Risk factors for long-term mortality in a large cohort of patients wait-listed for liver transplantation in Brazil

Liver Transplantation

Volumn 17, Issue 9, 2011, Pages 1013-1020

  Basto, Samanta T ^a   Villela Nogueira, Cristiane A ^a   Tura, Bernardo R ^b   Coelho, Henrique Sergio M ^a   Ribeiro, Joaquim ^a   Fernandes, Eduardo S M ^a   Schmal, Alice F ^a   Victor, Livia ^a   Luiz, Ronir R ^a   Perez, Renata M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b National Cardiology Institute   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CREATININE;

ADULT; ARTICLE; BILIRUBIN BLOOD LEVEL; BRAZIL; CREATININE BLOOD LEVEL; FEMALE; HOSPITAL ADMISSION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MODEL FOR END STAGE LIVER DISEASE SCORE; MORTALITY; ORGAN TRANSPLANTATION; OUTCOMES RESEARCH; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SCORING SYSTEM;

ADULT; AGED; BRAZIL; COHORT STUDIES; FEMALE; HUMANS; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TISSUE AND ORGAN PROCUREMENT; WAITING LISTS;

EID: 80052019006     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22344     Document Type: Article

References (51)

1. 2001 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry for Transplant Recipients: Transplant Data 1991-2000. Rockville, MD: U.S. Department of Health and Human Services; 2001.
2. Trotter JF, Osgood MJ,. MELD scores of liver transplant recipients according to size of waiting list: impact of organ allocation and patient outcomes. JAMA 2004; 291: 1871-1874. (Pubitemid 38509500)
3. Silberhumer GR, Hetz H, Rasoul-Rockenschaub S, Peck-Radosavljevic M, Soliman T, Steininger R, et al. Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival? Transpl Int 2006; 19: 275-281.
4. Zapata R, Innocenti F, Sanhueza E, Humeres R, Rios H, Suarez L, et al. Clinical characterization and survival of adult patients awaiting liver transplantation in Chile. Transplant Proc 2004; 36: 1669-1670. (Pubitemid 39200396)
5. Gheorghe L, Popescu I, Iacob R, Iacob S, Gheorghe C,. Predictors of death on the waiting list for liver transplantation characterized by a long waiting time. Transpl Int 2005; 18: 572-576. (Pubitemid 41726860)
6. Ferraz-Neto BH, Hidalgo R, Thomé T, Melo VA Jr, Lobue A, Zurstrassen MP, et al. Analysis of Model for End-Stage Liver Disease (MELD) score in a liver transplantation waiting list. Transplant Proc 2007; 39: 2511-2513. (Pubitemid 47588353)
7. Moylan CA, Brady CW, Johnson JL, Smith AD, Tuttle-Newhall JE, Muir AJ,. Disparities in liver transplantation before and after introduction of the MELD score. JAMA 2008; 300: 2371-2378.
8. Lee YM, Wai CT, Da Costa M, Lee KH, Sutedja D, Tan KC, et al. Bilirubin appears to be the only independent variable affecting mortality on liver transplant waiting list if waiting time exceeds 1 year. Transplant Proc 2005; 37: 4365-4366. (Pubitemid 43016032)
9. Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC,. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 2000; 31: 864-871. (Pubitemid 30169932)
10. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-470. (Pubitemid 32119037)
11. Said A, Williams J, Holden J, Remington P, Gangnon R, Musat A, Lucey MR,. Model for End Stage Liver Disease score predicts mortality across a broad spectrum of liver disease. J Hepatol 2004; 40: 897-903. (Pubitemid 38670122)
12. Botta F, Giannini E, Romagnoli P, Fasoli A, Malfatti F, Chiarbonello B, et al. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study. Gut 2003; 52: 134-139. (Pubitemid 36020780)
13. Edwards EB, Harper AM,. Application of a continuous disease severity score to the OPTN liver waiting list. Clin Transplant 2001: 19-24.
14. Freeman RB Jr, Wiesner RH, Harper A, McDiarmid SV, Lake J, Edwards E, et al.; for UNOS/OPTN Liver Disease Severity Score, UNOS/OPTN Liver and Intestine, and UNOS/OPTN Pediatric Transplantation Committees. The new liver allocation system: moving toward evidence-based transplantation policy. Liver Transpl 2002; 8: 851-858. (Pubitemid 35012300)
