Left atrial function: Physiology, assessment, and clinical implications

European Journal of Echocardiography

Volumn 12, Issue 6, 2011, Pages 421-430

  Blume, Gustavo G ^a   McLeod, Christopher J ^a   Barnes, Marion E ^b   Seward, James B ^a   Pellikka, Patricia A ^a   Bastiansen, Paul M ^a   Tsang, Teresa S M ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Echocardiography; Left atrial function; Left atrium

Indexed keywords

BIOLOGICAL MARKER;

DEATH; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; FUNCTIONAL ASSESSMENT; HEART AFTERLOAD; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HUMAN; NEUROENDOCRINOLOGY; PRIORITY JOURNAL; REVIEW; STROKE; THREE DIMENSIONAL IMAGING; TISSUE DOPPLER IMAGING; VOLUMETRY;

ATRIAL FIBRILLATION; ATRIAL FUNCTION, LEFT; BIOLOGICAL MARKERS; ECHOCARDIOGRAPHY, DOPPLER; HEART ATRIA; HEART FAILURE; HUMANS; MITRAL VALVE; NEUROENDOCRINE CELLS; PROGNOSIS;

EID: 80051983362     PISSN: 15252167     EISSN: 15322114     Source Type: Journal    
DOI: 10.1093/ejechocard/jeq175     Document Type: Review

References (146)

1. Serra JL, Bendersky M. Atrial fibrillation and renin-angiotensin system. Ther Adv Cardiovasc Dis 2008;2:215-23.
2. Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM. Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol 2009;341-66.
3. Garcia MJ. Left ventricular filling. Heart Fail Clin 2008;4:47-56. (Pubitemid 351289330)
4. Tsang TS, Abhayaratna WP, Barnes ME, Miyasaka Y, Gersh BJ, Bailey KR et al. Prediction of cardiovascular outcomes with left atrial size: is volume superior to area or diameter? J Am Coll Cardiol 2006;47:1018-23.
5. Benjamin EJ, D'Agostino RB, Belanger AJ, Wolf PA, Levy D. Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation 1995;92:835-41.
6. Laukkanen JA, Kurl S, Eranen J, Huttunen M, Salonen JT. Left atrium size and the risk of cardiovascular death in middle-aged men. Arch Intern Med 2005;165:1788-93. (Pubitemid 41138969)
7. Abhayaratna WP, Seward JB, Appleton CP, Douglas PS, Oh JK, Tajik AJ et al. Left atrial size: physiologic determinants and clinical applications. J Am Coll Cardiol 2006;47:2357-63. (Pubitemid 43866385)
8. Casaclang-Verzosa G, Gersh BJ, Tsang TS. Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation. J Am Coll Cardiol 2008;51:1-11.
9. Mitchell JH, Shapiro W. Atrial function and the hemodynamic consequences of atrial fibrillation in man. Am J Cardiol 1969;23:556-67.
10. Pagel PS, Kehl F, Gare M, Hettrick DA, Kersten JR, Warltier DC. Mechanical function of the left atrium: new insights based on analysis of pressure-volume relations and Doppler echocardiography. Anesthesiology 2003;98:975-94. (Pubitemid 36373235)
11. Appleton CP, Hatle LK, Popp RL. Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study. J Am Coll Cardiol 1988;12:426-40.
12. Pozzoli M, Capomolla S, Sanarico M, Pinna G, Cobelli F, Tavazzi L. Doppler evaluations of left ventricular diastolic filling and pulmonary wedge pressure provide similar prognostic information in patients with systolic dysfunction after myocardial infarction. Am Heart J 1995;129:716-25.
13. Toutouzas K, Trikas A, Pitsavos C, Barbetseas J, Androulakis A, Stefanadis C et al. Echocardiographic features of left atrium in elite male athletes. Am J Cardiol 1996;78:1314-7. (Pubitemid 126657219)
14. Tsang TS, Barnes ME, Gersh BJ, Bailey KR, Seward JB. Risks for atrial fibrillation and congestive heart failure in patients ≥65 years of age with abnormal left ventricular diastolic relaxation. Am J Cardiol 2004;93:54-8. (Pubitemid 38022033)
15. Thomas L, Levett K, Boyd A, Leung DY, Schiller NB, Ross DL. Compensatory changes in atrial volumes with normal aging: is atrial enlargement inevitable? J Am Coll Cardiol 2002;40:1630-5. (Pubitemid 35253641)
16. Thomas L, Levett K, Boyd A, Leung DY, Schiller NB, Ross DL. Changes in regional left atrial function with aging: evaluation by Doppler tissue imaging. Eur J Echocardiogr 2003;4:92-100. (Pubitemid 36582502)
17. Duygu H, Nalbantgil S, Ozerkan F, Zoghi M, Akilli A, Erturk U et al. Effects of levosimendan on left atrial functions in patients with ischemic heart failure. Clin Cardiol 2008;31:607-13.
