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Volumn 118, Issue 8, 2011, Pages 2116-2127

IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR;

EID: 80052153064     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-08-302513     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 34250205544 scopus 로고    scopus 로고
    • The protean nature of cells in the B lymphocyte lineage
    • Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007;26(6):703-714.
    • (2007) Immunity , vol.26 , Issue.6 , pp. 703-714
    • Hardy, R.R.1    Kincade, P.W.2    Dorshkind, K.3
  • 2
    • 47249099558 scopus 로고    scopus 로고
    • B lymphocytes: How they develop and function
    • 2008
    • LeBien TW, Tedder TF. 2008. B lymphocytes: how they develop and function. Blood. 2008;112(5):1570-1580.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1570-1580
    • LeBien, T.W.1    Tedder, T.F.2
  • 3
    • 3242878308 scopus 로고    scopus 로고
    • Regulation of immunoglobulin heavy chain rearrangements
    • Chowdhury D, Sen R. Regulation of immunoglobulin heavy chain rearrangements. Immunol Rev. 2004;200:182-196.
    • (2004) Immunol Rev , vol.200 , pp. 182-196
    • Chowdhury, D.1    Sen, R.2
  • 4
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol. 2006;24:541-570.
    • (2006) Annu Rev Immunol , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 6
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors and regulation
    • Gellert M. V(D)J recombination: RAG proteins, repair factors and regulation. Annu Rev Biochem. 2002;71:101-132.
    • (2002) Annu Rev Biochem , vol.71 , pp. 101-132
    • Gellert, M.1
  • 7
    • 61349179407 scopus 로고    scopus 로고
    • Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling
    • Herzog S, Reth M, Jumaa H. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling. Nat Rev Immunol. 2009;9(3):195-205.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 195-205
    • Herzog, S.1    Reth, M.2    Jumaa, H.3
  • 8
    • 34250212629 scopus 로고    scopus 로고
    • The transcriptional regulation of B cell lineage commitment
    • Nutt SL, Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity. 2007;26(6):715-725.
    • (2007) Immunity , vol.26 , Issue.6 , pp. 715-725
    • Nutt, S.L.1    Kee, B.L.2
  • 9
    • 0032567938 scopus 로고    scopus 로고
    • Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    • Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 1998;391(6670):904-907.
    • (1998) Nature , vol.391 , Issue.6670 , pp. 904-907
    • Corcoran, A.E.1    Riddell, A.2    Krooshoop, D.3    Venkitaraman, A.R.4
  • 10
    • 23944495647 scopus 로고    scopus 로고
    • Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
    • Bertolino E, Reddy K, Medina KL, Parganas E, Ihle J, Singh H. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol. 2005;6(8):836-843.
    • (2005) Nat Immunol , vol.6 , Issue.8 , pp. 836-843
    • Bertolino, E.1    Reddy, K.2    Medina, K.L.3    Parganas, E.4    Ihle, J.5    Singh, H.6
  • 11
    • 18244386710 scopus 로고    scopus 로고
    • IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    • Kikuchi K, Lai AY, Hsu C-L, Kondo M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J Exp Med. 2005;201(8):1197-1203.
    • (2005) J Exp Med , vol.201 , Issue.8 , pp. 1197-1203
    • Kikuchi, K.1    Lai, A.Y.2    Hsu, C.-L.3    Kondo, M.4
  • 12
    • 14844345051 scopus 로고    scopus 로고
    • Cutting Edge: Stat5 mediates the IL-7-induced accessibility of a representative D-distal VH gene
    • 2005
    • Stanton ML, Brodeur PH. 2005. Cutting Edge: Stat5 mediates the IL-7-induced accessibility of a representative D-distal VH gene. J Immunol. 2005;174(6):3164-3168.
