Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Gama, Bianca E ^a,b   Pereira Carvalho, Guilhermina A L ^a,b,c   Lutucuta Kosi, Florbela J I ^a,b,d   Almeida De Oliveira, Natália K ^a,b   Fortes, Filomeno ^b,c   Rosenthal, Philip J ^e   Do Rosário, Virgílio E ^b   Daniel Ribeiro, Cláudio ^a,b   Fátima Ferreira Da Cruz, Maria ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^c National Institute for Health Research   (Angola)

^d Universidade Agostinho Neto   (Angola)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; MOLECULAR MARKER; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; FOLIC ACID ANTAGONIST; PROTOZOAL PROTEIN;

ADULT; ANGOLA; ARTICLE; GENE; GENE AMPLIFICATION; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PARASITEMIA; PFDHFR GENE; PFDHPS GENE; PLASMODIUM FALCIPARUM; PREGNANCY; PROTEIN POLYMORPHISM; CHILD; DNA SEQUENCE; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENE FREQUENCY; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MALARIA FALCIPARUM; PARASITOLOGY; PRESCHOOL CHILD;

ADULT; ANGOLA; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE; FEMALE; FOLIC ACID ANTAGONISTS; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PREGNANCY; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 80052025032     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-248     Document Type: Article

References (31)