18. Stefanadis C, Dernellis J, Toutouzas P. A clinical appraisal of left atrial function. Eur Heart J 2001;22:22-36. (Pubitemid 32622186)
19. Nakao T, Shimizu M, Sugihara N, Kita Y, Shimizu K, Takeda R. Preload dependency of left atrial pump function in hypertrophic cardiomyopathy. Jpn Circ J 1993;57:47-54. (Pubitemid 23071862)
20. Yoshida N, Okamoto M, Makita Y, Nanba K, Yoshizumi M. Determinants of enhanced left atrial active emptying with aging: left atrial preload, contractility or both? Intern Med 2009;48:987-92.
21. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K. Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol 1983;245(Pt 1):H773-80. (Pubitemid 14245481)
22. Schabelman S, Schiller NB, Silverman NH, Ports TA. Left atrial volume estimation by two-dimensional echocardiography. Cathet Cardiovasc Diagn 1981;7:165-78. (Pubitemid 11090386)
23. Triposkiadis F, Tentolouris K, Androulakis A, Trikas A, Toutouzas K, Kyriakidis M et al. Left atrial mechanical function in the healthy elderly: new insights from a combined assessment of changes in atrial volume and transmitral flow velocity. J Am Soc Echocardiogr 1995;8:801-9.
24. Stone HL. Effect of heart rate on left atrial systolic shortening in the dog. J Appl Physiol 1975;38:1110-6.
25. Williams JF Jr, Sonnenblick EH, Braunwald E. Determinants of atrial contractile force in the intact heart. Am J Physiol 1965;209:1061-8.
26. Payne RM, Stone HL, Engelken EJ. Atrial function during volume loading. J Appl Physiol 1971;31:326-31.
27. Prioli A, Marino P, Lanzoni L, Zardini P. Increasing degrees of left ventricular filling impairment modulate left atrial function in humans. Am J Cardiol 1998;82:756-61.
28. Okamoto M, Tsubokura T, Morishita K, Nakagawa H, Yamagata T, Kawagoe T et al. Effects of volume loading on left atrial systolic time intervals. J Clin Ultrasound 1991;19:405-11.
29. Blondheim DS, Osipov A, Meisel SR, Frimerman A, Shochat M, Shotan A. Relation of left atrial size to function as determined by transesophageal echocardiography. Am J Cardiol 2005;96:457-63. (Pubitemid 41058884)
30. Abhayaratna WP, Fatema K, Barnes ME, Seward JB, Gersh BJ, Bailey KR et al. Left atrial reservoir function as a potent marker for first atrial fibrillation or flutter in persons ≥65 years of age. Am J Cardiol 2008;101:1626-9.
31. Gutman J, Wang YS, Wahr D, Schiller NB. Normal left atrial function determined by 2-dimensional echocardiography. Am J Cardiol 1983;51:336-40. (Pubitemid 13179407)
32. Gerstenblith G, Frederiksen J, Yin FC, Fortuin NJ, Lakatta EG, Weisfeldt ML. Echocardiographic assessment of a normal adult aging population. Circulation 1977;56:273-8. (Pubitemid 8247487)
33. Erol MK, Ugur M, Yilmaz M, Acikel M, Sevimli S, Alp N. Left atrial mechanical functions in elite male athletes. Am J Cardiol 2001;88:915-7, A9. (Pubitemid 32995935)
34. Rodrigues AC, Scannavacca MI, Caldas MA, Hotta VT, Pisani C, Sosa EA et al. Left atrial function after ablation for paroxysmal atrial fibrillation. Am J Cardiol 2009;103:395-8.
35. Verma A, Kilicaslan F, Adams JR, Hao S, Beheiry S, Minor S et al. Extensive ablation during pulmonary vein antrum isolation has no adverse impact on left atrial function: an echocardiography and cine computed tomography analysis. J Cardiovasc Electrophysiol 2006;17:741-6.
