메뉴 건너뛰기




Volumn 22, Issue 4, 2011, Pages 419-455

Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

Author keywords

brain hypotrophy; cognitive disability; dendritic pathology; neurogenesis impairment; pharmacotherapy; synaptic alterations

Indexed keywords

BRAIN DEVELOPMENT; DEVELOPMENTAL DISORDER; DOWN SYNDROME; HUMAN; INTELLECTUAL IMPAIRMENT; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRISOMY 21;

EID: 80051768234     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/RNS.2011.037     Document Type: Review
Times cited : (69)

References (331)
  • 4
    • 34248136006 scopus 로고    scopus 로고
    • Differential effects of trisomy on brain shape and volume in related aneuploid mouse models
    • DOI 10.1002/ajmg.a.31721
    • Aldridge, K., Reeves, R.H., Olson, L.E., and Richtsmeier, J.T. (2007). Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. Am. J. Med. Genet. A 143A, 1060-1070. (Pubitemid 46709276)
    • (2007) American Journal of Medical Genetics, Part A , vol.143 , Issue.10 , pp. 1060-1070
    • Aldridge, K.1    Reeves, R.H.2    Olson, L.E.3    Richtsmeier, J.T.4
  • 5
    • 0035445736 scopus 로고    scopus 로고
    • Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
    • Altafaj, X., Dierssen, M., Baamonde, C., Marti, E., Visa, J., Guimera, J., Oset, M., Gonzalez, J.R., Florez, J., Fillat, C., et al. (2001). Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum. Mol. Genet. 10, 1915-1923. (Pubitemid 32910536)
    • (2001) Human Molecular Genetics , vol.10 , Issue.18 , pp. 1915-1923
    • Altafaj, X.1    Dierssen, M.2    Baamonde, C.3    Marti, E.4    Visa, J.5    Guimera, J.6    Oset, M.7    Gonzalez, J.R.8    Florez, J.9    Fillat, C.10    Estivill, X.11
  • 7
    • 0025088801 scopus 로고
    • Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods
    • Altman, J. and Bayer, S.A. (1990). Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J. Comp. Neurol. 301, 365-381. (Pubitemid 20368500)
    • (1990) Journal of Comparative Neurology , vol.301 , Issue.3 , pp. 365-381
    • Altman, J.1    Bayer, S.A.2
  • 9
    • 3242794941 scopus 로고    scopus 로고
    • Dosage-dependent over-expression of genes in the trisomic region of Ts1 Cje mouse model for Down syndrome
    • DOI 10.1093/hmg/ddh154
    • Amano, K., Sago, H., Uchikawa, C., Suzuki, T., Kotliarova, S.E., Nukina, N., Epstein, C.J., and Yamakawa, K. (2004). Dosagedependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum. Mol. Genet. 13, 1333-1340. (Pubitemid 38967186)
    • (2004) Human Molecular Genetics , vol.13 , Issue.13 , pp. 1333-1340
    • Amano, K.1    Sago, H.2    Uchikawa, C.3    Suzuki, T.4    Kotliarova, S.E.5    Nukina, N.6    Epstein, C.J.7    Yamakawa, K.8
  • 11
    • 0036118916 scopus 로고    scopus 로고
    • Excessive expression of synaptojanin in brains with Down syndrome
    • DOI 10.1016/S0387-7604(01)00405-3, PII S0387760401004053
    • Arai, Y., Ijuin, T., Takenawa, T., Becker, L.E., and Takashima, S. (2002). Excessive expression of synaptojanin in brains with Down syndrome. Brain Dev. 24, 67-72. (Pubitemid 34224905)
    • (2002) Brain and Development , vol.24 , Issue.2 , pp. 67-72
    • Arai, Y.1    Ijuin, T.2    Takenawa, T.3    Becker, L.E.4    Takashima, S.5
  • 13
    • 78449295431 scopus 로고    scopus 로고
    • In vivo effects of APP are not exacerbated by BACE2 co-overexpression: Behavioural characterization of a double transgenic mouse model
    • Azkona, G., Levannon, D., Groner, Y., and Dierssen, M. (2010b). In vivo effects of APP are not exacerbated by BACE2 co-overexpression: Behavioural characterization of a double transgenic mouse model. Amino Acids 39, 1571-1580.