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3164-3168
    • Stanton, M.L.1    Brodeur, P.H.2
  • 13
    • 75649093758 scopus 로고    scopus 로고
    • Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    • Malin S, McManus S, Cobaleda C, et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 2010;11(2):171-179.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 171-179
    • Malin, S.1    McManus, S.2    Cobaleda, C.3
  • 14
    • 0034234756 scopus 로고    scopus 로고
    • Fates of human B-cell precursors
    • LeBien TW. Fates of human B-cell precursors. Blood. 2000;96(1):9-23.
    • (2000) Blood , vol.96 , Issue.1 , pp. 9-23
    • LeBien, T.W.1
  • 15
    • 2542461255 scopus 로고    scopus 로고
    • Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    • Buckley RH. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu Rev Immunol. 2004;22:625-655.
    • (2004) Annu Rev Immunol , vol.22 , pp. 625-655
    • Buckley, R.H.1
  • 16
    • 19944433384 scopus 로고    scopus 로고
    • Interleukin-7 receptor (IL-7Ralpha) deficiency; cellular and molecular bases: Analysis of clinical, immunological, and molecular features in 16 novel patients
    • Giliani S, Mori L, Basile GS, et al. Interleukin-7 receptor (IL-7Ralpha) deficiency; cellular and molecular bases: analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol Rev. 2005;203:110-126.
    • (2005) Immunol Rev , vol.203 , pp. 110-126
    • Giliani, S.1    Mori, L.2    Basile, G.S.3
  • 17
    • 28244453738 scopus 로고    scopus 로고
    • Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells
    • Johnson SE, Shah N, Panoskaltsis-Mortari A, LeBien TW. Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells. J Immunol. 2005;175(11):7325-7331.
    • (2005) J Immunol , vol.175 , Issue.11 , pp. 7325-7331
    • Johnson, S.E.1    Shah, N.2    Panoskaltsis-Mortari, A.3    LeBien, T.W.4
  • 18
    • 50949110014 scopus 로고    scopus 로고
    • IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors
    • Johnson SE, Shah N, Bajer AA, LeBien TW. IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors. J Immunol. 2008;180(12):8109-8117.
    • (2008) J Immunol , vol.180 , Issue.12 , pp. 8109-8117
    • Johnson, S.E.1    Shah, N.2    Bajer, A.A.3    LeBien, T.W.4
  • 19
    • 0030611385 scopus 로고    scopus 로고
    • Individual CD34+CD38lowCD19-CD10- Progenitor cells from human cord blood generate B-lymphocytes and granulocytes
    • Berardi AC, Meffre EF, Pflumio F, et al. Individual CD34+CD38lowCD19- CD10- progenitor cells from human cord blood generate B-lymphocytes and granulocytes. Blood. 1997;89(10):3554-3564.
    • (1997) Blood , vol.89 , Issue.10 , pp. 3554-3564
    • Berardi, A.C.1    Meffre, E.F.2    Pflumio, F.3
  • 20
    • 14444288760 scopus 로고    scopus 로고
    • A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5
    • Nishihara M, Wada Y, Ogami K, et al. A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5. Eur J Immunol. 1998;28(3):855-864.
    • (1998) Eur J Immunol , vol.28 , Issue.3 , pp. 855-864
    • Nishihara, M.1    Wada, Y.2    Ogami, K.3
  • 21
    • 0031944324 scopus 로고    scopus 로고
    • Culture system for extensive production of CD19+IgM+ cells by human cord blood CD34+ progenitors
    • Ohkawara JI, Ikebuchi K, Fujihara M, et al. Culture system for extensive production of CD19+IgM+ cells by human cord blood CD34+ progenitors. Leukemia. 1998;12(5):764-771.
    • (1998) Leukemia , vol.12 , Issue.5 , pp. 764-771
    • Ohkawara, J.I.1    Ikebuchi, K.2    Fujihara, M.3
  • 22
    • 0037438620 scopus 로고    scopus 로고
    • B lymphopoiesis is active throughout human life, but there are developmental age-related changes
    • Rossi MI, Yokota T, Medina KL, et al. B lymphopoiesis is active throughout human life, but there are developmental age-related changes. Blood. 2003;101(2):576-584.