36. Thomas L, McKay T, Byth K, Marwick TH. Abnormalities of left atrial function after cardioversion: an atrial strain rate study. Heart 2007;93:89-95. (Pubitemid 46094062)
37. Boyd AC, Schiller NB, Ross DL, Thomas L. Segmental atrial contraction in patients restored to sinus rhythm after cardioversion for chronic atrial fibrillation: a colour Doppler tissue imaging study. Eur J Echocardiogr 2008;9:12-7. (Pubitemid 351664792)
38. Thomas L, Thomas SP, Hoy M, Boyd A, Schiller NB, Ross DL. Comparison of left atrial volume and function after linear ablation and after cardioversion for chronic atrial fibrillation. Am J Cardiol 2004;93:165-70. (Pubitemid 38058724)
39. Mazzone C, Pandullo C, Scardi S, Salvi R, Miccio M, Cattarini G et al. Left atrial and appendage mechanical function after pharmacological or electrical cardioversion in patients with chronic atrial fibrillation: a multicenter, randomized study. Ital Heart J 2000;1:128-36.
40. Boyd AC, Schiller NB, Ross DL, Thomas L. Differential recovery of regional atrial contraction after restoration of sinus rhythm after intraoperative linear radiofrequency ablation for atrial fibrillation. Am J Cardiol 2009;103:528-34.
41. Okcun B, Yigit Z, Arat A, Baran T, Kucukoglu MS. Stunning of the left atrium after conversion of atrial fibrillation: predictor for maintenance of sinus rhythm? Echocardiography 2005;22:402-7. (Pubitemid 40684487)
42. Parmley WW. Neuroendocrine changes in heart failure and their clinical relevance. Clin Cardiol 1995;18:440-5.
43. Francis GS. Neuroendocrine activity in congestive heart failure. Am J Cardiol 1990;66:33D-8D; discussion 8D-9D.
44. Dietz JR. Mechanisms of atrial natriuretic peptide secretion from the atrium. Cardiovasc Res 2005;68:8-17. (Pubitemid 41268613)
45. Tsioufis C, Stougiannos P, Taxiarchou E, Skiadas I, Chatzis D, Thomopoulos C et al. The interplay between haemodynamic load, brain natriuretic peptide and left atrial size in the early stages of essential hypertension. J Hypertens 2006;24:965-72. (Pubitemid 43670469)
46. Weber KT, Brilla CG, Campbell SE, Guarda E, Zhou G, Sriram K. Myocardial fibrosis: role of angiotensin II and aldosterone. Basic Res Cardiol 1993;88(Suppl. 1):107-24. (Pubitemid 23226442)
47. Brilla CG, Reams GP, Maisch B, Weber KT. Renin-angiotensin system and myocardial fibrosis in hypertension: regulation of the myocardial collagen matrix. Eur Heart J 1993;14(Suppl. J):57-61. (Pubitemid 23355392)
48. Brilla CG, Matsubara LS, Weber KT. Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J Mol Cell Cardiol 1993;25:563-75. (Pubitemid 23208145)
49. Hara H, Virmani R, Holmes DR Jr, Buchbinder M, Lesser JR, Van Tassel RA et al. Is the left atrial appendage more than a simple appendage? Cathet Cardiovasc Interv 2009;74:234-42.
50. Yoshihara F, Nishikimi T, Kosakai Y, Isobe F, Matsuoka H, Takishita S et al. Atrial natriuretic peptide secretion and body fluid balance after bilateral atrial appendectomy by the maze procedure. J Thorac Cardiovasc Surg 1998;116:213-9. (Pubitemid 28367086)
51. De Bold AJ, Bruneau BG, Kuroski de Bold ML. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc Res 1996;31:7-18. (Pubitemid 26093751)
52. Henry JP, Gauer OH, Reeves JL. Evidence of the atrial location of receptors influencing urine flow. Circ Res 1956;4:85-90.
