메뉴 건너뛰기




Volumn 8, Issue , 2011, Pages

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Author keywords

[No Author keywords available]

Indexed keywords

BEVIRIMAT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; PROTEIN VP2; 3-O-(3',3'-DIMETHYLSUCCINYL)BETULINIC ACID; GAG PROTEIN; GAG PROTEIN P1, HUMAN IMMUNODEFICIENCY VIRUS; SUCCINIC ACID DERIVATIVE; TRITERPENE;

EID: 80052028225     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-8-70     Document Type: Article
Times cited : (19)

References (37)
  • 1
    • 0031846317 scopus 로고    scopus 로고
    • Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
    • 110025, 9696866
    • Mammano F, Petit C, Clavel F. Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients. J Virol 1998, 72:7632-7637. 110025, 9696866.
    • (1998) J Virol , vol.72 , pp. 7632-7637
    • Mammano, F.1    Petit, C.2    Clavel, F.3
  • 4
    • 67649576660 scopus 로고    scopus 로고
    • Novel mechanisms of HIV protease inhibitor resistance
    • 10.1097/COH.0b013e3283136cd9, 19373034
    • Nijhuis M, van Maarseveen NM, Verheyen J, Boucher CA. Novel mechanisms of HIV protease inhibitor resistance. Curr Opin HIV AIDS 2008, 3:627-632. 10.1097/COH.0b013e3283136cd9, 19373034.
    • (2008) Curr Opin HIV AIDS , vol.3 , pp. 627-632
    • Nijhuis, M.1    van Maarseveen, N.M.2    Verheyen, J.3    Boucher, C.A.4
  • 5
    • 63449110982 scopus 로고    scopus 로고
    • Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss
    • 10.1371/journal.ppat.1000345, 2652074, 19300491
    • Dam E, Quercia R, Glass B, Descamps D, Launay O, Duval X, Krausslich HG, Hance AJ, Clavel F. Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss. PLoS Pathog 2009, 5:e1000345. 10.1371/journal.ppat.1000345, 2652074, 19300491.
    • (2009) PLoS Pathog , vol.5
    • Dam, E.1    Quercia, R.2    Glass, B.3    Descamps, D.4    Launay, O.5    Duval, X.6    Krausslich, H.G.7    Hance, A.J.8    Clavel, F.9
  • 11
    • 34548844198 scopus 로고    scopus 로고
    • Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein
    • 10.1016/j.jmb.2007.07.070, 2066180, 17826792
    • Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP. Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol 2007, 373:355-366. 10.1016/j.jmb.2007.07.070, 2066180, 17826792.
    • (2007) J Mol Biol , vol.373 , pp. 355-366
    • Kelly, B.N.1    Kyere, S.2    Kinde, I.3    Tang, C.4    Howard, B.R.5    Robinson, H.6    Sundquist, W.I.7    Summers, M.F.8    Hill, C.P.9
  • 12
  • 16
    • 78951488338 scopus 로고    scopus 로고
    • HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
    • 10.1128/JVI.01926-10, 3028903, 21106735
    • Keller PW, Adamson CS, Heymann JB, Freed EO, Steven AC. HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice. J Virol 2011, 85:1420-1428. 10.1128/JVI.01926-10, 3028903, 21106735.
    • (2011) J Virol , vol.85 , pp. 1420-1428
    • Keller, P.W.1    Adamson, C.S.2    Heymann, J.B.3    Freed, E.O.4    Steven, A.C.5
  • 18
    • 66149150956 scopus 로고    scopus 로고
    • Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1
    • 10.1128/AAC.01650-08, 2681549, 19223634
    • Van Baelen K, Salzwedel K, Rondelez E, Van Eygen V, De Vos S, Verheyen A, Steegen K, Verlinden Y, Allaway GP, Stuyver LJ. Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1. Antimicrob Agents Chemother 2009, 53:2185-2188. 10.1128/AAC.01650-08, 2681549, 19223634.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2185-2188
    • Van Baelen, K.1    Salzwedel, K.2    Rondelez, E.3    Van Eygen, V.4    De Vos, S.5    Verheyen, A.6    Steegen, K.7    Verlinden, Y.8    Allaway, G.P.9    Stuyver, L.J.10
  • 20
    • 65349162716 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)
    • 10.1128/JVI.02659-08, 2682084, 19279107
    • Adamson CS, Waki K, Ablan SD, Salzwedel K, Freed EO. Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457). J Virol 2009, 83:4884-4894. 10.1128/JVI.02659-08, 2682084, 19279107.
    • (2009) J Virol , vol.83 , pp. 4884-4894
    • Adamson, C.S.1    Waki, K.2    Ablan, S.D.3    Salzwedel, K.4    Freed, E.O.5
  • 21
    • 0030769354 scopus 로고    scopus 로고
    • Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
    • 191944, 9261388
    • Zhang YM, Imamichi H, Imamichi T, Lane HC, Falloon J, Vasudevachari MB, Salzman NP. Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J Virol 1997, 71:6662-6670. 191944, 9261388.
