Melamine-tainted milk product-associated urinary stones in children

Pediatrics International

Volumn 53, Issue 4, 2011, Pages 489-496

  Wang, Zheng ^a   Luo, Hong ^a   Tu, Wenwei ^a,c   Yang, Hui ^a   Wong, Wilfred Hing Sang ^c   Wong, Wing Tak ^c   Yung, Ka Fu ^c   Zhou, Nan ^b   Zhang, Jingti ^b   Li, Xiaoqing ^b   Wang, Zerong ^a   Guo, Wenjun ^a   Mu, Dezhi ^a   Li, Fanghong ^a   Mao, Meng ^a,c   Lau, Yu Lung ^c  

^a SICHUAN UNIVERSITY   (China)

^b Xian Children's Hospital   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

cyanuric acid; melamine; milk; uric acid; urinary stones

Indexed keywords

MELAMINE; URIC ACID;

ARTICLE; ARTIFICIAL MILK; BREAST FEEDING; CHILD; CHINA; DAIRY PRODUCT; DIETARY INTAKE; FEMALE; FOOD CONTAMINATION; HUMAN; HYDRONEPHROSIS; INFANT; LIQUID CHROMATOGRAPHY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MELAMINE TAINTED MILK PRODUCT; NEPHROLITHIASIS; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCANNING ELECTRON MICROSCOPY; STONE FORMATION; TANDEM MASS SPECTROMETRY; ULTRASOUND; URETER STONE; UROLITHIASIS; X RAY DIFFRACTION;

ANIMALS; CHILD, PRESCHOOL; CHINA; FEMALE; FOOD CONTAMINATION; HUMANS; INFANT; INFANT FORMULA; LOGISTIC MODELS; MALE; MILK; ODDS RATIO; RESINS, SYNTHETIC; RISK FACTORS; TRIAZINES; URINARY CALCULI;

EID: 80051998321     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2010.03284.x     Document Type: Article

References (30)

1. World Health Organization. Melamine-contamination Event, China, 2008. [Accessed 6 December 2008.] Available from URL
2. Ministry of Health of People's Republic of China. [Infants and Young Children with Urolithiasis Associated with Sanlu Infant Milk Formula] (in Chinese). [Accessed 16 September 2008.] Available from URL
3. Ministry of Health of People's Republic of China. [Report on the Management of Children Involved in the Infant Milk Formula Incident] (in Chinese). [Accessed 20 October 2008.] Available from URL
4. Chinese Centre for Disease Control and Prevention. More than 12,000 Babies Hospitalized for Taking Tainted Milk. [Accessed 28 October 2008.] Available from URL
5. Ministry of Health of People's Republic of China. [The Sanlu Infant Milk Formula Incident] (in Chinese). [Accessed 4 December 2008.] Available from URL
6. Bhalla V, Grimm PC, Chertow GM, Pao AC,. Melamine nephrotoxicity: An emerging epidemic in an era of globalization. Kidney Int. 2009; 75: 774-9.
7. Kuehn BM,. Melamine scandals highlight hazards of increasingly globalized food chain. JAMA 2009; 301: 473-5.
8. Brown CA, Jeong KS, Poppenga RH, et al,. Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J. Vet. Diagn. Invest. 2007; 19: 525-31. (Pubitemid 351202195)
9. Cianciolo RE, Bischoff K, Ebel JG, Van Winkle TJ, Goldstein RE, Serfillippi LM,. Clinicopathologic, histologic, and toxicologic findings in 70 cats inadvertently exposed to pet food contaminated with melamine and cyanuric acid. J. Am. Vet. Med. Assoc. 2008; 233: 729-37.
10. Lam CW, Lau L, Che X, et al,. Diagnosis and spectrum of melamine-related renal disease. Plausible mechanism of stone formation in humans. Clin. Chim. Acta 2009; 402: 150-55.
11. Hau AKC, Kwan TH, Li PKT,. Melamine toxicity and the kidney. J. Am. Soc. Nephrol. 2009; 20: 245-50.
12. General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China. [Announcement of the National Investigation of Melamine Content of Liquid Milk Formulae] (in Chinese). [Accessed 3 October 2008.] Available from URL
13. General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China. [Announcement of the Melamine Investigation of Ordinary Milk Formulae] (in Chinese). [Accessed 3 October 2008.] Available from URL
14. Zhou YC, Guo WX,. Ultrasonography, 4th edn. Science & Technology Press, Beijing, 2003; 1142-87 (in Chinese).
15. US Food and Drug Administration. Determination of Melamine Residues in Catfish Tissue by Triple Quadrupole LC-MS-MS with HILIC Chromatography. Laboratory Information Bulletin, LIB No. 4396. [Accessed 1 November 2008.] Available from URL
16. US Food and Drug Administration. Interim Method for Determination of Melamine and Cyanuric Acid Residues in Foods using LC-MS/MS: Version 1.0. Laboratory Information Bulletin, LIB No. 4422. [Accessed 1 November 2008.] Available from URL
17. Guan N, Fan Q, Ding J, et al,. Melamine-contaminated powdered formula and urolithiasis in young children. N. Engl. J. Med. 2009; 360: 1067-74.
18. Hu P, Lu L, Hu B, Zhang CR,. The size of melamine-induced stones is dependent on the melamine content of the formula fed, but not on duration of exposure. Pediatr. Nephrol. 2010; 25: 565-6.
19. Sun N, Shen Y, Sun Q, et al,. Melamine related urinary calculus and acute renal failure in infants. Chin. J. Pediatr. 2008; 46: 810-15.
20. Shen Y, Liu XR, Zhang GJ, Zhou N,. Blood purification therapy in treatment of acute renal failure in infants with melamine-induced stones. Chin. Med. J. 2009; 122: 257-61.
21. Sun Q, Shen Y, Sun N, et al,. Diagnosis, treatment and follow-up of 25 patients with melamine-induced kidney stones complicated by acute obstructive renal failure in Beijing Children's Hospital. Eur. J. Pediatr. 2010; 169: 483-9.
22. Dobson RLM, Motlagh S, Quijano M, et al,. Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol. Sci. 2008; 106: 251-62.
23. Reimschuessel R, Gieseker CM, Miller RA, et al,. Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs. J. Am. Vet. Med. Assoc. 2008; 69: 1217-28.
24. Ding J,. Childhood urinary stones induced by melamine-tainted formula: How much we know, how much we don't know. Kidney Int. 2009; 75: 780-82.
25. Kobayashi T, Okada A, Jujii Y, et al,. The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid. Urol. Res. 2010; 38: 117-25.
26. Jia LQ, Shen Y, Wang XM, He LJ, Xin Y, Hu YX,. Ultrasonographic diagnosis of urinary calculus caused by melamine in children. Chin. Med. J. 2009; 122: 252-6.
27. Zhang L, Wu LL, Wang YP, Liu AM, Zou CC, Zhao ZY,. Melamine-contaminated milk products induced urinary tract calculi in children. World J. Pediatr. 2009; 5: 31-5.
28. Zhu SL, Li JH, Chen L, et al,. Conservative management of pediatric nephrolithiasis caused by melamine-contaminated milk powder. Pediatrics 2009; 123: e1099-102.
29. Ministry of Health of the People's Republic of China. [Announcement of the Limit of Melamine Concentration in Dairy Products] (in Chinese). [Accessed 12 October 2008.] Available from URL
30. World Health Organization. Experts Set Tolerable Level for Melamine Intake. [Accessed 8 December 2008.] Available from URL