    • (2003) Blood , vol.101 , Issue.2 , pp. 576-584
    • Rossi, M.I.1    Yokota, T.2    Medina, K.L.3
  • 23
    • 27144461642 scopus 로고    scopus 로고
    • Ig gene rearrangement steps are initiated in early human B cell precursor subsets and correlate with specific transcription factor expression
    • van Zelm MC, van der Burg M, de Ridder D, et al. Ig gene rearrangement steps are initiated in early human B cell precursor subsets and correlate with specific transcription factor expression. J Immunol. 2005;175(9):5912-5922.
    • (2005) J Immunol , vol.175 , Issue.9 , pp. 5912-5922
    • Van Zelm, M.C.1    Van Der Burg, M.2    De Ridder, D.3
  • 24
    • 0028878890 scopus 로고
    • The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34
    • Dittel BN, LeBien TW. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J Immunol. 1995;154(1):58-67.
    • (1995) J Immunol , vol.154 , Issue.1 , pp. 58-67
    • Dittel, B.N.1    LeBien, T.W.2
  • 25
    • 35748940965 scopus 로고    scopus 로고
    • Characterization of early stages of human B cell development by gene expression profiling
    • Hystad ME, Myklebust JH, Bo TH, et al. Characterization of early stages of human B cell development by gene expression profiling. J Immunol. 2007;179(6):3662-3671.
    • (2007) J Immunol , vol.179 , Issue.6 , pp. 3662-3671
    • Hystad, M.E.1    Myklebust, J.H.2    Bo, T.H.3
  • 26
    • 64249139290 scopus 로고    scopus 로고
    • IL-7 dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow
    • Parrish YK, Baez I, Milford T-A, et al. IL-7 dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow. J Immunol. 2009;182(7):4255-4266.
    • (2009) J Immunol , vol.182 , Issue.7 , pp. 4255-4266
    • Parrish, Y.K.1    Baez, I.2    Milford, T.-A.3
  • 27
    • 0033181326 scopus 로고    scopus 로고
    • Biased VH usage in early lineage human B cells: Evidence for preferential Ig gene rearrangement in the absence of selection
    • Rao SP, Riggs JM, Friedman DF, Scully MS, LeBien TW, Silberstein LE. Biased VH usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol. 1999;163(5):2732- 2740.
    • (1999) J Immunol , vol.163 , Issue.5 , pp. 2732-2740
    • Rao, S.P.1    Riggs, J.M.2    Friedman, D.F.3    Scully, M.S.4    LeBien, T.W.5    Silberstein, L.E.6
  • 28
    • 4644327999 scopus 로고    scopus 로고
    • Unraveling the consecutive recombination events in the human IGK locus
    • Langerak AW, Nadel B, De Torbal A, et al. Unraveling the consecutive recombination events in the human IGK locus. J Immunol. 2004;173(6):3878-3888.
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 3878-3888
    • Langerak, A.W.1    Nadel, B.2    De Torbal, A.3
  • 29
    • 0035865613 scopus 로고    scopus 로고
    • Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus
    • van der Burg M, Tumkaya T, Boerma M, de Bruin-Versteeg S, Langerak AW, van Dongen JJ. Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus. Blood. 2001;97(4):1001-1008.
    • (2001) Blood , vol.97 , Issue.4 , pp. 1001-1008
    • Van Der Burg, M.1    Tumkaya, T.2    Boerma, M.3    De Bruin-Versteeg, S.4    Langerak, A.W.5    Van Dongen, J.J.6
  • 30
    • 19344376101 scopus 로고    scopus 로고
    • Identification and characterization of circulating human transitional B cells
    • Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood. 2005;105(11):4390-4398.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4390-4398
    • Sims, G.P.1    Ettinger, R.2    Shirota, Y.3    Yarboro, C.H.4    Illei, G.G.5    Lipsky, P.E.6
  • 31
    • 13244275244 scopus 로고    scopus 로고
    • Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells
    • Sayegh T, Jhunjhunwala S, Riblet R, Murre C. Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Genes Dev. 2005;19(3):322-327.