53. Panagiotopoulos K, Toumanidis S, Saridakis N, Vemmos K, Moulopoulos S. Left atrial and left atrial appendage functional abnormalities in patients with cardioembolic stroke in sinus rhythm and idiopathic atrial fibrillation. J Am Soc Echocardiogr 1998;11:711-9. (Pubitemid 28335129)
54. Handke M, Harloff A, Hetzel A, Olschewski M, Bode C, Geibel A. Left atrial appendage flow velocity as a quantitative surrogate parameter for thromboembolic risk: determinants and relationship to spontaneous echocontrast and thrombus formation-a transesophageal echocardiographic study in 500 patients with cerebral ischemia. J Am Soc Echocardiogr 2005;18:1366-72. (Pubitemid 41821184)
55. Handke M, Harloff A, Hetzel A, Olschewski M, Bode C, Geibel A. Predictors of left atrial spontaneous echocardiographic contrast or thrombus formation in stroke patients with sinus rhythm and reduced left ventricular function. Am J Cardiol 2005;96:1342-4. (Pubitemid 41505422)
56. Fatkin D, Feneley M. Stratification of thromboembolic risk of atrial fibrillation by transthoracic echocardiography and transesophageal echocardiography: the relative role of left atrial appendage function, mitral valve disease, and spontaneous echocardiographic contrast. Prog Cardiovasc Dis 1996;39:57-68. (Pubitemid 26255923)
57. Sick PB, Schuler G, Hauptmann KE, Grube E, Yakubov S, Turi ZG et al. Initial worldwide experience with the WATCHMAN left atrial appendage system for stroke prevention in atrial fibrillation. J Am Coll Cardiol 2007;49:1490-5. (Pubitemid 46505070)
58. Itoh T, Okamoto H, Nimi T, Morita S, Sawazaki M, Ogawa Y et al. Left atrial function after Cox's maze operation concomitant with mitral valve operation. Ann Thorac Surg 1995;60:354-9; discussion 9-60.
59. Kurt M, Wang J, Torre-Amione G, Nagueh SF. Left atrial function in diastolic heart failure. Circ Cardiovasc Imaging 2009;2:10-5.
60. Lester SJ, Ryan EW, Schiller NB, Foster E. Best method in clinical practice and in research studies to determine left atrial size. Am J Cardiol 1999;84:829-32. (Pubitemid 29469795)
61. Kircher B, Abbott JA, Pau S, Gould RG, Himelman RB, Higgins CB et al. Left atrial volume determination by biplane two-dimensional echocardiography: validation by cine computed tomography. Am Heart J 1991;121(Pt 1):864-71.
62. Rodevan O, Bjornerheim R, Ljosland M, Maehle J, Smith HJ, Ihlen H. Left atrial volumes assessed by three-and two-dimensional echocardiography compared to MRI estimates. Int J Card Imaging 1999;15:397-410.
63. Triposkiadis F, Pitsavos C, Boudoulas H, Trikas A, Toutouzas P. Left atrial myopathy in idiopathic dilated cardiomyopathy. Am Heart J 1994;128:308-15. (Pubitemid 24259155)
64. Dernellis J, Panaretou M. Left atrial function in patients with a high C-reactive protein level and paroxysmal atrial fibrillation. Acta Cardiol 2006;61:507-11. (Pubitemid 44641702)
65. Jenkins C, Bricknell K, Marwick TH. Use of real-time three-dimensional echocardiography to measure left atrial volume: comparison with other echocardiographic techniques. J Am Soc Echocardiogr 2005;18:991-7. (Pubitemid 41253959)
66. Anwar AM, Soliman OI, Geleijnse ML, Nemes A, Vletter WB, ten Cate FJ. Assessment of left atrial volume and function by real-time three-dimensional echocardiography. Int J Cardiol 2008;123:155-61. (Pubitemid 350250890)
67. Anwar AM, Geleijnse ML, Soliman OI, Nemes A, ten Cate FJ. Left atrial Frank-Starling law assessed by real-time, three-dimensional echocardiographic left atrial volume changes. Heart 2007;93:1393-7. (Pubitemid 351480138)
68. Vasan RS, Larson MG, Levy D, Galderisi M, Wolf PA, Benjamin EJ. Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study). Am J Cardiol 2003;91:1079-83. (Pubitemid 36514923)
69. Perez-Paredes M, Gonzalvez M, Ruiz Ros JA, Gimenez DM, Carnero A, Carrillo A et al. [Assessment of left atrial wall velocities by pulsed wave tissue Doppler imaging. A new approach to the study of atrial function]. Rev Esp Cardiol 2004;57:1059-65. (Pubitemid 40017324)
70. Miyatake K, Okamoto M, Kinoshita N, Owa M, Nakasone I, Sakakibara H et al. Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. Am J Cardiol 1984;53:586-9. (Pubitemid 14188834)
71. Choong CY, Herrmann HC, Weyman AE, Fifer MA. Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. J Am Coll Cardiol 1987;10:800-8. (Pubitemid 17163104)
72. Mattioli AV, Tarabini Castellani E, Vivoli D, Molinari R, Mattioli G. Restoration of atrial function after atrial fibrillation of different etiological origins. Cardiology 1996;87:205-11. (Pubitemid 26108376)
73. Yuda S, Nakatani S, Isobe F, Kosakai Y, Miyatake K. Comparative efficacy of the maze procedure for restoration of atrial contraction in patients with and without giant left atrium associated with mitral valve disease. J Am Coll Cardiol 1998;31:1097-102. (Pubitemid 28212512)
74. Shizukuda Y, Bolan CD, Tripodi DJ, Yau YY, Nguyen TT, Botello G et al. Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis. Am J Cardiol 2006;98:954-9. (Pubitemid 44402270)
75. Manning WJ, Leeman DE, Gotch PJ, Come PC. Pulsed Doppler evaluation of atrial mechanical function after electrical cardioversion of atrial fibrillation. J Am Coll Cardiol 1989;13:617-23. (Pubitemid 19073928)
76. Oki T, Fukuda N, Iuchi A, Tabata T, Tanimoto M, Manabe K et al. Left atrial systolic performance in the presence of elevated left ventricular end-diastolic pressure: evaluation by transesophageal pulsed Doppler echocardiography of left ventricular inflow and pulmonary venous flow velocities. Echocardiography 1997;14:23-32. (Pubitemid 27121406)
77. Oki T, Iuchi A, Tabata T, Yamada H, Manabe K, Kageji Y et al. Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy: combined analysis of transmitral and pulmonary venous flow velocities. Clin Cardiol 1997;20:47-54.
