing disorders in Rett Syndrome: progressive neurochemical dysfunction in the respiratory network after birth. Respir Physiol Neurobiol 168:101-108.
20. Kline DD, Takacs KN, Ficker E, Kunze DL (2002) Dopamine modulates synaptic transmission in the nucleus of the solitary tract. J Neurophysiol 88:2736-2744.
21. Kline DD, Kunze DL, Katz DM (2010) Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice. J Neurosci 30:5303-5310.
22. La Rovere MT, Bigger JT, Marcus FI, Mortara A, Schwartz PJ (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351:478-484.
23. Martin J, Jenkins V, Hsieh H, Balkowiec A (2008) Brain-derived neurotrophic factor in arterial baroreceptor pathways: implications for activity-dependent plasticity at baroreceptor synapses. J Neurochem 108:450-464.
24. Mueller PJ, Hasser EM (2006) Putative role of the NTS in alterations in neural control of the circulation following exercise training in rats. Am J Physiol Regul Integr Comp Physiol 290:R383-R392.
25. Ogier M, Wang H, Hong E, Wang Q, Greenberg M, Katz D (2007) Brainderived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. J Neurosci 27:10912-10917.
26. Ohta H, Talman WT (1994) Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am J Physiol 267:R1065-R1070.
27. Pawloski-Dahm C, Gordon FJ (1992) Evidence for a kynurenateinsensitive glutamate receptor in nucleus tractus solitarii. AmJ Physiol 262:H1611-1615.
28. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. New York: Elsevier.
29. Sanchez A, Matthews B, Meynard M, Hu B, Javed S, Cohen Cory S (2006) BDNF increases synapse density in dendrites of developing tectal neurons in vivo. Development 133:2477-2486.
30. Wang H, Ward N, Boswell M, Katz DM (2006a) Secretion of brain-derived neurotrophic factor from brain microvascular endothelial cells. Eur J Neurosci 23:1665-1670.
31. Wang H, Chan SA, Ogier M, Hellard D, Wang Q, Smith C, Katz DM (2006b) Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2-null mice. J Neurosci 26:10911-10915.
32. Weese-Mayer DE, Lieske SP, Boothby CM, Kenny AS, Bennett HL, Silverstri JM, Ramirez JM (2006) Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome. Pediatr Res 4:443-449.
33. Zhang W, Mifflin S (2010) Plasticity of GABAergic mechanisms within the nucleus of the solitary tract in hypertension. Hypertension 201-206.
34. Zhou H, Helke C (1996) Presence and localization of neurotrophin receptor tyrosine kinase (TrkA, TrkB, TrkC) mRNAs in visceral afferent neurons of the nodose and petrosal ganglia. Brain Res Mol Brain Res 38:63-70.