    • (2010) Amino Acids , vol.39 , pp. 1571-1580
    • Azkona, G.1    Levannon, D.2    Groner, Y.3    Dierssen, M.4
  • 15
    • 0024470138 scopus 로고
    • Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21
    • Baffico, M., Perroni, L., Rasore-Quartino, A., and Scartezzini, P. (1989). Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21. Hum. Genet. 83, 295-296. (Pubitemid 19250493)
    • (1989) Human Genetics , vol.83 , Issue.3 , pp. 295-296
    • Baffico, M.1    Perroni, L.2    Rasore-Quartino, A.3    Scartezzini, P.4
  • 16
    • 0037176537 scopus 로고    scopus 로고
    • Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study
    • DOI 10.1016/S0140-6736(02)07497-4
    • Bahn, S., Mimmack, M., Ryan, M., Caldwell, M.A., Jauniaux, E., Starkey, M., Svendsen, C.N., and Emson, P. (2002). Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet 359, 310-315. (Pubitemid 34119295)
    • (2002) Lancet , vol.359 , Issue.9303 , pp. 310-315
    • Bahn, S.1    Mimmack, M.2    Ryan, M.3    Caldwell, M.A.4    Jauniaux, E.5    Starkey, M.6    Svendsen, C.N.7    Emson, P.8
  • 17
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • DOI 10.1042/BJ20021535
    • Bain, J., McLauchlan, H., Elliott, M., and Cohen, P. (2003). The specificities of protein kinase inhibitors: An update. Biochem. J. 371, 199-204. (Pubitemid 36458094)
    • (2003) Biochemical Journal , vol.371 , Issue.1 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 18
    • 33845917359 scopus 로고    scopus 로고
    • Developmental and behavioral consequences of prenatal fluoxetine
    • DOI 10.1159/000096645
    • Bairy, K.L., Madhyastha, S., Ashok, K.P., Bairy, I., and Malini, S. (2007). Developmental and behavioral consequences of prenatal fluoxetine. Pharmacology 79, 1-11. (Pubitemid 46034171)
    • (2007) Pharmacology , vol.79 , Issue.1 , pp. 1-11
    • Bairy, K.L.1    Madhyastha, S.2    Ashok, K.P.3    Bairy, I.4    Malini, S.5
  • 19
    • 0016749568 scopus 로고
    • Biochemical studies on myelin isolated from the brains of patients with Down's syndrome
    • Banik, N.L., Davison, A.N., Palo, J., and Savolainen, H. (1975). Biochemical studies on myelin isolated from the brains of patients with Down's syndrome. Brain 98, 213-218.
    • (1975) Brain , vol.98 , pp. 213-218
    • Banik, N.L.1    Davison, A.N.2    Palo, J.3    Savolainen, H.4
  • 20
  • 21
    • 0029757963 scopus 로고    scopus 로고
    • Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons
    • DOI 10.1073/pnas.93.16.8530
    • Bar-Peled, O., Korkotian, E., Segal, M., and Groner, Y. (1996). Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons. Proc. Natl. Acad. Sci. USA 93, 8530-8535. (Pubitemid 26269593)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.16 , pp. 8530-8535
    • Bar-Peled, O.1    Korkotian, E.2    Segal, M.3    Groner, Y.4
  • 22
    • 0033978891 scopus 로고    scopus 로고
    • Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
    • Baxter, L.L., Moran, T.H., Richtsmeier, J.T., Troncoso, J., and Reeves, R.H. (2000). Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum. Mol. Genet. 9, 195-202. (Pubitemid 30052743)
    • (2000) Human Molecular Genetics , vol.9 , Issue.2 , pp. 195-202
    • Baxter, L.L.1    Moran, T.H.2    Richtsmeier, J.T.3    Troncoso, J.4    Reeves, R.H.5
  • 23
    • 0022506009 scopus 로고
    • Dendritic atrophy in children with Down's syndrome
    • Becker, L.E., Armstrong, D.L., and Chan, F. (1986). Dendritic atrophy in children with Down's syndrome. Ann. Neurol. 20, 520-526. (Pubitemid 16005672)
    • (1986) Annals of Neurology , vol.20 , Issue.4 , pp. 520-526
    • Becker, L.E.1    Armstrong, D.L.2    Chan, F.3
  • 26
    • 34548795562 scopus 로고    scopus 로고
    • Synaptic and cognitive abnormalities in mouse models of Down syndrome: Exploring genotype-phenotype relationships
    • DOI 10.1002/cne.21433
    • Belichenko, P.V., Kleschevnikov, A.M., Salehi, A., Epstein, C.J., and Mobley, W.C. (2007). Synaptic and cognitive abnormalities in mouse models of Down syndrome: Exploring genotype-phenotype relationships. J. Comp. Neurol. 504, 329-345. (Pubitemid 47437199)
    • (2007) Journal of Comparative Neurology , vol.504 , Issue.4 , pp. 329-345
    • Belichenko, P.V.1    Kleschevnikov, A.M.2    Salehi, A.3    Epstein, C.J.4    Mobley, W.C.5
  • 27
    • 65949098892 scopus 로고    scopus 로고
    • The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    • Belichenko, N.P., Belichenko, P.V., Kleschevnikov, A.M., Salehi, A., Reeves, R.H., and Mobley, W.C. (2009a). The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J. Neurosci. 29, 5938-5948.
