Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 1-2, 2011, Pages 57-67

  Meng, Jianing ^a   Sturgis, Timothy F ^a   Youan, Bi Botti C ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Chitosan nanoparticles; HIV prevention; Mucoadhesion; Tenofovir; Vaginal drug delivery

Indexed keywords

CHITOSAN; NANOPARTICLE; TENOFOVIR;

ANIMAL CELL; ANIMAL TISSUE; BIOENGINEERING; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; FEMALE; FLUOROMETRY; HUMAN IMMUNODEFICIENCY VIRUS; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LIGHT SCATTERING; MUCOADHESION; NANOMEDICINE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SWINE; ULTRAVIOLET SPECTROSCOPY; VAGINA EPITHELIUM; VIRUS TRANSMISSION;

ADENINE; ADHESIVENESS; ANALYSIS OF VARIANCE; ANIMALS; ANTI-HIV AGENTS; CELL SURVIVAL; CHITOSAN; DRUG CARRIERS; DRUG COMPOUNDING; EPITHELIAL CELLS; EPITHELIUM; FEMALE; HIV INFECTIONS; HUMANS; LACTOBACILLUS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; PHOSPHONIC ACIDS; SOLUBILITY; SURFACE PROPERTIES; SWINE; VAGINA;

EID: 80052029739     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.06.007     Document Type: Conference Paper

References (68)