15. Longheval G, Vereerstraeten P, Thiry P, Delhaye M, Le Moine O, Devière J, et al. Predictive models of short- and long-term survival in patients with nonbiliary cirrhosis. Liver Transpl 2003; 9: 260-267. (Pubitemid 36322328)
16. Papatheodoridis GV, Cholongitas E, Dimitriadou E, Touloumi G, Sevastianos V, Archimandritis AJ,. MELD vs Child-Pugh and creatinine-modified Child-Pugh score for predicting survival in patients with decompensated cirrhosis. World J Gastroenterol 2005; 11: 3099-3104. (Pubitemid 40790670)
17. Schepke M, Roth F, Fimmers R, Brensing KA, Sudhop T, Schild HH, Sauerbruch T,. Comparison of MELD, Child-Pugh, and Emory model for the prediction of survival in patients undergoing transjugular intrahepatic portosystemic shunting. Am J Gastroenterol 2003; 98: 1167-1174. (Pubitemid 36733783)
18. Merion RM, Schaubel DE, Dykstra DM, Freeman RB, Port FK, Wolfe RA,. The survival benefit of liver transplantation. Am J Transplant 2005; 5: 307-313. (Pubitemid 40179517)
19. Lee YM, Fernandez M, Da Costa M, Lee KH, Sutedja DS, Tai BC, et al. MELD may not be the better system for organ allocation in liver transplantation patients in Singapore. Singapore Med J 2006; 47: 592-594. (Pubitemid 44048969)
20. Lim SG, Wai CT, Da Costa M, Sutedja DS, Lee YM, Lee KH, et al. Referral patterns and waiting times for liver transplantation in Singapore. Singapore Med J 2006; 47: 599-603. (Pubitemid 44048971)
21. Gotthardt D, Weiss KH, Baumgärtner M, Zahn A, Stremmel W, Schmidt J, et al. Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation. BMC Gastroenterol 2009; 9: 72.
22. Sumskiene J, Kupcinskas L, Pundzius J, Sumskas L,. Prognostic factors for short and long-term survival in patients selected for liver transplantation. Medicina (Kaunas) 2005; 41: 39-46.
23. Kim WR, Therneau TM, Benson JT, Kremers WK, Rosen CB, Gores GJ, Dickson ER,. Deaths on the liver transplant waiting list: an analysis of competing risks. Hepatology 2006; 43: 345-351.
24. Fink MA, Angus PW, Gow PJ, Berry SR, Wang BZ, Muralidharan V, et al. Liver transplant recipient selection: MELD vs. clinical judgment. Liver Transpl 2005; 11: 621-626. (Pubitemid 40872899)
25. Heuman DM, Abou-Assi SG, Habib A, Williams LM, Stravitz RT, Sanyal AJ, et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death. Hepatology 2004; 40: 802-810. (Pubitemid 39288112)
26. Institute of Medicine Committee on Organ Procurement and Transplantation Policy. Organ Procurement and Transplantation: Assessing Current Policies and the Potential Impact of the DHHS Final Rule. Washington, DC: National Academies Press; 1999: 1-29.
27. Hussong S,. Administrative developments: DHHS issues organ allocation final rule. J Law Med Ethics 1999; 27: 380-382.
28. Fink MA, Berry SR, Gow PJ, Angus PW, Wang BZ, Muralidharan V, et al. Risk factors for liver transplantation waiting list mortality. J Gastroenterol Hepatol 2007; 22: 119-124. (Pubitemid 44953426)
29. D'Amico G, Garcia-Tsao G, Pagliaro L,. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44: 217-231. (Pubitemid 41772537)
30. Luca A, Angermayr B, Bertolini G, Koenig F, Vizzini G, Ploner M, et al. An integrated MELD model including serum sodium and age improves the prediction of early mortality in patients with cirrhosis. Liver Transpl 2007; 13: 1174-1180. (Pubitemid 47307228)
31. Prakoso E, Verran D, Dilworth P, Kyd G, Tang P, Tse C, et al. Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney. Intern Med J 2010; 40: 619-625.
32. Walker NM, Stuart KA, Ryan RJ, Desai S, Saab S, Nicol JA, et al. Serum ferritin concentration predicts mortality in patients awaiting liver transplantation. Hepatology 2010; 51: 1683-1691.