    • (2009) J. Neurosci. , vol.29 , pp. 5938-5948
    • Belichenko, N.P.1    Belichenko, P.V.2    Kleschevnikov, A.M.3    Salehi, A.4    Reeves, R.H.5    Mobley, W.C.6
  • 29
    • 65349122404 scopus 로고    scopus 로고
    • Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: Evidence for disruption of neuronal networks
    • Belichenko, P.V., Wright, E.E., Belichenko, N.P., Masliah, E., Li, H.H., Mobley, W.C., and Francke, U. (2009c). Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: Evidence for disruption of neuronal networks. J. Comp. Neurol. 514, 240-258.
    • (2009) J. Comp. Neurol. , vol.514 , pp. 240-258
    • Belichenko, P.V.1    Wright, E.E.2    Belichenko, N.P.3    Masliah, E.4    Li, H.H.5    Mobley, W.C.6    Francke, U.7
  • 30
    • 85047691446 scopus 로고    scopus 로고
    • Harm avoidance, anxiety, and response to novelty in the adolescent S-100β transgenic mouse: Role of serotonin and relevance to down syndrome
    • DOI 10.1038/sj.npp.1300241
    • Bell, K., Shokrian, D., Potenzieri, C., and Whitaker-Azmitia, P.M. (2003). Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: Role of serotonin and relevance to Down syndrome. Neuropsychopharmacology 28, 1810-1816. (Pubitemid 41070846)
    • (2003) Neuropsychopharmacology , vol.28 , Issue.10 , pp. 1810-1816
    • Bell, K.1    Shokrian, D.2    Potenzieri, C.3    Whitaker-Azmitia, P.M.4
  • 32
    • 0030897317 scopus 로고    scopus 로고
    • Behavioral consequences of abnormal cortical development: Insights into developmental disabilities
    • DOI 10.1016/S0166-4328(96)02251-6, PII S0166432896022516
    • Berger-Sweeney, J. and Hohmann, C.F. (1997). Behavioral consequences of abnormal cortical development: Insights into developmental disabilities. Behav. Brain Res. 86, 121-142. (Pubitemid 27154256)
    • (1997) Behavioural Brain Research , vol.86 , Issue.2 , pp. 121-142
    • Berger-Sweeney, J.1    Hohmann, C.F.2
  • 33
    • 33846404179 scopus 로고    scopus 로고
    • B-induced potassium current
    • DOI 10.1152/jn.00626.2006
    • Best, T.K., Siarey, R.J., and Galdzicki, Z. (2007). Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J. Neurophysiol. 97, 892-900. (Pubitemid 46143403)
    • (2007) Journal of Neurophysiology , vol.97 , Issue.1 , pp. 892-900
    • Best, T.K.1    Siarey, R.J.2    Galdzicki, Z.3
  • 34
    • 70450237623 scopus 로고    scopus 로고
    • A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells
    • Bhattacharyya, A., McMillan, E., Chen, S.I., Wallace, K., and Svendsen, C.N. (2009). A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. Dev. Neurosci. 31, 497-510.
