Mobilisation of hematopoietic CD34 + precursor cells in patients with acute stroke is safe - results of an open-labeled non randomized phase I/II trial

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Boy, Sandra ^a   Sauerbruch, Sophie ^a   Kraemer, Mathias ^b   Schormann, Thorsten ^c   Schlachetzki, Felix ^a   Schuierer, Gerhard ^a   Luerding, Ralph ^a   Hennemann, Burkhard ^a   Orso, Evelyn ^a   Dabringhaus, Andreas ^d   Winkler, Jürgen ^a   Bogdahn, Ulrich ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b Neurological Therapy Center   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d St Mauritius Therapy Clinic   (Germany)

^e Regeneration in Acute Ischemic Stroke) Study Group

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; HEPARIN; INSULIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; CD34 ANTIGEN;

ACUTE ISCHEMIC STROKE; ADULT; AGED; ARTICLE; ATTENTION; BARTHEL INDEX; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN ATROPHY; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG MONITORING; DRUG SAFETY; DRUG WITHDRAWAL; ERYTHROCYTE SEDIMENTATION RATE; FATIGUE; FEMALE; FIBRINOLYTIC THERAPY; FINGER SPAN TEST; GRAY MATTER; HEART RATE; HEMATOPOIETIC CD34+ STEM CELL; HEMATOPOIETIC STEM CELL; HEMIPARESIS; HEMIPLEGIA; HEMISPHERE; HUMAN; INTELLIGENCE QUOTIENT; INTRACRANIAL PRESSURE; LEUKOCYTOSIS; LONG TERM MEMORY; MALE; MIDDLE CEREBRAL ARTERY; MITRAL VALVE REGURGITATION; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NAUSEA; NEUROPSYCHOLOGICAL TEST; NONVERBAL COMMUNICATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; REY COMPLEX FIGURE COPY; REY COMPLEX FIGURE DELAY; RUFF 2 AND 7 TEST; SIDE EFFECT; STEM CELL MOBILIZATION; THROMBOCYTOPENIA; TRAIL MAKING TEST A; TRAIL MAKING TEST B; TREATMENT DURATION; VERBAL MEMORY; VISION; VOMITING; VOXEL BASED MORPHOMETRY; WECHSLER MEMORY SCALE; WHITE MATTER; WORKING MEMORY; BIOASSAY; CLINICAL TRIAL; INTENTION TO TREAT ANALYSIS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR; STROKE; TIME; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD34; COGNITION; ENDPOINT DETERMINATION; FEMALE; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 80052051110     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023099     Document Type: Article

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