The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in mooren's ulcer

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 6680-6689

  Hatou, Shin ^a   Dogru, Murat ^a   brahim, Osama M A ^a   Wakamatsu, Tais ^a   Sato, Enrique Adan ^a   Shimmura, Shigeto ^a   Negishi, Kazuno ^a   Tsubota, Kazuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; CYCLOSPORIN; METHYLPREDNISOLONE; PREDNISOLONE; IMMUNOSUPPRESSIVE AGENT;

ADULT; AGED; ARTICLE; CELL DENSITY; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONJUNCTIVA; CORNEA LIMBUS; CORNEA PERFORATION; CORNEA RODENT ULCER; DISEASE SEVERITY; EPIKERATOPLASTY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REMISSION; SLIT LAMP; TREATMENT OUTCOME; BIOLOGICAL MODEL; CELL COUNT; CLINICAL TRIAL; CONFOCAL MICROSCOPY; CORNEA ULCER; DRUG MONITORING; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY;

ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; CELL COUNT; COMBINED MODALITY THERAPY; CORNEAL ULCER; CYCLOSPORINE; DRUG MONITORING; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MODELS, BIOLOGICAL; PROSPECTIVE STUDIES; REMISSION INDUCTION;

EID: 80052005892     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5906     Document Type: Article

References (22)

1. Zaidman GW, Mondino BJ. Mooren's ulcer. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. 2nd ed. London: Elsevier Mosby; 2005:1241-1244.
2. Brown SI. Mooren's ulcer: histopathology and proteolytic enzymes of adjacent conjunctiva. Br J Ophthalmol. 1975;59:670-674.
3. Brown SI, Mondino BJ. Therapy of Mooren's ulcer. Am J Ophthalmol. 1984;98:1-6.
4. Wakefield D, Robinson LP. Cyclosporine therapy in Mooren's ulcer. Br J Ophthalmol. 1987;71:415-417.
5. Foster CS. Systemic immunosuppressive therapy for progressive bilateral Mooren's ulcer. Ophthalmology. 1985;92:1436-1439.
6. Sangwan VS, Zafirakis P, Foster CS. Mooren's ulcer: current concepts in management. Indian J Ophthalmol. 1997;45:7-17.
7. Martin NF, Stark WJ, Maumenee AE. Treatment of Mooren's and Mooren's-like ulcer by lamellar keratectomy: report of six eyes and literature review. Ophthalmic Surg. 1987;18:564-569.
8. Kinoshita S, Ohashi Y, Ohji M, et al. Long-term results of keratoepithelioplasty in Mooren's ulcer. Ophthalmology. 1991;98:438-445.
9. Solomon A, Meller D, Prabhasawat P, et al. Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers. Ophthalmology. 2002;109:694-703.
10. Brown SI, Mondino BJ. Penetrating keratoplasty in Mooren's ulcer. Am J Ophthalmol. 1980;89:255-258.
11. Kaufman SC, Musch DC, Belin MW, et al. Confocal microscopy; a report by the American Academy of Ophthalmology. Ophthalmology. 2004;111:396-406.
12. Matsumoto Y, Dogru M, Sato EA, et al. The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. Mol Vis. 2007;13:1319-1326.
13. Kobayashi A, Yoshita T, Sugiyama K. In vivo findings of the bulbar/palpebral conjunctiva and presumed meibomian glands by laser scanning confocal microscopy. Cornea. 2005;24:985-988.
14. Messmer EM, Torres Suarez E, Mackert MI, et al. In vivo confocal microscopy in blepharitis. Klin Monatsbl Augenheilkd. 2005;222: 894-900.
15. De Nicola R, Labbe A, Amar N, et al. In vivo confocal microscopy and ocular surface disease: anatomical-clinical correlations (in French). J Fr Ophtalmol. 2005;28:691-698.
16. Wakamatsu TH, Sato EA, Matsumoto Y, et al. Conjunctival in vivo confocal scanning laser microscopy in patients with Sjögren syndrome (SS). Invest Ophthalmol Vis Sci. 2010;51:144-150.
17. Hu Y, Sato EA Matsumoto Y, et al. Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. Mol Vis. 2007;13:1379-1389.
18. Matsumoto Y, Sato EA, Osama MA, et al. The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction. Mol Vis. 2008;14:1263-1271.
19. Young RD, Watson PG. Light and electron microscopy of corneal melting syndrome (Mooren's ulcer). Br J Ophthalmol. 1982;66: 341-356.
20. Lopez JS, Price FW, Whitcap SM, et al. Immunohistochemistry of Terrien's and Mooren's corneal degeneration. Arch Ophthalmol. 1991;109:988-992.
21. Schaap OL, Feltkamp TEW, Breebaart AC. Circulating antibodies to corneal tissue in a patient suffering from Mooren's ulcer (ulcus rodens corneae). Clin Exp Immunol. 1969;5:365-370.
22. Brown SI, Mondino BJ, Rabin BS. Autoimmune phenomenon in Mooren's ulcer. Am J Ophthalmol. 1976;82:835-840.