HER2 expression in breast cancer cells is downregulated upon active targeting by antibody-engineered multifunctional nanoparticles in mice

ACS Nano

Volumn 5, Issue 8, 2011, Pages 6383-6393

  Corsi, Fabio ^a   Fiandra, Luisa ^a   De Palma, Clara ^a   Colombo, Miriam ^a,b   Mazzucchelli, Serena ^a   Verderio, Paolo ^b   Allevi, Raffaele ^a   Tosoni, Antonella ^a   Nebuloni, Manuela ^a   Clementi, Emilio ^a,c   Prosperi, Davide ^b,d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c SCIENTIFIC INSTITUTE   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

breast cancer; imaging; ligand receptor recognition; magnetic nanoparticles; theranostic agent; tumor targeting

Indexed keywords

BREAST CANCER; LIGAND-RECEPTOR; MAGNETIC NANOPARTICLES; THERANOSTIC AGENT; TUMOR TARGETING;

ANTIBODIES; CELL MEMBRANES; DISEASES; MAGNETIC RESONANCE IMAGING; MAMMALS; MOLECULAR BIOLOGY; NANOCRYSTALS; NANOPARTICLES; RESONANCE; TUMORS;

NANOMAGNETICS;

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MONOCLONAL ANTIBODY; NANOPARTICLE; TRASTUZUMAB;

ANIMAL; ARTICLE; BREAST TUMOR; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; ENGINEERING; FEMALE; GENETICS; HUMAN; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL LINE, TUMOR; DOWN-REGULATION; ENGINEERING; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; NANOPARTICLES; RECEPTOR, ERBB-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052069976     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn201570n     Document Type: Article

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