Low-density lipoprotein lowering does not improve calf muscle perfusion, energetics, or exercise performance in peripheral arterial disease

Journal of the American College of Cardiology

Volumn 58, Issue 10, 2011, Pages 1068-1076

  West, Amy M ^a   Anderson, Justin D ^a   Epstein, Frederick H ^b,c   Meyer, Craig H ^b,c   Wang, Hongkun ^d   Hagspiel, Klaus D ^a,b   Berr, Stuart S ^b,c   Harthun, Nancy L ^e   Weltman, Arthur L ^a   Dimaria, Joseph M ^b   Hunter, Jennifer R ^b   Christopher, John M ^b   Kramer, Christopher M ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c University of Virginia   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

lipids; magnetic resonance imaging; peripheral vascular disease

Indexed keywords

ACETYLSALICYLIC ACID PLUS CLOPIDOGREL; ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLESTEROL; CREATINE PHOSPHATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; FIBRIC ACID DERIVATIVE; FISH OIL; GADOLINIUM; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MEVINOLIN; NICOTINIC ACID; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL;

6 MINUTE WALK TEST; ADULT; AGED; ANKLE BRACHIAL INDEX; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; ENERGY EXPENDITURE; ENERGY TRANSFER; EXERCISE; FEMALE; FUNCTIONAL ASSESSMENT; GASTROCNEMIUS MUSCLE; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MUSCLE EXERCISE; MUSCLE PERFUSION; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREADMILL EXERCISE; TRIACYLGLYCEROL BLOOD LEVEL; WALKING;

AGED; ANTICHOLESTEREMIC AGENTS; AZETIDINES; CHOLESTEROL, LDL; ENERGY METABOLISM; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HUMANS; LEG; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PERIPHERAL ARTERIAL DISEASE; PHOSPHOCREATINE; SIMVASTATIN;

EID: 80052080530     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.04.034     Document Type: Article

References (33)