78. Sakai H, Kunichika H, Murata K, Seki K, Katayama K, Hiro T et al. Improvement of afterload mismatch of left atrial booster pump function with positive inotropic agent. J Am Coll Cardiol 2001;37:270-7. (Pubitemid 32051750)
79. Iuchi A, Oki T, Tabata T, Manabe K, Kageji Y, Sasaki M et al. [Changes in pulmonary venous and transmitral flow velocity patterns after cardioversion of atrial fibrillation]. J Cardiol 1995;25:317-24.
80. Appleton CP, Galloway JM, Gonzalez MS, Gaballa M, Basnight MA. Estimation of left ventricular filling pressures using two-dimensional and Doppler echocardiography in adult patients with cardiac disease. Additional value of analyzing left atrial size, left atrial ejection fraction and the difference in duration of pulmonary venous and mitral flow velocity at atrial contraction. J Am Coll Cardiol 1993;22:1972-82. (Pubitemid 23359661)
81. Nakatani S, Garcia MJ, Firstenberg MS, Rodriguez L, Grimm RA, Greenberg NL et al. Noninvasive assessment of left atrial maximum dP/dt by a combination of transmitral and pulmonary venous flow. J Am Coll Cardiol 1999;34:795-801. (Pubitemid 29436186)
82. Gentile F, Mantero A, Lippolis A, Ornaghi M, Azzollini M, Barbier P et al. Pulmonary venous flow velocity patterns in 143 normal subjects aged 20 to 80 years old. An echo 2D colour Doppler cooperative study. Eur Heart J 1997;18:148-64. (Pubitemid 27105783)
83. Basnight MA, Gonzalez MS, Kershenovich SC, Appleton CP. Pulmonary venous flow velocity: relation to hemodynamics, mitral flow velocity and left atrial volume, and ejection fraction. J Am Soc Echocardiogr 1991;4:547-58.
84. Manning WJ, Silverman DI, Katz SE, Douglas PS. Atrial ejection force: a noninvasive assessment of atrial systolic function. J Am Coll Cardiol 1993;22:221-5. (Pubitemid 23189956)
85. Chinali M, de Simone G, Roman MJ, Bella JN, Liu JE, Lee ET et al. Left atrial systolic force and cardiovascular outcome. The Strong Heart Study. Am J Hypertens 2005;18(Pt 1):1570-6; discussion 7. (Pubitemid 41814677)
86. Triposkiadis F, Harbas C, Sitafidis G, Skoularigis J, Demopoulos V, Kelepeshis G. Echocardiographic assessment of left atrial ejection force and kinetic energy in chronic heart failure. Int J Cardiovasc Imaging 2008;24:15-22. (Pubitemid 350263098)
87. Dardas PS, Pitsis AA, Tsikaderis DD, Mezilis NE, Geleris PN, Boudoulas HK. Left atrial volumes, function and work before and after mitral valve repair in chronic mitral regurgitation. J Heart Valve Dis 2004;13:27-32.
88. Kiani A, Kocharian A, Shabanian R, Rahimzadeh M, Shakibi JG. Left atrial ejection force in healthy newborn infants. J Am Soc Echocardiogr 2008;21:725-8.
