Reducing noninfectious risks of blood transfusion

Anesthesiology

Volumn 115, Issue 3, 2011, Pages 635-649

  Gilliss, Brian M ^a   Looney, Mark R ^b   Gropper, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cardiovascular Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD TRANSFUSION; BLOOD TRANSFUSION REACTION; CAUSE OF DEATH; ERYTHROCYTE LIFESPAN; ERYTHROCYTE PRESERVATION; EVIDENCE BASED PRACTICE; FEBRILE TRANSFUSION REACTION; GRAFT VERSUS HOST REACTION; HUMAN; HYPOTENSIVE TRANSFUSION REACTION; MICROCHIMERISM; MORBIDITY; MORTALITY; NONHUMAN; PLASMA; POSTTRANSFUSION PURPURA; PRIORITY JOURNAL; PRURITUS; REVIEW; RISK ASSESSMENT; SCREENING TEST; TRANSFUSION ASSOCIATED CIRCULATORY OVERLOAD; TRANSFUSION RELATED ACUTE KIDNEY INJURY; TRANSFUSION RELATED ACUTE LUNG INJURY; TRANSFUSION RELATED IMMUNOMODULATION; UNITED STATES; UNIVERSAL LEUKOREDUCTION; URTICARIA;

EID: 80052149875     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31822a22d9     Document Type: Review

References (90)

1. Toner RW, Pizzi L, Leas B, Ballas SK, Quigley A, Goldfarb NI: Costs to hospitals of acquiring and processing blood in the US: A survey of hospital-based blood banks and transfusion services. Appl Health Econ Health Policy 2011; 9:29-37
2. Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR: Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 2010; 50:753-765
3. Dodd RY, Notari EP 4th, Stramer SL: Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion 2002; 42:975-979
4. Liumbruno GM, Catalano L, Piccinini V, Pupella S, Grazzini G: Reduction of the risk of bacterial contamination of blood components through diversion of the first part of the donation of blood and blood components. Blood Transfus 2009; 7:86-93
5. Brecher ME, Hay SN: Bacterial contamination of blood components. Clin Microbiol Rev 2005; 18:195-204 (Pubitemid 40170668)
6. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, Meier-Hellmann A, Nollet G, Peres-Bota D, ABC (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
7. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, MacIntyre NR, Shabot MM, Duh MS, Shapiro MJ: The CRIT Study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States. Crit Care Med 2004; 32:39-52 (Pubitemid 38125561)
8. Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA, American College of Critical Care Medicine of the Society of Critical Care Medicine, Eastern Association for the Surgery of Trauma Practice Management Workgroup: Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009; 37:3124-3157
9. Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340:409-417 (Pubitemid 29084771)
10. Wu WC, Rathore SS, Wang Y, Radford MJ, Krumholz HM: Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 2001; 345:1230-1236 (Pubitemid 34951486)
11. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL, International Surviving Sepsis Campaign Guidelines Committee, American Association of Critical-Care Nurses, American College of Chest Physicians, American College of Emergency Physicians, Canadian Critical Care Society, European Society of Clinical Microbiology and Infectious Diseases, European Society of Intensive Care Medicine, European Respiratory Society, International Sepsis Forum, Japanese Association for Acute Medicine, Japanese Society of Intensive Care Medicine, Society of Critical Care Medicine, Society of Hospital Medicine, Surgical Infection Society, World Federation of Societies of Intensive and Critical Care Medicine: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
12. Roback JD, Caldwell S, Carson J, Davenport R, Drew MJ, Eder A, Fung M, Hamilton M, Hess JR, Luban N, Perkins JG, Sachais BS, Shander A, Silverman T, Snyder E, Tormey C, Waters J, Djulbegovic B, American Association for the Study of Liver, American Academy of Pediatrics, United States Army, American Society of Anesthesiology, American Society of Hematology: Evidence-based practice guidelines for plasma transfusion. Transfusion 2010; 50:1227-1239