    • (2005) Genes Dev , vol.19 , Issue.3 , pp. 322-327
    • Sayegh, T.1    Jhunjhunwala, S.2    Riblet, R.3    Murre, C.4
  • 32
    • 41949121201 scopus 로고    scopus 로고
    • 3D-Architecture of the immunoglobulin heavy chain locus: Implications for long-range genomic interactions
    • Jhunjhunwala S, van Zelm MC, Peak MM, et al. 3D-Architecture of the immunoglobulin heavy chain locus: implications for long-range genomic interactions. Cell. 2008;133(2):265-279.
    • (2008) Cell , vol.133 , Issue.2 , pp. 265-279
    • Jhunjhunwala, S.1    Van Zelm, M.C.2    Peak, M.M.3
  • 33
    • 0037023361 scopus 로고    scopus 로고
    • Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    • Kosak ST, Skok JA, Medina KL, et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science. 2002;296(5565):158- 162.
    • (2002) Science , vol.296 , Issue.5565 , pp. 158-162
    • Kosak, S.T.1    Skok, J.A.2    Medina, K.L.3
  • 34
    • 12344270023 scopus 로고    scopus 로고
    • Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavychain gene
    • Roldán E, Fuxa M, Chong W, et al. Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavychain gene. Nat Immunol. 2005;6(1):31-41.
    • (2005) Nat Immunol , vol.6 , Issue.1 , pp. 31-41
    • Roldán, E.1    Fuxa, M.2    Chong, W.3
  • 35
    • 0034787189 scopus 로고    scopus 로고
    • Detection of illegitimate rearrangement within the immunoglobulin locus on 14q32.3 in B-cell malignancies using end-sequenced probes
    • Poulsen TS, Silahtaroglu AN, Gisselø CG, et al. Detection of illegitimate rearrangement within the immunoglobulin locus on 14q32.3 in B-cell malignancies using end-sequenced probes. Genes Chromosomes Cancer. 2001;32(3):265-274
    • (2001) Genes Chromosomes Cancer , vol.32 , Issue.3 , pp. 265-274
    • Poulsen, T.S.1    Silahtaroglu, A.N.2    Gisselø, C.G.3
  • 36
    • 77953494012 scopus 로고    scopus 로고
    • Bcl-6 is critical for the development of a diverse primary B cell repertoire
    • Duy C, Yu JJ, Nahar R, et al. Bcl-6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 2010;207(6):1209-1221.
    • (2010) J Exp Med , vol.207 , Issue.6 , pp. 1209-1221
    • Duy, C.1    Yu, J.J.2    Nahar, R.3
  • 37
    • 0029812552 scopus 로고    scopus 로고
    • Interleukin 7 independent development of human B cells
    • Prieyl JA, LeBien TW. Interleukin 7 independent development of human B cells. Proc Natl Acad Sci U S A. 1996;93(19):10348-10353.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.19 , pp. 10348-10353
    • Prieyl, J.A.1    LeBien, T.W.2
  • 38
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbánek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell. 1994;79(5):901-912.
    • (1994) Cell , vol.79 , Issue.5 , pp. 901-912
    • Urbánek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 39
    • 1542343974 scopus 로고    scopus 로고
    • Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
    • Fuxa M, Slok J, Souabni A, Salvagiotto G, Roldan E, Busslinger M. Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev. 2004;18(4):411-422.
    • (2004) Genes Dev , vol.18 , Issue.4 , pp. 411-422
    • Fuxa, M.1    Slok, J.2    Souabni, A.3    Salvagiotto, G.4    Roldan, E.5    Busslinger, M.6
  • 40
    • 33744462581 scopus 로고    scopus 로고
    • Transcription factor Pax5 (BSAP) transactivates the RAG-mediated VH-to-DJH rearrangement of immunoglobulin genes
    • Zhang Z, Espinoza CR, Yu Z et al. Transcription factor Pax5 (BSAP) transactivates the RAG-mediated VH-to-DJH rearrangement of immunoglobulin genes. Nat Immunol. 2006;7(6):616-624.