1. Q. Abdool Karim, S.S. Abdool Karim, J.A. Frohlich, A.C. Grobler, C. Baxter, L.E. Mansoor, A.B. Kharsany, S. Sibeko, K.P. Mlisana, Z. Omar, T.N. Gengiah, S. Maarschalk, N. Arulappan, M. Mlotshwa, L. Morris, and D. Taylor Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women Science 329 2010 1168 1174
2. S.A. Agnihotri, N.N. Mallikarjuna, and T.M. Aminabhavi Recent advances on chitosan-based micro- and nanoparticles in drug delivery J. Control Release 100 2004 5 28 (Pubitemid 39445982)
3. D. Alukda, T. Sturgis, and B.B. Youan Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention J. Pharm. Sci. 100 2011 3345 3356
4. P.L. Anderson, J.J. Kiser, E.M. Gardner, J.E. Rower, A. Meditz, and R.M. Grant Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection J. Antimicrob. Chemother. 66 2 2010 240 250
5. I. Aranaz, M. Mengíbar, R. Harris, I. Paños, B. Miralles, N. Acosta, G. Galed, and A. Heras Functional characterization of chitin and chitosan Curr. Chem. Biol. 3 2009 203 230
6. Arya, G., Vandana, M., Acharya, S., Sahoo, S.K., 2011. Enhanced antiproliferative activity of Herceptin (HER2)-conjugated gemcitabine-loaded chitosan nanoparticle in pancreatic cancer therapy. Nanomedicine.
7. E. Baloglu, Z.A. Senyigit, S.Y. Karavana, and A. Bernkop-Schnurch Strategies to prolong the intravaginal residence time of drug delivery systems J. Pharm. Pharm. Sci. 12 2009 312 336
8. J. Balzarini, C. Pannecouque, E. De Clercq, S. Aquaro, C.F. Perno, H. Egberink, and A. Holy Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates Antimicrob. Agents Chemother. 46 2002 2185 2193 (Pubitemid 34665915)
9. H. Bao, L. Li, and H. Zhang Influence of cetyltrimethylammonium bromide on physicochemical properties and microstructures of chitosan-TPP nanoparticles in aqueous solutions J. Colloid Interface Sci. 328 2008 270 277
10. D. Bei, J. Marszalek, and B.B. Youan Formulation of dacarbazine-loaded Cubosomes-part II: influence of process parameters AAPS PharmSciTech. 10 2009 1040 1047
11. D. Bei, J. Marszalek, and B.B. Youan Formulation of dacarbazine-loaded cubosomes-part I: influence of formulation variables AAPS PharmSciTech. 10 2009 1032 1039
12. D.C. Bhatt, A.S. Dhake, R.K. Khar, and D.N. Mishra Development and in-vitro evaluation of transdermal matrix films of metoprolol tartrate Yakugaku Zasshi 128 2008 1325 1331
13. I. Bravo-Osuna, C. Vauthier, A. Farabollini, G.F. Palmieri, and G. Ponchel Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles Biomaterials 28 2007 2233 2243 (Pubitemid 46216448)
14. P. Calvo, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines Pharm. Res. 14 1997 1431 1436 (Pubitemid 27481075)
15. M. Cordova, M. Cheng, J. Trejo, S.J. Johnson, G.P. Willhite, J.T. Liang, and C. Berkland Delayed HPAM gelation via transient sequestration of chromium in polyelectrolyte complex nanoparticles Macromolecules 41 2008 4398 4404
16. P. Costa, and J.M. Sousa Lobo Modeling and comparison of dissolution profiles Eur. J. Pharm. Sci. 13 2001 123 133 (Pubitemid 32288781)
17. das Neves, J., Amiji, M., Sarmento, B., 2011. Mucoadhesive nanosystems for vaginal microbicide development: friend or foe? Wiley Interdiscip Rev Nanomed Nanobiotechnol. 10.1002/wnan.144.
18. A.M. De Campos, A. Sanchez, R. Gref, P. Calvo, and M.J. Alonso The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa Eur. J. Pharm. Sci. 20 2003 73 81 (Pubitemid 37103234)
19. E.D. Denkba, M. Seyyalb, and E. Pikin Implantable 5-fluorouracil loaded chitosan scaffolds prepared by wet spinning J. Membr. Sci. 172 2000 33 38
20. Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., Huang, B., 2010. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int. J. Pharm.
21. A. Dudhania, and S. Kosaraju Bioadhesive chitosan nanoparticles: Preparation and characterization Carbohydrate Polymers 81 2010 243 251
22. R. Fernandez-Urrusuno, P. Calvo, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Enhancement of nasal absorption of insulin using chitosan nanoparticles Pharm. Res. 16 1999 1576 1581 (Pubitemid 29510555)
23. R. Ghaderi, and J. Carlfors Biological activity of lysozyme after entrapment in poly(d, l-lactide-co-glycolide)-microspheres Pharm. Res. 14 1997 1556 1562 (Pubitemid 28009206)
