Hematogones in immune thrombocytopenic purpura: Diagnostic implication

Turkish Journal of Pediatrics

Volumn 53, Issue 2, 2011, Pages 219-224

  Akyay, Arzu ^a   Falay, Mesude ^b   Öztürkmen, Seda ^a   Biçakci, Zafer ^a   Tavil, Betül ^a   Ozet, Gülsüm ^b   Olcay, Lale ^a  

^a Training and Research Hospital   (Turkey)

^b ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Hematogones; Immune thrombocytopenic purpura; Myelodysplastic syndrome

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; FIBRINOGEN RECEPTOR; HEMOGLOBIN; HLA DR ANTIGEN; METHYLPREDNISOLONE;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BASOPHIL; BODY RASH; BONE MARROW BIOPSY; BONE MARROW EXAMINATION; CASE REPORT; CLINICAL FEATURE; DRUG MEGADOSE; ECCHYMOSIS; EOSINOPHIL; ERYTHROBLAST; ERYTHROID CELL; FEMALE; FLOW CYTOMETRY; HEMATOCRIT; HEMATOGONES; HUMAN; HUMAN TISSUE; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INFANT; LEUKOCYTE COUNT; LEUKOCYTE DISORDER; LYMPHOCYTE COUNT; MALE; MEGAKARYOCYTE; MEGALOCYTOSIS; MICROSCOPY; MONOCYTE; MYELODYSPLASTIC SYNDROME; NEUTROPHIL COUNT; PERIODIC ACID SCHIFF STAIN; PETECHIA; PHYSICAL EXAMINATION; PROMYELOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADOLESCENT; B-LYMPHOCYTES; FEMALE; HUMANS; INFANT; MALE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 80052076395     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Fisgin T, Yarali N, Duru F, Kara A. CMV-induced immune thrombocytopenia and excessive hematogones mimicking an acute B-precursor lymphoblastic leukemia. Leuk Res 2003; 27: 93-96.
2. Koca E, Buyukasik Y, Cetiner D, et al. Copper deficiency with increased hematogones mimicking refractory anemia with excess blasts. Leuk Res 2008; 32: 495-499.
3. Rimsza LM, Larson RS, Winter SS, et al. Benign hematogone-rich lymphoid proliferations can be distinguished from B-lineage acute lymphoblastic leukemia by integration of morphology, immunophenotype, adhesion molecule expression, and architectural features. Am J Clin Pathol 2000; 114: 66-75.
4. van Wering ER, van der Linden-Schrever BE, Szczepanski T, et al. Regenerating normal B-cell precursors during and after treatment of acute lymphoblastic leukaemia: implications for monitoring of minimal residual disease. Br J Haematol 2000; 110: 139-146.
5. Hasle H, Niemeyer CM, Chessells JM, et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia 2003; 17: 277-282.
6. Özsoylu Ş, Şayli TR, Öztürk G. Oral megadose methylprednisolone versus intravenous immunoglobulin for acute childhood idiopathic thrombocytopenic purpura. Pediatr Hematol Oncol 1993; 10: 317-321.
7. McKenna RW, Asplund SL, Kroft SH. Immunophenotypic analysis ofhematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry. Leuk Lymphoma 2004; 45: 277-285.
8. Foucar K. Bone Marrow Pathology. Chicago: ASCP Press; 1994: 229-273.
9. Longacre TA, Foucar K, Crago S, et al. Hematogones: a multiparameter analysis of bone marrow precursor cells. Blood 1989; 73: 543-552.
10. Pagliuca A. Clinicomorphological features of myelodysplastic syndromes. In: Mufti GJ, Galton DA (eds). The Myelodysplastic Syndromes. Edinburg: Churchill Livingstone; 1992: 1-13.
11. Kroft SH, Asplund SL, McKenna RW, Karandikar NJ. Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients. Br J Haematol 2004; 126: 209-212.
12. Olcay L, Tuncer AM, Okur H, et al. Excessive naked megakaryocyte nuclei in myelodysplastic syndrome mimicking idiopathic thrombocytopenic purpura: a complicated pre and post-transplantation course. Pediatr Hematol Oncol 2009; 26: 387-397.
13. Olcay L, Yetgin S, Okur H, Erekul S, Tuncer M. Dysplastic changes in idiopathic thrombocytopenic purpura and the effect of corticosteroids to increase dysplasia and cause hyperdiploid macropolycytes. Am J Hematol 2000; 65: 99-104.