-
1
-
-
22044433989
-
Natural history of hepatitis C
-
DOI 10.1016/j.cld.2005.05.003, PII S1089326105000358, Hepatitis C Virus
-
Thomas DL, Seeff LB,. Natural history of hepatitis C. Clin Liver Dis 2005; 9: 383-98. (Pubitemid 40968202)
-
(2005)
Clinics in Liver Disease
, vol.9
, Issue.3
, pp. 383-398
-
-
Thomas, D.L.1
Seeff, L.B.2
-
2
-
-
65449136656
-
Diagnosis, management, and treatment of hepatitis C: An update
-
Ghany MG, Strader DB, Thomas DL, Seeff LB,. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49: 1335-74.
-
(2009)
Hepatology
, vol.49
, pp. 1335-1374
-
-
Ghany, M.G.1
Strader, D.B.2
Thomas, D.L.3
Seeff, L.B.4
-
3
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR, et al., Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
4
-
-
1542378867
-
Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
-
Hadziyannis SJ, Sette H Jr, Morgan TR, et al., Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004; 140: 346-55.
-
(2004)
Ann Intern Med
, vol.140
, pp. 346-355
-
-
Hadziyannis, S.J.1
Sette, Jr.H.2
Morgan, T.R.3
-
5
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
DOI 10.1016/S0140-6736(01)06102-5
-
Manns MP, McHutchison JG, Gordon SC, et al., Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-65. (Pubitemid 32913521)
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.-H.9
Albrecht, J.K.10
-
6
-
-
0345017740
-
Sampling Variability of Liver Fibrosis in Chronic Hepatitis C
-
DOI 10.1016/j.hep.2003.09.022
-
Bedossa P, DargÃre D, Paradis V,. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003; 38: 1449-57. (Pubitemid 37466971)
-
(2003)
Hepatology
, vol.38
, Issue.6
, pp. 1449-1457
-
-
Bedossa, P.1
Dargere, D.2
Paradis, V.3
-
7
-
-
0022656928
-
Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver
-
Maharaj B, Maharaj RJ, Leary WP, et al., Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet 1986; i: 523-5. (Pubitemid 16138427)
-
(1986)
Lancet
, vol.1
, Issue.8480
, pp. 523-525
-
-
Maharaj, B.1
Maharaj, R.J.2
Leary, W.P.3
-
8
-
-
0036792679
-
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
-
Regev A, Berho M, Jeffers LJ, et al., Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002; 97: 2614-8.
-
(2002)
Am J Gastroenterol
, vol.97
, pp. 2614-2618
-
-
Regev, A.1
Berho, M.2
Jeffers, L.J.3
-
9
-
-
12844282183
-
Sources of variability in histological scoring of chronic viral hepatitis
-
DOI 10.1002/hep.20535
-
Rousselet MC, Michalak S, Dupre F, et al., Sources of variability in histological scoring of chronic viral hepatitis. Hepatology 2005; 41: 257-64. (Pubitemid 40165369)
-
(2005)
Hepatology
, vol.41
, Issue.2
, pp. 257-264
-
-
Rousselet, M.-C.1
Michalak, S.2
Dupre, F.3
Croue, A.4
Bedossa, P.5
Saint-Andre, J.-P.6
Cales, P.7
-
10
-
-
0032717037
-
Pain experienced during percutaneous liver biopsy
-
Castera L, Negre I, Samii K, Buffet C,. Pain experienced during percutaneous liver biopsy. Hepatology 1999; 30: 1529-30.
-
(1999)
Hepatology
, vol.30
, pp. 1529-1530
-
-
Castera, L.1
Negre, I.2
Samii, K.3
Buffet, C.4
-
11
-
-
0033849619
-
Practices of liver biopsy in France: Results of a prospective nationwide survey
-
Cadranel JF, Rufat P, Degos F,. Practices of liver biopsy in France: results of a prospective nationwide survey. Hepatology 2000; 32: 477-81.
