Sample dispersion in isotachophoresis

Journal of Fluid Mechanics

Volumn 679, Issue , 2011, Pages 455-475

  Garcia Schwarz, G ^a   Bercovici, M ^b   Marshall, L A ^a   Santiago, J G ^a  

^a Stanford University   (United States)

^b Stanford University   (United States)

Author keywords

MHD and electrohydrodynamics; microfluidics

Indexed keywords

ANALYTICAL MODELS; ELECTROHYDRODYNAMICS; ELECTROLYTES; ELECTROMIGRATION; ELECTROOSMOSIS; ELECTROPHORESIS; FLOW OF FLUIDS; MICROFLUIDICS; PRESSURE GRADIENT;

CONCENTRATION FIELDS; CONTROLLED EXPERIMENT; EFFECTIVE DISPERSION COEFFICIENT; ELECTROOSMOTIC FLOW; FUNDAMENTAL MECHANISMS; NUMERICAL AND EXPERIMENTAL STUDY; ONE DIMENSIONAL ANALYTICAL MODEL; SAMPLE DISTRIBUTIONS;

DISPERSIONS;

COMPUTER SIMULATION; FLOW MODELING; FLUID FLOW; FLUID MECHANICS; MAGNETOHYDRODYNAMICS; PRESSURE GRADIENT;

EID: 80052149715     PISSN: 00221120     EISSN: 14697645     Source Type: Journal    
DOI: 10.1017/jfm.2011.139     Document Type: Article

References (33)

