Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 817-827

  Chong, Soo Ching ^a   Dollah, Mohamad Aziz ^a   Chong, Pei Pei ^a   Maha, Abdullah ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Hypercholesterolemia; LDL receptor; Lipids; Phaleria macrocarpa (Scheff.) Boerl fruit; Proprotein convertase subtilisin kexin type 9; Traditional medicine Asia Oceania

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PHALERIA MACROCARPA EXTRACT; PLANT EXTRACT; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; SIMVASTATIN; SIMVOR 40; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; BODY WEIGHT; CELL STRAIN HEPG2; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERCHOLESTEROLEMIA; MALE; MEDICINAL PLANT; NONHUMAN; PHALERIA MACROCARPA; RAT; RNA ANALYSIS; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT CONTROL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; LIPIDS; LIVER; MALE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LDL; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIMVASTATIN; SOLVENTS; THYMELAEACEAE; TIME FACTORS; UP-REGULATION; WATER; WEIGHT GAIN;

PHALERIA MACROCARPA; RATTUS;

EID: 80052026750     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.041     Document Type: Article

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