Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-β and CCAAT/enhancer-binding homologous protein

Neurosurgery

Volumn 69, Issue 3, 2011, Pages 713-721

  Venza, Mario ^a   Visalli, Maria ^a   Alafaci, Concetta ^a   Caffo, Maria ^a   Caruso, Gerardo ^a   Salpietro, Francesco Maria ^a   Tomasello, Francesco ^a   Teti, Diana ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Gene expression; Gliomas; Granulocyte chemokine; PGES 1; Transcription factors

Indexed keywords

CCAAT BINDING FACTOR; CCAAT ENHANCER BINDING HOMOLOGOUS PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 8; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASTROCYTOMA; CANCER CELL; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

APOPTOSIS; ASTROCYTOMA; BRAIN NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; CELL PROLIFERATION; DINOPROSTONE; GENE EXPRESSION REGULATION; GENE SILENCING; GLIOMA; HUMANS; INTERLEUKIN-8; INTRAMOLECULAR OXIDOREDUCTASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 80051789018     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e31821954c6     Document Type: Article

References (26)

1. VanMeir E, Ceska M, Effenberger F, et al. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Res. 1992;52(16):4297-4305.
2. Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005;7(2):122-133.
3. Birnbaum T, Roider J, Schankin CJ, et al. Malignant gliomas actively recruit bonemarrow stromal cells by secreting angiogenic cytokines. J Neurooncol. 2007;83(3):241-247.
4. Samaras V, Piperi C, Levidou G, et al. Analysis of interleukin (IL)-8 expression in human astrocytomas: Associations with IL-6, cyclooxygenase-2, vascularendothelial growth factor, and microvessel morphometry. Hum Immunol. 2009;70(6):391-397.
5. Caristi S, Piraino G, Cucinotta M, Valenti A, Loddo S, Teti D. Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes. J Biol Chem. 2005;280(15):14433- 14442.
6. ZhongWW, Burke PA, Drotar ME, Chavali SR, Forse RA. Effects of prostaglandin E2, cholera toxin and 8-bromo-cyclic AMP on lipopolysaccharide- induced gene expression of cytokines in human macrophages. Immunology. 1995;84(3):446-452.
7. Cucinotta M, Visalli M, Aguennouz M, et al. Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells. J Biol Chem. 2008;283(44):29760-29769.
8. Vij N, Amoako MO, Mazur S, Zeitlin PL. CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008;38(2):176-184.
9. Payner T, Leaver HA, Knapp B, et al. Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A. Mol Cancer Ther. 2006;5(7):1817-1826.
10. Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell. 2004;6(5):447-458.
11. Yao XH, Ping YF, Chen JH, et al. Production of angiogenic factors by human glioblastoma cells following activation of the G-protein coupled formylpeptide receptor FPR. J Neurooncol. 2008;86(1):47-53.
12. Mattila S, Tuominen H, Koivukangas J, Stenbäck F. The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Neuropathology. 2009;29(2):156-165.
13. Hara A, Okayasu I. Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: Correlation with angiogenesis and prognostic significance. Acta Neuropathol. 2004;108(1):43-48.
14. Joki T, Heese O, Nikas DC, et al. Expression of cyclooxygenase-2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res. 2000;60(17):4926-4931.
15. Shono T, Tofilon PJ, Bruner JM, Owolabi O, Lang FF. Cyclooxygenase-2 expression in human gliomas: Prognostic significance and molecular correlations. Cancer Res. 2001;61(11):4375-4381.
16. Dai C, Lyustikman Y, Shih A, et al. The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. Neoplasia. 2005;7(4):397-406.
17. Homma J, Yamanaka R, Yajima N, et al. Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients. Oncol Rep. 2006;15(3):595-601.
18. Yamanaka R, Lekstrom-Himes J, Barlow C, Wynshaw-Boris A, Xanthopoulos KG. CCAAT/enhancer binding proteins are critical components of the transcriptional regulation of hematopoiesis. Int J Mol Med. 1998;1(1):213-221.
19. Landschulz WH, Johnson PF, Adashi EY, Graves BJ and McKnight SL. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 1988;2(7):786-800.
20. Akira S, Isshiki H, Sugita T, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 1990;9(6):1897-1906.
21. Yamanaka R, Kim GD, Radomska HS, et al. CCAAT/enhancer binding protein epsilon is preferentially upregulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci USA. 1997;94(12):6462-6467.
22. Ron D and Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6(3):439-453.
23. Cortes-Canteli M, Pignatelli M, Santos A, Perez-Castillo A. CCAAT/enhancerbinding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol Chem. 2002;277(7):5460-5467.
24. Kinoshita S, Akira S, Kishimoto T. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci USA. 1992;89(4):1473-1476.
25. Akira S, Kishimoto T. NF-IL6 and NF-kappa B in cytokine gene regulation. Adv Immunol. 1997;65:1-46.
26. Matsusaka T, Fujikawa K, Nishio Y, et al. Transcription factors NF-IL6 and NFkappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA. 1993;90(21):10193-10197.