    • (2009) Dev. Neurosci. , vol.31 , pp. 497-510
    • Bhattacharyya, A.1    McMillan, E.2    Chen, S.I.3    Wallace, K.4    Svendsen, C.N.5
  • 35
    • 71549157180 scopus 로고    scopus 로고
    • Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome
    • Bianchi, P., Ciani, E., Contestabile, A., Guidi, S., and Bartesaghi, R. (2010a). Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. Brain Pathol. 20, 106-118.
    • (2010) Brain Pathol. , vol.20 , pp. 106-118
    • Bianchi, P.1    Ciani, E.2    Contestabile, A.3    Guidi, S.4    Bartesaghi, R.5
  • 37
    • 0037450168 scopus 로고    scopus 로고
    • Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome
    • DOI 10.1016/S0166-4328(02)00082-7, PII S0166432802000827
    • Bimonte-Nelson, H.A., Hunter, C.L., Nelson, M.E., and Granholm, A.C. (2003). Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav. Brain Res. 139, 47-57. (Pubitemid 36300789)
    • (2003) Behavioural Brain Research , vol.139 , Issue.1-2 , pp. 47-57
    • Bimonte-Nelson, H.A.1    Hunter, C.L.2    Nelson, M.E.3    Granholm, A.-C.E.4
  • 38
    • 9644295698 scopus 로고    scopus 로고
    • Clinical potential of minocycline for neurodegenerative disorders
    • DOI 10.1016/j.nbd.2004.07.012, PII S0969996104001652
    • Blum, D., Chtarto, A., Tenenbaum, L., Brotchi, J., and Levivier, M. (2004). Clinical potential of minocycline for neurodegenerative disorders. Neurobiol. Dis. 17, 359-366. (Pubitemid 39574870)
    • (2004) Neurobiology of Disease , vol.17 , Issue.3 , pp. 359-366
    • Blum, D.1    Chtarto, A.2    Tenenbaum, L.3    Brotchi, J.4    Levivier, M.5
  • 39
    • 33847092919 scopus 로고    scopus 로고
    • Psychopharmacologic treatment of pediatric major depressive disorder
    • DOI 10.1007/s00213-006-0442-z, Pediatric Psychopharmacology
    • Boylan, K., Romero, S., and Birmaher, B. (2007). Psychopharmacologic treatment of pediatric major depressive disorder. Psychopharmacology (Berl) 191, 27-38. (Pubitemid 46294941)
    • (2007) Psychopharmacology , vol.191 , Issue.1 , pp. 27-38
    • Boylan, K.1    Romero, S.2    Birmaher, B.3
  • 40
    • 0037217206 scopus 로고    scopus 로고
    • Roles of the mammalian subventricular zone in brain development
    • DOI 10.1016/S0301-0082(03)00002-9
    • Brazel, C.Y., Romanko, M.J., Rothstein, R.P., and Levison, S.W. (2003). Roles of the mammalian subventricular zone in brain development. Prog. Neurobiol. 69, 49-69. (Pubitemid 36293991)
    • (2003) Progress in Neurobiology , vol.69 , Issue.1 , pp. 49-69
    • Brazel, C.Y.1    Romanko, M.J.2    Rothstein, R.P.3    Levison, S.W.4
  • 41
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • DOI 10.1038/378776a0
    • Busciglio, J., and Yankner, B.A. (1995). Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779. (Pubitemid 26004408)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 42
    • 0037186074 scopus 로고    scopus 로고
    • Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome
    • DOI 10.1016/S0896-6273(02)00604-9
    • Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., and Yankner, B.A. (2002). Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33, 677-688. (Pubitemid 34219240)
    • (2002) Neuron , vol.33 , Issue.5 , pp. 677-688