33. Piekarska A, Zboinska J, Szymczak W, Kuydowicz J,. Independent prognostic factors in patients with liver cirrhosis. Hepatogastroenterology 2008; 55: 1034-1040. (Pubitemid 351975981)
34. Ripoll C, Bañares R, Rincõn D, Catalina MV, Lo Iacono O, Salcedo M, et al. Influence of hepatic venous pressure gradient on the prediction of survival of patients with cirrhosis in the MELD era. Hepatology 2005; 42: 793-801. (Pubitemid 41401116)
35. Angermayr B, Luca A, König F, Bertolini G, Ploner M, Gridelli B, et al. Aetiology of cirrhosis of the liver has an impact on survival predicted by the Model of End-Stage Liver Disease score. Eur J Clin Invest 2009; 39: 65-71.
36. Angermayr B, Cejna M, Karnel F, Gschwantler M, Koenig F, Pidlich J, et al. Child-Pugh versus MELD score in predicting survival in patients undergoing transjugular intrahepatic portosystemic shunt. Gut 2003; 52: 879-885. (Pubitemid 36613497)
37. Ginès P, Guevara M,. Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management. Hepatology 2008; 48: 1002-1010.
38. Ruf AE, Kremers WK, Chavez LL, Descalzi VI, Podesta LG, Villamil FG,. Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl 2005; 11: 336-343. (Pubitemid 40458408)
39. Biggins SW, Rodriguez HJ, Bacchetti P, Bass NM, Roberts JP, Terrault NA,. Serum sodium predicts mortality in patients listed for liver transplantation. Hepatology 2005; 41: 32-39. (Pubitemid 40066380)
40. Arroyo V, Colmenero J,. Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management. J Hepatol 2003; 38 (suppl 1): S69-S89.
41. Londoño MC, Cárdenas A, Guevara M, Quintõ L, de Las Heras D, Navasa M, et al. MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation. Gut 2007; 56: 1283-1290. (Pubitemid 47300431)
42. Kim WR, Biggins SW, Kremers WK, Wiesner RH, Kamath PS, Benson JT, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008; 359: 1018-1026.
43. Huo TI, Lin HC, Wu JC, Lee FY, Hou MC, Lee PC, et al. Proposal of a modified Child-Turcotte-Pugh scoring system and comparison with the Model for End-Stage Liver Disease for outcome prediction in patients with cirrhosis. Liver Transpl 2006; 12: 65-71.
44. Perkins JD, Halldorson JB, Bakthavatsalam R, Fix OK, Carithers RL Jr, Reyes JD,. Should liver transplantation in patients with Model for End-Stage Liver Disease scores 14 be avoided? A decision analysis approach. Liver Transpl 2009; 15: 242-254.
45. Lladõ L, Figueras J, Memba R, Xiol X, Baliellas C, Vázquez S, et al. Is MELD really the definitive score for liver allocation? Liver Transpl 2002; 8: 795-798. (Pubitemid 35012289)
46. Boursier J, Cesbron E, Tropet AL, Pilette C,. Comparison and improvement of MELD and Child-Pugh score accuracies for the prediction of 6-month mortality in cirrhotic patients. J Clin Gastroenterol 2009; 43: 580-585.
47. Cholongitas E, Marelli L, Shusang V, Senzolo M, Rolles K, Patch D, Burroughs AK,. A systematic review of the performance of the Model for End-Stage Liver Disease (MELD) in the setting of liver transplantation. Liver Transpl 2006; 12: 1049-1061. (Pubitemid 44063778)
48. Salerno F, Merli M, Cazzaniga M, Valeriano V, Rossi P, Lovaria A, et al. MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol 2002; 36: 494-500. (Pubitemid 34407337)
49. Chalasani N, Kahi C, Francois F, Pinto A, Marathe A, Bini EJ, et al. Model for End-Stage Liver Disease (MELD) for predicting mortality in patients with acute variceal bleeding. Hepatology 2002; 35: 1282-1284. (Pubitemid 34454029)
50. Amitrano L, Guardascione MA, Bennato R, Manguso F, Balzano A,. MELD score and hepatocellular carcinoma identify patients at different risk of short-term mortality among cirrhotics bleeding from esophageal varices. J Hepatol 2005; 42: 820-825. (Pubitemid 40693198)
51. Bambha K, Kim WR, Kremers WK, Therneau TM, Kamath PS, Wiesner R, et al. Predicting survival among patients listed for liver transplantation: an assessment of serial MELD measurements. Am J Transplant 2004; 4: 1798-1804. (Pubitemid 39434440)