13. Sihler KC, Napolitano LM: Massive transfusion: New insights. Chest 2009; 136:1654-1667
14. Sihler KC, Napolitano LM: Complications of massive transfusion. Chest 2010; 137:209-220
15. Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G, Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Work Group: Recommendations for the transfusion of plasma and platelets. Blood Transfus 2009; 7:132-150
16. Slichter SJ: Evidence-based platelet transfusion. Hematology Am Soc Hematol Educ Program 2007:172-178
17. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM: Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: A meta-analysis. JAMA 2008; 299: 2304-2312 (Pubitemid 351724397)
18. Geiger TL, Howard SC: Acetaminophen and diphenhydramine premedication for allergic and febrile nonhemolytic transfusion reactions: Good prophylaxis or bad practice? Transfus Med Rev 2007; 21:1-12 (Pubitemid 44881259)
19. Hendrickson JE, Hillyer CD: Noninfectious serious hazards of transfusion. Anesth Analg 2009; 108:759-769
20. Vamvakas EC, Blajchman MA: Universal WBC reduction: The case for and against. Transfusion 2001; 41:691-712 (Pubitemid 32845014)
21. Hébert PC, Fergusson D, Blajchman MA, Wells GA, Kmetic A, Coyle D, Heddle N, Germain M, Goldman M, Toye B, Schweitzer I, vanWalraven C, Devine D, Sher GD, Leukoreduction Study Investigators: Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA 2003; 289:1941-1949 (Pubitemid 37430225)
22. Wang SE, Lara PN Jr, Lee-Ow A, Reed J, Wang LR, Palmer P, Tuscano JM, Richman CM, Beckett L, Wun T: Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double-blind placebo-controlled trial. Am J Hematol 2002; 70:191-194 (Pubitemid 34680679)
23. Sanders RP, Maddirala SD, Geiger TL, Pounds S, Sandlund JT, Ribeiro RC, Pui CH, Howard SC: Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol 2005; 130:781-787
24. Kennedy LD, Case LD, Hurd DD, Cruz JM, Pomper GJ: A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion 2008; 48:2285-2291
25. Martí-Carvajal AJ, Solà I, Gonzàlez LE, Leon de Gonzalez G, Rodriguez-Malagon N: Pharmacological interventions for the prevention of allergic and febrile non-haemolytic transfusion reactions. Cochrane Database Syst Rev 2010; 16(6): CD007539
26. Gajic O, Gropper MA, Hubmayr RD: Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med 2006; 34:S109-113 (Pubitemid 43670476)
27. Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD. Blood Banking and Transfusion Medicine: Basic Principles and Practice, 2nd edition. Philadelphia, Churchill Livingstone Elsevier, 2007, pp 678-679
28. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D, National Heart, Lung and Blood Institute Working Group on TRALI: Transfusion-related acute lung injury: Definition and review. Crit Care Med 2005; 33:721-726
29. Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S, Meade M, Morrison D, Pinsent T, Robillard P, Slinger P: Toward an understanding of transfusion-related acute lung injury: Statement of a consensus panel. Transfusion 2004; 44:1774-1789 (Pubitemid 39644064)
30. Palfi M, Berg S, Ernerudh J, Berlin G: A randomized controlled trial of transfusion-related acute lung injury: Is plasma from multiparous blood donors dangerous? Transfusion 2001; 41:317-322 (Pubitemid 32238527)
31. Gajic O, Yilmaz M, Iscimen R, Kor DJ, Winters JL, Moore SB, Afessa B: Transfusion from male-only versus female donors in critically ill recipients of high plasma volume components. Crit Care Med 2007; 35:1645-1648 (Pubitemid 46985863)