    • Busciglio, J.1    Pelsman, A.2    Wong, C.3    Pigino, G.4    Yuan, M.5    Mori, H.6    Yankner, B.A.7
  • 43
  • 44
    • 0029563213 scopus 로고
    • Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin
    • Bustin, M., Alfonso, P.J., Pash, J.M., Ward, J.M., Gearhart, J.D., and Reeves, R.H. (1995). Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin. DNA Cell Biol. 14, 997-1005. (Pubitemid 26002056)
    • (1995) DNA and Cell Biology , vol.14 , Issue.12 , pp. 997-1005
    • Bustin, M.1    Alfonso, P.J.2    Pash, J.M.3    Ward, J.M.4    Gearhart, J.D.5    Reeves, R.H.6
  • 45
    • 0842312322 scopus 로고    scopus 로고
    • Retrograde transport of neurotrophins: Fact and function
    • DOI 10.1002/neu.10322
    • Campenot, R.B. and MacInnis, B.L. (2004). Retrograde transport of neurotrophins: Fact and function. J. Neurobiol. 58, 217-229. (Pubitemid 38173720)
    • (2004) Journal of Neurobiology , vol.58 , Issue.2 , pp. 217-229
    • Campenot, R.B.1    MacInnis, B.L.2
  • 46
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
    • DOI 10.1126/science.1058783
    • Cao, X. and Sudhof, T.C. (2001). A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120. (Pubitemid 32625507)
    • (2001) Science , vol.293 , Issue.5527 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 48
    • 0031060636 scopus 로고    scopus 로고
    • Long-term memory in mental retardation: Evidence for a specific impairment in subjects with Down's syndrome
    • DOI 10.1016/S0028-3932(96)00055-3, PII S0028393296000553
    • Carlesimo, G.A., Marotta, L., and Vicari, S. (1997). Long-term memory in mental retardation: Evidence for a specific impairment in subjects with Down's syndrome. Neuropsychologia 35, 71-79. (Pubitemid 26418235)
    • (1997) Neuropsychologia , vol.35 , Issue.1 , pp. 71-79
    • Carlesimo, G.A.1    Marotta, L.2    Vicari, S.3
  • 49
    • 0028946820 scopus 로고
    • Menopause in women with learning disabilities
    • Carr, J. and Hollins, S. (1995). Menopause in women with learning disabilities. J Intellect. Disabil. Res. 39 (Pt 2), 137-139.
    • (1995) J. Intellect. Disabil. Res , vol.39 , Issue.PART. 2 , pp. 137-139
    • Carr, J.1    Hollins, S.2
  • 51
    • 35548970343 scopus 로고    scopus 로고
    • Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome
    • DOI 10.1523/JNEUROSCI.3406-07.2007
    • Chakrabarti, L., Galdzicki, Z., and Haydar, T.F. (2007). Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J. Neurosci. 27, 11483-11495. (Pubitemid 350006912)
    • (2007) Journal of Neuroscience , vol.27 , Issue.43 , pp. 11483-11495
    • Chakrabarti, L.1    Galdzicki, Z.2    Haydar, T.F.3
  • 53
    • 36849017423 scopus 로고    scopus 로고
    • Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome
    • DOI 10.1016/j.nlm.2007.05.007, PII S1074742707000846
    • Chang, Q. and Gold, P.E. (2008). Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol. Learn. Mem. 89, 167-177. (Pubitemid 350235961)
    • (2008) Neurobiology of Learning and Memory , vol.89 , Issue.2 , pp. 167-177
    • Chang, Q.1    Gold, P.E.2
  • 54
  • 55
    • 0029021457 scopus 로고
    • P75 and Trk: A tworeceptor system
    • Chao, M.V. and Hempstead, B.L. (1995). p75 and Trk: A tworeceptor system. Trends Neurosci. 18, 321-326.
