Evaluation of performance of new, isotopically labeled internal standard ([13c2d4]RAD001) for everolimus using a novel high-performance liquid chromatography tandem mass spectrometry method

Therapeutic Drug Monitoring

Volumn 33, Issue 4, 2011, Pages 460-463

  Korecka, Magdalena A ^a   Patel, Ravi ^a   Shaw, Leslie M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Everolimus; HPLC MS MS; Isotopically labeled internal standard

Indexed keywords

EVEROLIMUS; METHANOL; UNCLASSIFIED DRUG; WATER; ZINC SULFATE; [13C2D4]RAD001;

ARTICLE; DRUG DETERMINATION; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; PRIORITY JOURNAL; QUALITY CONTROL; STANDARD; TANDEM MASS SPECTROMETRY;

EID: 80051814428     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Novartis: "Novartis receives US FDA approval for Zortress (everolimus) to prevent organ rejection in adult kidney transplant recipients." http://www.novartiscom/newsroom/media-releases/en/ 2010/1406625shtm 2010. Accessed September 2010.
2. Korecka M, Solari SG, Shaw LM. Sensitive, high throughput HPLC-MS/ MS method with on-line sample clean-up for everolimus measurement. Ther Drug Monit. 2006;28:484-490. (Pubitemid 44191893)
3. Annesley TM, Clayton L. Simple extraction protocol for analysis of immunosuppressant drugs in whole blood. Clin Chem. 2004;50: 1845-1848. (Pubitemid 39298023)
4. FDA: Guidance for industry-bioanalytical method validation, http://www.fda.gov/cder/guidance, 2001. Accessed May 2010.
5. Annesley TM. Ion suppression in mass spectrometry. Clin Chem. 2003; 49:1041-1044. (Pubitemid 36751088)
6. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem. 2003;75:3019-3030. (Pubitemid 36830428)
7. Brignol N, McMahon LM, Luo S, et al. High-throughput semi-automated 96-well liquid/liquid extraction and liquid chromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood. Rapid Commun Mass Spectrom. 2001;15:898-907. (Pubitemid 32587177)
8. Korecka M, Shaw LM. Review of the newest HPLC methods with mass spectrometry detection for determination of immunosuppressive drugs in clinical practice. Ann Transplant. 2009;14:61-72.
9. Taylor PJ. Internal standard selection for immunosuppressant drugs measured by high-performance liquid chromatography tandem mass spectrometry. Ther Drug Monit. 2007;29:131-132. (Pubitemid 46279889)
10. Hoogtanders K, van der Heijden J, Stolk LM, et al. Internal standard selection for the high-performance liquid chromatography tandem mass spectroscopy assay of everolimus in blood. Ther Drug Monit. 2007;29: 673-674. (Pubitemid 47494074)