New tricks with old dogs: Personalised medicine and clinical trials

British Journal of Cancer

Volumn 105, Issue 5, 2011, Pages 599-601

  Koziol, J A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Bayesian trials; nomograms; Phase 2 trials

Indexed keywords

ACCURACY; ALGORITHM; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CLINICAL RESEARCH; DATA ANALYSIS; HIGH RISK PATIENT; HUMAN; METHODOLOGY; NOMOGRAM; OUTCOME ASSESSMENT; PHASE 2 CLINICAL TRIAL (TOPIC); PREDICTION; PRIORITY JOURNAL; PROBABILITY; PROPORTIONAL HAZARDS MODEL; PROSTATE CANCER; PROSTATECTOMY; REVIEW; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ANIMALS; CARCINOMA; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; DOGS; HUMANS; INDIVIDUALIZED MEDICINE; MALE; NOMOGRAMS; PROGNOSIS; PROSTATIC NEOPLASMS; RESEARCH DESIGN; TREATMENT OUTCOME; WIT AND HUMOR AS TOPIC;

EID: 80052004394     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.299     Document Type: Review

References (8)

1. Adjei AA, Christian M, Ivy P (2009) Novel designs and end points for phase II clinical trials. Clin Cancer Res 15: 1866-1872
2. Berry DA (2006) Bayesian clinical trials. Nat Rev Drug Discov 5: 27-36
3. Feller W (1968) An Introduction to Probability Theory and Its Applications, Vol. 1, 3rd edn. John Wiley: New York, pp 264-285
4. Kattan MW, Eastham JA, Stapleton AMF, Wheeler TM, Scardino PT (1998) A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst 90: 766-771 (Pubitemid 28259189)
5. Kattan MW, Wheeler TM, Scardino PT (1999) Postoperative nomogram for disease recurrence after radical prostatectomy for prostate cancer. J Clin Oncol 17: 1499-1507 (Pubitemid 29220858)
6. Roach III M, Weinberg V, Nash M, Sandler HM, McLaughlin PW, Kattan MW (2006) Defining high risk prostate cancer with risk groups and nomograms: implications for designing clinical trials. J Urol 76: S16-S20 (Pubitemid 44754980)
7. Shariat SF, Karakiewicz PI, Suardi N, Kattan MW (2008) Comparison of nomograms with other methods for predicting outcomes in prostate cancer: a critical analysis of the literature. Clin Cancer Res 14: 4400-4407
8. Stephenson AJ, Scardino PT, Eastham JA, Bianco Jr FJ, Dotan ZA, DiBlasio CJ, Reuther A, Klein EA, Kattan MW (2005) Postoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy. J Clin Oncol 23: 7005-7012