Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosis TB patients

Clinical Microbiology and Infection

Volumn 17, Issue 9, 2011, Pages 1323-1331

  Jacobsen, M ^a,d   Repsilber, D ^b   Kleinsteuber, K ^a   Gutschmidt, A ^c   Schommer Leitner, S ^d   Black, G ^c   Walzl, G ^c   Kaufmann, S H E ^d  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Latent Mycobacterium tuberculosis infection; Suppressor of cytokine signalling; T cell subpopulations; T cells; Tuberculosis

Indexed keywords

CYTOKINE; CYTOKINE INDUCIBLE SH2 CONTAINING PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 2 RECEPTOR ALPHA; JANUS KINASE; MYC PROTEIN; PROTEIN KINASE PIM 1; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MICROARRAY ANALYSIS; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA ANALYSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 80051890565     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2010.03326.x     Document Type: Article

References (35)

1. Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C. Mycobacterium tuberculosis and the host response. J Exp Med 2005; 201: 1693-1697.
2. Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol 2001; 19: 93-129.
3. Kaufmann SH, Flesch IE. The role of T cell-macrophage interactions in tuberculosis. Springer Semin Immunopathol 1988; 10: 337-358.
4. Lewinsohn DM, Alderson MR, Briden AL, Riddell SR, Reed SG, Grabstein KH. Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells. J Exp Med 1998; 187: 1633-1640.
5. Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 1992; 89: 12013-12017.
6. Lalvani A, Brookes R, Wilkinson RJ et al. Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1998; 95: 270-275.
7. Stenger S, Hanson DA, Teitelbaum R et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998; 282: 121-125.
8. Jacobsen M, Detjen AK, Mueller H et al. Clonal expansion of CD8+ effector T cells in childhood tuberculosis. J Immunol 2007; 179: 1331-1339.
9. Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev 2009; 9: 480-490.
10. Alexander WS, Hilton DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004; 22: 503-529.
11. Paukku K, Silvennoinen O. STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev 2004; 15: 435-455.
12. White E. The pims and outs of survival signaling: role for the PIM-2 protein kinase in the suppression of apoptosis by cytokines. Genes Dev 2003; 17: 1813-1816.
13. Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev 2008; 224: 265-283.
14. Chen Z, Laurence A, Kanno Y et al. Selective regulatory function of SOCS3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci USA 2006; 103: 8137-8142.
15. Pillemer BB, Xu H, Oriss TB, Qi Z, Ray A. Deficient SOCS3 expression in CD4+CD25+FOXP3+ regulatory T cells and SOCS3-mediated suppression of TREG function. Eur J Immunol 2007; 37: 2082-2089.
16. Brender C, Tannahill GM, Jenkins BJ et al. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood 2007; 110: 2528-2536.
17. Wang Z, Bhattacharya N, Weaver M et al. PIM-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. J Vet Sci (Suwon-si, Korea) 2001; 2: 167-179.
18. Bachmann M, Moroy T. The serine/threonine kinase PIM-1. Int J Biochem Cell Biol 2005; 37: 726-730.
19. Mueller H, Detjen AK, Schuck SD et al. Mycobacterium tuberculosis-specific CD4+, IFNgamma+, and TNFalpha+ multifunctional memory T cells coexpress GM-CSF. Cytokine 2008; 43: 143-148.
20. Landgrebe J, Bretz F, Brunner E. Efficient two-sample designs for microarray experiments with biological replications. In Silico Biol 2004; 4: 461-470.
21. Jacobsen M, Schweer D, Ziegler A et al. A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet 2000; 26: 495-499.
22. Gentleman RC, Carey VJ, Bates DM et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80 1-16.
23. Smyth GK, Michaud J, Scott HS. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005; 21: 2067-2075.
24. Ritchie ME, Silver J, Oshlack A et al. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007; 23: 2700-2707.
25. Smyth GK, Speed T. Normalization of cDNA microarray data. Methods 2003; 31: 265-273.
26. Efron B, Tibshirani R. Empirical Bayes methods and false discovery rates for microarrays. Genet Epidemiol 2002; 23: 70-86.
27. Yang YH, Dudoit S, Luu P et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 2002; 30: e15 1-10.
28. Jacobsen M, Repsilber D, Gutschmidt A et al. Deconfounding microarray analysis-independent measurements of cell type proportions used in a regression model to resolve tissue heterogeneity bias. Methods Inf Med 2006; 45: 557-563.
29. Jacobsen M, Repsilber D, Gutschmidt A et al. Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med 2007; 85: 613-621.
30. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100: 9440-9445.
31. Rook GA. Th2 cytokines in susceptibility to tuberculosis. Curr Mol Med 2007; 7: 327-337.
32. Harris J, De Haro SA, Master SS et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007; 27: 505-517.
33. Kahnert A, Seiler P, Stein M et al. Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. Eur J Immunol 2006; 36: 631-647.
34. Mistry R, Cliff JM, Clayton CL et al. Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis. J Infect Dis 2007; 195: 357-365.
35. Kinjyo I, Inoue H, Hamano S et al. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med 2006; 203: 1021-1031.