메뉴 건너뛰기




Volumn 19, Issue 9, 2011, Pages 1796-1803

Orlistat 60mg reduces visceral adipose tissue: A 24-week randomized, placebo-controlled, multicenter trial

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TETRAHYDROLIPSTATIN; ANTIOBESITY AGENT; ENZYME INHIBITOR; LACTONE; TRIACYLGLYCEROL LIPASE;

EID: 80052160446     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.143     Document Type: Article
Times cited : (35)

References (33)
  • 1
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • DOI 10.1038/nature05488, PII NATURE05488
    • Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881-887. (Pubitemid 46024995)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 881-887
    • Despres, J.-P.1    Lemieux, I.2
  • 3
    • 55849106577 scopus 로고    scopus 로고
    • Role of body fat distribution and the metabolic complications of obesity
    • Jensen MD. Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab 2008;93:S57-S63.
    • (2008) J Clin Endocrinol Metab , vol.93
    • Jensen, M.D.1
  • 5
    • 34250198675 scopus 로고    scopus 로고
    • Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men
    • McMillan KP, Kuk JL, Church TS, Blair SN, Ross R. Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men. Appl Physiol Nutr Metab 2007;32:265-272.
    • (2007) Appl Physiol Nutr Metab , vol.32 , pp. 265-272
    • McMillan, K.P.1    Kuk, J.L.2    Church, T.S.3    Blair, S.N.4    Ross, R.5
  • 6
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • DOI 10.2337/db06-1656
    • Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007;56:1010-1013. (Pubitemid 46525079)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 7
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • DOI 10.1210/en.2003-0870
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-5165. (Pubitemid 37476041)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5159-5165
    • Unger, R.H.1
  • 9
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    • Fabbrini E, Magkos F, Mohammed BS et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009;106:15430-15435.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15430-15435
    • Fabbrini, E.1    Magkos, F.2    Mohammed, B.S.3
  • 11
    • 33749638780 scopus 로고    scopus 로고
    • Low-dose orlistat effects on body weight of mildly to moderately overweight individuals: A 16 week, double-blind, placebo-controlled trial
    • DOI 10.1345/aph.1H234
    • Anderson JW, Schwartz SM, Hauptman J et al. Low-dose orlistat effects on body weight of mildly to moderately overweight individuals: a 16 week, double-blind, placebo-controlled trial. Ann Pharmacother 2006;40: 1717-1723. (Pubitemid 44544866)
    • (2006) Annals of Pharmacotherapy , vol.40 , Issue.10 , pp. 1717-1723
    • Anderson, J.W.1    Schwartz, S.M.2    Hauptman, J.3    Boldrin, M.4    Rossi, M.5    Bansal, V.6    Hale, C.A.7
  • 12
    • 34548058704 scopus 로고    scopus 로고
    • Orlistat for the management of overweight individuals and obesity: A review of potential for the 60-mg, over-the-counter dosage
    • DOI 10.1517/14656566.8.11.1733
    • Anderson JW. Orlistat for the management of overweight individuals and obesity: a review of potential for the 60-mg, over-the-counter dosage. Expert Opin Pharmacother 2007;8:1733-1742. (Pubitemid 47288178)
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.11 , pp. 1733-1742
    • Anderson, J.W.1
  • 14
    • 80455174019 scopus 로고    scopus 로고
    • Pragmatic study of orlistat 60 mg on abdominal Obesity
    • in press
    • Thomas EL, Makwana A, Newbould R et al. Pragmatic study of orlistat 60 mg on abdominal Obesity. Eur J Clin Nutr 2011. (in press)
    • (2011) Eur J Clin Nutr
    • Thomas, E.L.1    Makwana, A.2    Newbould, R.3
  • 15
    • 80052162752 scopus 로고    scopus 로고
    • Orlistat reduces the visceral adipose tissue according to the central obesity grade