32. Wright SE, Snowden CP, Athey SC, Leaver AA, Clarkson JM, Chapman CE, Roberts DR, Wallis JP: Acute lung injury after ruptured abdominal aortic aneurysm repair: The effect of excluding donations from females from the production of fresh frozen plasma. Crit Care Med 2008; 36:1796-1802
33. Silliman CC: The two-event model of transfusion-related acute lung injury. Crit Care Med 2006; 34:S124-131 (Pubitemid 43670479)
34. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA: Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 2009; 119:3450-3461
35. Eder AF, Herron RM Jr, Strupp A, Dy B, White J, Notari EP, Dodd RY, Benjamin RJ: Effective reduction of transfusionrelated acute lung injury risk with male-predominant plasma strategy in the American Red Cross (2006-2008). Transfusion 2010; 50:1732-1742
36. Vamvakas EC, Pineda AA, Reisner R, Santrach PJ, Moore SB: The differentiation of delayed hemolytic and delayed serologic transfusion reactions: Incidence and predictors of hemolysis. Transfusion 1995; 35:26-32
37. Opelz G, Sengar DP, Mickey MR, Terasaki PI: Effect of blood transfusions on subsequent kidney transplants. Transplant Proc 1973; 5:253-259
38. Klein HG: Immunomodulatory aspects of transfusion: A once and future risk? Anesthesiology 1999; 91:861-865 (Pubitemid 29418669)
39. Opelz G, Vanrenterghem Y, Kirste G, Gray DW, Horsburgh T, Lachance JG, Largiader F, Lange H, Vujaklija-Stipanovic K, Alvarez-Grande J, Schott W, Hoyer J, Schnuelle P, Descoeudres C, Ruder H, Wujciak T, Schwarz V: Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 1997; 63:964-967 (Pubitemid 27173018)
40. Vamvakas EC, Blajchman MA: Transfusion-related immunomodulation (TRIM): An update. Blood Rev 2007; 21:327-348 (Pubitemid 47498679)
41. Gantt CL: Red blood cells for cancer patients. Lancet 1981; 2(8242):363
42. Kaplan J, Sarnaik S, Gitlin J, Lusher J: Diminished helper/suppressor lymphocyte ratios and natural killer activity in recipients of repeated blood transfusions. Blood 1984; 64: 308-310 (Pubitemid 14083893)
43. Castillo JJ, Dalia S, Pascual SK: Association between red blood cell transfusions and development of non-Hodgkin lymphoma: A meta-analysis of observational studies. Blood 2010; 116:2897-2907
44. Busch OR, Hop WC, Hoynck van Papendrecht MA, Marquet RL, Jeekel J: Blood transfusions and prognosis in colorectal cancer. N Engl J Med 1993; 328:1372-1376 (Pubitemid 23131389)
45. Houbiers JG, Brand A, van de Watering LM, Hermans J, Verwey PJ, Bijnen AB, Pahlplatz P, Eeftinck Schattenkerk M, Wobbes T, de Vries JE: Randomised controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancer. Lancet 1994; 344: 573-578 (Pubitemid 24267215)
46. Heiss MM, Mempel W, Delanoff C, Jauch KW, Gabka C, Mempel M, Dieterich HJ, Eissner HJ, Schildberg FW: Blood transfusion-modulated tumor recurrence: First results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. J Clin Oncol 1994; 12:1859-1867 (Pubitemid 24349388)
47. Utter GH, Reed WF, Lee TH, Busch MP: Transfusion-associated microchimerism. Vox Sang 2007; 93:188-195 (Pubitemid 47373988)
48. Sweeney JD, Dupuis MP, Mega AP: Hypotensive reactions to red cells filtered at the bedside, but not to those filtered before storage, in patients taking ACE inhibitors. Transfusion 1998; 38:410-411
49. Shiba M, Tadokoro K, Sawanobori M, Nakajima K, Suzuki K, Juji T: Activation of the contact system by filtration of platelet concentrates with a negatively charged white cell-removal filter and measurement of venous blood bradykinin level in patients who received filtered platelets. Transfusion 1997; 37:457-462 (Pubitemid 27203932)
50. Cyr M, Eastlund T, Blais C Jr, Rouleau JL, Adam A: Bradykinin metabolism and hypotensive transfusion reactions. Transfusion 2001; 41:136-150 (Pubitemid 32143749)