1. B.A. Golomb, T.T. Dang, and M.H. Criqui Peripheral arterial disease: morbidity and mortality implications Circulation 114 2006 688 699 (Pubitemid 44252311)
2. M.M. McDermott, K. Liu, and P. Greenland Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms JAMA 292 2004 453 461 (Pubitemid 38988954)
3. W.R. Hiatt Medical treatment of peripheral arterial disease and claudication N Engl J Med 344 2001 1608 1621 (Pubitemid 32479915)
4. H.H.H. Feringa, S.E. Karagiannis, and V.H. van Waning The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease J Vasc Surg 45 2007 936 943 (Pubitemid 46661787)
5. A.T. Hirsch, Z.J. Haskal, and N.R. Hertzer ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary J Am Coll Cardiol 47 2006 1239 1312
6. E.R. Mohler III, W.R. Hiatt, M.A. Creager Study Investigators Cholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease Circulation 108 2003 1481 1486 (Pubitemid 37176455)
7. M.M. McDermott, J.M. Guralnik, and P. Greenland Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease Circulation 107 2003 757 761 (Pubitemid 36222606)
8. C. Gagne, H.E. Bays, and S.R. Weiss Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia Am J Cardiol 90 2002 1084 1091 (Pubitemid 35339435)
9. J.J.P. Kastelein, F. Akdim, and E.S.G. Stroes Simvastatin with or without ezetimibe in familial hypercholesterolemia N Engl J Med 358 2008 1431 1443 (Pubitemid 351482735)
10. A.J. Taylor, T.C. Villines, and E.J. Stanek Extended-release niacin or ezetimibe and carotid intima-media thickness N Engl J Med 361 2009 2113 2122
11. J.L. Fleg, M. Mete, and B.V. Howard Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial J Am Coll Cardiol 52 2008 2198 2205
12. J.D. Anderson, F.H. Epstein, and C.H. Meyer Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism J Am Coll Cardiol 54 2009 628 634
13. M. Takemoto, and J.K. Liao Pleiotropic effects of 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitors Arterioscler Thromb Vasc Biol 21 2001 1712 1719 (Pubitemid 34219772)
14. A.M. West, J.D. Anderson, and C.H. Meyer The effect of ezetimibe on peripheral arterial atherosclerosis depends upon timing of statin initiation Atherosclerosis 2011 In press
15. D.C. Isbell, F.H. Epstein, and X. Zhong Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first pass contrast-enhanced magnetic resonance imaging J Magn Reson Imaging 25 2007 1013 1020 (Pubitemid 46697572)
16. D.C. Isbell, S.S. Berr, and A.Y. Toledano Delayed calf muscle phosphocreatine recovery after exercise identifies peripheral arterial disease J Am Coll Cardiol 47 2006 2289 2297
17. A.W. Gardner, J.S. Skinner, B.W. Cantwell, and L.K. Smith Progressive vs. single-stage treadmill tests for evaluation of claudication Med Sci Sports Exerc 23 1991 402 408
18. H.W. Kohl, S.N. Blair, R.S. Paffenbarger, C.A. Macera, and J.J. Kronefeld A mail survey of physical activity habits as related to measured physical fitness Am J Epidemiol 127 1988 1228 1239
19. J.F. Sallis, W.L. Haskell, and P.D. Wood Physical activity assessment methodology in the Five-City Project Am J Epidemiol 21 1985 91 106 (Pubitemid 15150692)
20. B.E. Ainsworth, W.L. Haskell, and M.C. Whitt Compendium of physical activities: an update of activity codes and MET intensities Med Sci Sports Exerc 32 2000 S498 S516
21. W.S. Aronow, and C. Ahn Frequency of new coronary events in older persons with peripheral arterial disease and serum low-density lipoprotein cholesterol >125 mg/dl treated with statins versus no lipid-lowering drug Am J Cardiol 90 2002 789 791 (Pubitemid 35279409)
22. T.R. Pedersen, J. Kjekshus, and K. Pyorala Effect of simvastatin on ischemic signs and symptoms in the Scandinavian Simvastatin Survival Study (4S) Am J Cardiol 81 1998 333 335 (Pubitemid 28099310)
23. Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 2002 7 22
24. G.J. Hankey, P.E. Norman, and J.W. Eikelboom Medical treatment of peripheral arterial disease JAMA 295 2006 547 553 (Pubitemid 43200349)
25. J.G. Regensteiner, and K.J. Stewart Established and evolving medical therapies for claudication in patients with peripheral arterial disease Nat Clin Pract Cardiovasc Med 3 2006 604 610 (Pubitemid 44636907)
26. S.E. Hoeks, W.J.M. Scholte op Reimer, and Y.R.B.M. van Gestel Medication underuse during long-term follow-up in patients with peripheral arterial disease Circ Cardiovasc Qual Outcomes 2 2009 338 343
27. J. Giri, M.M. McDermott, and P. Greenland Statin use and functional decline in patients with and without peripheral arterial disease J Am Coll Cardiol 47 2006 998 1004
28. W.R. Hiatt, A.T. Hirsch, and M.A. Creager Effect of niacin ER/lovastatin on claudication symptoms in patients with peripheral artery disease Vasc Med 15 2010 171 179
29. S. Spring, R. Simon, and B. van der Loo High-dose atorvastatin in peripheral arterial disease (PAD): effect on endothelial function, intima-media-thickness and local progression of PAD An open randomized controlled pilot trial J Thromb Haemost 99 2008 182 189
30. S.E. Nissen, E.M. Tuzcu, and P. Schoenhagen Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial JAMA 291 2004 1071 1080 (Pubitemid 38541684)
31. B. Pitt, D. Waters, and W.V. Brown Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease N Engl J Med 341 1999 70 76 (Pubitemid 29314237)
32. W.C. Wu, E. Mohler III, and S.J. Ratcliffe Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging J Am Coll Cardiol 53 2009 2372 2377
33. H. Ledermann, A.C. Schulte, and H.G. Heidecker Blood oxygenation level-dependent magnetic resonance imaging of the skeletal muscle in patients with peripheral arterial occlusive disease Circulation 113 2006 2929 2935 (Pubitemid 44297234)