-
(2000)
Hepatology
, vol.32
, pp. 477-481
-
-
Cadranel, J.F.1
Rufat, P.2
Degos, F.3
-
12
-
-
0342936460
-
Patient-administered nitrous oxide/oxygen inhalation provides safe and effective analgesia for percutaneous liver biopsy: A randomized placebo-controlled trial
-
DOI 10.1016/S0002-9270(01)02339-5
-
Castera L, Negre I, Samii K, Buffet C,. Patient-administered nitrous oxide/oxygen inhalation provides safe and effective analgesia for percutaneous liver biopsy: a randomized placebo-controlled trial. Am J Gastroenterol 2001; 96: 1553-7. (Pubitemid 32455089)
-
(2001)
American Journal of Gastroenterology
, vol.96
, Issue.5
, pp. 1553-1557
-
-
Castera, L.1
Negre, I.2
Samii, K.3
Buffet, C.4
-
14
-
-
9144249563
-
Transient elastography: A new noninvasive method for assessment of hepatic fibrosis
-
DOI 10.1016/j.ultrasmedbio.2003.07.001
-
Sandrin L, Fourquet B, Hasquenoph JM, et al., Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705-13. (Pubitemid 38091720)
-
(2003)
Ultrasound in Medicine and Biology
, vol.29
, Issue.12
, pp. 1705-1713
-
-
Sandrin, L.1
Fourquet, B.2
Hasquenoph, J.-M.3
Yon, S.4
Fournier, C.5
Mal, F.6
Christidis, C.7
Ziol, M.8
Poulet, B.9
Kazemi, F.10
Beaugrand, M.11
Palau, R.12
-
15
-
-
39049101883
-
Technology Insight: Noninvasive assessment of liver fibrosis by biochemical scores and elastography
-
DOI 10.1038/ncpgasthep1025, PII NCPGASTHEP1025
-
Pinzani M, Vizzutti F, Arena U, Marra F,. Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography. Nat Clin Pract Gastroenterol Hepatol 2008; 5: 95-106. (Pubitemid 351234279)
-
(2008)
Nature Clinical Practice Gastroenterology and Hepatology
, vol.5
, Issue.2
, pp. 95-106
-
-
Pinzani, M.1
Vizzutti, F.2
Arena, U.3
Marra, F.4
-
16
-
-
63549099586
-
Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis
-
Castera L,. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. J Viral Hepat 2009; 16: 300-14.
-
(2009)
J Viral Hepat
, vol.16
, pp. 300-314
-
-
Castera, L.1
-
17
-
-
77952305743
-
Non-invasive assessment of liver fibrosis: Are we ready?
-
Castera L, Pinzani M,. Non-invasive assessment of liver fibrosis: are we ready? Lancet 2010; 375: 1419-20.
-
(2010)
Lancet
, vol.375
, pp. 1419-1420
-
-
Castera, L.1
Pinzani, M.2
-
18
-
-
41249100719
-
Non-invasive evaluation of liver fibrosis using transient elastography
-
Castera L, Forns X, Alberti A,. Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008; 48: 835-47.
-
(2008)
J Hepatol
, vol.48
, pp. 835-847
-
-
Castera, L.1
Forns, X.2
Alberti, A.3
-
19
-
-
11144328418
-
Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C
-
DOI 10.1002/hep.20506
-
Ziol M, Handra-Luca A, Kettaneh A, et al., Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology 2005; 41: 48-54. (Pubitemid 40066382)
-
(2005)
Hepatology
, vol.41
, Issue.1
, pp. 48-54
-
-
Ziol, M.1
Handra-Luca, A.2
Kettaneh, A.3
Christidis, C.4
Mal, F.5
Kazemi, F.6
De Ledinghen, V.7
Marcellin, P.8
Dhumeaux, D.9
Trinchet, J.-C.10
Beaugrand, M.11
-
20
-
-
12344309018
-
Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
-
DOI 10.1053/j.gastro.2004.11.018
-
Castera L, Vergniol J, Foucher J, et al., Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005; 128: 343-50. (Pubitemid 40439195)
-
(2005)
Gastroenterology
, vol.128
, Issue.2
, pp. 343-350
-
-
Castera, L.1
Vergniol, J.2
Foucher, J.3
Le Bail, B.4
Chanteloup, E.5
Haaser, M.6
Darriet, M.7
Couzigou, P.8
De Ledinghen, V.9
-
21
-
-
41349094999
-
Performance of transient elastography for the staging of liver fibrosis: A meta-analysis
-
Friedrich-Rust M, Ong MF, Martens S, et al., Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134: 960-74.
