Major birth defects after exposure to newer-generation antiepileptic drugs [2]

JAMA

Volumn 306, Issue 8, 2011, Pages 826-827

  Tomson, Torbjörn ^a   Battino, Dina ^b   Perucca, Emilio ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; GABAPENTIN; TOPIRAMATE; VALPROIC ACID;

BIRTH DEFECT; DRUG SAFETY; FIRST TRIMESTER PREGNANCY; HUMAN; LETTER; LIVE BIRTH; MONOTHERAPY; PRENATAL DRUG EXPOSURE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; ADULT; COHORT ANALYSIS; CONGENITAL MALFORMATION; DENMARK; FEMALE; NOTE; PREGNANCY; REGISTER; REPRODUCIBILITY; STATISTICAL ANALYSIS; STATISTICS; EPIDEMIOLOGY; EPILEPSY; SAMPLE SIZE;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANTICONVULSANTS; COHORT STUDIES; DATA INTERPRETATION, STATISTICAL; DENMARK; FEMALE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; REGISTRIES; REPRODUCIBILITY OF RESULTS; CONFOUNDING FACTORS (EPIDEMIOLOGY); EPILEPSY; SAMPLE SIZE;

EID: 80052057436     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2011.1185     Document Type: Letter

References (5)

1. Mølgaard-Nielsen D, Hviid A. Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA. 2011;305(19):1996-2002.
2. Tomson T, Battino D, Craig J, et al; ILAE Commission on Therapeutic Strategies. Pregnancy registries: differences, similarities, and possible harmonization. Epilepsia. 2010;51(5):909-915.
3. Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry. 2006;77(2):193-198. (Pubitemid 43220841)
4. Holmes LB, Mittendorf R, Shen A, Smith CR, Hernandez-Diaz S. Fetal effects of anticonvulsant polytherapies: different risks from different combinations [published online June 13, 2011]. Arch Neurol. doi:10.1001/ archneurol.2011.113.
5. Veiby G, Daltveit AK, Engelsen BA, Gilhus NE. Pregnancy, delivery, and outcome for the child in maternal epilepsy. Epilepsia. 2009;50(9):2130-2139.