89. Khankirawatana B, Khankirawatana S, Peterson B, Mahrous H, Porter TR. Peak atrial systolic mitral annular velocity by Doppler tissue reliably predicts left atrial systolic function. J Am Soc Echocardiogr 2004;17:353-60. (Pubitemid 38869450)
90. Stefanadis C, Dernellis J, Lambrou S, Toutouzas P. Left atrial energy in normal subjects, in patients with symptomatic mitral stenosis, and in patients with advanced heart failure. Am J Cardiol 1998;82:1220-3. (Pubitemid 28541278)
91. Leung DY, Boyd A, Ng AA, Chi C, Thomas L. Echocardiographic evaluation of left atrial size and function: current understanding, pathophysiologic correlates, and prognostic implications. Am Heart J 2008;156:1056-64.
92. Nakatani S, Masuyama T, Kodama K, Kitabatake A, Fujii K, Kamada T. Value and limitations of Doppler echocardiography in the quantification of stenotic mitral valve area: comparison of the pressure half-time and the continuity equation methods. Circulation 1988;77:78-85. (Pubitemid 18031003)
93. Chinali M, de Simone G, Liu JE, Bella JN, Oberman A, Hopkins PN et al. Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Am J Hypertens 2005;18:899-905. (Pubitemid 41040258)
94. Chinali M, de Simone G, Roman MJ, Lee ET, Best LG, Howard BV et al. Impact of obesity on cardiac geometry and function in a population of adolescents: the Strong Heart Study. J Am Coll Cardiol 2006;47:2267-73. (Pubitemid 43795058)
95. Chinali M, de Simone G, Wachtell K, Gerdts E, Gardin JM, Boman K et al. Left atrial systolic force in hypertensive patients with left ventricular hypertrophy: the LIFE study. J Hypertens 2008;26:1472-6.
96. Lee ET, Welty TK, Fabsitz R, Cowan LD, Le NA, Oopik AJ et al. The Strong Heart Study. A study of cardiovascular disease in American Indians: design and methods. Am J Epidemiol 1990;132:1141-55.
97. Boudoulas H, Boudoulas D, Sparks EA, Pearson AC, Nagaraja HN, Wooley CF. Left atrial performance indices in chronic mitral valve disease. J Heart Valve Dis 1995;4(Suppl. 2):S242-7; discussion S8.
98. Boudoulas KD, Sparks EA, Rittgers SE, Wooley CF, Boudoulas H. Factors determining left atrial kinetic energy in patients with chronic mitral valve disease. Herz 2003;28:437-44. (Pubitemid 37040095)
99. Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 1997;30:474-80.
100. Palka P, Lange A, Fleming AD, Sutherland GR, Fenn LN, McDicken WN. Doppler tissue imaging: myocardial wall motion velocities in normal subjects. J Am Soc Echocardiogr 1995;8(Pt 1):659-68.
101. Yu CM, Fang F, Zhang Q, Yip GW, Li CM, Chan JY et al. Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure. J Am Coll Cardiol 2007;50:778-85. (Pubitemid 47243797)
102. Zhang Q, Yip GW, Yu CM. Approaching regional left atrial function by tissue Doppler velocity and strain imaging. Europace 2008;10(Suppl. 3):iii62-9.
103. Hesse B, Schuele SU, Thamilasaran M, Thomas J, Rodriguez L. A rapid method to quantify left atrial contractile function: Doppler tissue imaging of the mitral annulus during atrial systole. Eur J Echocardiogr 2004;5:86-92. (Pubitemid 38219625)
104. Gulel O, Yuksel S, Soylu K, Kaplan O, Yilmaz O, Kahraman H et al. Evaluation of left atrial functions by color tissue Doppler imaging in adults with body mass indexes ≥30 kg/m (2) versus those <30 kg/m (2). Int J Cardiovasc Imaging 2008;25:371-7.
105. Telagh R, Hui W, Abd El Rahman M, Berger F, Lange PE, Abdul-Khaliq H. Assessment of regional atrial function in patients with hypertrophic cardiomyopathies using tissue Doppler imaging. Pediatr Cardiol 2008;29:301-8. (Pubitemid 351414874)
106. Yu CM, Fung JW, Zhang Q, Kum LC, Lin H, Yip GW et al. Tissue Doppler echocardiographic evidence of atrial mechanical dysfunction in coronary artery disease. Int J Cardiol 2005;105:178-85. (Pubitemid 41512484)
107. Choi JI, Park SM, Park JS, Hong SJ, Pak HN, Lim do S et al. Changes in left atrial structure and function after catheter ablation and electrical cardioversion for atrial fibrillation. Circ J 2008;72:2051-7.
