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Volumn 21, Issue 5, 2011, Pages 501-515

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis

Author keywords

axonal loss; capsid antigens; demyelination; Theiler's murine encephalomyelitis virus (TMEV)

Indexed keywords

CAPSID PROTEIN; EPITOPE; VIRUS DNA;

EID: 80051966363     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00474.x     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 0028200937 scopus 로고
    • b gene become resistant to persistent infection by Theiler's virus
    • Azoulay A, Brahic M, Bureau JF, (1994) FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus. J Virol 68: 4049-4052. (Pubitemid 24177435)
    • (1994) Journal of Virology , vol.68 , Issue.6 , pp. 4049-4052
    • Azoulay, A.1    Brahic, M.2    Bureau, J.-F.3
  • 2
  • 3
    • 0030985924 scopus 로고    scopus 로고
    • b molecules complexed with a viral VP2 peptide lacking a consensus anchor residue
    • Borson ND, Paul C, Lin X, Nevala WK, Strausbauch MA, Rodriguez M, Wettstein PJ, (1997) Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue. J Virol 71: 5244-5250. (Pubitemid 27258197)
    • (1997) Journal of Virology , vol.71 , Issue.7 , pp. 5244-5250
    • Borson, N.D.1    Paul, C.2    Lin, X.3    Nevala, W.K.4    Strausbauch, M.A.5    Rodriguez, M.6    Wettstein, P.J.7
  • 4
    • 0022640034 scopus 로고
    • Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: Correlation with clinical signs
    • Clatch RJ, Lipton HL, Miller SD, (1986) Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J Immunol 136: 920-927. (Pubitemid 16146377)
    • (1986) Journal of Immunology , vol.136 , Issue.3 , pp. 920-927
    • Clatch, R.J.1    Lipton, H.L.2    Miller, S.D.3
  • 5
    • 0022386163 scopus 로고
    • Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: Correlation with TEMV-specific delayed-type hypersensitivity
    • Clatch RJ, Melvold RW, Miller SD, Lipton HL, (1985) Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity. J Immunol 135: 1408-1414. (Pubitemid 16237053)
    • (1985) Journal of Immunology , vol.135 , Issue.2 , pp. 1408-1414
    • Clatch, R.J.1    Melvold, R.W.2    Miller, S.D.3    Lipton, H.L.4
  • 6
    • 0031852514 scopus 로고    scopus 로고
    • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study
    • DOI 10.1093/brain/121.8.1469
    • De Stefano N, Matthews PM, Fu L, Narayanan S, Stanley J, Francis GS, et al, (1998) Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 121: 1469-1477. (Pubitemid 28349900)
    • (1998) Brain , vol.121 , Issue.8 , pp. 1469-1477
    • De Stefano, N.1    Matthews, P.M.2    Fu, L.3    Narayanan, S.4    Stanley, J.5    Francis, G.S.6    Antel, J.P.7    Arnold, D.L.8
  • 8
    • 70449370458 scopus 로고    scopus 로고
    • Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: Marker of demyelination and repair in spinal cord
    • Denic A, Bieber A, Warrington A, Mishra PK, Macura S, Rodriguez M, (2009) Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: marker of demyelination and repair in spinal cord. Ann Neurol 66: 559-564.
    • (2009) Ann Neurol , vol.66 , pp. 559-564
    • Denic, A.1    Bieber, A.2    Warrington, A.3    Mishra, P.K.4    MacUra, S.5    Rodriguez, M.6
  • 9
    • 0030700427 scopus 로고    scopus 로고
    • Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis
    • Drescher KM, Pease LR, Rodriguez M, (1997) Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis. Immunol Rev 159: 177-193. (Pubitemid 27499868)
    • (1997) Immunological Reviews , vol.159 , pp. 177-193
    • Drescher, K.M.1    Pease, L.R.2    Rodriguez, M.3
  • 10
    • 33846327273 scopus 로고    scopus 로고
    • Absence of perforin expression confers axonal protection despite demyelination
    • DOI 10.1016/j.nbd.2006.10.001, PII S0969996106002531
    • Howe CL, Adelson JD, Rodriguez M, (2007) Absence of perforin expression confers axonal protection despite demyelination. Neurobiol Dis 25: 354-359. (Pubitemid 46124015)
    • (2007) Neurobiology of Disease , vol.25 , Issue.2 , pp. 354-359
    • Howe, C.L.1    Adelson, J.D.2    Rodriguez, M.3
  • 11
    • 0032899121 scopus 로고    scopus 로고
    • 121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28
    • Johnson AJ, Njenga MK, Hansen MJ, Kuhns ST, Chen L, Rodriguez M, Pease LR, (1999) Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. J Virol 73: 3702-3708. (Pubitemid 29189811)
    • (1999) Journal of Virology , vol.73 , Issue.5 , pp. 3702-3708
    • Johnson, A.J.1    Njenga, M.K.2    Hansen, M.J.3    Kuhns, S.T.4    Chen, L.5    Rodriguez, M.6    Pease, L.R.7
  • 12
    • 0035656533 scopus 로고    scopus 로고
    • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection
    • Johnson AJ, Upshaw J, Pavelko KD, Rodriguez M, Pease LR, (2001) Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J 15: 2760-2762.