    • (2006) Nat Immunol , vol.7 , Issue.6 , pp. 616-624
    • Zhang, Z.1    Espinoza, C.R.2    Yu, Z.3
  • 41
    • 0024553137 scopus 로고
    • Light chain gene expression before heavy chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus
    • Kubagawa H, Cooper MD, Carroll AJ, Burrows PD. Light chain gene expression before heavy chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus. Proc Natl Acad Sci U S A. 1989;86(7):2356-2360.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.7 , pp. 2356-2360
    • Kubagawa, H.1    Cooper, M.D.2    Carroll, A.J.3    Burrows, P.D.4
  • 42
    • 0033521627 scopus 로고    scopus 로고
    • Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice
    • Novobrantseva TI, Martin VM, Pelanda R, Muller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999;189(1):75-88.
    • (1999) J Exp Med , vol.189 , Issue.1 , pp. 75-88
    • Novobrantseva, T.I.1    Martin, V.M.2    Pelanda, R.3    Muller, W.4    Rajewsky, K.5    Ehlich, A.6
  • 44
    • 32544448486 scopus 로고    scopus 로고
    • IL-7: A key regulator of B lymphopoiesis
    • Milne CD, Paige CJ. IL-7: a key regulator of B lymphopoiesis. Semin Immunol. 2006;18(1):20-30.
    • (2006) Semin Immunol , vol.18 , Issue.1 , pp. 20-30
    • Milne, C.D.1    Paige, C.J.2
  • 45
    • 33846632842 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression: Intelligent design
    • Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol. 2007;7(2):144-154.
    • (2007) Nat Rev Immunol , vol.7 , Issue.2 , pp. 144-154
    • Mazzucchelli, R.1    Durum, S.K.2
  • 46
    • 0033871151 scopus 로고    scopus 로고
    • E2A and EBF act in synergy with the V (D) J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
    • Romanow WJ, Langerak AW, Goebel P, et al. E2A and EBF act in synergy with the V (D) J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol Cell. 2000;5(2):343-353.
    • (2000) Mol Cell , vol.5 , Issue.2 , pp. 343-353
    • Romanow, W.J.1    Langerak, A.W.2    Goebel, P.3
  • 47
    • 56349127778 scopus 로고    scopus 로고
    • Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    • Dengler HS, Barocho GV, Omori SA, et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol. 2008;9(12):1388-1398.
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1388-1398
    • Dengler, H.S.1    Barocho, G.V.2    Omori, S.A.3
  • 48
    • 44049091757 scopus 로고    scopus 로고
    • Foxo1 directly regulates the transcription of recombination activating genes during B cell development
    • Amin RH, Schlissel MS. Foxo1 directly regulates the transcription of recombination activating genes during B cell development. Nat Immunol. 2008;9(6):613-622.
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 613-622
    • Amin, R.H.1    Schlissel, M.S.2
  • 49
    • 0035890244 scopus 로고    scopus 로고
    • Stepwise activation of the immunoglobulin mu heavy chain gene locus
    • Chowdhury D, Sen R. Stepwise activation of the immunoglobulin mu heavy chain gene locus. EMBO J. 2001;20(22):6394-6403.
    • (2001) EMBO J , vol.20 , Issue.22 , pp. 6394-6403
    • Chowdhury, D.1    Sen, R.2
  • 50
    • 74549117108 scopus 로고    scopus 로고
    • Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy
    • Sportès C, Babb RR, Krumlauf MC, et al. Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy. Clin Cancer Res. 2010;16(2):727-735.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 727-735
    • Sportès, C.1    Babb, R.R.2    Krumlauf, M.C.3


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