51. Anderson KC, Goodnough LT, Sayers M, Pisciotto PT, Kurtz SR, Lane TA, Anderson CS, Silberstein LE: Variation in blood component irradiation practice: Implications for prevention of transfusion-associated graft-versus-host disease. Blood 1991; 77:2096-2102
52. Habib RH, Zacharias A, Schwann TA, Riordan CJ, Engoren M, Durham SJ, Shah A: Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: Implications on operative outcome. Crit Care Med 2005; 33:1749-1756 (Pubitemid 41153700)
53. Huybregts RA, de Vroege R, Jansen EK, van Schijndel AW, Christiaans HM, van Oeveren W: The association of hemodilution and transfusion of red blood cells with biochemical markers of splanchnic and renal injury during cardiopulmonary bypass. Anesth Analg 2009; 109:331-339
54. O'Keeffe SD, Davenport DL, Minion DJ, Sorial EE, Endean ED, Xenos ES: Blood transfusion is associated with increased morbidity and mortality after lower extremity revascularization. J Vasc Surg 2010; 51:616-621
55. Shaz BH, Hillyer CD: Is there transfusion-related acute renal injury? Anesthesiology 2010; 113:1012-1013
56. Dzik WH: Leukoreduction of blood components. Curr Opin Hematol 2002; 9:521-526 (Pubitemid 35191123)
57. Kopko PM, Holland PV: Universal leukocyte reduction. Curr Opin Hematol 2000; 7:397-401
58. Sweeney JD: Universal leukoreduction of cellular blood components in 2001? Yes. Am J Clin Pathol 2001; 115:666-673 (Pubitemid 33051532)
59. Blumberg N, Fine L, Gettings KF, Heal JM: Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions. Transfusion 2005; 45:1632-1639
60. Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB: An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions. Transfusion 2010; 50:2738-2744
61. Englehart MS, Cho SD, Morris MS, Gee AC, Riha G, Underwood SJ, Differding JA, Luem ND, Wiesberg TT, Boshkov LK, Schreiber MA: Use of leukoreduced blood does not reduce infection, organ failure, or mortality following trauma. World J Surg 2009; 33:1626-1632
62. Llewelyn CA, Taylor RS, Todd AA, Stevens W, Murphy MF, Williamson LM, Leucodepletion Study Group: The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery. Transfusion 2004; 44:489-500 (Pubitemid 38437583)
63. Vamvakas EC: Why have meta-analyses of randomized controlled trials of the association between non-white-bloodcell-reduced allogeneic blood transfusion and postoperative infection produced discordant results? Vox Sang 2007; 93: 196-207 (Pubitemid 47373992)
64. Bilgin YM, van de Watering LM, Eijsman L, Versteegh MI, Brand R, van Oers MH, Brand A: Double-blind, randomized controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery. Circulation 2004; 109:2755-2760 (Pubitemid 38744552)
65. Blumberg N, Zhao H, Wang H, Messing S, Heal JM, Lyman GH: The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients. Transfusion 2007; 47:573-581 (Pubitemid 46449617)
66. Fergusson D, Khanna MP, Tinmouth A, Hébert PC: Transfusion of leukoreduced red blood cells may decrease postoperative infections: Two meta-analyses of randomized controlled trials. Can J Anaesth 2004; 51:417-424
67. Vamvakas EC: White-blood-cell-containing allogeneic blood transfusion and postoperative infection or mortality: An updated meta-analysis. Vox Sang 2007; 92:224-232 (Pubitemid 46365029)
68. Fergusson D, Aaron SD, Guyatt G, Hébert P: Post-randomisation exclusions: The intention to treat principle and excluding patients from analysis. BMJ 2002; 325:652-654
69. Kunz R, Guyatt G: Which patients to include in the analysis? Transfusion 2006; 46:881-884 (Pubitemid 43800904)
70. Popovsky MA, Moore SB: Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion 1985; 25:573-577 (Pubitemid 16174471)
71. Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA: Transfusion-related acute lung injury: Report of a clinical look-back investigation. JAMA 2002; 287:1968-1971 (Pubitemid 34309755)