    • (2001) FASEB J , vol.15 , pp. 2760-2762
    • Johnson, A.J.1    Upshaw, J.2    Pavelko, K.D.3    Rodriguez, M.4    Pease, L.R.5
  • 13
    • 70450170922 scopus 로고    scopus 로고
    • Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination
    • Kerkvliet J, Zoecklein L, Papke L, Denic A, Bieber AJ, Pease LR, et al, (2009) Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination. J Virol 83: 12279-12289.
    • (2009) J Virol , vol.83 , pp. 12279-12289
    • Kerkvliet, J.1    Zoecklein, L.2    Papke, L.3    Denic, A.4    Bieber, A.J.5    Pease, L.R.6
  • 14
    • 0018178003 scopus 로고
    • Autoimmune and virus-induced demyelinating diseases. A review
    • Lampert PW, (1978) Autoimmune and virus-induced demyelinating diseases. A review. Am J Pathol 91: 176-208.
    • (1978) Am J Pathol , vol.91 , pp. 176-208
    • Lampert, P.W.1
  • 15
    • 0036310249 scopus 로고    scopus 로고
    • b mice inhibits resistance to virus-induced demyelination
    • DOI 10.1128/JVI.76.15.7799-7811.2002
    • Lin X, Njenga MK, Johnson AJ, Pavelko KD, David CS, Pease LR, Rodriguez M, (2002) Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination. J Virol 76: 7799-7811. (Pubitemid 34761002)
    • (2002) Journal of Virology , vol.76 , Issue.15 , pp. 7799-7811
    • Lin, X.1    Njenga, M.K.2    Johnson, A.J.3    Pavelko, K.D.4    David, C.S.5    Pease, L.R.6    Rodriguez, M.7
  • 16
    • 0032103047 scopus 로고    scopus 로고
    • Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent vital or major myelin antigenic specificity
    • Lin X, Pease LR, Murray PD, Rodriguez M, (1998) Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J Immunol 160: 5661-5668. (Pubitemid 28267862)
    • (1998) Journal of Immunology , vol.160 , Issue.11 , pp. 5661-5668
    • Lin, X.1    Pease, L.R.2    Murray, P.D.3    Rodriguez, M.4
  • 17
    • 0031002731 scopus 로고    scopus 로고
    • Differential generation of class I H-2D- versus H-2K-restricted cytotoxicity against a demyelinating virus following central nervous system infection
    • DOI 10.1002/eji.1830270424
    • Lin X, Pease LR, Rodriguez M, (1997) Differential generation of class I H-2D- versus H-2K-restricted cytotoxicity against a demyelinating virus following central nervous system infection. Eur J Immunol 27: 963-970. (Pubitemid 27153667)
    • (1997) European Journal of Immunology , vol.27 , Issue.4 , pp. 963-970
    • Lin, X.1    Pease, L.R.2    Rodriguez, M.3
  • 18
    • 0017273551 scopus 로고
    • Theiler's virus-induced demyelination: Prevention by immunosuppression
    • Lipton HL, Dal Canto MC, (1976) Theiler's virus-induced demyelination: prevention by immunosuppression. Science 192: 62-64.