1. Alberty, R. A. 1950 Moving boundary systems formed by weak electrolytes. Theory of simple systems formed by weak acids and bases. J. Am. Chem. Soc. 72 (6), 2361-2367.
2. Anderson, J. L. & Idol, W. K. 1985 Electroosmosis through pores with nonuniformly charged walls. Chem. Engng Commun. 38 (3), 93.
3. Aris, R. 1956 On the dispersion of a solute in a fluid flowing through a tube. Proc. R. Soc. Lond. A 235 (1200), 67-77.
4. Bahga, S. S., Bercovici, M. & Santiago, J. G. 2010 Ionic strength effects on electrophoretic focusing and separations. Electrophoresis 31 (5), 910-919.
5. Bharadwaj, R., Huber, D. E, Khurana, T. & Santiago, J. G. 2008 Taylor dispersion in sample preconcentration methods. In Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, pp. 1085-1120. CRC Press.
6. Chen, C.-H., Lin, H., Lele, S. K. & Santiago, J. G. 2005 Convective and absolute electrokinetic instability with conductivity gradients. J. Fluid Mech. 524, 263-303. (Pubitemid 40350643)
7. Everaerts, F. M., Beckers, J. L. & Verheggen, T. P. E. M. 1976 Isotachophoresis: Theory, Instrumentation, and Applications. Elsevier.
8. Gebauer, P., Malá, Z. & Bociek, P. 2007 Recent progress in capillary ITP. Electrophoresis 28 (1-2), 26-32. (Pubitemid 46178947)
9. Ghosal, S. 2002 Band broadening in a microcapillary with a stepwise change in the zeta-potential. Anal. Chem. 74 (16), 4198-4203. (Pubitemid 34912922)
10. Herr, A. E., Molho, J. I., Santiago, J. G., Mungal, M. G., Kenny, T. W. & Garguilo, M. G. 2000 Electroosmotic capillary flow with nonuniform zeta potential. Anal. Chem. 72 (5), 1053-1057. (Pubitemid 30127414)
11. Hirokawa, T., Nishino, M., Aoki, N., Kiso, Y., Sawamoto, Y., Yagi, T. & Akiyama, J. I 1983 Table of isotachophoretic indices. I. Simulated qualitative and quantitative indices of 287 anionic substances in the range pH 3-10. J. Chromatogr. A 271 (2), D1-D106.
12. Jaros, M., Hruska, V., Stedrỳ, M., Zusková, I. & Gas, B. 2004 Eigenmobilities in background electrolytes for capillary zone electrophoresis. IV. Computer program peakmaster. Electrophoresis 25 (18-19), 3080-3085. (Pubitemid 39480872)
13. Jovin, T. M. 1973 Multiphasic zone electrophoresis. I. Steady-state moving-boundary systems formed by different electrolyte combinations. Biochemistry 12 (5), 871-879.
14. Khurana, T. K. & Santiago, J. G. 2008 Sample zone dynamics in peak mode isotachophoresis. Anal. Chem. 80 (16), 6300-6307.
15. Khurana, T. K & Santiago, J. G. 2009 Effects of carbon dioxide on peak mode isotachophoresis: simultaneous preconcentration and separation. Lab Chip 9 (10), 1377-1384.
16. Kirby, B. J. & Hasselbrink, E. F. 2004 Zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations. Electrophoresis 25 (2), 187-202. (Pubitemid 38219784)
17. K̈ohlrausch, F. 1897 Uber concentrations-verschiebungen durch electrolyse im inneren von lösungen und lösungsgemischen. Ann. Phys. 298 (10), 209-239.
18. Konstantinov, B. P. & Oshurkova, O. V. 1966 Instrument for analyzing electrolyte solutions by ionic mobilities. Sov. Phys.-Tech. Phys. 11 (5), 693-704.
19. Lin, H., Storey, B. D., Oddy, M. H., Chen, C.-H. & Santiago, J. G. 2004 Instability of electrokinetic microchannel flows with conductivity gradients. Phys. Fluids 16 (6), 1922.
20. MacInnes, D. A. & Longsworth, L. G. 1932 Transference numbers by the method of moving boundaries. Chem. Rev. 11 (2), 171-230.
21. Martin, A. J. P. & Everaerts, F. M. 1970 Displacement electrophoresis. Proc. R. Soc. Lond. A 316 (1527), 493-514.
22. Martin, M. M. & Lindqvist, L. 1975 The pH dependence of fluorescein fluorescence. J. Lumin. 10 (6), 381-390.
23. Mchedlov-Petrossyan, N. O., Kukhtik, V. I. & Alekseeva, V. I. 1994 Ionization and tautomerism of fluorescein, rhodamine b, n,n-diethylrhodol and related dyes in mixed and nonaqueous solvents. Dyes Pigment. 24 (1), 11-35.
24. Persat, A. & Santiago, J. G. 2009 Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis. New J. Phys. 11 (7), 075026.
25. Probstein, R. F. 1994 Physicochemical Hydrodynamics: An Introduction. Wiley-Interscience.
26. Santiago, J. G. 2001 Electroosmotic flows in microchannels with finite inertial and pressure forces. Anal. Chem. 73 (10), 2353-2365. (Pubitemid 32880705)
27. Santos, J. J. & Storey, B. D. 2008 Instability of electro-osmotic channel flow with streamwise conductivity gradients. Phys. Rev. E 78 (4), 46316.
28. Saville, D. A. 1990 The effects of electroosmosis on the structure of isotachophoresis boundaries. Electrophoresis 11 (11), 899-902.
29. Saville, D. A. & Palusinski, O. A. 1986 Theory of electrophoretic separations. Part I. Formulation of a mathematical model. AIChE J. 32 (2), 207-214.
30. Schönfeld, F., Goet, G., Baier, T. & Hardt, S. 2009 Transition zone dynamics in combined isotachophoretic and electro-osmotic transport. Phys. Fluids 21 (9), 092002.
31. Shakalisava, Y., Poitevin, M., Viovy, J. L. & Descroix, S. 2009 Versatile method for electroosmotic flow measurements in microchip electrophoresis. J. Chromatogr. A 1216 (6), 1030-1033.
32. Sounart, T. L. & Baygents, J. C. 2007 Lubrication theory for electro-osmotic flow in a non-uniform electrolyte. J. Fluid Mech. 576, 139-172. (Pubitemid 47039345)
33. Taylor, G. 1953 Dispersion of soluble matter in solvent flowing slowly through a tube. Proc. R. Soc. Lond. A 219 (1137), 186-203.