    • Bellido GD. Orlistat reduces the visceral adipose tissue according to the central obesity grade. Int J Obes 2007:S170
    • (2007) Int J Obes
    • Bellido, G.D.1
  • 18
    • 0034107084 scopus 로고    scopus 로고
    • Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    • Goodpaster BH, Thaete FL, Kelley DE. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 2000;71:885-892. (Pubitemid 30176569)
    • (2000) American Journal of Clinical Nutrition , vol.71 , Issue.4 , pp. 885-892
    • Goodpaster, B.H.1    Thaete, F.L.2    Kelley, D.E.3
  • 21
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • DOI 10.1007/BF00280883
    • Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28: 412-419. (Pubitemid 15018832)
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 23
    • 0032933425 scopus 로고    scopus 로고
    • Visceral adipose tissue: A critical review of intervention strategies
    • Smith SR, Zachwieja JJ. Visceral adipose tissue: a critical review of intervention strategies. Int J Obes Relat Metab Disord 1999;23: 329-335. (Pubitemid 29182389)
    • (1999) International Journal of Obesity , vol.23 , Issue.4 , pp. 329-335
    • Smith, S.R.1    Zachwieja, J.J.2
  • 24
  • 25
    • 0033629936 scopus 로고    scopus 로고
    • Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity
    • European Orlistat Obesity Study Group
    • Rössner S, Sjöström L, Noack R, Meinders AE, Noseda G. Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. European Orlistat Obesity Study Group. Obes Res 2000;8:49-61.
    • (2000) Obes Res , vol.8 , pp. 49-61
    • Rössner, S.1    Sjöström, L.2    Noack, R.3    Meinders, A.E.4    Noseda, G.5
  • 26
    • 0033646909 scopus 로고    scopus 로고
    • Effect of orlistat treatment on body composition and resting energy expenditure during a two-year weight-reduction programme in obese Finns
    • Karhunen L, Franssila-Kallunki A, Rissanen P et al. Effect of orlistat treatment on body composition and resting energy expenditure during a two-year weight-reduction programme in obese Finns. Int J Obes Relat Metab Disord 2000;24:1567-1572.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1567-1572
    • Karhunen, L.1    Franssila-Kallunki, A.2    Rissanen, P.3
  • 28
    • 42149186337 scopus 로고    scopus 로고
    • Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: Findings from a systematic review
    • DOI 10.1038/sj.ijo.0803761, PII 0803761
    • Chaston TB, Dixon JB. Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int J Obes (Lond) 2008;32:619-628. (Pubitemid 351536009)
    • (2008) International Journal of Obesity , vol.32 , Issue.4 , pp. 619-628
    • Chaston, T.B.1    Dixon, J.B.2
  • 30
  • 31
    • 68049120181 scopus 로고    scopus 로고
    • Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    • Schwenzer NF, Springer F, Schraml C et al. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009;51:433-445.
    • (2009) J Hepatol , vol.51 , pp. 433-445
    • Schwenzer, N.F.1    Springer, F.2    Schraml, C.3
  • 32
    • 12744262843 scopus 로고    scopus 로고
    • Identification of individuals with insulin resistance using routine clinical measurements
    • Stern SE, Williams K, Ferrannini E et al. Identification of individuals with insulin resistance using routine clinical measurements. Diabetes 2005;54:333-339.
    • (2005) Diabetes , vol.54 , pp. 333-339
    • Stern, S.E.1    Williams, K.2    Ferrannini, E.3
  • 33
    • 75749145838 scopus 로고    scopus 로고
    • Quantitative magnetic resonance (QMR) for longitudinal evaluation of body composition changes with two dietary regimens
    • Swe Myint K, Napolitano A, Miller SR et al. Quantitative magnetic resonance (QMR) for longitudinal evaluation of body composition changes with two dietary regimens. Obesity (Silver Spring) 2010;18: 391-396.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 391-396
    • Swe Myint, K.1    Napolitano, A.2    Miller, S.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.