    • (1997) J Virol , vol.71 , pp. 6662-6670
    • Zhang, Y.M.1    Imamichi, H.2    Imamichi, T.3    Lane, H.C.4    Falloon, J.5    Vasudevachari, M.B.6    Salzman, N.P.7
  • 22
    • 0032804864 scopus 로고    scopus 로고
    • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
    • 10.1097/00002030-199912030-00006, 10597776
    • Nijhuis M, Schuurman R, de Jong D, Erickson J, Gustchina E, Albert J, Schipper P, Gulnik S, Boucher CA. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. Aids 1999, 13:2349-2359. 10.1097/00002030-199912030-00006, 10597776.
    • (1999) Aids , vol.13 , pp. 2349-2359
    • Nijhuis, M.1    Schuurman, R.2    de Jong, D.3    Erickson, J.4    Gustchina, E.5    Albert, J.6    Schipper, P.7    Gulnik, S.8    Boucher, C.A.9
  • 23
    • 0035163687 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir
    • 10.1128/JVI.75.2.589-594.2001, 113954, 11134271
    • Cote HC, Brumme ZL, Harrigan PR. Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir. J Virol 2001, 75:589-594. 10.1128/JVI.75.2.589-594.2001, 113954, 11134271.
    • (2001) J Virol , vol.75 , pp. 589-594
    • Cote, H.C.1    Brumme, Z.L.2    Harrigan, P.R.3
  • 24
    • 0346688636 scopus 로고    scopus 로고
    • Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation
    • 10.1128/JVI.78.2.922-929.2004, 368845, 14694123
    • Zhou J, Yuan X, Dismuke D, Forshey BM, Lundquist C, Lee KH, Aiken C, Chen CH. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J Virol 2004, 78:922-929. 10.1128/JVI.78.2.922-929.2004, 368845, 14694123.
    • (2004) J Virol , vol.78 , pp. 922-929
    • Zhou, J.1    Yuan, X.2    Dismuke, D.3    Forshey, B.M.4    Lundquist, C.5    Lee, K.H.6    Aiken, C.7    Chen, C.H.8
  • 25
    • 77950929797 scopus 로고    scopus 로고
    • Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat
    • 10.1186/1742-4690-7-36, 2873507, 20406463
    • Adamson CS, Sakalian M, Salzwedel K, Freed EO. Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat. Retrovirology 2010, 7:36. 10.1186/1742-4690-7-36, 2873507, 20406463.
    • (2010) Retrovirology , vol.7 , pp. 36
    • Adamson, C.S.1    Sakalian, M.2    Salzwedel, K.3    Freed, E.O.4
  • 26
    • 78650883987 scopus 로고    scopus 로고
    • In Vitro Selection of Clinically Relevant Bevirimat Resistance Mutations Revealed by "Deep" Sequencing of Serially Passaged, Quasispecies-Containing Recombinant HIV-1
    • 10.1128/JCM.01868-10, 3020451, 21084518
    • Knapp DJ, Harrigan PR, Poon AF, Brumme ZL, Brockman M, Cheung PK. In Vitro Selection of Clinically Relevant Bevirimat Resistance Mutations Revealed by "Deep" Sequencing of Serially Passaged, Quasispecies-Containing Recombinant HIV-1. J Clin Microbiol 2011, 49:201-208. 10.1128/JCM.01868-10, 3020451, 21084518.
    • (2011) J Clin Microbiol , vol.49 , pp. 201-208
    • Knapp, D.J.1    Harrigan, P.R.2    Poon, A.F.3    Brumme, Z.L.4    Brockman, M.5    Cheung, P.K.6
  • 27
    • 77952635262 scopus 로고    scopus 로고
    • Phenotypic Susceptibility to Bevirimat in Isolates from HIV-1-Infected Patients without Prior Exposure to Bevirimat
    • 10.1128/AAC.01784-09, 2876391, 20308382
    • Margot NA, Gibbs CS, Miller MD. Phenotypic Susceptibility to Bevirimat in Isolates from HIV-1-Infected Patients without Prior Exposure to Bevirimat. Antimicrob Agents Chemother 2010, 54:2345-2353. 10.1128/AAC.01784-09, 2876391, 20308382.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2345-2353
    • Margot, N.A.1    Gibbs, C.S.2    Miller, M.D.3
  • 28
    • 33846417968 scopus 로고    scopus 로고
    • Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation
    • 10.1086/510533, 17205479
    • van Maarseveen NM, Wensing AM, de Jong D, Taconis M, Borleffs JC, Boucher CA, Nijhuis M. Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation. J Infect Dis 2007, 195:399-409. 10.1086/510533, 17205479.
    • (2007) J Infect Dis , vol.195 , pp. 399-409
    • van Maarseveen, N.M.1    Wensing, A.M.2    de Jong, D.3    Taconis, M.4    Borleffs, J.C.5    Boucher, C.A.6    Nijhuis, M.7
  • 29
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug
    • 10.1128/JVI.74.18.8524-8531.2000, 116364, 10954553
    • Mammano F, Trouplin V, Zennou V, Clavel F. Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J Virol 2000, 74:8524-8531. 10.1128/JVI.74.18.8524-8531.2000, 116364, 10954553.
    • (2000) J Virol , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 30
