Acute and sub-acute toxicity of the methanolic extract of Pteleopsis hylodendron stem bark

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 70-76

  Nana, H Magnifouet ^a   Ngane, R A Ngono ^b   Kuiate, J R ^a   Mogtomo, L M Koanga ^b   Tamokou, J D ^a   Ndifor, F ^b   Mouokeu, R S ^a   Etame, R M Ebelle ^a   Biyiti, L ^c   Zollo, P H Amvam ^c  

^a UNIVERSITY OF DSCHANG   (Cameroon)

^b UNIVERSITY OF DOUALA   (Cameroon)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

Acute and sub acute toxicity; Hematological and biochemical parameters; Methanolic extract; Pteleopsis hylodendron

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; HIGH DENSITY LIPOPROTEIN; PLANT EXTRACT; PTELEOPSIS HYLODENDRON EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ARTICLE; BARK; BIOCHEMISTRY; CHRONIC TOXICITY; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE COUNT; FEMALE; GROWTH RETARDATION; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; INFLAMMATION; LD 50; LEUKOCYTE COUNT; MALE; MOUSE; NONHUMAN; PLANT; PLANT STEM; PTELEOPSIS HYLODENDRON; RAT;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; BODY WEIGHT; CAMEROON; COMBRETACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; EATING; FEMALE; KIDNEY; LETHAL DOSE 50; LIVER; MALE; MEDICINE, AFRICAN TRADITIONAL; METHANOL; MICE; ORGAN SIZE; PLANT BARK; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; RISK ASSESSMENT; SOLVENTS; TIME FACTORS; TOXICITY TESTS, ACUTE; TOXICITY TESTS, SUBACUTE;

HYLODENDRON; MUS; PTELEOPSIS; RATTUS;

EID: 80052030804     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.04.032     Document Type: Article

References (24)

1. C. Ashley Renal failure: how drugs can damage the kidney Royal Free Hamstead NHS Trust 11 2004 48 53 (Pubitemid 38724223)
2. Atta-Ur-Rahman, M.I. Choudhary, F.N. Ngounou, S. Malik, S. Zareen, R. Ali, D. Lontsi, and B.L. Sondengam New antioxidant and antimicrobial ellagic acid derivates from Pteleopsis hylodendron Planta Medica 67 2001 335 339 (Pubitemid 32588569)
3. O. Bever Medicinal Plants in Tropical West Africa 1986 Cambridge University Press New-York 376 p.
4. B. Behrens, and G. Karber Mathematics for Naturalists and Agriculturalists 1983 PWN Warszawa 218 p.
5. J. Delongeas, D. Burnel, P. Netter, M. Grignon, J. Mor, R. Royer, and G. Grignon Toxicité et Pharmacocinétique de l'oxychlorure de zirconium chez les rats Journal of Pharmacology 14 1983 437 447 (Pubitemid 14185568)
6. D. Gatsing, R. Aliyu, J.R. Kuiate, I.H. Garba, K.H. Jaryum, N. Tedongmo, F.M. Tchouanguep, and G.I. Adogo Toxicological evaluation of the extract of Allium sativum bulbs on laboratory mice and rats Cameroon Journal of Experimental Biology 1 2005 39 45
7. A.G. Gornall, G.S. Bardwill, and M.M. David Determination of serum proteins by means of the biuret reaction Journal of Biological Chemistry 177 1949 751 766
8. F.B. Hu, M.J. Stampfer, E. Rimm, A. Wolk, G.A. Colditz, C.H. Hennekens, and W.C. Willet A prospective study of egg consumption and risk of cardiovascular disease in Men and Women Journal of the American Medical Association 281 1999 1387 1394 (Pubitemid 29190216)
9. F.R. Irvin Woody Plants of Ghana 1961 Oxford University press London pp. 129-130
10. T. Kobayashi, and S. Narumiya Function of prostanoid receptors: studies on knockout mice Prostaglandins Other Lipid Mediators 68-69 2002 557 573 (Pubitemid 35247420)
11. J. Koolman, and K.H. Röhm Atlas de poche de Biochimie 3me ed. 2004 Flammarion Médecine-Sciences Paris 480 p.
12. J.R. Kuiate, J.M. Bessiere, Z.P. Amvam, and S.P. Kuate Chemical composition and antidermatophytic properties of volatiles fractions of hexanic extract from leaves of Cupressus lusitanica Mill from Cameroun Flavour and Fragrance Journal 26 2005 693 697 (Pubitemid 44083815)
13. A.H. Loh, and A.H. Cohen Drug induced kidney disease - pathology and current concepts Annals Academy of Medicine 38 2009 240 250
14. E.N. Marieb Anatomie et physiologie humaine 1999 Edition du Renouveau Pédagodique Québec 1194 p.
15. Mokale, K.A.L., 2009. Evaluation des propriétés antibactériennes et antioxydantes des extraits méthanoliques d'écorces de Pteleopsis hylodendron et feuilles de Peucedanum zenkeri. Thse de Master de Biochimie, Université de Dschang, 61 p.
16. C.P.R. Motso Recensement de quelques plantes camerounaises activité antivirale. Mémoire de Maîtrise de Biochimie 2007 Université de Douala pp. 25-27
17. N.F. Ngounou, Atta-Ur-Rahman, M.I. Choudhary, S. Malik, S. Zareen, R. Ali, and D. Lontsi New saponins from Pteleopsis hylodendron Phytochemistry 52 1999 917 921
18. M.F. Odou Sémiologie et hématologie 2005 Forum santé/Doctissimo 16 p.
19. OECD Guidelines for the Testing of Chemicals. Assayn 407 2008 14 p.
20. K.E. Panter, and L.F. James Natural plant toxicants in milk: a review Journal of Animal Science 68 1990 892 904
21. I Raskin, D.M. Ribnieky, S. Komarnytsky, N. Ilic, A. Poulev, N. Borisjuk, D.A. Moreno, C. Ripio, N. Yakoby, J.M. O'neal, T. Cornwell, I. Paster, and B. Frindler Plants and human health in the twenty first century Trends in the Biotechnology 12 2002 522 531 (Pubitemid 35356407)
22. A.B. Thomson, and E.A. Shaffer Principes fondamentaux de gastro-entérologie États pathologiques et démarches thérapeutiques 5e éd 2005 Association canadienne de gastroentérologie 972 p.
23. N.W. Tiez Fundamentals of Clinical Chemistry 2nd ed. 1982 Martila Philippines 38 p.
24. WHO General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, Geneva 2000 80 p.