72. Fadeyi EA, De Los Angeles Muniz M, Wayne AS, Klein HG, Leitman SF, Stroncek DF: The transfusion of neutrophilspecific antibodies causes leukopenia and a broad spectrum of pulmonary reactions. Transfusion 2007; 47:545-550
73. Chapman CE, Williamson LM: National Blood Service TRALI Reduction Policies: Implementation and effect. Transfus Med Hemother 2008; 35:93-6 (Pubitemid 351555899)
74. Welsby IJ, Troughton M, Phillips-Bute B, Ramsey R, Campbell ML, Bandarenko N, Mathew JP, Stafford-Smith M, Cardiothoracic Anesthesiology Research Endeavors: The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery. J Thorac Cardiovasc Surg 2010; 140:1353-1360
75. Zimrin AB, Hess JR: Current issues relating to the transfusion of stored red blood cells. Vox Sang 2009; 96:93-103
76. Bennett-Guerrero E, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, Mulherin MA, Zhu H, Buck RD, Califf RM, McMahon TJ: Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci 2007; 104:17063-7068 (Pubitemid 350210992)
77. Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH: Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008; 358:1229-1239 (Pubitemid 351439224)
78. Leal-Noval SR, Jara-López I, García-Garmendia JL, Marín-Niebla A, Herruzo-Avilés A, Camacho-Laraña P, Loscertales J: Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology 2003; 98:815-822 (Pubitemid 36373213)
79. Vamvakas EC, Carven JH: Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: Effect of the length of storage of transfused red cells. Transfusion 1999; 39:701-710 (Pubitemid 29328482)
80. Vamvakas EC, Carven JH: Length of storage of transfused red cells and postoperative morbidity in patients undergoing coronary artery bypass graft surgery. Transfusion 2000; 40: 101-109 (Pubitemid 30053552)
81. Purdy FR, Tweeddale MG, Merrick PM: Association of mortality with age of blood transfused in septic ICU patients. Can J Anesth 1997; 44:1256-1261 (Pubitemid 28080688)
82. Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999; 178:570-572 (Pubitemid 30058313)
83. Yap CH, Lau L, Krishnaswamy M, Gaskell M, Yii M: Age of transfused red cells and early outcomes after cardiac surgery. Ann Thorac Surg 2008; 86:554-559 (Pubitemid 351978040)
84. van de Watering L, Lorinser J, Versteegh M, Westendord R, Brand A: Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006; 46:1712-1718 (Pubitemid 44435723)
85. Mynster T, Nielsen HJ, Danish RANX05 Colorectal Cancer Study Group: Storage time of transfused blood and disease recurrence after colorectal cancer surgery. Dis Colon Rectum 2001; 44:955-964 (Pubitemid 32652718)
86. Edgren G, Hjalgrim H, Tran TN, Rostgaard K, Shanwell A, Titlestad K, Jakobsson L, Gridley G, Wideroff L, Jersild C, Adami J, Melbye M, Reilly M, Nyrén O: A population-based binational register for monitoring long-term outcome and possible disease concordance among blood donors and recipients. Vox Sang 2006; 91:316-323 (Pubitemid 44720166)
87. Palmieri TL, Lee T, O'Mara MS, Greenhalgh DG: Effects of a restrictive blood transfusion policy on outcomes in children with burn injury. J Burn Care Res 2007; 28:65-70 (Pubitemid 46087858)
88. Despotis GJ, Grishaber JE, Goodnough LT: The effect of an intraoperative treatment algorithm on physicians' transfusion practice in cardiac surgery. Transfusion 1994; 34:290-296 (Pubitemid 24136183)
89. Gonzalez-Porras JR, Colado E, Conde MP, Lopez T, Nieto MJ, Corral M: An individualized pre-operative blood saving protocol can increase pre-operative haemoglobin levels and reduce the need for transfusion in elective total hip or knee arthroplasty. Transfus Med 2009; 19:35-42
90. Cook DJ, Montori VM, McMullin JP, Finfer SR, Rocker GM: Improving patients' safety locally: Changing clinician behaviour. Lancet 2004; 363:1224-1230 (Pubitemid 38481851)