Off-label thrombolysis for acute ischemic stroke: Rate, clinical outcome and safety are influenced by the definition of 'minor stroke'

Cerebrovascular Diseases

Volumn 32, Issue 2, 2011, Pages 177-185

  Breuer, L ^a   Blinzler, C ^a   Huttner, H B ^a   Kiphuth, I C ^a   Schwab, S ^a   Kohrmann M ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Acute ischemic stroke; Minor stroke; Off label use; Thrombolysis

Indexed keywords

FIBRINOLYTIC AGENT;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; DISEASE SEVERITY; DRUG SAFETY; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MAJOR SURGERY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OFF LABEL DRUG USE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; EUROPE; FIBRINOLYTIC AGENTS; GERMANY; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OFF-LABEL USE; PROGNOSIS; RETROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 80051925214     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000328811     Document Type: Article

References (25)

1. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P: Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet 1998; 352: 1245-1251. (Pubitemid 28470336)
2. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH, et al: Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995; 274: 1017-1025.
3. Meretoja A, Putaala J, Tatlisumak T, Atula S, Artto V, Curtze S, Happola O, Lindsberg PJ, Mustanoja S, Piironen K, Pitkaniemi J, Rantanen K, Sairanen T, Salonen O, Silvennoinen H, Soinne L, Strbian D, Tiainen M, Kaste M: Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke 2010; 41: 1450-1458.
4. Rubiera M, Ribo M, Santamarina E, Maisterra O, Delgado-Mederos R, Delgado P, Ortega G, Alvarez-Sabin J, Molina CA: Is it time to reassess the SITS-MOST criteria for thrombolysis?: A comparison of patients with and without SITS-MOST exclusion criteria. Stroke 2009; 40: 2568-2571.
5. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359: 1317-1329.
6. Kohrmann M, Juttler E, Fiebach JB, Huttner HB, Siebert S, Schwark C, Ringleb PA, Schellinger PD, Hacke W: MRI versus CTbased thrombolysis treatment within and beyond the 3 h time window after stroke onset: A cohort study. Lancet Neurol 2006; 5: 661-667. (Pubitemid 44062409)
7. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee: Guidelines for management of ischaemic stroke and transient ischaemic attack 2008.
8. Aleu A, Mellado P, Lichy C, Kohrmann M, Schellinger PD: Hemorrhagic complications after off-label thrombolysis for ischemic stroke. Stroke 2007; 38: 417-422. (Pubitemid 46184319)
9. Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): An observational study. Lancet 2007; 369: 275-282. (Pubitemid 46138121)
10. Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF: Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007; 38: 1655-1711.
11. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995; 333: 1581-1587.
12. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S: Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999; 282: 2019-2026.
13. Cocho D, Belvis R, Marti-Fabregas J, Molina-Porcel L, Diaz-Manera J, Aleu A, Pagonabarraga J, Garcia-Bargo D, Mauri A, Marti-Vilalta JL: Reasons for exclusion from thrombolytic therapy following acute ischemic stroke. Neurology 2005; 64: 719-720. (Pubitemid 40261906)
14. Katzan IL, Hammer MD, Hixson ED, Furlan AJ, Abou-Chebl A, Nadzam DM: Utilization of intravenous tissue plasminogen activator for acute ischemic stroke. Arch Neurol 2004; 61: 346-350. (Pubitemid 38327350)
15. Khatri P, Kleindorfer DO, Yeatts SD, Saver JL, Levine SR, Lyden PD, Moomaw CJ, Palesch YY, Jauch EC, Broderick JP: Strokes with minor symptoms. An exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials. Stroke 2010; 41: 2581-2586.
16. Kleindorfer D, Kissela B, Schneider A, Woo D, Khoury J, Miller R, Alwell K, Gebel J, Szaflarski J, Pancioli A, Jauch E, Moomaw C, Shukla R, Broderick JP: Eligibility for recombinant tissue plasminogen activator in acute ischemic stroke: A population-based study. Stroke 2004; 35:e27-e29.
17. Nedeltchev K, Schwegler B, Haefeli T, Brekenfeld C, Gralla J, Fischer U, Arnold M, Remonda L, Schroth G, Mattle HP: Outcome of stroke with mild or rapidly improving symptoms. Stroke 2007; 38: 2531-2535. (Pubitemid 47329633)
18. Rajajee V, Kidwell C, Starkman S, Ovbiagele B, Alger JR, Villablanca P, Vinuela F, Duckwiler G, Jahan R, Fredieu A, Suzuki S, Saver JL: Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology 2006; 67: 980-984. (Pubitemid 44454588)
19. Berrouschot J, Rother J, Glahn J, Kucinski T, Fiehler J, Thomalla G: Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old ( 1 or = 80 years) stroke patients. Stroke 2005; 36: 2421-2425. (Pubitemid 41566970)
20. Engelter ST, Bonati LH, Lyrer PA: Intravenous thrombolysis in stroke patients of 1 or = 80 versus ! 80 years of age -a systematic review across cohort studies. Age Ageing 2006; 35: 572-580. (Pubitemid 44614151)
21. Engelter ST, Reichhart M, Sekoranja L, Georgiadis D, Baumann A, Weder B, Muller F, Luthy R, Arnold M, Michel P, Mattle HP, Tettenborn B, Hungerbuhler HJ, Baumgartner RW, Sztajzel R, Bogousslavsky J, Lyrer PA: Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology 2005; 65: 1795-1798.
22. Sylaja PN, Cote R, Buchan AM, Hill MD: Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study. J Neurol Neurosurg Psychiatry 2006; 77: 826-829. (Pubitemid 44023176)
23. Tanne D, Gorman MJ, Bates VE, Kasner SE, Scott P, Verro P, Binder JR, Dayno JM, Schultz LR, Levine SR: Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: The tPA stroke survey experience. Stroke 2000; 31: 370-375. (Pubitemid 30078168)
24. van Oostenbrugge RJ, Hupperts RM, Lodder J: Thrombolysis for acute stroke with special emphasis on the very old: Experience from a single Dutch centre. J Neurol Neurosurg Psychiatry 2006; 77: 375-377.
25. Mishra NK, Ahmed N, Andersen G, Egido JA, Lindsberg PJ, Ringleb PA, Wahlgren NG, Lees KR: Thrombolysis in very elderly people: Controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ 2010; 341:c6046.