-
(2008)
Gastroenterology
, vol.134
, pp. 960-974
-
-
Friedrich-Rust, M.1
Ong, M.F.2
Martens, S.3
-
22
-
-
56949092205
-
Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: Comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
-
Castera L, Le Bail B, Roudot-Thoraval F, et al., Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores. J Hepatol 2009; 50: 59-68.
-
(2009)
J Hepatol
, vol.50
, pp. 59-68
-
-
Castera, L.1
Le Bail, B.2
Roudot-Thoraval, F.3
-
23
-
-
77950619459
-
Pitfalls of liver stiffness measurement: A 5-year prospective study of 13,369 examinations
-
Castera L, Foucher J, Bernard PH, et al., Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 2010; 51: 828-35.
-
(2010)
Hepatology
, vol.51
, pp. 828-835
-
-
Castera, L.1
Foucher, J.2
Bernard, P.H.3
-
24
-
-
66749184153
-
Performance of the Abbott real-time PCR assay using m2000sp and m2000rt for hepatitis C virus RNA quantification
-
Chevaliez S, Bouvier-Alias M, Pawlotsky JM,. Performance of the Abbott real-time PCR assay using m2000sp and m2000rt for hepatitis C virus RNA quantification. J Clin Microbiol 2009; 47: 1726-32.
-
(2009)
J Clin Microbiol
, vol.47
, pp. 1726-1732
-
-
Chevaliez, S.1
Bouvier-Alias, M.2
Pawlotsky, J.M.3
-
25
-
-
15644380122
-
Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy
-
Marcellin P, Boyer N, Gervais A, et al., Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy. Ann Intern Med 1997; 127: 875-81.
-
(1997)
Ann Intern Med
, vol.127
, pp. 875-881
-
-
Marcellin, P.1
Boyer, N.2
Gervais, A.3
-
26
-
-
17144455384
-
Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
-
Shiratori Y, Imazeki F, Moriyama M, et al., Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 2000; 132: 517-24. (Pubitemid 30171890)
-
(2000)
Annals of Internal Medicine
, vol.132
, Issue.7
, pp. 517-524
-
-
Shiratori, Y.1
Imazeki, F.2
Moriyama, M.3
Yano, M.4
Arakawa, Y.5
Yokosuka, O.6
Kuroki, T.7
Nishiguchi, S.8
Sata, M.9
Yamada, G.10
Fujiyama, S.11
Yoshida, H.12
Omata, M.13
-
27
-
-
0036242165
-
Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
-
Poynard T, McHutchison J, Manns M, et al., Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002; 122: 1303-13. (Pubitemid 34465173)
-
(2002)
Gastroenterology
, vol.122
, Issue.5
, pp. 1303-1313
-
-
Poynard, T.1
McHutchison, J.2
Manns, M.3
Trepo, C.4
Lindsay, K.5
Goodman, Z.6
Ling, M.7
Albrecht, J.8
-
28
-
-
10744232465
-
Effect of Peginterferon Alfa-2a on Liver Histology in Chronic Hepatitis C: A Meta-analysis of Individual Patient Data
-
DOI 10.1002/hep.20073
-
