Orthostatic haemodynamics may be impaired in frailty

Age and Ageing

Volumn 40, Issue 5, 2011, Pages 576-583

  Romero Ortuno, Roman ^a   Cogan, Lisa ^a   O'shea, Diarmuid ^c   Lawlor, Brian A ^a   Kenny, Rose Anne ^a,b  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Elderly; Finometer ; Frail; Haemodynamics; Heart rate; Hypotension; Orthostatic

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

ADULT; AGED; ARTICLE; AUTONOMIC NEUROPATHY; BLOOD VESSEL REACTIVITY; COMMUNITY SAMPLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMENTIA; DIASTOLIC BLOOD PRESSURE; FEMALE; FRAIL ELDERLY; GERIATRIC HOSPITAL; HEART RATE; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; ORTHOSTATIC HYPOTENSION; PATIENT CODING; PATIENT MONITORING; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE;

AGE FACTORS; AGED; BLOOD PRESSURE; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; FEMALE; FRAIL ELDERLY; HEALTH STATUS; HEALTH STATUS INDICATORS; HEART RATE; HEMODYNAMICS; HUMANS; HYPOTENSION, ORTHOSTATIC; INDEPENDENT LIVING; IRELAND; LINEAR MODELS; MALE; MULTIVARIATE ANALYSIS; PHENOTYPE; PILOT PROJECTS;

EID: 80051778072     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afr076     Document Type: Article

References (30)

1. Low PA. Prevalence of orthostatic hypotension. Clin Auton Res 2008; 18(Suppl. 1): 8-13.
2. Hiitola P, Enlund H, Kettunen R, Sulkava R, Hartikainen S. Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older. J Hum Hypertens 2009; 23: 33-9.
3. Moya A, Sutton R, Ammirati F et al. Guidelines for the diagnosis and management of syncope (version 2009): the Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC). Eur Heart J 2009; 30: 2631-71.
4. Verwoert GC, Mattace-Raso FU, Hofman A et al. Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study. J Am Geriatr Soc 2008; 56: 1816-20.
5. Shibao C, Grijalva CG, Raj SR, Biaggioni I, Griffin MR. Orthostatic hypotension-related hospitalizations in the United States. Am J Med 2007; 120: 975-80.
6. Wieling W, Schatz IJ. The consensus statement on the definition of orthostatic hypotension: a revisit after 13 years. J Hypertens 2009; 27: 935-8.
7. Masaki KH, Schatz IJ, Burchfiel CM et al. Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 1998; 98: 2290-5.
8. Ejaz AA, Kazory A, Heinig ME. 24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotension. J Clin Hypertens (Greenwich) 2007; 9: 952-5.
9. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-56.
10. Cullen B, Fahy S, Cunningham CJ et al. Screening for dementia in an Irish community sample using MMSE: a comparison of norm-adjusted versus fixed cut-points. Int J Geriatr Psychiatry 2005; 20: 371-6.
11. van der Velde N, van den Meiracker AH, Stricker BH, van der Cammen TJ. Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant?. Blood Press Monit 2007; 12: 167-71.
12. Orme JG, Reis J, Herz EJ. Factorial and discriminant validity of the Center for Epidemiological Studies Depression (CES-D) scale. J Clin Psychol 1986; 42: 28-33.
13. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Neurology 1996; 46: 1470.
14. Wieling W, Krediet CT, van Dijk N, Linzer M, Tschakovsky ME. Initial orthostatic hypotension: review of a forgotten condition. Clin Sci (Lond) 2007; 112: 157-65.
15. Hall WH, Ramachandran R, Narayan S, Jani AB, Vijayakumar S. An electronic application for rapidly calculating Charlson comorbidity score. BMC Cancer 2004; 4: 94.
16. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59: 255-63.
17. Cybulski G, Niewiadomski W. Influence of age on the immediate heart rate response to the active orthostatic test. J Physiol Pharmacol 2003; 54: 65-80.
18. White NJ. Heart-rate changes on standing in elderly patients with orthostatic hypotension. Clin Sci (Lond) 1980; 58: 411-3.
19. Ho JE, Bittner V, Demicco DA, Breazna A, Deedwania PC, Waters DD. Usefulness of heart rate at rest as a predictor of mortality, hospitalization for heart failure, myocardial infarction, and stroke in patients with stable coronary heart disease (Data from the Treating to New Targets [TNT] trial). Am J Cardiol 2010; 105: 905-11.
20. Cooney MT, Vartiainen E, Laatikainen T, Juolevi A, Dudina AGraham IM. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J 2010; 159: 612-9 e3.
21. Jensen MT, Marott JL, Jensen GB. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers. Int J Cardiol 2010; in press.
22. Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. The mortality rate as a function of accumulated deficits in a frailty index. Mech Ageing Dev 2002; 123: 1457-60.
23. Graham JE, Snih SA, Berges IM, Ray LA, Markides KS, Ottenbacher KJ. Frailty and 10-year mortality in communityliving Mexican American older adults. Gerontology 2009; 55: 644-51.
24. Chaves PH, Varadhan R, Lipsitz LA et al. Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women. J Am Geriatr Soc 2008; 56: 1698-703.
25. Varadhan R, Chaves PH, Lipsitz LA et al. Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices. J Gerontol A Biol Sci Med Sci 2009; 64: 682-7.
26. Nowak A, Hubbard RE. Falls and frailty: lessons from complex systems. J R Soc Med 2009; 102: 98-102.
27. Liu BA, Topper AK, Reeves RA, Gryfe C, Maki BE. Falls among older people: relationship to medication use and orthostatic hypotension. J Am Geriatr Soc 1995; 43: 1141-5.
28. Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ. Will my patient fall? JAMA 2007; 297: 77-86.
29. Thomas S, Miller M, Whitehead C, Crotty M. Falls Clinics: an opportunity to address frailty and improve health outcomes (preliminary evidence). Aging Clin Exp Res 2010; 22: 170-4.
30. Kenny RA, Kalaria R, Ballard C. Neurocardiovascular instability in cognitive impairment and dementia. Ann N Y Acad Sci 2002; 977: 183-95.