    • (1995) Trends Neurosci. , vol.18 , pp. 321-326
    • Chao, M.V.1    Hempstead, B.L.2
  • 56
    • 0032079107 scopus 로고    scopus 로고
    • Neurotrophin receptors: Mediators of life and death
    • DOI 10.1016/S0165-0173(97)00036-2, PII S0165017397000362
    • Chao, M., Casaccia-Bonnefil, P., Carter, B., Chittka, A., Kong, H., and Yoon, S.O. (1998). Neurotrophin receptors: Mediators of life and death. Brain Res. Brain Res. Rev. 26, 295-301. (Pubitemid 28318084)
    • (1998) Brain Research Reviews , vol.26 , Issue.2-3 , pp. 295-301
    • Chao, M.1    Casaccia-Bonnefil, P.2    Carter, B.3    Chittka, A.4    Kong, H.5    Yoon, S.O.6
  • 57
    • 32644451922 scopus 로고    scopus 로고
    • Neurotrophin signalling in health and disease
    • DOI 10.1042/CS20050163
    • Chao, M.V., Rajagopal, R., and Lee, F.S. (2006). Neurotrophin signalling in health and disease. Clin. Sci. (Lond) 110, 167-173. (Pubitemid 43241478)
    • (2006) Clinical Science , vol.110 , Issue.2 , pp. 167-173
    • Chao, M.Y.1    Rajagopal, R.2    Lee, F.S.3
  • 60
    • 0037124086 scopus 로고    scopus 로고
    • Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate
    • DOI 10.1074/jbc.M111101200
    • Chen-Hwang, M.C., Chen, H.R., Elzinga, M., and Hwang, Y.W. (2002). Dynamin is a minibrain kinase/dual specificity Yak1- related kinase 1A substrate. J. Biol. Chem. 277, 17597-17604. (Pubitemid 34967562)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.20 , pp. 17597-17604
    • Chen-Hwang, M.-C.1    Chen, H.-R.2    Elzinga, M.3    Hwang, Y.-W.4
  • 62
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • DOI 10.1128/MMBR.65.2.232-260.2001
    • Chopra, I. and Roberts, M. (2001). Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65, 232-260. (Pubitemid 32538179)
    • (2001) Microbiology and Molecular Biology Reviews , vol.65 , Issue.2 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 63
    • 0033852958 scopus 로고    scopus 로고
    • Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome
    • Chrast, R., Scott, H.S., Madani, R., Huber, L., Wolfer, D.P., Prinz, M., Aguzzi, A., Lipp, H.P., and Antonarakis, S.E. (2000). Mice trisomic for a bacterial artificial chromosome with the singleminded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum. Mol. Genet. 9, 1853-1864. (Pubitemid 30608618)
    • (2000) Human Molecular Genetics , vol.9 , Issue.12 , pp. 1853-1864
    • Chrast, R.1    Scott, H.S.2    Madani, R.3    Huber, L.4    Wolfer, D.P.5    Prinz, M.6    Aguzzi, A.7    Lipp, H.-P.8    Antonarakis, S.E.9
  • 64
    • 33845600030 scopus 로고    scopus 로고
    • Uptake and distribution of catechins in fetal organs following in utero exposure in rats
    • DOI 10.1093/humrep/del353
    • Chu, K.O., Wang, C.C., Chu, C.Y., Choy, K.W., Pang, C.P., and Rogers, M.S. (2007). Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Hum. Reprod. 22, 280-287. (Pubitemid 44942698)
    • (2007) Human Reproduction , vol.22 , Issue.1 , pp. 280-287
    • Chu, K.O.1    Wang, C.C.2    Chu, C.Y.3    Choy, K.W.4    Pang, C.P.5    Rogers, M.S.6
  • 65
    • 33746047443 scopus 로고    scopus 로고
    • Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
    • DOI 10.1152/japplphysiol.01402.2005, PII S001448860600063X
    • Clark, S., Schwalbe, J., Stasko, M.R., Yarowsky, P.J., and Costa, A.C. (2006). Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Exp. Neurol. 200, 256-261. (Pubitemid 44080763)
    • (2006) Experimental Neurology , vol.200 , Issue.1 , pp. 256-261
    • Clark, S.1    Schwalbe, J.2    Stasko, M.R.3    Yarowsky, P.J.4    Costa, A.C.S.5
  • 66
    • 33645323789 scopus 로고    scopus 로고
    • Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    • Contestabile, A., Fila, T., Bartesaghi, R., Contestabile, A., Ciani, E. (2006). Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J. Neurochem. 97, 515-526.
    • (2006) J. Neurochem. , vol.97 , pp. 515-526
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Contestabile, A.4    Ciani, E.5
  • 67
    • 34548102066 scopus 로고    scopus 로고
    • Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice
    • DOI 10.1002/hipo.20308
    • Contestabile, A., Fila, T., Ceccarelli, C., Bonasoni, P., Bonapace, L., Santini, D., Bartesaghi, R., and Ciani, E. (2007). Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus 17, 665-678. (Pubitemid 47292037)
    • (2007) Hippocampus , vol.17 , Issue.8 , pp. 665-678
    • Contestabile, A.1    Fila, T.2    Ceccarelli, C.3    Bonasoni, P.4    Bonapace, L.5    Santini, D.6    Bartesaghi, R.7    Ciani, E.8
  • 68
    • 61649106285 scopus 로고    scopus 로고
    • Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome
    • Contestabile, A., Fila, T., Bartesaghi, R., and Ciani, E. (2009). Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. Brain Pathol. 19, 224-237.