    • (1976) Science , vol.192 , pp. 62-64
    • Lipton, H.L.1    Dal Canto, M.C.2
  • 19
    • 0023199765 scopus 로고
    • Distribution of Theiler's virus in the CNS of athymic nude mice: Effect of varying the route of inoculation
    • DOI 10.1016/0022-510X(87)90183-3
    • Love S, (1987) Distribution of Theiler's virus in the CNS of athymic nude mice: effect of varying the route of inoculation. J Neurol Sci 81: 55-66. (Pubitemid 17140515)
    • (1987) Journal of the Neurological Sciences , vol.81 , Issue.1 , pp. 55-66
    • Love, S.1
  • 20
    • 0029943412 scopus 로고    scopus 로고
    • Multiple sclerosis: The proinflammatory cytokines lymphotoxin-α and tumour necrosis factor-α are upregulated in cerebrospinal fluid mononuclear cells
    • DOI 10.1016/0165-5728(96)00032-X
    • Matusevicius D, Navikas V, Soderstrom M, Xiao BG, Haglund M, Fredrikson S, Link H, (1996) Multiple sclerosis: the proinflammatory cytokines lymphotoxin-alpha and tumour necrosis factor-alpha are upregulated in cerebrospinal fluid mononuclear cells. J Neuroimmunol 66: 115-123. (Pubitemid 26193944)
    • (1996) Journal of Neuroimmunology , vol.66 , Issue.1-2 , pp. 115-123
    • Matusevicius, D.1    Navikas, V.2    Soderstrom, M.3    Xiao, B.-G.4    Haglund, M.5    Fredrikson, S.6    Link, H.7
  • 21
    • 0033975629 scopus 로고    scopus 로고
    • Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
    • McGavern DB, Murray PD, Rivera-Quinones C, Schmelzer JD, Low PA, Rodriguez M, (2000) Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis. Brain 123 (Pt 3): 519-531. (Pubitemid 30099537)
    • (2000) Brain , vol.123 , Issue.3 , pp. 519-531
    • McGavern, D.B.1    Murray, P.D.2    Rivera-Quinones, C.3    Schmelzer, J.D.4    Low, P.A.5    Rodriguez, M.6
  • 22
    • 0032868603 scopus 로고    scopus 로고
    • Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination
    • DOI 10.1006/exnr.1999.7082
    • McGavern DB, Zoecklein L, Drescher KM, Rodriguez M, (1999) Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination. Exp Neurol 158: 171-181. (Pubitemid 29344329)
    • (1999) Experimental Neurology , vol.158 , Issue.1 , pp. 171-181
    • McGavern, D.B.1    Zoecklein, L.2    Drescher, K.M.3    Rodriguez, M.4
  • 23
    • 0141427768 scopus 로고    scopus 로고
    • + T cell response against a single immunodominant viral peptide
    • DOI 10.1002/eji.200324007
    • Mendez-Fernandez YV, Johnson AJ, Rodriguez M, Pease LR, (2003) Clearance of Theiler's virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide. Eur J Immunol 33: 2501-2510. (Pubitemid 37138982)
    • (2003) European Journal of Immunology , vol.33 , Issue.9 , pp. 2501-2510
    • Mendez-Fernandez, Y.V.1    Johnson, A.J.2    Rodriguez, M.3    Pease, L.R.4
  • 27
    • 33947510838 scopus 로고    scopus 로고
    • Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination
    • DOI 10.1111/j.1750-3639.2007.00062.x
    • Pavelko KD, Pease LR, David CS, Rodriguez M, (2007) Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination. Brain Pathol 17: 184-196. (Pubitemid 46466138)
    • (2007) Brain Pathology , vol.17 , Issue.2 , pp. 184-196
    • Pavelko, K.D.1    Pease, L.R.2    David, C.S.3    Rodriguez, M.4
  • 28
    • 0024342935 scopus 로고
    • Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus
    • Paya CV, Patick AK, Leibson PJ, Rodriguez M, (1989) Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus. J Immunol 143: 95-102. (Pubitemid 19174205)
    • (1989) Journal of Immunology , vol.143 , Issue.1 , pp. 95-102
    • Paya, C.V.1    Patick, A.K.2    Leibson, P.J.3    Rodriguez, M.4
  • 29
    • 0031439343 scopus 로고    scopus 로고
    • Nitric oxide donors reversibly block axonal conduction: Demyelinated axons are especially susceptible
    • DOI 10.1093/brain/120.12.2149
    • Redford EJ, Kapoor R, Smith KJ, (1997) Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible. Brain 120 (Pt 12): 2149-2157. (Pubitemid 28014591)
    • (1997) Brain , vol.120 , Issue.12 , pp. 2149-2157
    • Redford, E.J.1    Kapoor, R.2    Smith, K.J.3