Camma C, Di Bona D, Schepis F, et al., Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: a meta-analysis of individual patient data. Hepatology 2004; 39: 333-42. (Pubitemid 38222174)
-
(2004)
Hepatology
, vol.39
, Issue.2
, pp. 333-342
-
-
Camma, C.1
Di Bona, D.2
Schepis, F.3
Heathcote, J.4
Zeuzem, S.5
Pockros, P.J.6
Marceliln, P.7
Balart, L.8
Alberti, A.9
Craxi, A.10
-
29
-
-
39849091806
-
Histological benefits of virological response to peginterferon alfa-2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis
-
DOI 10.1111/j.1365-2036.2008.03620.x
-
Everson GT, Balart L, Lee SS, et al., Histological benefits of virological response to peginterferon alfa-2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis. Aliment Pharmacol Ther 2008; 27: 542-51. (Pubitemid 351316789)
-
(2008)
Alimentary Pharmacology and Therapeutics
, vol.27
, Issue.7
, pp. 542-551
-
-
Everson, G.T.1
Balart, L.2
Lee, S.S.3
Reindollar, R.W.4
Shiffman, M.L.5
Minuk, G.Y.6
Pockros, P.J.7
Govindarajan, S.8
Lentz, E.9
Heathcote, E.J.10
-
30
-
-
34247631059
-
Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
-
DOI 10.1136/gut.2006.111302
-
Fraquelli M, Rigamonti C, Casazza G, et al., Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007; 56: 968-73. (Pubitemid 46999083)
-
(2007)
Gut
, vol.56
, Issue.7
, pp. 968-973
-
-
Fraquelli, M.1
Rigamonti, C.2
Casazza, G.3
Conte, D.4
Donato, M.F.5
Ronchi, G.6
Colombo, M.7
-
31
-
-
55149113975
-
Reproducibility of liver stiffness measurement by ultrasonographic elastometry
-
Boursier J, Konate A, Gorea G, et al., Reproducibility of liver stiffness measurement by ultrasonographic elastometry. Clin Gastroenterol Hepatol 2008; 6: 1263-9.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 1263-1269
-
-
Boursier, J.1
Konate, A.2
Gorea, G.3
-
32
-
-
67349145420
-
The longitudinal quantitative assessment by transient elastography of chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin
-
Ogawa E, Furusyo N, Toyoda K, Takeoka H, Maeda S, Hayashi J,. The longitudinal quantitative assessment by transient elastography of chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin. Antiviral Res 2009; 83: 127-34.
-
(2009)
Antiviral Res
, vol.83
, pp. 127-134
-
-
Ogawa, E.1
Furusyo, N.2
Toyoda, K.3
Takeoka, H.4
Maeda, S.5
Hayashi, J.6
-
33
-
-
59149088279
-
Changes of non-invasive markers and FibroScan values during HCV treatment
-
Vergniol J, Foucher J, Castera L, et al., Changes of non-invasive markers and FibroScan values during HCV treatment. J Viral Hepat 2009; 16: 132-40.