    • (2009) Brain Pathol. , vol.19 , pp. 224-237
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Ciani, E.4
  • 72
    • 0033407499 scopus 로고    scopus 로고
    • Motor dysfunction in a mouse model for Down syndrome
    • DOI 10.1016/S0031-9384(99)00178-X, PII S003193849900178X
    • Costa, A.C., Walsh, K., and Davisson, M.T. (1999). Motor dysfunction in a mouse model for Down syndrome. Physiol. Behav. 68, 211-220. (Pubitemid 30009803)
    • (1999) Physiology and Behavior , vol.68 , Issue.1-2 , pp. 211-220
    • Costa, A.C.S.1    Walsh, K.2    Davisson, M.T.3
  • 73
    • 0022548320 scopus 로고
    • The neurobiologic consequences of Down syndrome
    • DOI 10.1016/0361-9230(86)90074-2
    • Coyle, J.T., Oster-Granite, M.L., and Gearhart, J.D. (1986). The neurobiologic consequences of Down syndrome. Brain Res. Bull. 16, 773-787. (Pubitemid 16041613)
    • (1986) Brain Research Bulletin , vol.16 , Issue.6 , pp. 773-787
    • Coyle, J.T.1    Oster-Granite, M.L.2    Gearhart, J.D.3
  • 78
    • 0031959496 scopus 로고    scopus 로고
    • p53- and CD95-associated apoptosis in neurodegenerative diseases
    • de la Monte, S.M., Sohn, Y.K., Ganju, N., and Wands, J.R. (1998). P53-and CD95-associated apoptosis in neurodegenerative diseases. Lab. Invest. 78, 401-411. (Pubitemid 28207853)
    • (1998) Laboratory Investigation , vol.78 , Issue.4 , pp. 401-411
    • De La Monte, S.M.1    Sohn, Y.K.2    Ganju, N.3    Wands, J.R.4
  • 81
    • 0030463644 scopus 로고    scopus 로고
    • Spatial memory deficits in segmental trisomic Ts65Dn mice
    • DOI 10.1016/S0166-4328(97)81111-4, PII S0166432896000721
    • Demas, G.E., Nelson, R.J., Krueger, B.K., and Yarowsky, P.J. (1996). Spatial memory deficits in segmental trisomic Ts65Dn mice. Behav. Brain Res. 82, 85-92. (Pubitemid 27033629)
    • (1996) Behavioural Brain Research , vol.82 , Issue.1 , pp. 85-92
    • Demas, G.E.1    Nelson, R.J.2    Krueger, B.K.3    Yarowsky, P.J.4
  • 82
    • 0025061151 scopus 로고
    • Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down's syndrome. Age-specific changes
    • Devinsky, O., Sato, S., Conwit, R.A., and Schapiro, M.B. (1990). Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down's syndrome. Agespecific changes. Arch. Neurol. 47, 58-62. (Pubitemid 20024156)
    • (1990) Archives of Neurology , vol.47 , Issue.1 , pp. 58-62
    • Devinsky, O.1    Sato, S.2    Conwit, R.A.3    Schapiro, M.B.4
  • 83
    • 0031055509 scopus 로고    scopus 로고
    • Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome
    • DOI 10.1016/S0006-8993(96)01173-0, PII S0006899396011730
    • Dierssen, M., Vallina, I.F., Baamonde, C., Garcia-Calatayud, S., Lumbreras, M.A., and Florez, J. (1997). Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res. 749, 238-244. (Pubitemid 27104205)
    • (1997) Brain Research , vol.749 , Issue.2 , pp. 238-244
    • Dierssen, M.1    Vallina, I.F.2    Baamonde, C.3    Garcia-Calatayud, S.4    Lumbreras, M.A.5    Florez, J.6
  • 85
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of environmental enrichment
    • DOI 10.1093/cercor/13.7.758
    • Dierssen, M., Benavides-Piccione, R., Martinez-Cue, C., Estivill, X., Florez, J., Elston, G.N., and DeFelipe, J. (2003). Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of environmental enrichment. Cereb. Cortex 13, 758-764. (Pubitemid 36758962)
    • (2003) Cerebral Cortex , vol.13 , Issue.7 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martinez-Cue, C.3    Estivill, X.4    Florez, J.5    Elston, G.N.6    DeFelipe, J.7