  • 30
    • 0345432117 scopus 로고    scopus 로고
    • Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis
    • DOI 10.1038/nm0298-187
    • Rivera-Quinones C, McGavern D, Schmelzer JD, Hunter SF, Low PA, Rodriguez M, (1998) Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nat Med 4: 187-193. (Pubitemid 28137373)
    • (1998) Nature Medicine , vol.4 , Issue.2 , pp. 187-193
    • Rivera-Quinones, C.1    McGavern, D.2    Schmelzer, J.D.3    Hunter, S.F.4    Low, P.A.5    Rodriguez, M.6
  • 31
    • 0022393468 scopus 로고
    • Demyelination induced by Theiler's virus: Influence of the H-2 haplotype
    • Rodriguez M, David CS, (1985) Demyelination induced by Theiler's virus: influence of the H-2 haplotype. J Immunol 135: 2145-2148. (Pubitemid 16240050)
    • (1985) Journal of Immunology , vol.135 , Issue.3 , pp. 2145-2148
    • Rodriguez, M.1    David, C.S.2
  • 32
    • 0029258005 scopus 로고
    • H-2 Dd transgene suppresses Theiler's virus-induced demyelination in susceptible strains of mice
    • Rodriguez M, David CS, (1995) H-2 Dd transgene suppresses Theiler's virus-induced demyelination in susceptible strains of mice. J Neurovirol 1: 111-117.
    • (1995) J Neurovirol , vol.1 , pp. 111-117
    • Rodriguez, M.1    David, C.S.2
  • 34
    • 0025335068 scopus 로고
    • Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene
    • DOI 10.1016/0882-4010(90)90005-B
    • Rodriguez M, Kenny JJ, Thiemann RL, Woloschak GE, (1990) Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene. Microb Pathog 8: 23-35. (Pubitemid 20222889)
    • (1990) Microbial Pathogenesis , vol.8 , Issue.1 , pp. 23-35
    • Rodriguez, M.1    Kenny, J.J.2    Thiemann, R.L.3    Woloschak, G.E.4
  • 35
    • 0022655687 scopus 로고
    • Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia-antigens)
    • Rodriguez M, Lafuse WP, Leibowitz J, David CS, (1986) Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens). Neurology 36: 964-970. (Pubitemid 16098240)
    • (1986) Neurology , vol.36 , Issue.7 , pp. 964-970
    • Rodriguez, M.1    Lafuse, W.P.2    Leibowitz, J.3    David, C.S.4
  • 36
    • 0022571627 scopus 로고
    • Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region
    • Rodriguez M, Leibowitz J, David CS, (1986) Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region. J Exp Med 163: 620-631. (Pubitemid 16141965)
    • (1986) Journal of Experimental Medicine , vol.163 , Issue.3 , pp. 620-631
    • Rodriguez, M.1    Leibowitz, J.2    David, C.S.3
  • 37
    • 0025174796 scopus 로고
    • Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation
    • DOI 10.1016/0165-5728(90)90001-4
    • Rodriguez M, Patick AK, Pease LR, (1990) Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation. J Neuroimmunol 26: 189-199. (Pubitemid 20046138)
    • (1990) Journal of Neuroimmunology , vol.26 , Issue.3 , pp. 189-199
    • Rodriguez, M.1    Patick, A.K.2    Pease, L.R.3
  • 38
    • 0030589225 scopus 로고    scopus 로고
    • The Balance between Persistent Virus Infection and Immune Cells Determines Demyelination
    • Rodriguez M, Pavelko KD, Njenga MK, Logan WC, Wettstein PJ, (1996) The balance between persistent virus infection and immune cells determines demyelination. J Immunol 157: 5699-5709. (Pubitemid 126448995)
    • (1996) Journal of Immunology , vol.157 , Issue.12 , pp. 5699-5709
    • Rodriguez, M.1    Pavelko, K.D.2    Njenga, M.K.3    Logan, W.C.4    Wettstein, P.J.5
  • 39
    • 0022994784 scopus 로고
    • Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination
    • DOI 10.1016/0165-5728(86)90062-7
    • Rodriguez M, Quddus J, (1986) Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination. J Neuroimmunol 13: 159-174. (Pubitemid 17171357)
    • (1986) Journal of Neuroimmunology , vol.13 , Issue.2 , pp. 159-174
    • Rodriguez, M.1    Quddus, J.2
  • 40
    • 0023910268 scopus 로고
    • Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody
    • Rodriguez M, Sriram S, (1988) Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody. J Immunol 140: 2950-2955.