108. Zhang Q, Kum LC, Lee PW, Lam YY, Wu EB, Lin H et al. Effect of age and heart rate on atrial mechanical function assessed by Doppler tissue imaging in healthy individuals. J Am Soc Echocardiogr 2006;19:422-8.
109. Donal E, Raud-Raynier P, Racaud A, Coisne D, Herpin D. Quantitative regional analysis of left atrial function by Doppler tissue imaging-derived parameters discriminates patients with posterior and anterior myocardial infarction. J Am Soc Echocardiogr 2005;18:32-8. (Pubitemid 40051193)
110. Quintana M, Lindell P, Saha SK, Del Furia F, Lind B, Govind S et al. Assessment of atrial regional and global electromechanical function by tissue velocity echocardiography: a feasibility study on healthy individuals. Cardiovasc Ultrasound 2005;3:4.
111. Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-33. (Pubitemid 27486472)
112. Lindstrom L, Wranne B. Pulsed tissue Doppler evaluationofmitral annulus motion:a new window to assessment of diastolic function. Clin Physiol 1999;19:1-10. (Pubitemid 29057324)
113. Wang M, Yip GW, Wang AY, Zhang Y, Ho PY, Tse MK et al. Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value. J Am Coll Cardiol 2003;41:820-6. (Pubitemid 36308391)
114. Terzi S, Sayar N, Bilsel T, Enc Y, Yildirim A, Ciloglu F et al. Tissue Doppler imaging adds incremental value in predicting exercise capacity in patients with congestive heart failure. Heart Vessels 2007;22:237-44. (Pubitemid 47163372)
115. D'Hooge J, Heimdal A, Jamal F, Kukulski T, Bijnens B, Rademakers F et al. Regional strain and strain rate measurements by cardiac ultrasound: principles, implementation and limitations. Eur J Echocardiogr 2000;1:154-70.
116. Wang Z, Tan H, Zhong M, Jiang G, Zhang Y, Zhang W. Strain rate imaging for noninvasive functional quantification of the left atrium in hypertensive patients with paroxysmal atrial fibrillation. Cardiology 2008;109:15-24. (Pubitemid 350242701)
117. Di Salvo G, Pacileo G, Caso P, Verrengia M, Rea A, Santoro G et al. Strain rate imaging is a superior method for the assessment of regional myocardial function compared with Doppler tissue imaging: a study on patients with transcatheter device closure of atrial septal defect. J Am Soc Echocardiogr 2005;18:398-400. (Pubitemid 40704577)
118. Schneider C, Malisius R, Krause K, Lampe F, Bahlmann E, Boczor S et al. Strain rate imaging for functional quantification of the left atrium: atrial deformation predicts the maintenance of sinus rhythm after catheter ablation of atrial fibrillation. Eur Heart J 2008;29:1397-409. (Pubitemid 351806490)
119. Di Salvo G, Drago M, Pacileo G, Rea A, Carrozza M, Santoro G et al. Atrial function after surgical and percutaneous closure of atrial septal defect: a strain rate imaging study. J Am Soc Echocardiogr 2005;18:930-3. (Pubitemid 41253943)
120. Mirsky I. Assessment of passive elastic stiffness of cardiac muscle: mathematical concepts, physiologic and clinical considerations, directions of future research. Prog Cardiovasc Dis 1976;18:277-308.