24. V. Grabovac, D. Guggi, and A. Bernkop-Schnurch Comparison of the mucoadhesive properties of various polymers Adv. Drug Deliv. Rev. 57 2005 1713 1723 (Pubitemid 41443475)
25. A.C. Grayson, A.M. Doody, and D. Putnam Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro Pharm. Res. 23 2006 1868 1876 (Pubitemid 44200551)
26. S.A. Grim, and F. Romanelli Tenofovir disoproxil fumarate Ann. Pharmacother. 37 2003 849 859 (Pubitemid 36618375)
27. V.A. Hackley, and C.F. Ferraris The use of nomenclature in dispersion science and technology NIST Recommended Practice Guide. Special Publication. 960 2001 76
28. M. Hamidi, A. Azadi, and P. Rafiei Hydrogel nanoparticles in drug delivery Adv. Drug Deliv. Rev. 60 2008 1638 1649
29. M. Hu, Y. Li, E.A. Decker, H. Xiao, and D.J. McClements Influence of tripolyphosphate cross-linking on the physical stability and lipase digestibility of chitosan-coated lipid droplets J. Agric Food Chem. 58 2010 1283 1289
30. G. Ikinci, S. Senel, H. Akincibay, S. Kas, S. Ercis, C.G. Wilson, and A.A. Hincal Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis Int. J. Pharm. 235 2002 121 127 (Pubitemid 34185443)
31. S.J. Jackson, and A.C. Perkins In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa Eur. J. Pharm. Biopharm. 52 2001 121 127 (Pubitemid 32755889)
32. T.J. Johnson, K.M. Gupta, J. Fabian, T.H. Albright, and P.F. Kiser Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir Eur. J. Pharm. Sci. 39 2010 203 212
33. T. Jung, W. Kamm, A. Breitenbach, E. Kaiserling, J.X. Xiao, and T. Kissel Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50 2000 147 160 (Pubitemid 30326694)
34. S.J. Klebanoff, and R.W. Coombs Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission J. Exp. Med. 174 1991 289 292
35. C. Lackman-Smith, C. Osterling, K. Luckenbaugh, M. Mankowski, B. Snyder, G. Lewis, J. Paull, A. Profy, R.G. Ptak, R.W. Buckheit Jr., K.M. Watson, J.E. Cummins Jr., and B.E. Sanders-Beer Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides Antimicrob. Agents Chemother. 52 2008 1768 1781 (Pubitemid 351614671)
36. M.M. Leane, R. Nankervis, A. Smith, and L. Illum Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms Int. J. Pharm. 271 2004 241 249 (Pubitemid 38210102)
37. Lide, D.R. (Ed.), 1999-2000. CRC Handbook of Chemistry and Physics, 80th ed. pp. 6-179.
38. L. Ma, and C. Liu Preparation of chitosan microspheres by ionotropic gelation under a high voltage electrostatic field for protein delivery Colloids Surf. B Biointerfaces 75 2010 448 453
39. Z. Ma, and L.Y. Lim Uptake of chitosan and associated insulin in CaCo-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles Pharm Res. 20 2003 1812 1819 (Pubitemid 37449455)
40. J.C. Miller, and J.N. Miller Statistics for Analytical Chemistry, third ed. 1993 Ellis Horwood New York
41. N. Mohammadpourdounighi, A. Behfar, A. Ezabadi, H. Zolfagharian, and M. Heydari Preparation of chitosan nanoparticles containing Naja naja oxiana snake venom Nanomedicine 6 2010 137 143
42. A. Nasti, N.M. Zaki, P. de Leonardis, S. Ungphaiboon, P. Sansongsak, M.G. Rimoli, and N. Tirelli Chitosan/TPP and chitosan/TPP-hyaluronic acid nanoparticles: systematic optimisation of the preparative process and preliminary biological evaluation Pharm Res. 26 2009 1918 1930
43. D.H. Owen, and D.F. Katz A vaginal fluid simulant Contraception 59 1999 91 95 (Pubitemid 29244754)
44. R. Pandey, Z. Ahmad, S. Sharma, and G.K. Khuller Nano-encapsulation of azole antifungals: potential applications to improve oral drug delivery Int. J. Pharm. 301 2005 268 276 (Pubitemid 41206612)
45. J.H. Park, G. Saravanakumar, K. Kim, and I.C. Kwon Targeted delivery of low molecular drugs using chitosan and its derivatives Adv. Drug Deliv. Rev. 62 2010 28 41
46. S. Parveen, M. Mitra, S. Krishnakumar, and S.K. Sahoo Enhanced antiproliferative activity of carboplatin-loaded chitosan-alginate nanoparticles in a retinoblastoma cell line Acta Biomater. 6 2010 3120 3131