    • (1988) J Immunol , vol.140 , pp. 2950-2955
    • Rodriguez, M.1    Sriram, S.2
  • 41
    • 0020325698 scopus 로고
    • The effect of short-term and chronic immunosuppression on Theiler's virus demyelination
    • Roos RP, Firestone S, Wollmann R, Variakojis D, Arnason BG, (1982) The effect of short-term and chronic immunosuppression on Theiler's virus demyelination. J Neuroimmunol 2: 223-234. (Pubitemid 12042611)
    • (1982) Journal of Neuroimmunology , vol.2 , Issue.3-4 , pp. 223-234
    • Roos, R.P.1    Firestone, S.2    Wollmann, R.3
  • 42
    • 0021358208 scopus 로고
    • DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice
    • Roos RP, Wollmann R, (1984) DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice. Ann Neurol 15: 494-499. (Pubitemid 14145578)
    • (1984) Annals of Neurology , vol.15 , Issue.5 , pp. 494-499
    • Roos, R.P.1    Wollmann, R.2
  • 43
    • 44949231424 scopus 로고    scopus 로고
    • T method
    • DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
    • Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108. (Pubitemid 351818697)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 45
    • 0035067635 scopus 로고    scopus 로고
    • Electrically active axons degenerate when exposed to nitric oxide
    • DOI 10.1002/ana.96
    • Smith KJ, Kapoor R, Hall SM, Davies M, (2001) Electrically active axons degenerate when exposed to nitric oxide. Ann Neurol 49: 470-476. (Pubitemid 32281330)
    • (2001) Annals of Neurology , vol.49 , Issue.4 , pp. 470-476
    • Smith, K.J.1    Kapoor, R.2    Hall, S.M.3    Davies, M.4
  • 46
    • 36349002847 scopus 로고    scopus 로고
    • Targeting inflammatory demyelinating lesions to sites of wallerian degeneration
    • DOI 10.2353/ajpath.2007.070147
    • Tsunoda I, Tanaka T, Saijoh Y, Fujinami RS, (2007) Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am J Pathol 171: 1563-1575. (Pubitemid 350158317)
    • (2007) American Journal of Pathology , vol.171 , Issue.5 , pp. 1563-1575
    • Tsunoda, I.1    Tanaka, T.2    Saijoh, Y.3    Fujinami, R.S.4
  • 47
    • 0028080014 scopus 로고
    • Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus
    • DOI 10.1084/jem.180.5.1901
    • von Herrath MG, Dockter J, Nerenberg M, Gairin JE, Oldstone MB, (1994) Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus. J Exp Med 180: 1901-1910. (Pubitemid 24328579)
    • (1994) Journal of Experimental Medicine , vol.180 , Issue.5 , pp. 1901-1910
    • Von Herrath, M.G.1    Dockter, J.2    Nerenberg, M.3    Gairin, J.E.4    Oldstone, M.B.A.5
  • 48
    • 0023251015 scopus 로고
    • The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice
    • Welsh CJ, Tonks P, Nash AA, Blakemore WF, (1987) The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice. J Gen Virol 68: 1659-1667. (Pubitemid 17115727)
    • (1987) Journal of General Virology , vol.68 , Issue.6 , pp. 1659-1667
    • Welsh, C.J.R.1    Tonks, P.2    Nash, A.A.3    Blakemore, W.F.4
  • 49
    • 0033987174 scopus 로고    scopus 로고
    • Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis
    • DOI 10.1002/1521-4141(200001)30:1<272::AID-IMMU272>3.0.CO;2-X
    • Xu H, Wawrousek EF, Redmond TM, Nickerson JM, Wiggert B, Chan CC, Caspi RR, (2000) Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol 30: 272-278. (Pubitemid 30011789)
    • (2000) European Journal of Immunology , vol.30 , Issue.1 , pp. 272-278
    • Xu, H.1    Wawrousek, E.F.2    Redmond, T.M.3    Nickerson, J.M.4    Wiggert, B.5    Chan, C.-C.6    Caspi, R.R.7


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