1. WHO, World Malaria Report 2010 http://www.who.int/malaria/publications/ country-profiles/profile-ago-en.pdf
2. History, dynamics, and public health importance of malaria parasite resistance. Talisuna A, Bloland P, D'Alessandro U, Clin Microbiol Rev 2004 17 235 254 (Pubitemid 38120936)
3. Intermittent preventive treatment against malaria: an update. Gosling R, Cairns M, Chico R, Chandramohan D, Expert Rev Anti Infect Ther 2010 8 589 606
4. Reducing the burden of malaria in pregnancy 2004. http://www.who.int/ malaria/publications/atoz/merajan2003.pdf
5. Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. ter Kuile F, van Eijk A, Filler S, JAMA 2007 297 2603 2616 (Pubitemid 46961032)
6. Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Aponte J, Schellenberg D, Egan A, Breckenridge A, Carneiro I, Critchley J, Danquah I, Dodoo A, Kobbe R, Lell B, May J, Premji Z, Sanz S, Sevene E, Soulaymani-Becheikh R, Winstanley P, Adjei S, Anemana S, Chandramohan D, Issifou S, Mockenhaupt F, Owusu-Agyei S, Greenwood B, Grobusch MP, Kremsner PG, Macete E, Mshinda H, Newman RD, Slutsker L, Tanner M, Alonso P, Menendez C, Lancet 2009 374 1533 1542
7. Intermittent preventive therapy for malaria in pregnancy: is sulfadoxine-pyrimethamine the right drug? Parikh S, Rosenthal PJ, Clin Pharmacol Ther 2010 87 160 162
8. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Cowman A, Morry M, Biggs B, Cross G, Foote S, Proc Natl Acad Sci USA 1988 85 9109 9113 (Pubitemid 19001849)
9. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Brooks D, Wang P, Read M, Watkins W, Sims P, Hyde J, Eur J Biochem 1994 224 397 405 (Pubitemid 24282821)
10. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Plowe C, Cortese J, Djimde A, Nwanyanwu O, Watkins W, Winstanley P, Estrada-Franco J, Mollinedo R, Avila J, Cespedes J, Carter D, Doumbo OK, J Infect Dis 1997 176 1590 1596 (Pubitemid 27518161)
11. Molecular assays for surveillance of antifolate-resistant malaria. Kublin J, Witzig R, Shankar A, Zurita J, Gilman R, Guarda J, Cortese J, Plowe C, Lancet 1998 351 1629 1630 (Pubitemid 28252181)
12. Mechanisms of resistance of malaria parasites to antifolates. Gregson A, Plowe C, Pharmacol Rev 2005 57 117 145 (Pubitemid 40283971)
13. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. Kublin J, Dzinjalamala F, Kamwendo D, Malkin E, Cortese J, Martino L, Mukadam R, Rogerson S, Lescano A, Molyneux M, Winstanley PA, Chimpeni P, Taylor TE, Plowe CV, J Infect Dis 2002 185 380 388 (Pubitemid 34107252)
14. Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. Pearce R, Pota H, Evehe M, Be H, Mombo-Ngoma G, Malisa A, Ord R, Inojosa W, Matondo A, Diallo D, Mbacham W, van den Broek IV, Swarthout TD, Getachew A, Dejene S, Grobusch MP, Njie F, Dunyo S, Kweku M, Owusu-Agyei S, Chandramohan D, Bonnet M, Guthmann JP, Clarke S, Barnes KI, Streat E, Katokele ST, Uusiku P, Agboghoroma CO, Elegba OY, Cissé B, A-Elbasit IE, Giha HA, Kachur SP, Lynch C, Rwakimari JB, Chanda P, Hawela M, Sharp B, Naidoo I, Roper C, PLoS Med 2009 6 1000055
15. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ, Am J Trop Med Hyg 2004 71 758 763 (Pubitemid 40075626)
16. WHO Policy recommendation on Intermittent Preventive Treatment during infancy with sulphadoxine-pyrimethamine (SP-IPTi) for Plasmodium falciparum malaria control in Africa. http://www.who.int/malaria/news/WHO-policy- recommendation-IPTi-032010.pdf
17. Malaria Operational Plan, Year Five (FY2010)-Angola. http://www. fightingmalaria.gov/countries/mops/fy10/angola-mop-fy10.pdf
18. Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania. Pearce R, Drakeley C, Chandramohan D, Mosha F, Roper C, Antimicrob Agents Chemother 2003 47 1347 1354 (Pubitemid 36368596)
19. ChromaPipe: a pipeline for analysis, quality control and management for a DNA sequencing facility. Otto T, Vasconcellos E, Gomes L, Moreira A, Degrave W, Mendonça-Lima L, Alves-Ferreira M, Genet Mol Res 2008 7 861 871
20. High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. Gesase S, Gosling RD, Hashim R, Ord R, Naidoo I, Madebe R, Mosha JF, Joho A, Mandia V, Mrema H, Mapunda E, Savael Z, Lemnge M, Mosha FW, Greenwood B, Roper C, Chandramohan D, PLoS One 2009 4 4569
21. Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine- pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola. Guthmann J, Ampuero J, Fortes F, van Overmeir C, Gaboulaud V, Tobback S, Dunand J, Saraiva N, Gillet P, Franco J, Denoncin A, van Herp M, Balkan S, Dujardin JC, D'Alessandro U, Legros D, Trans R Soc Trop Med Hyg 2005 99 485 492 (Pubitemid 40692060)
22. Drug resistance in malaria. Bloland PB, World Health Organization, Geneva 2001 http://www.who.int/csr/resources/publications/drugresist/malaria.pdf WHO/CDS/CSR/DRS/2001.4
23. Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda. Checchi F, Piola P, Kosack C, Ardizzoni E, Klarkowski D, Kwezi E, Priotto G, Balkan S, Bakyaita N, Brockman A, Guthmann JP, Trop Med Int Health 2004 9 445 450 (Pubitemid 38582227)
24. Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan. Stivanello E, Cavailler P, Cassano F, Omar SA, Kariuki D, Mwangi J, Piola P, Guthmann JP, Trop Med Int Health 2004 9 975 980 (Pubitemid 39278998)
25. Evaluation of prevalence's of pfdhfr and pfdhps mutations in Angola. Fortes F, Dimbu R, Figueiredo P, Neto Z, do Rosário VE, Lopes D, Malar J 2011 10 22
26. Monitoring for multidrug-resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola. Menegon M, Pearce R, Inojosa W, Pisani V, Abel P, Matondo A, Bisoffi Z, Majori G, Ord R, Warhurst D, Roper C, Severini C, Trop Med Int Health 2009 14 1251 1257
27. Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant. Fernandes N, Figueiredo P, do Rosário VE, Cravo P, Malar J 2007 6 35
28. Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. Ndounga M, Tahar R, Basco L, Casimiro P, Malonga D, Ntoumi F, Trop Med Int Health 2007 12 1164 1171 (Pubitemid 47621998)
29. Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia. Mkulama MA, Chishimba S, Sikalima J, Rouse P, Thuma PE, Mharakurwa S, Malar J 2008 7 87
30. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. Cortese JF, Caraballo A, Contreras CE, Plowe CV, J Infect Dis 2002 186 999 1006
31. Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. McCollum A, Poe A, Hamel M, Huber C, Zhou Z, Shi Y, Ouma P, Vulule J, Bloland P, Slutsker L, Barnwell JW, Udhayakumar V, Escalante AA, J Infect Dis 2006 194 189 197 (Pubitemid 44087190)