47. L. Plapied, G. Vandermeulen, B. Vroman, V. Preat, and A. des Rieux Bioadhesive nanoparticles of fungal chitosan for oral DNA delivery Int. J. Pharm. 398 2010 210 218
48. A.J. Quayle The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells J. Reprod. Immunol. 57 2002 61 79 (Pubitemid 35245740)
49. L.C. Rohan, B.J. Moncla, R.P. Kunjara Na Ayudhya, M. Cost, Y. Huang, F. Gai, N. Billitto, J.D. Lynam, K. Pryke, P. Graebing, N. Hopkins, J.F. Rooney, D. Friend, and C.S. Dezzutti In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide PLoS One 5 2010 e9310
50. M. Sano, O. Hosoya, S. Takao, T. Seki, T. Kawaguchi, K. Sugibayashi, K. Juni, and Y. Morimoto Relationship between Solubility of Chitosan in Alcoholic Solution and Its Gelation Chem. pharmaceutical bulletin 47 1999 1044 1046 (Pubitemid 29357394)
51. B. Sayin, S. Somavarapu, X.W. Li, D. Sesardic, S. Senel, and O.H. Alpar TMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccines Eur. J. Pharm. Sci. 38 2009 362 369
52. K. Songsurang, N. Praphairaksit, K. Siraleartmukul, and N. Muangsin Electrospray fabrication of doxorubicin-chitosan-tripolyphosphate nanoparticles for delivery of doxorubicin Arch. Pharm. Res. 34 2011 583 592
53. C.A. Squier, M.J. Mantz, P.M. Schlievert, and C.C. Davis Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa J. Pharm. Sci. 97 2008 9 21
54. W. Sun, S. Mao, Y. Wang, V.B. Junyaprasert, T. Zhang, L. Na, and J. Wang Bioadhesion and oral absorption of enoxaparin nanocomplexes Int. J. Pharm. 386 2010 275 281
55. T. Tadros, P. Izquierdo, J. Esquena, and C. Solans Formation and stability of nano-emulsions Adv. Colloid Interface Sci. 108-109 2004 303 318
56. J. Thongborisute, H. Takeuchi, H. Yamamoto, and Y. Kawashima Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine J. Liposome Res. 16 2006 127 141 (Pubitemid 43861149)
57. W. Tiyaboonchai, and N. Limpeanchob Formulation and characterization of amphotericin B-chitosan-dextran sulfate nanoparticles Int. J. Pharm. 329 2007 142 149 (Pubitemid 44937518)
58. M. Tobyna, J. Johnsona, and P. Dettmar Factors affecting in vitro gastric mucoadhesion IV. Influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers Eur. J. Pharm. Biopharm. 43 1997 65 71 (Pubitemid 28298812)
59. J. Van Gelder, M. Witvrouw, C. Pannecouque, G. Henson, G. Bridger, L. Naesens, E. De Clercq, P. Annaert, M. Shafiee, G. Van den Mooter, R. Kinget, and P. Augustijns Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA Int. J. Pharm. 186 1999 127 136 (Pubitemid 29459039)
60. Y. Vander Heyden, A. Nijhuis, J. Smeyers-Verbeke, B.G. Vandeginste, and D.L. Massart Guidance for robustness/ruggedness tests in method validation J. Pharm. Biomed. Anal. 24 2001 723 753 (Pubitemid 32209131)
61. Vllasaliu, D., Exposito-Harris, R., Heras, A., Casettari, L., Garnett, M., Illum, L., Stolnik, S., 2010. Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution. Int. J. Pharm.
62. C. Wiegand, D. Winter, and U.C. Hipler Molecular-weight-dependent toxic effects of chitosans on the human keratinocyte cell line HaCaT Skin Pharmacol. Physiol. 23 2010 164 170
63. M. Wilks, R. Wiggins, A. Whiley, E. Hennessy, S. Warwick, H. Porter, A. Corfield, and M. Millar Identification and H(2)O(2) production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome J. Clin. Microbiol. 42 2004 713 717 (Pubitemid 38222651)
64. K.A. Woodrow, Y. Cu, C.J. Booth, J.K. Saucier-Sawyer, M.J. Wood, and W.M. Saltzman Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA Nat. Mater. 8 2009 526 533
65. Y. Wu, Y. Wang, G. Luo, and Y. Dai In situ preparation of magnetic Fe3O4-chitosan nanoparticles for lipase immobilization by cross-linking and oxidation in aqueous solution Bioresour. Technol. 100 2009 3459 3464
66. Y. Wu, W. Yang, C. Wang, J. Hu, and S. Fu Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate Int. J. Pharm. 295 2005 235 245 (Pubitemid 40558806)
67. C.Y. Yu, H. Cao, X.C. Zhang, F.Z. Zhou, S.X. Cheng, X.Z. Zhang, and R.X. Zhuo Hybrid nanospheres and vesicles based on pectin as drug carriers Langmuir 25 2009 11720 11726
68. S. Zhang, and K. Kawakami One-step preparation of chitosan solid nanoparticles by electrospray deposition Int. J. Pharm. 397 2010 211 217