Machine learning for drug design, molecular machines and evolvable artificial cells

Genetic and Evolutionary Computation Conference, GECCO'11 - Companion Publication

Volumn , Issue , 2011, Pages 831-832

  Caschera, Filippo ^a   Hanczyc, Martin ^a   Rasmussen, Steen ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

cell free expression system; fitness function; fusion; high throughput screening; life cycle; liposome

Indexed keywords

ARTIFICIAL CELL; CELL-FREE EXPRESSION; CHEMICAL SYSTEMS; DRUG DESIGN; DRUG FORMULATIONS; EVOLVABLE; FITNESS FUNCTIONS; GREEN FLUORESCENT PROTEIN; HIGH DIMENSIONAL SPACES; HIGH THROUGHPUT SCREENING; IN-VITRO; LIPID VESICLES; LIQUID HANDLING; MACHINE-LEARNING; METABOLIC SYSTEMS; MOLECULAR COMPONENTS; MOLECULAR MACHINES; MOLECULAR SPECIES; NON-TRIVIAL; ROBOTIC WORKSTATION; SUB-SYSTEMS; VESICLE FUSION;

BIOSYNTHESIS; DESIGN; DESIGN OF EXPERIMENTS; LEARNING SYSTEMS; LIFE CYCLE; MACHINE COMPONENTS; OPTIMIZATION;

CELLS;

EID: 80051944283     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1145/2001858.2002111     Document Type: Conference Paper

References (10)

1. Rasmussen S., et al., Transitions from nonliving to living matter. Science 303: 963-5. 2004 (Pubitemid 38209688)
2. Rasmussen S., et al., Protocells: Bridging nonliving and living matter, MIT Press, Cambridge, 2009
3. Caschera F., et al., Automated Discovery of Novel Drug Formulations Using Predictive Iterated High Throughput Experimentation. PLoS ONE 5(1): e8546. 2010
4. Caschera F, et al., Coping with complexity: machine learning optimization of cell-free protein synthesis. Biotechnol. Bioeng. (In press). 2011
5. Caschera F., Stano P., Luisi P.L. Reactivity and fusion between cationic vesicles and fatty acids anionic vesicles. J. Colloid Interf. Sci. 345: 561-565. 2010
6. Sunami T*. Caschera F*, et al., Detection of Association and Fusion of Giant Vesicles Using a Fluorescence-Activated Cell Sorter, Langmuir 26: 15098-15103. 2010
7. Caschera F., et. al., Programmed vesicles fusion triggers gene expression Langmuir (Submitted). 2011
8. Hosoda K., et al., Quantitative study of the structure of multilamellar giant liposomes as a container of protein synthesis reaction. Langmuir 24: 13540-13548. 2008
9. Szostak J.W., Bartel D.P., Luisi P.L. Synthesizing life. Nature 409:387-390. 2001 (Pubitemid 32151251)
10. Irving R.A., et al., Ribosome display and affinity maturation from antibodies to single V-domains and steps towards cancer therapeutics. J. Immun. Methods 248: 31-45. 2001 (Pubitemid 32167023)