Randomized phase III trial (GORTEC 98-03) comparing re-irradiation plus chemotherapy versus methotrexate in patients with recurrent or a second primary head and neck squamous cell carcinoma, treated with a palliative intent

Radiotherapy and Oncology

Volumn 100, Issue 1, 2011, Pages 70-75

  Tortochaux, Jacques ^a   Tao, Yungan ^b   Tournay, Elodie ^b   Lapeyre, Michel ^a   Lesaunier, Francois ^c   Bardet, Etienne ^d   Janot, Franois ^b   Lusinchi, Antoine ^b   Benhamou, Ellen ^b   Bontemps, Patrick ^e   Maingon, Philippe ^f   Calais, Gilles ^g   Daly Schveitzer, Nicolas ^b   Verrelle, Pierre ^a   Bourhis, Jean ^b  

^a CENTRE JEAN PERRIN   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c Centre Franois Baclesse   (France)

^d CENTRE RENÉ GAUDUCHEAU   (France)

^e UNIVERSITY HOSPITAL OF BESANÇON   (France)

^f Centre George Fra ois Leclerc   (France)

^g CHU BRETONNEAU   (France)

Author keywords

Chemotherapy; Methotrexate; Phase III; Re irradiation; Recurrent head and neck cancer

Indexed keywords

FLUOROURACIL; HYDROXYUREA; METHOTREXATE;

ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER PALLIATIVE THERAPY; CHEMORADIOTHERAPY; CONTINUOUS INFUSION; CONTROLLED STUDY; DYSPHAGIA; FEVER; FIBROSIS; HAND FOOT SYNDROME; HEAD AND NECK CARCINOMA; HUMAN; LARYNX DISORDER; LEUKOPENIA; LUNG DISEASE; MAJOR CLINICAL STUDY; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEPHROTOXICITY; NEUROPATHY; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DERMATITIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; SHOCK; SKIN TOXICITY; SQUAMOUS CELL CARCINOMA; STOMATITIS; THROMBOCYTOPENIA; TREATMENT RESPONSE; XEROSTOMIA;

CARCINOMA, SQUAMOUS CELL; CAUSE OF DEATH; CHEMORADIOTHERAPY; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, SECOND PRIMARY; PALLIATIVE CARE;

EID: 80051784529     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.06.025     Document Type: Article

References (35)

