Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction

Journal of Aerosol Science

Volumn 42, Issue 11, 2011, Pages 811-819

  Tong, Z B ^a   Adi, S ^b   Yang, R Y ^a   Chan, H K ^b   Yu, A B ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Agglomerates; Computational fluid dynamics; Discrete element method; Impact angle; Powder dispersion

Indexed keywords

AGGLOMERATION; DEPOSITION; DISPERSIONS; FINITE DIFFERENCE METHOD; NUMERICAL METHODS; SHEAR FLOW;

AGGLOMERATES; DISPERSION MECHANISMS; DISPERSION PERFORMANCE; FINE PARTICLE FRACTIONS; IMPACT ANGLES; NUMERICAL INVESTIGATIONS; PARTICLE-FLUID INTERACTION; POWDER DISPERSIONS;

COMPUTATIONAL FLUID DYNAMICS;

MANNITOL;

AEROSOL FORMATION; ATMOSPHERIC DEPOSITION; COMPUTATIONAL FLUID DYNAMICS; DISCRETE ELEMENT METHOD; DISPERSION; DRUG; FLOW VELOCITY; MEDICINE; NUMERICAL MODEL; PARTICLE SIZE; TECHNOLOGICAL DEVELOPMENT;

ARTICLE; COMPRESSION; COMPUTATIONAL FLUID DYNAMICS; DE AGGLOMERATION; DISPERSION; ENERGY; FLOW RATE; PARTICLE SIZE; PHYSICAL PHENOMENA; POWDER; POWDER DEVICE IMPACTION; POWDER DISPERSION; POWDER INHALER; PRIORITY JOURNAL; VELOCITY;

EID: 80051796910     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2011.07.004     Document Type: Article

References (18)

1. Adi S., Tong Z.B., Chan H.K., Yang R.Y., Yu A.B. Impact angles as an alternative way to improve aerosolisation of powders for inhalation?. European Journal of Pharmaceutical Sciences 2010, 41:320-327.
2. Bagster D.F., Tomi D. The stresses within a sphere in simple flow fields. Chemical Engineering Science 1974, 29:1773-1783.
3. Brown D.P., Kauppinen E.I., Jokiniemi J.K. Agglomerate deaggregation potential during dry powder inhaler operation and characterization under steady and unsteady conditions. Journal of Aerosol Science 2003, 34:1417-1428.
4. Coates M.S., Fletcher D.F., Chan H.-K., Raper J.A. The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research 2005, 22:923-932.
5. Dunbar C.A., Hickey A.J., Holzner P. Dispersion and characterization of pharmaceutical dry powder aerosols. Kona 1998, 16:7-45.
6. Finlay W.H. The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction 2001, Academic Press, London.
7. French D.L., Edwards D.A., Niven R.W. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation. Journal of Aerosol Science 1996, 27:769-783.
8. Li W.-I., Perzl M., Heyder J., Langer R., Brain J.D., Englmeier K.H., Niven R.W., Edwards D.A. Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities. Journal of Aerosol Science 1996, 27:1269-1286.
9. Moreno R., Ghadiri M. Mechanistic analysis and computer simulation of impact breakage of agglomerates: effect of surface energy. Chemical Engineering Science 2006, 61:2476-2481.
10. Moreno R., Ghadiri M., Antony S.J. Effect of the impact angle on the breakage of agglomerates: a numerical study using DEM. Powder Technology 2003, 130:132-137.
11. Rumpf H. The Strength of Granules and Agglomerates 1962, Interscience, New York.
12. Samimi A., Moreno R., Ghadiri M. Analysis of impact damage of agglomerates: effect of impact angle. Powder Technology 2004, 143:97-109.
13. Timsina M.P., Martin G.P., Marriott C., Ganderton D., Yianneskis M. Drug delivery to the respiratory tract using dry powder inhalers. International Journal of Pharmaceutics 1994, 101:1-13.
14. Tong Z.B., Yang R.Y., Chu K.W., Yu A.B., Adi S., Chan H.K. Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal 2010, 164:432-441.
15. Tong Z.B., Yang R.Y., Yu A.B., Adi S., Chan H.K. Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technology 2009, 196:213-221.
16. Voss A., Finlay W.H. Deagglomeration of dry powder pharmaceutical aerosols. International Journal of Pharmaceutics 2002, 248:39-50.
17. Xu C.B., Zhu J. Parametric study of fine particle fluidization under mechanical vibration. Powder Technology 2006, 161:135-144.
18. Yang R.Y., Yu A.B., Choi S.K., Coates M.S., Chan H.K. Agglomeration of fine particles subjected to centripetal compaction. Powder Technology 2008, 184:122-129.