    • 0036337934 scopus 로고    scopus 로고
    • Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly
    • 10.1128/JVI.76.17.8659-8666.2002, 136408, 12163585
    • Resch W, Ziermann R, Parkin N, Gamarnik A, Swanstrom R. Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly. J Virol 2002, 76:8659-8666. 10.1128/JVI.76.17.8659-8666.2002, 136408, 12163585.
    • (2002) J Virol , vol.76 , pp. 8659-8666
    • Resch, W.1    Ziermann, R.2    Parkin, N.3    Gamarnik, A.4    Swanstrom, R.5
  • 31
    • 4344641898 scopus 로고    scopus 로고
    • Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases
    • 10.1128/AAC.48.9.3552-3555.2004, 514783, 15328124
    • Gonzalez LM, Brindeiro RM, Aguiar RS, Pereira HS, Abreu CM, Soares MA, Tanuri A. Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases. Antimicrob Agents Chemother 2004, 48:3552-3555. 10.1128/AAC.48.9.3552-3555.2004, 514783, 15328124.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3552-3555
    • Gonzalez, L.M.1    Brindeiro, R.M.2    Aguiar, R.S.3    Pereira, H.S.4    Abreu, C.M.5    Soares, M.A.6    Tanuri, A.7
  • 32
    • 32344453358 scopus 로고    scopus 로고
    • A genotypic assay for the amplification and sequencing of gag and protease from diverse human immunodeficiency virus type 1 group M subtypes
    • 10.1016/j.jviromet.2005.10.008, 16271771
    • Van Laethem K, Schrooten Y, Dedecker S, Van Heeswijck L, Deforche K, Van Wijngaerden E, Van Ranst M, Vandamme AM. A genotypic assay for the amplification and sequencing of gag and protease from diverse human immunodeficiency virus type 1 group M subtypes. J Virol Methods 2006, 132:181-186. 10.1016/j.jviromet.2005.10.008, 16271771.
    • (2006) J Virol Methods , vol.132 , pp. 181-186
    • Van Laethem, K.1    Schrooten, Y.2    Dedecker, S.3    Van Heeswijck, L.4    Deforche, K.5    Van Wijngaerden, E.6    Van Ranst, M.7    Vandamme, A.M.8
  • 33
    • 33645319712 scopus 로고    scopus 로고
    • A novel real-time PCR assay to determine relative replication capacity for HIV-1 protease variants and/or reverse transcriptase variants
    • 10.1016/j.jviromet.2005.11.008, 16368153
    • van Maarseveen NM, Huigen MC, de Jong D, Smits AM, Boucher CA, Nijhuis M. A novel real-time PCR assay to determine relative replication capacity for HIV-1 protease variants and/or reverse transcriptase variants. J Virol Methods 2006, 133:185-194. 10.1016/j.jviromet.2005.11.008, 16368153.
    • (2006) J Virol Methods , vol.133 , pp. 185-194
    • van Maarseveen, N.M.1    Huigen, M.C.2    de Jong, D.3    Smits, A.M.4    Boucher, C.A.5    Nijhuis, M.6
  • 34
    • 33745114356 scopus 로고    scopus 로고
    • An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs
    • 10.1097/01.qai.0000219787.65915.56, 16645546
    • van Maarseveen NM, de Jong D, Boucher CA, Nijhuis M. An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs. J Acquir Immune Defic Syndr 2006, 42:162-168. 10.1097/01.qai.0000219787.65915.56, 16645546.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 162-168
    • van Maarseveen, N.M.1    de Jong, D.2    Boucher, C.A.3    Nijhuis, M.4
  • 35
    • 0029816733 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay
    • 163542, 8891152
    • Boucher CA, Keulen W, van Bommel T, Nijhuis M, de Jong D, de Jong MD, Schipper P, Back NK. Human immunodeficiency virus type 1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay. Antimicrob Agents Chemother 1996, 40:2404-2409. 163542, 8891152.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2404-2409
    • Boucher, C.A.1    Keulen, W.2    van Bommel, T.3    Nijhuis, M.4    de Jong, D.5    de Jong, M.D.6    Schipper, P.7    Back, N.K.8
  • 36
    • 44949137457 scopus 로고    scopus 로고
    • Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region
    • 10.1128/JVI.02325-07, 2395164, 18400858
    • Kozisek M, Saskova KG, Rezacova P, Brynda J, van Maarseveen NM, De Jong D, Boucher CA, Kagan RM, Nijhuis M, Konvalinka J. Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region. J Virol 2008, 82:5869-5878. 10.1128/JVI.02325-07, 2395164, 18400858.
    • (2008) J Virol , vol.82 , pp. 5869-5878
    • Kozisek, M.1    Saskova, K.G.2    Rezacova, P.3    Brynda, J.4    van Maarseveen, N.M.5    De Jong, D.6    Boucher, C.A.7    Kagan, R.M.8    Nijhuis, M.9    Konvalinka, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.