Statin effect on thrombin inhibitor effectiveness during percutaneous coronary intervention: A post-hoc analysis from the ISAR-REACT 3 trial

Clinical Research in Cardiology

Volumn 100, Issue 7, 2011, Pages 579-585

  Khattab, Ahmed A ^a,f   Ndrepepa, Gjin ^b   Schulz, Stefanie ^b   Neumann, Franz Josef ^c   Mehilli, Julinda ^b   Büttner, Heinz Joachim ^c   Pache, Jürgen ^b   Seyfarth, Melchior ^b   Dirschinger, Josef ^d   Kastrati, Adnan ^b   Berger, Peter B ^e   Schömig, Albert ^b   Richardt, Gert ^a  

^a Segeberger Kliniken GmbH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e GEISINGER MEDICAL CENTER   (United States)

^f BERN UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Antithrombotics; Bivalirudin; Heparin; Statins; Stents

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEPARIN; HIRULOG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CARDIOVASCULAR RISK; CLINICAL TRIAL; CORONARY ARTERY CIRCUMFLEX BRANCH; DEATH; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEART INFARCTION; HUMAN; INCIDENCE; LEFT CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; POST HOC ANALYSIS; REVASCULARIZATION; RIGHT CORONARY ARTERY; TREATMENT OUTCOME;

AGED; ANGIOPLASTY, BALLOON, CORONARY; ANTITHROMBINS; CORONARY ARTERY DISEASE; DRUG INTERACTIONS; FEMALE; HEPARIN; HIRUDINS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 80051787306     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-011-0282-7     Document Type: Article

References (23)

1. Ndrepepa G, Berger PB, Mehilli J, Seyfarth M, Neumann FJ, Schömig A, Kastrati A (2008) Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point. J Am Coll Cardiol 51:690-697 (Pubitemid 351221218)
2. Lincoff AM, Bittl JA, Harrington RA et al (2003) Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA 289:853-863 (Pubitemid 37430344)
3. Stone GW, White HD, Ohman EM, Bertrand ME, Lincoff AM, McLaurin BT, Cox DA, Pocock SJ, Ware JH, Feit F, Colombo A, Manoukian SV, Lansky AJ, Mehran R, Moses JW (2007) Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet 369:907-919 (Pubitemid 46400858)
4. Stone GW, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Gersh BJ, Pocock SJ, Dangas G, Wong SC, Kirtane AJ, Parise H, Mehran R (2008) Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 358:2218-2230 (Pubitemid 351724451)
5. Kastrati A, Neumann FJ, Mehilli J, Byrne RA, Iijima R, Büttner HJ, Khattab AA, Schulz S, Blankenship JC, Pache J, Minners J, Seyfarth M, Graf I, Skelding KA, Drischinger J, Richardt G, Berger PB, Schömig A (2008) ISAR-REACT 3 Trial investigators. Bivalirudin versus unfractionated heparin during percutaneous coronary intervention for angina pectoris. N Engl J Med 359:688-696
6. Stone GW, Ware JH, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, White HD, Feit F, Colombo A, McLaurin BT, Cox DA, Manoukian SV, Fahy M, Clayton TC, Mehran R, Pocock SJ (2007) Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management: one-year results from the ACUITY trial. JAMA 298:2497-2506 (Pubitemid 350223536)
7. Ebrahimi R, Saleh J, Toggart E, Shah AP, Azmoon S, Babaei H, Lee J, Smith R, Movahed R, Rubin S (2008) Effect of preprocedural statin use on procedural myocardial infarction and major adverse cardiac adverse events in percutaneous coronary intervention: a meta-analysis. J Invasive Cardiol 20:292-295 (Pubitemid 351940887)
8. Mood GR, Bavry AA, Roukoz H, Bhatt DL (2007) Meta-analysis of the role of statin therapy in reducing myocardial infarction following elective percutaneous coronary intervention. Am J Cardiol 100:919-923 (Pubitemid 47368096)
9. Di Sciascio G, Patti G, Pasceri V, Gaspardone A, Colonna G, Montinaro A (2009) Efficacy of atorvastatin reload in patients on chronic statin therapy undergoing percutaneous coronary intervention: results of the ARMYDA-RECAPTURE (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) Randomized Trial. J Am Coll Cardiol 54:558-565
10. Zhao JL, Yang YJ, Pei WD, Sun YH, Chen JL, Gao RL (2008) Effect of statin therapy on reperfusion arrhythmia in patients who underwent successful primary angioplasty. Clin Res Cardiol 97:147-151
11. Levine GN, Keaney JF Jr, Vita JA (1995) Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med 332:512-521
12. Dangas G, Smith DA, Unger AH, Shao JH, Meraj P, Fier C, Cohen AM, Fallon JT, Badimon JJ, Ambrose JA (2000) Pravastatin: an antithrombotic effect independent of the cholesterollowering effect. Thromb Haemost 83:688-692 (Pubitemid 30248515)
13. Wolfrum S, Grimm M, Heidbreder M, Dendorfer A, Katus HA, Liao JK, Richardt G (2003) Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase. J Cardiovasc Pharmacol 41:474-480 (Pubitemid 36255308)
14. Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K, Klein HH, Dominiak P, Richardt G (2004) Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol 44:348-355 (Pubitemid 39129454)
15. van der Harst P, Böhm M, van Gilst WH, van Veldhuisen DJ (2008) The case for statin therapy in chronic heart failure. Clin Res Cardiol 97:139-146 (Pubitemid 351712813)
16. Caron MF, McKendall GR (2003) Bivalirudin in percutaneous coronary intervention. Am J Health Syst Pharm 60:1841-1849 (Pubitemid 39610564)
17. Ramana RK (2008) Lewis BE: percutaneous coronary intervention in patients with acute coronary syndrome: focus on bivalirudin. Vasc Health Risk Manag 4:493-505 (Pubitemid 352037911)
18. Undas A, Brummel-Ziedins KE, Mann KG (2005) Statins and blood coagulation. Arterioscler Thromb Vasc Biol 25:287-294 (Pubitemid 40189147)
19. Undas A, Celinska-Lowenhoff M, Brummel-Ziedins KE, Brozek J, Szczeklik A, Mann KG (2005) Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients. Arterioscler Thromb Vasc Biol 25:1524-1525 (Pubitemid 40923379)
20. Tousoulis D, Antoniades C, Bosinakou E, Kotsopoulou M, Tsioufis C, Tentolouris C, Trikas A, Pitsavos C, Stefanadis C (2005) Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure. Heart 91:27-31 (Pubitemid 39664987)
21. Avidan MS, Levy JH, van Aken H, Feneck RO, Latimer RD, Ott E, Martin E, Birnbaum DE, Bonfiglio LJ, Kajdasz DK, Despotis GJ (2005) Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass. J Thorac Cardiovasc Surg 130:107-113 (Pubitemid 40941676)
22. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ (2008) JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359:2195-2207
23. Iijima R, Ndrepepa G, Mehilli J, Byrne RA, Schulz S, Neumann FJ, Richardt G, Berger PB, Schömig A, Kastrati A (2009) Profile of bleeding and ischemic complications with bivalirudin and unfractionated heparin after percutaneous coronary intervention. Eur Heart J 30:290-296