Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells

Lasers in Surgery and Medicine

Volumn 43, Issue 7, 2011, Pages 548-556

  Ziegler, Verena G ^a   Knaup, Julia ^a   Stahl, Dorothea ^b,c   Krammer, Barbara ^a   Plaetzer, Kristjan ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c Haema AG   (Germany)

Author keywords

aminolevulinic acid (ALA); circulating tumor cell (CTC); fluorescence diagnosis (FD); photodynamic therapy (PDT); protoporphyrin IX (PPIX)

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; BREAST CANCER; CANCER CELL CULTURE; CELL ASSAY; CELL SPECIFICITY; CELL VIABILITY; CIRCULATING TUMOR CELL; COCULTURE; CONTROLLED STUDY; DEPLETION; ENDOTHELIUM CELL; ERYTHROCYTE; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; TUMOR ESCAPE; TUMOR RECURRENCE;

ADENOCARCINOMA; AMINOLEVULINIC ACID; ANIMALS; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; ENDOTHELIAL CELLS; ERYTHROCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKOCYTES, MONONUCLEAR; NEOPLASTIC CELLS, CIRCULATING; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; RATS;

EID: 80052058791     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.21089     Document Type: Article

References (25)

1. Riethdorf S, Pantel K,. Disseminated tumor cells in bone marrow and circulating tumor cells in blood of breast cancer patients: Current state of detection and characterization. Pathobiology 2008; 75 (2): 140-148. (Pubitemid 351820732)
2. Graves H, Czerniecki BJ,. Circulating tumor cells in breast cancer patients: An evolving role in patient prognosis and disease progression. Patholog Res Int 2011; 2011: 621090.
3. Pantel K, Brakenhoff RH,. Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4 (6): 448-456. (Pubitemid 38745530)
4. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massague J,. Tumor self-seeding by circulating cancer cells. Cell 2009; 139 (7): 1315-1326.
5. Mocellin S, Keilholz U, Rossi CR, Nitti D,. Circulating tumor cells: The 'leukemic phase' of solid cancers. Trends Mol Med 2006; 12 (3): 130-139.
6. Mostert B, Sleijfer S, Foekens JA, Gratama JW,. Circulating tumor cells (CTCs): Detection methods and their clinical relevance in breast cancer. Cancer Treat Rev 2009; 35 (5): 463-474.
7. Peng Q, Berg K, Moan J, Kongshaug M, Nesland JM,. 5-Aminolevulinic acid-based photodynamic therapy: Principles and experimental research. Photochem Photobiol 1997; 65 (2): 235-251. (Pubitemid 27158805)
8. Zenzen V, Zankl H,. In vitro evaluation of the cytotoxic and mutagenic potential of the 5-aminolevulinic acid hexylester-mediated photodynamic therapy. Mutat Res 2004; 561 (1-2): 91-100. (Pubitemid 38845057)
9. Krammer B, Plaetzer K,. ALA and its clinical impact, from bench to bedside. Photochem Photobiol Sci 2008; 7 (3): 283-289. (Pubitemid 351501306)
10. Grebenova D, Cajthamlova H, Bartosova J, Marinov J, Klamova H, Fuchs O, Hrkal Z,. Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX. J Photochem Photobiol B 1998; 47 (1): 74-81. (Pubitemid 29060528)
11. Levy JG, Dowding C, Mitchell D, Sorrenti R, Yip S, Jamieson C,. Selective elimination of malignant stem cells using photosensitizers followed by light treatment. Stem Cells 1995; 13 (4): 336-343.
12. Trannoy LL, Lagerberg JW, Dubbelman TM, Schuitmaker HJ, Brand A,. Positively charged porphyrins: A new series of photosensitizers for sterilization of RBCs. Transfusion 2004; 44 (8): 1186-1196. (Pubitemid 38989751)
13. Greenwood J, Pryce G, Devine L, Male DK, dos Santos WL, Calder VL, Adamson P,. SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics. J Neuroimmunol 1996; 71 (1-2): 51-63. (Pubitemid 26413256)
14. Kubin A, Loew HG, Burner U, Jessner G, Kolbabek H, Wierrani F,. How to make hypericin water-soluble. Pharmazie 2008; 63 (4): 263-269. (Pubitemid 351543023)
15. Datasheet: LED-r5ca 5111 p; Roithner Lasertechnik. 2010.
16. O'Brien J, Wilson I, Orton T, Pognan F,. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 2000; 267 (17): 5421-5426.
17. R-Development-Core-Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2010.
18. Berlanda J, Kiesslich T, Oberdanner CB, Obermair FJ, Krammer B, Plaetzer K,. Characterization of apoptosis induced by photodynamic treatment with hypericin in A431 human epidermoid carcinoma cells. J Environ Pathol Toxicol Oncol 2006; 25 (1-2): 173-188. (Pubitemid 43341239)
19. Braun S, Kentenich C, Janni W, Hepp F, de Waal J, Willgeroth F, Sommer H, Pantel K,. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 2000; 18 (1): 80-86. (Pubitemid 30036339)
20. Schwalbe MPK, Höffken K, Clement JH,. Improvement of the separation of tumour cells from peripheral blood cells using magnetic nanoparticles. J Phys: Condens Matter 2006; 18: 2865-2876.
21. Clement JH, Schwalbe M, Buske N, Wagner K, Schnabelrauch M, Gornert P, Kliche KO, Pachmann K, Weitschies W, Hoffken K,. Differential interaction of magnetic nanoparticles with tumor cells and peripheral blood cells. J Cancer Res Clin Oncol 2006; 132 (5): 287-292.
22. Bissonnette R, Zeng H, McLean DI, Korbelik M, Lui H,. Oral aminolevulinic acid induces protoporphyrin IX fluorescence in psoriatic plaques and peripheral blood cells. Photochem Photobiol 2001; 74 (2): 339-345.
23. Grubinger M, Hammerl P, Banieghbal E, Krammer B,. Accumulation if aminolevulinic acid-induced protoporphyrin IX as a photosensitizer in L-929cells. Res Adv Photochem Photobiol 2000; 1: 137-145.
24. Gamaleia NF, Shishko ED, Gluzman DF, Sklyarenko LM,. Sensitivity of normal and malignant human lymphocytes to 5-aminolevulinic acid-mediated photodynamic damage. Exp Oncol 2008; 30 (1): 65-69. (Pubitemid 351518107)
25. Fuchs J, Weber S, Kaufmann R,. Genotoxic potential of porphyrin type photosensitizers with particular emphasis on 5-aminolevulinic acid: Implications for clinical photodynamic therapy. Free Radic Biol Med 2000; 28 (4): 537-548. (Pubitemid 30136035)