1. J. Bernier, C. Domenge, and M. Ozsahin Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer N Engl J Med 350 2004 1945 1952 (Pubitemid 38580197)
2. J.S. Cooper, T.F. Pajak, and A.A. Forastiere Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck N Engl J Med 350 2004 1937 1944
3. J.P. Pignon, J. Bourhis, C. Domenge, and L. Designe Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer Lancet 355 2000 949 955 (Pubitemid 30148259)
4. J.P. Pignon, A. le Maitre, E. Maillard, and J. Bourhis Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17, 346 patients Radiother Oncol 92 2009 4 14
5. Y. Tao, N. Daly-Schveitzer, A. Lusinchi, and J. Bourhis Advances in radiotherapy of head and neck cancers Curr Opin Oncol 22 2010 194 199
6. M. Lambrecht, P. Dirix, W. Van den Bogaert, and S. Nuyts Incidence of isolated regional recurrence after definitive (chemo-) radiotherapy for head and neck squamous cell carcinoma Radiother Oncol 93 2009 498 502
7. N. Choong, and E. Vokes Expanding role of the medical oncologist in the management of head and neck cancer CA Cancer J Clin 58 2008 32 53
8. F. Janot, D. de Raucourt, and E. Benhamou Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma J Clin Oncol 26 2008 5518 5523
9. R. De Crevoisier, C. Domenge, and P. Wibault Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma Cancer 91 2001 2071 2076 (Pubitemid 32476371)
10. J.K. Salama, and E.E. Vokes Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer Semin Oncol 35 2008 251 261 (Pubitemid 351787700)
11. A.A. Forastiere, B. Metch, and D.E. Schuller Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study J Clin Oncol 10 1992 1245 1251
12. J.H. Schornagel, J. Verweij, and P.H. de Mulder Randomized phase III trial of edatrexate versus methotrexate in patients with metastatic and/or recurrent squamous cell carcinoma of the head and neck: a European Organization for Research and Treatment of Cancer Head and Neck Cancer Cooperative Group study J Clin Oncol 13 1995 1649 1655
13. J.S. Stewart, E.E. Cohen, and L. Licitra Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected] J Clin Oncol 27 2009 1864 1871
14. E.E. Vokes, W.R. Panje, and R.L. Schilsky Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II study J Clin Oncol 7 1989 761 768 (Pubitemid 19145598)
15. D.J. Haraf, R.R. Weichselbaum, and E.E. Vokes Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease Ann Oncol 7 1996 913 918 (Pubitemid 26426265)
16. R. De Crevoisier, J. Bourhis, and C. Domenge Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients J Clin Oncol 16 1998 3556 3562 (Pubitemid 28506768)
17. S.A. Spencer, J. Harris, and R.H. Wheeler RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck Int J Radiat Oncol Biol Phys 51 2001 1299 1304 (Pubitemid 33116324)
18. J.K. Salama, E.E. Vokes, and S.J. Chmura Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma Int J Radiat Oncol Biol Phys 64 2006 382 391 (Pubitemid 43083422)
19. B. Weppelmann, R.H. Wheeler, and G.E. Peters Treatment of recurrent head and neck cancer with 5-fluorouracil, hydroxyurea, and reirradiation Int J Radiat Oncol Biol Phys 22 1992 1051 1056
20. C.J. Langer, J. Harris, and E.M. Horwitz Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Protocol 9911 J Clin Oncol 25 2007 4800 4805 (Pubitemid 350086484)
21. J.J. Mazeron, J.M. Ardiet, and C. Haie-Meder GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas Radiother Oncol 91 2009 150 156
22. A. Popovtzer, I. Gluck, and D.B. Chepeha The pattern of failure after reirradiation of recurrent squamous cell head and neck cancer: implications for defining the targets Int J Radiat Oncol Biol Phys 74 2009 1342 1347
23. J. Bourhis, J. Overgaard, and H. Audry Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis Lancet 368 2006 843 854 (Pubitemid 44292807)
24. M.T. Milano, E.E. Vokes, and J.K. Salama Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy Int J Radiat Oncol Biol Phys 61 2005 1096 1106 (Pubitemid 40340903)
25. N.M. Kramer, E.M. Horwitz, and J. Cheng Toxicity and outcome analysis of patients with recurrent head and neck cancer treated with hyperfractionated split-course reirradiation and concurrent cisplatin and paclitaxel chemotherapy from two prospective phase I and II studies Head Neck 27 2005 406 414 (Pubitemid 40593895)
26. J.A. Langendijk, and J. Bourhis Reirradiation in squamous cell head and neck cancer: recent developments and future directions Curr Opin Oncol 19 2007 202 209 (Pubitemid 46597478)
27. T. Zilli, P. Nouet, and N. Casanova Unilateral radiotherapy for tonsil cancer: potential dose distribution optimization with a simple two-field intensity-modulated radiation therapy beam arrangement Radiother Oncol 94 2010 334 338
28. A. Bertelsen, C.R. Hansen, J. Johansen, and C. Brink Single arc volumetric modulated arc therapy of head and neck cancer Radiother Oncol 95 2010 142 148
29. F. Duprez, I. Madani, and K. Bonte Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory Radiother Oncol 93 2009 563 569
30. N. Lee, K. Chan, and J.E. Bekelman Salvage re-irradiation for recurrent head and neck cancer Int J Radiat Oncol Biol Phys 68 2007 731 740 (Pubitemid 46818729)
31. M.R. Posner, D.M. Hershock, and C.R. Blajman Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer N Engl J Med 357 2007 1705 1715 (Pubitemid 350005152)
32. J.B. Vermorken, E. Remenar, and C. van Herpen Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer N Engl J Med 357 2007 1695 1704 (Pubitemid 350005151)
33. T. Hehr, J. Classen, and C. Belka Reirradiation alternating with docetaxel and cisplatin in inoperable recurrence of head-and-neck cancer: a prospective phase I/II trial Int J Radiat Oncol Biol Phys 61 2005 1423 1431 (Pubitemid 40470424)
34. J.A. Bonner, P.M. Harari, and J. Giralt Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 2006 567 578 (Pubitemid 43209104)
35. J.B. Vermorken, R. Mesia, and F. Rivera Platinum-based chemotherapy plus cetuximab in head and neck cancer N Engl J Med 359 2008 1116 1127