B RAF KINASE;
CETUXIMAB;
EPIDERMAL GROWTH FACTOR RECEPTOR;
GENE PRODUCT;
PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;
PROTEIN KINASE B;
PROTEIN NRAS;
PROTEIN PIK3CA;
SIMVASTATIN;
UNCLASSIFIED DRUG;
CANCER CELL CULTURE;
CANCER PATIENT;
COLORECTAL CANCER;
DRUG EFFICACY;
DRUG MECHANISM;
ERRATUM;
GENE MUTATION;
HUMAN;
ONCOGENE K RAS;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
TREATMENT RESPONSE;
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations [published online ahead of print march 11, 2010]
Lee J, Lee I, Han B, et al. Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations [published online ahead of print March 11, 2010]. J Natl Cancer Inst. 2011;103(8):674-688.
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359(17):1757-1765.
(2008)N Engl J Med, vol.359, Issue.17, pp. 1757-1765
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
DOI 10.1158/0008-5472.CAN-07-5659
Jhawer M, Goel S, Wilson AJ, et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 2008;68(6):1953-1961. (Pubitemid 351416582)
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
Sartore-Bianchi A, Martini M, Molinari F, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 2009;69(5):1851-1857.
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
Siena S, Sartore-Bianchi A, Di Nicolantonio F, et al. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst. 2009;101(19):1308-1324.
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11(8): 753-762.
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib [published online ahead of print]
Irwin ME, Mueller KL, Bohin N, et al. Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib [published online ahead of print]. J Cell Physiol. 2011;226(9):2316-2328.