DNA ploidy is stronger than lymph node metastasis as prognostic factor in cervical carcinoma: 10-year results of a prospective study

International Journal of Gynecological Cancer

Volumn 21, Issue 4, 2011, Pages 678-684

  Susini, Tommaso ^a   Olivieri, Simone ^a   Molino, Cecilia ^a   Amunni, Gianni ^a   Rapi, Stefano ^b   Taddei, Gianluigi ^c   Scarselli, Gianfranco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cervical carcinoma; DNA ploidy; Flow cytometry; Lymph node metastasis; Prognosis

Indexed keywords

DNA;

ADULT; ANEUPLOIDY; CANCER INVASION; CANCER RESEARCH; CANCER STAGING; CANCER SURVIVAL; DISEASE DURATION; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; REVIEW; UTERINE CERVIX CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; DNA, NEOPLASM; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; PLOIDIES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 80051899659     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e3182126f85     Document Type: Review

References (20)

1. van Dam PA, Watson JV, Lowe DG, et al. Flow cytometric DNA analysis in gynecological oncology. Int J Gynecol Cancer. 1992;2:57-65.
2. Atkin NB. Prognostic significance of ploidy level in human tumors. I. Carcinoma of the uterus. J Natl Cancer Inst. 1976;56:909-910.
3. Jakobsen A. Ploidy level and short-time prognosis of early cervix cancer. Radiat Oncol. 1984;1:271-275.
4. Jakobsen A. Prognostic impact of ploidy level in carcinoma of the cervix. Am J Clin Oncol. 1984;7:475-480.
5. Davis JR, Aristizabal S, Way DL, et al. DNA ploidy, grade, and stage in prognosis of uterine cervical cancer. Gynecol Oncol. 1989;32:4-7. (Pubitemid 19029858)
6. Strang P, Stendahl U, Bergström R, et al. Prognostic flow cytometric information in cervical squamous cell carcinoma: a multivariate analysis of 307 patients. Gynecol Oncol. 1991;43:3-8.
7. Zanetta GM, Katzmann JA, Kenney GL, et al. Flow-cytometric DNA analysis of stages IB and IIA cervical carcinoma. Gynecol Oncol. 1992;46:13-19.
8. Sǿrensen FB, Bichel P, Jakobsen A. DNA level and stereologic estimates of nuclear volume in squamous cell carcinomas of the uterine cervix. A comparative study with analysis of prognostic impact. Cancer. 1992;69:187-199.
9. Connor JP, Miller DS, Bauer KD, et al. Flow cytometric evaluation of early invasive cervical cancer. Obstet Gynecol. 1993;81:367-371. (Pubitemid 23085292)
10. Lai CH, Chang HC, Chang TC, et al. Prognostic factors and impacts of adjuvant therapy in early-stage cervical carcinoma with pelvic node metastasis. Gynecol Oncol. 1993;51:390-396.
11. Lutgens LC, Schutte B, de Jong JM, et al. DNA content as prognostic factor in cervix carcinoma stage IB-III treated with radiotherapy. Gynecol Oncol. 1994;54:275-281. (Pubitemid 24301900)
12. Kristensen GB, Kaern J, Abeler VM, et al. No prognostic impact of flow-cytometric measured DNA ploidy and s-phase fraction in cancer of the uterine cervix: a prospective study of 465 patients. Gynecol Oncol. 1995;57:79-85.
13. Kaspar HG, Dinh TV, Hanningan EV. Flow cytometry in cervical adenocarcinoma: correlating DNA content analysis with the clinical picture. J Reprod Med. 1997;42:170-172. (Pubitemid 27164441)
14. Anton M, Nenutil R, Rejthar A, et al. DNA flow cytometry: a predictor of a high-risk group in cervical cancer. Cancer Detect Prev. 1997;21:242-246. (Pubitemid 27222394)
15. Wimberger P, Hillemanns P, Kapsner T, et al. Evaluation of prognostic factors following flow-cytometric DNA analysis after cytokeratin labelling: II. Cervical and endometrial cancer. Anal Cell Pathol. 2002;24:147-158. (Pubitemid 36384397)
16. Wolfson AH, Winter K, Crook W, et al. Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial. Int J Radiat Oncol Biol Phys. 2008;70:111-117. (Pubitemid 350251035)
17. Massi G, Susini T, Amunni G. Extraperitoneal pelvic lymphadenectomy to complement vaginal operations for cervical and endometrial cancer. Int J Gynaecol Obstet. 2000;69:27-35. (Pubitemid 30173373)
18. Kallioniemi OP. Comparison of fresh and paraffin-embedded tissue as starting material for DNA flow cytometry and evaluation of intratumor heterogeneity. Cytometry. 1988;9:164-169.
19. Susini T, Rapi S, Savino L, et al. Prognostic value of flow cytometric deoxyribonucleic acid index in endometrial carcinoma: comparison with other clinical-pathologic parameters. Am J Obstet Gynecol. 1994;170:527-534. (Pubitemid 24089010)
20. Susini T, Amunni G, Molino C, et al. Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: DNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors. Cancer. 2007;109:882-890. (Pubitemid 46333530)