-
(2009)
J Viral Hepat
, vol.16
, pp. 132-140
-
-
Vergniol, J.1
Foucher, J.2
Castera, L.3
-
34
-
-
34247102658
-
Transient elastography: A new surrogate marker of liver fibrosis influenced by major changes of transaminases
-
DOI 10.1111/j.1365-2893.2006.00811.x
-
Coco B, Oliveri F, Maina AM, et al., Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases. J Viral Hepat 2007; 14: 360-9. (Pubitemid 46587854)
-
(2007)
Journal of Viral Hepatitis
, vol.14
, Issue.5
, pp. 360-369
-
-
Coco, B.1
Oliveri, F.2
Maina, A.M.3
Ciccorossi, P.4
Sacco, R.5
Colombatto, P.6
Bonino, F.7
Brunetto, M.R.8
-
35
-
-
39549115031
-
Acute viral hepatitis increases liver stiffness values measured by transient elastography
-
DOI 10.1002/hep.22007
-
Arena U, Vizzutti F, Corti G, et al., Acute viral hepatitis increases liver stiffness values measured by transient elastography. Hepatology 2008; 47: 380-4. (Pubitemid 351280705)
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 380-384
-
-
Arena, U.1
Vizzutti, F.2
Corti, G.3
Ambu, S.4
Stasi, C.5
Bresci, S.6
Moscarella, S.7
Boddi, V.8
Petrarca, A.9
Laffi, G.10
Marra, F.11
Pinzani, M.12
-
36
-
-
63449112448
-
Liver stiffness in the hepatitis B virus carrier: A non-invasive marker of liver disease influenced by the pattern of transaminases
-
Oliveri F, Coco B, Ciccorossi P, et al., Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases. World J Gastroenterol 2008; 14: 6154-62.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 6154-6162
-
-
Oliveri, F.1
Coco, B.2
Ciccorossi, P.3
-
37
-
-
34248680523
-
Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis
-
DOI 10.1002/hep.21665
-
Vizzutti F, Arena U, Romanelli RG, et al., Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology 2007; 45: 1290-7. (Pubitemid 46775793)
-
(2007)
Hepatology
, vol.45
, Issue.5
, pp. 1290-1297
-
-
Vizzutti, F.1
Arena, U.2
Romanelli, R.G.3
Rega, L.4
Foschi, M.5
Colagrande, S.6
Petrarca, A.7
Moscarella, S.8
Belli, G.9
Zignego, A.L.10
Marra, F.11
Laffi, G.12
Pinzani, M.13
-
38
-
-
77952704228
-
Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study
-
Bruno S, Crosignani A, Facciotto C, et al., Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study. Hepatology 2010; 51: 2069-76.
-
(2010)
Hepatology
, vol.51
, pp. 2069-2076
-
-
Bruno, S.1
Crosignani, A.2
Facciotto, C.3
-
39
-
-
33947360829
-
Sustained virological response to interferon-α is with improved outcome in HCV-related cirrhosis: A retrospective study
-
DOI 10.1002/hep.21492
-
Bruno S, Stroffolini T, Colombo M, et al., Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology 2007; 45: 579-87. (Pubitemid 46453759)
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 579-587
-
-
Bruno, S.1
Stroffolini, T.2
Colombo, M.3
Bollani, S.4
Benvegnu, L.5
Mazzella, G.6
Ascione, A.7
Santantonio, T.8
Piccinino, F.9
Andreone, P.10
Mangia, A.11
Gaeta, G.B.12
Persico, M.13
Fagiuoli, S.14
Almasio, P.L.15
-
40
-
-
51949117672
-
Brief communication: The relationship of regression of cirrhosis to outcome in chronic hepatitis C
-
Mallet V, Gilgenkrantz H, Serpaggi J, et al., Brief communication: the relationship of regression of cirrhosis to outcome in chronic hepatitis C. Ann Intern Med 2008; 149: 399-403.
-
(2008)
Ann Intern Med
, vol.149
, pp. 399-403
-
-
Mallet, V.1
Gilgenkrantz, H.2
Serpaggi, J.3
-
41
-
-
38449091418
-
Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
-
Veldt BJ, Heathcote EJ, Wedemeyer H, et al., Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007; 147: 677-84. (Pubitemid 351664462)
-
(2007)
Annals of Internal Medicine
, vol.147
, Issue.10
, pp. 677-684
-
-
Veldt, B.J.1
Heathcote, E.J.2
Wedemeyer, H.3
Reichen, J.4
Hofmann, W.P.5
Zeuzem, S.6
Manns, M.P.7
Hansen, B.E.8
Schalm, S.W.9
Janssen, H.L.A.10
-
42
-
-
28844480321
-
Management of hepatocellular carcinoma
-
DOI 10.1002/hep.20933
-
Bruix J, Sherman M,. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36. (Pubitemid 43112690)
-
(2005)
Hepatology
, vol.42
, Issue.5
, pp. 1208-1236
-
-
Bruix, J.1
Sherman, M.2
|