Synthesis and structure of fluorescent chelate boron complexes of 4-anilinomethylidene-1-benzazepine-2,5-dione ligands

Synthesis

Volumn , Issue 17, 2011, Pages 2848-2858

  Tolle, Nadine ^a   Dunkel, Ute ^a   Oehninger, Luciano ^a   Ott, Ingo ^a   Preu, Lutz ^a   Haase, Tobias ^a   Behrends, Soenke ^a   Jones, Peter G ^a   Totzke, Frank ^b   Schächtele, Christoph ^b   Kubbutat, Michael H G ^b   Kunick, Conrad ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b PROQINASE GMBH   (Germany)

Author keywords

boron; chelates; lactams; ligands; spectroscopy

Indexed keywords

ARYL RINGS; BORON CHELATES; BORON TRIFLUORIDE ETHERATE; CHELATES; COMPOUND DISTRIBUTIONS; CONFOCAL LASER MICROSCOPY; DIMETHYLSULFOXIDE SOLUTIONS; FLUORESCENT PROPERTY; HETEROCYCLIC RINGS; KINASE INHIBITORS; LACTAMS; TRIPHENYLBORANE; X RAY STRUCTURE ANALYSIS;

AMIDES; BORON; BORON COMPOUNDS; ELECTRONIC PROPERTIES; ETHERS; FLUORESCENCE; LIGANDS;

CHELATION;

4 (2 TOLUIDINOMETHYLIDENE) 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 (4 TOLUIDINOMETHYLIDENE) 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 (ANILINOMETHYLIDENE) 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 (ANILINOMETHYLIDENE) 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE DERIVATIVE; 4 [(2 CHLOROANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(2 METHOXYANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(3 METHOXYANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(3,5 DICHLOROANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(4 ETHOXYANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(4 ETHYLANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(4 IODOANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(4 METHOXYANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(4 NITROANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [(DIMETHYLAMINO)METHYLIDENE] 7 IODO 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 [[4 (TRIFLUOROMETHYL)ANILINO]METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; 4 ANILINOMETHYLIDENE 1 BENZAZEPINE 2,5 DIONE DERIVATIVE; 7 IODO 4 [(2 METHOXYANILINO)METHYLIDENE] 3,4 DIHYDRO 1H 1 BENZAZEPINE 2,5 DIONE; BORON DERIVATIVE; DIFLUORO [(4) 4 [(PHENYLAMINO KAPPA N)METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [(PHENYLAMINO KAPPA N)METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON DERIVATIVE; DIFLUORO [(4) 4 [[2 CHLORO(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 (TRIFLUOROMETHYL)(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 ETHOXY(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 ETHYL(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 IODO(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 METHOXY(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 METHYL(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; DIFLUORO [(4) 4 [[4 NITRO(PHENYLAMINO KAPPA N)]METHYLIDENE] 3,4 DIHYDRO 1H 1BENZAZEPINE 2,5 DIONATO KAPPA O5] BORON; ENZYME INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CHEMICAL REACTION; COLON CANCER; CONCENTRATION RESPONSE; CRYSTALLIZATION; DIASTEREOISOMER; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

EID: 80052060639     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260165     Document Type: Article

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