Paramagnetic microparticles do not elicit islet cytotoxicity with co-culture or host immune reactivity after implantation

Xenotransplantation

Volumn 18, Issue 4, 2011, Pages 239-244

  Suszynski, Thomas M ^a   Rizzari, Michael D ^a,b   Kidder, Louis S ^a   Mueller, Kate ^a   Chapman, Christopher S ^a   Kitzmann, Jennifer P ^a   Pongratz, Rebecca L ^c   Cline, Gary W ^c   Todd, Paul W ^d,e   Kennedy, David J ^e   O'Brien, Timothy D ^f   Avgoustiniatos, Efstathios S ^a   Schuurman, Henk Jan ^a   Papas, Klearchos K ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Techshot Inc   (United States)

^e IKOTECH LLC   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

islet purification; islet xenotransplantation; magnetic separation; paramagnetic microparticles; quadrupole magnetic sorting

Indexed keywords

BIOMEDICAL AND DENTAL MATERIALS; DNA; FERRIC OXIDE; FERRIC OXIDE PARAMAGNETIC MICROPARTICLE; GLUCOSE; INSULIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; CYTOLOGY; CYTOTOXICITY; DNA CONTENT; GRAFT VERSUS HOST REACTION; HISTOLOGY; INSULIN RELEASE; MOUSE; NONHUMAN; NUDE MOUSE; OXYGEN CONSUMPTION; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PURIFICATION; STREPTOZOCIN DIABETES; SWINE; THERAPY EFFECT;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MAGNETIC PHENOMENA; MATERIALS TESTING; MICE; MICE, INBRED C57BL; MICE, NUDE; MICROSPHERES; TRANSPLANTATION, HETEROLOGOUS;

EID: 80051891508     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00648.x     Document Type: Article

References (19)

1. Shapiro AM, Lakey JR, Ryan EA, et al., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238. (Pubitemid 30490390)
2. Froud T, Ricordi C, Baidal DA, et al., Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant 2005; 5: 2037-2046. (Pubitemid 41039883)
3. Bellin MD, Kandaswamy R, Parkey J, et al., Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant 2008; 8: 2463-2470.
4. Balamurugan AN, Bottino R, Giannoukakis N, Smetanka C,. Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes. Pancreas 2006; 32: 231-243.
5. Abdelli S, Ansite J, Roduit R, et al., Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 2004; 53: 2815-2823. (Pubitemid 39425906)
6. Gray DW,. The role of exocrine tissue in pancreatic islet transplantation. Transpl Int 1989; 2: 41-45.
7. Heuser M, Wolf B, Vollmar B, Menger MD,. Exocrine contamination of isolated islets of Langerhans deteriorates the process of revascularization after free transplantation. Transplantation 2000; 69: 756-761. (Pubitemid 30174093)
8. London NJ, Swift SM, Clayton HA,. Isolation, culture and functional evaluation of islets of Langerhans. Diabetes Metab 1998; 24: 200-207. (Pubitemid 28289812)
9. Sekine N, Cirulli V, Regazzi R, et al., Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 1994; 269: 4895-4902.
10. Davies JE, Winoto-Morbach S, Ulrichs K, James RF, Robertson GS,. A comparison of the use of two immunomagnetic microspheres for secondary purification of pancreatic islets. Transplantation 1996; 62: 1301-1306. (Pubitemid 27008559)
11. Fujioka T, Terasaki PI, Heintz R, et al., Rapid purification of islets using magnetic microspheres coated with anti-acinar cell monoclonal antibodies. Transplantation 1990; 49: 404-407. (Pubitemid 20088185)
12. Pinkse GG, Steenvoorde E, Hogendoorn S, et al., Stable transplantation results of magnetically retracted islets: a novel method. Diabetologia 2004; 47: 55-61. (Pubitemid 38141940)
13. Kennedy DJ, Todd P, Logan S, Becker M, Papas KK, Moore LR,. Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets. J Magn Magn Mater 2007; 311: 388-395. (Pubitemid 46401014)
14. Shenkman RM, Chalmers JJ, Hering BJ, Kirchhof N, Papas KK,. Quadrupole magnetic sorting of porcine islets of Langerhans. Tissue Eng Part C Methods 2009; 15: 147-156.
15. Rowley SD, Loken M, Radich J, et al., Isolation of CD34+ cells from blood stem cell components using the Baxter isolex system. Bone Marrow Transplant 1998; 21: 1253-1262. (Pubitemid 28318754)
16. Hering BJ, Wijkstrom M, Graham ML, et al., Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303. (Pubitemid 43355076)
17. Papas KK, Pisania A, Wu H, Weir GC, Colton CK,. A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng 2007; 98: 1071-1082. (Pubitemid 350205583)
18. Pongratz RL, Kibbey RG, Kirkpatrick CL, et al., Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. J Biol Chem 2009; 284: 16808-16821.
19. Papas KK, Colton CK, Nelson RA, et al., Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant 2007; 7: 707-713. (Pubitemid 46376439)