Anemia associated with depressive symptoms in mild cognitive impairment with severe white matter hyperintensities

Journal of Geriatric Psychiatry and Neurology

Volumn 24, Issue 3, 2011, Pages 161-167

  Son, Sang Joon ^a,b   Lee, Kang Soo ^c   Na, Duk L ^d   Seo, Sang Won ^d   Kim, Chi Hun ^d   Kim, Jong Hun ^d   Oh, Byoung Hoon ^a,b   Hong, Chang Hyung ^e  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Kwandong University College of Medicine   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

^e Ajou University School of Medicine   (South Korea)

Author keywords

anemia; depression; mild cognitive impairment; subcortical ischemic vascular disease; white matter hyperintensities

Indexed keywords

AGED; ANALYSIS OF COVARIANCE; ANEMIA; ARTICLE; BLOOD SAMPLING; BRAIN CORTEX LESION; BRAIN DISEASE; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GERIATRIC DEPRESSION SCALE; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SUBCORTEX; WHITE MATTER; WHITE MATTER HYPERINTENSITY;

AGED; AGED, 80 AND OVER; ANEMIA; BRAIN; DEPRESSION; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NERVE FIBERS, MYELINATED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS;

EID: 80052000295     PISSN: 08919887     EISSN: 15525708     Source Type: Journal    
DOI: 10.1177/0891988711417132     Document Type: Article

References (37)

1. Ritchie K, Touchon J. Mild cognitive impairment: conceptual basis and current nosological status. Lancet. 2000 ; 355 (9199). 225-228 (Pubitemid 30068229)
2. Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009 ; 66 (12). 1447-1455
3. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002 ; 288 (12). 1475-1483
4. Green RC, Cupples LA, Kurz A, Auerbach S, Go R, Sadovnick D, et al. Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Arch Neurol. 2003 ; 60 (5). 753-759 (Pubitemid 36569895)
5. Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology. 2010 ; 75 (1). 35-41
6. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry. 2006 ; 63 (5). 530-538
7. Modrego PJ, Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch Neurol. 2004 ; 61 (8). 1290-1293 (Pubitemid 39062687)
8. Steffens DC, Krishnan KR, Crump C, Burke GL. Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke. 2002 ; 33 (6). 1636-1644 (Pubitemid 34619971)
9. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry. 2000 ; 57 (11). 1071-1076
10. Lavretsky H, Roybal DJ, Ballmaier M, Toga AW, Kumar A. Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression. J Clin Psychiatry. 2005 ; 66 (8). 964-967 (Pubitemid 41191786)
11. Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, et al. Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study. Am J Psychiatry. 2010 ; 167 (5). 589-597
12. Schoevers RA, Geerlings MI, Deeg DJ, Holwerda TJ, Jonker C, Beekman AT. Depression and excess mortality: evidence for a dose response relation in community living elderly. Int J Geriatr Psychiatry. 2009 ; 24 (2). 169-176
13. Inzitari M, Studenski S, Rosano C, Zakai NA, Longstreth WT, Cushman M, et al. Anemia is associated with the progression of white matter disease in older adults with high blood pressure: the cardiovascular health study. J Am Geriatr Soc. 2008 ; 56 (10). 1867-1872
14. Penninx BW, Pahor M, Cesari M, Corsi AM, Woodman RC, Bandinelli S, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004 ; 52 (5). 719-724 (Pubitemid 38596489)
15. Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PHM. Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: the women's health and aging study II. J Am Geriatr Soc. 2009 ; 57 (9). 1604-1611
16. Onder G, Penninx BW, Cesari M, Bandinelli S, Lauretani F, Bartali B, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005 ; 60 (9). 1168-1172 (Pubitemid 41384488)
17. Lucca U, Tettamanti M, Mosconi P, Apolone G, Gandini F, Nobili A, et al. Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the "Health and Anemia" study. PLoS One. 2008 ; 3 (4). e1920
18. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999 ; 56 (3). 303-308 (Pubitemid 29120227)
19. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993 ; 43 (11). 2412-2414 (Pubitemid 23346995)
20. Kang Y, Na DL, Hanhn S. A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J Korean Neurol Assoc. 1997 ; 15 (2). 300-307
21. Sheikh JI, Yesavage JA Clinical Gerontology: A Guide to Assessment and Intervention. Brink TL, ed. New York, NY: Haworth Press Inc ; 1986: 165-173.
22. Ahn HJ, Chin J, Park A, Lee BH, Suh MK, Seo SW, et al. Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci. 2010 ; 25 (7). 1071-1076
23. Kang Y, Na DL Seoul Neuropsychological Screening Battery (SNSB). Seoul: Human Brain Research & Consulting Co ; 2003 :
24. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. Am J Roentgenol. 1987 ; 149 (2). 351-356 (Pubitemid 17104996)
25. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Vermersch P, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci. 1993 ; 114 (1). 7-12 (Pubitemid 23025201)
26. Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006 ; 63 (3). 273-279
27. Blazer DG. Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci. 2003 ; 58 (3). 249-265 (Pubitemid 36307597)
28. Alexopoulos GS. Vascular disease, depression, and dementia. J Am Geriatr Soc. 2003 ; 51 (8). 1178-1180 (Pubitemid 36993481)
29. Tettamanti M, Lucca U, Gandini F, Recchia A, Mosconi P, Apolone G, et al. Prevalence, incidence and types of mild anemia in the elderly: the "Health and Anemia" population-based study. Haematologica. 2010 ; 95 (11). 1849-1856
30. Ishine M, Wada T, Akamatsu K, Cruz MR, Sakagami T, Kita T, et al. No positive correlation between anemia and disability in older people in Japan. J Am Geriatr Soc. 2005 ; 53 (4). 733-734 (Pubitemid 41623505)
31. Mega MS, Cummings JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci. 1994 ; 6 (4). 358-370 (Pubitemid 24344856)
32. Oda K, Okubo Y, Ishida R, Murata Y, Ohta K, Matsuda T, et al. Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity. Biol Psychiatry. 2003 ; 53 (2). 150-156 (Pubitemid 36126478)
33. Bakker SL, de Leeuw FE, de Groot JC, Hofman A, Koudstaal PJ, Breteler MM. Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly. Neurology. 1999 ; 52 (3). 578-583 (Pubitemid 29075607)
34. Vorstrup S. Tomographic cerebral blood flow measurements in patients with ischemic cerebrovascular disease and evaluation of the vasodilatory capacity by the acetazolamide test. Acta Neurol Scand Suppl. 1988 ; 114: 1-48
35. Matsuo K, Onodera Y, Hamamoto T, Muraki K, Kato N, Kato T. Hypofrontality and microvascular dysregulation in remitted late-onset depression assessed by functional near-infrared spectroscopy. Neuroimage. 2005 ; 26 (1). 234-242 (Pubitemid 40602902)
36. Kuwabara Y, Sasaki M, Hirakata H, Koga H, Nakagawa M, Chen T, et al. Cerebral blood flow and vasodilatory capacity in anemia secondary to chronic renal failure. Kidney Int. 2002 ; 61 (2). 564-569 (Pubitemid 34102597)
37. Mitrache C, Passweg JR, Libura J, Petrikkos L, Seiler WO, Gratwohl A, et al. Anemia: an indicator for malnutrition in the elderly. Ann Hematol. 2001 ; 80 (5). 295-298 (Pubitemid 32515052)