121. Pislaru C, Abraham TP, Belohlavek M. Strain and strain rate echocardiography. Curr Opin Cardiol 2002;17:443-54. (Pubitemid 35265780)
122. Yip G, Abraham T, Belohlavek M, Khandheria BK. Clinical applications of strain rate imaging. J Am Soc Echocardiogr 2003;16:1334-42. (Pubitemid 37494287)
123. Modesto KM, Dispenzieri A, Cauduro SA, Lacy M, Khandheria BK, Pellikka PA et al. Left atrial myopathy in cardiac amyloidosis: implications of novel echocardiographic techniques. Eur Heart J 2005;26:173-9. (Pubitemid 40282786)
124. Thomas L. Assessment of atrial function. Heart Lung Circ 2007;16:234-42. (Pubitemid 46760679)
125. Di Salvo G, Caso P, Lo Piccolo R, Fusco A, Martiniello AR, Russo MG et al. Atrial myocardial deformation properties predict maintenance of sinus rhythm after external cardioversion of recent-onset lone atrial fibrillation: a color Doppler myocardial imaging and transthoracic and transesophageal echocardiographic study. Circulation 2005;112:387-95. (Pubitemid 41022080)
126. Sirbu C, Herbots L, D'Hooge J, Claus P, Marciniak A, Langeland T et al. Feasibility of strain and strain rate imaging for the assessment of regional left atrial deformation: a study in normal subjects. Eur J Echocardiogr 2006;7:199-208. (Pubitemid 43670984)
127. Wang T, Wang M, Fung JW, Yip GW, Zhang Y, Ho PP et al. Atrial strain rate echocardiography can predict success or failure of cardioversion for atrial fibrillation: a combined transthoracic tissue Doppler and transoesophageal imaging study. Int J Cardiol 2007;114:202-9. (Pubitemid 44802894)
128. Castro PL, Greenberg NL, Drinko J, Garcia MJ, Thomas JD. Potential pitfalls of strain rate imaging: angle dependency. Biomed Sci Instrum 2000;36:197-202. (Pubitemid 30237442)
129. Edvardsen T, Gerber BL, Garot J, Bluemke DA, Lima JA, Smiseth OA. Quantitative assessment of intrinsic regional myocardial deformation by Doppler strain rate echocardiography in humans: validation against three-dimensional tagged magnetic resonance imaging. Circulation 2002;106:50-6. (Pubitemid 34747441)
130. Langeland S, D'Hooge J, Wouters PF, Leather HA, Claus P, Bijnens B et al. Experimental validation of a new ultrasound method for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle. Circulation 2005;112:2157-62. (Pubitemid 41475810)
131. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M et al. Twodimensional strain 34a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr 2004;17:1021-9. (Pubitemid 39273478)
132. Suffoletto MS, Dohi K, Cannesson M, Saba S, Gorcsan J III. Novel speckletracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation 2006;113:960-8. (Pubitemid 43879471)
133. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol 2006;47:789-93. (Pubitemid 43243102)
134. Vianna-Pinton R, Moreno CA, Baxter CM, Lee KS, Tsang TS, Appleton CP. Twodimensional speckle-tracking echocardiography of the left atrium: feasibility and regional contraction and relaxation differences in normal subjects. J Am Soc Echocardiogr 2009;22:299-305.
135. D'Andrea A, De Corato G, Scarafile R, Romano S, Reigler L, Mita C et al. Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy: a two-dimensional speckle strain study. Br J Sports Med 2008;42:696-702.
136. Triposkiadis F, Moyssakis I, Hadjinikolaou L, Makris T, Zioris H,
137. Maruyama T, Kishikawa T, Ito H, Kaji Y, Sasaki Y, Ishihara Y. Augmentation of pulmonary vein backflow velocity during left atrial contraction: a novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients. Cardiology 2008;109:33-40. (Pubitemid 350242703)
138. Kasikcioglu E, Oflaz H, Akhan H, Kayserilioglu A, Umman B, Bugra Z et al. Left atrial geometric and functional remodeling in athletes. Int J Sports Med 2006;27:267-71.
139. Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA. Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons ≥65 years of age (the cardiovascular health study). Am J Cardiol 2006;97:83-9. (Pubitemid 41828128)
140. Spencer KT, Mor-Avi V, Gorcsan J III, DeMaria AN, Kimball TR, Monaghan MJ et al. Effects of aging on left atrial reservoir, conduit, and booster pump function: a multi-institution acoustic quantification study. Heart 2001;85:272-7. (Pubitemid 32973557)
141. Thomas L, Boyd A, Thomas SP, Schiller NB, Ross DL. Atrial structural remodelling and restoration of atrial contraction after linear ablation for atrial fibrillation. Eur Heart J 2003;24:1942-51. (Pubitemid 37322704)
142. Uretsky S, Shah A, Bangalore S, Rosenberg L, Sarji R, Cantales DR et al. Assessment of left atrial appendage function with transthoracic tissue Doppler echocardiography. Eur J Echocardiogr 2009;10:363-71.
143. Inaba Y, Yuda S, Kobayashi N, Hashimoto A, Uno K, Nakata T et al. Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation. J Am Soc Echocardiogr 2005;18:729-36. (Pubitemid 40909857)
144. D'Andrea A, Caso P, Romano S, Scarafile R, Cuomo S, Salerno G et al. Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two-dimensional speckle strain study. Int J Cardiol 2009;132:354-63.
145. D'Andrea A, Caso P, Romano S, Scarafile R, Riegler L, Salerno G et al. Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study. Eur Heart J 2007;28:2738-48. (Pubitemid 350135540)
146. Cameli M, Caputo M, Mondillo S, Ballo P, Palmerini E, Lisi M et al. Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking. Cardiovasc Ultrasound 2009;7:6.