  • 86
    • 0030979469 scopus 로고    scopus 로고
    • Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain
    • Doetsch, F., Garcia Verdugo, J.M., and Alvarez Buylla, A. (1997). Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17, 5046-5061. (Pubitemid 27263818)
    • (1997) Journal of Neuroscience , vol.17 , Issue.13 , pp. 5046-5061
    • Doetsch, F.1    Garcia-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 87
    • 57349119307 scopus 로고    scopus 로고
    • Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease
    • Dong, H., Yuede, C.M., Coughlan, C., Lewis, B., and Csernansky, J.G. (2008). Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease. Neuropsychopharmacology 33, 3226-3236.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 3226-3236
    • Dong, H.1    Yuede, C.M.2    Coughlan, C.3    Lewis, B.4    Csernansky, J.G.5
  • 88
    • 33745487381 scopus 로고    scopus 로고
    • In Vivo Restoration of Physiological Levels of Truncated TrkB.T1 Receptor Rescues Neuronal Cell Death in a Trisomic Mouse Model
    • DOI 10.1016/j.neuron.2006.06.009, PII S0896627306004624
    • Dorsey, S.G., Renn, C.L., Carim-Todd, L., Barrick, C.A., Bambrick, L., Krueger, B.K., Ward, C.W., and Tessarollo, L. (2006). In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron 51, 21-28. (Pubitemid 43963340)
    • (2006) Neuron , vol.51 , Issue.1 , pp. 21-28
    • Dorsey, S.G.1    Renn, C.L.2    Carim-Todd, L.3    Barrick, C.A.4    Bambrick, L.5    Krueger, B.K.6    Ward, C.W.7    Tessarollo, L.8
  • 90
    • 0028197715 scopus 로고
    • Profiles and development of adaptive behavior in children with Down syndrome
    • Dykens, E., Hodapp, R., and Evans, D. (1994). Profiles and development of adaptive behavior in children with Down syndrome. Am. J. Ment. Retard. 98, 580-587. (Pubitemid 24096754)
    • (1994) American Journal on Mental Retardation , vol.98 , Issue.5 , pp. 580-587
    • Dykens, E.M.1    Hodapp, R.M.2    Evans, D.W.3
  • 91
    • 65349133569 scopus 로고    scopus 로고
    • Incidence of major malformations in infants following antidepressant exposure in pregnancy: Results of a large prospective cohort study
    • Einarson, A., Choi, J., Einarson, T.R., and Koren, G. (2009). Incidence of major malformations in infants following antidepressant exposure in pregnancy: Results of a large prospective cohort study. Can. J. Psychiatry 54, 242-246.
    • (2009) Can. J. Psychiatry , vol.54 , pp. 242-246
    • Einarson, A.1    Choi, J.2    Einarson, T.R.3    Koren, G.4
  • 93
    • 0028347355 scopus 로고
    • Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: Implication for gene dosage in trisomy 21
    • Elson, A., Levanon, D., Weiss, Y., and Groner, Y. (1994). Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: Implication for gene dosage in trisomy 21. Biochem. J. 299 (Pt 2), 409-415. (Pubitemid 24114133)
    • (1994) Biochemical Journal , vol.299 , Issue.2 , pp. 409-415
    • Elson, A.1    Levanon, D.2    Weiss, Y.3    Groner, Y.4
  • 95
    • 0142226953 scopus 로고    scopus 로고
    • Aberrant protein expression in cerebral cortex of fetus with Down syndrome
    • DOI 10.1016/S0306-4522(03)00605-5
    • Engidawork, E., Gulesserian, T., Fountoulakis, M., and Lubec, G. (2003). Aberrant protein expression in cerebral cortex of fetus with Down syndrome. Neuroscience 122, 145-154. (Pubitemid 37329954)
    • (2003) Neuroscience , vol.122 , Issue.1 , pp. 145-154
    • Engidawork, E.1    Gulesserian, T.2    Fountoulakis, M.3    Lubec, G.4
  • 97
    • 38749133061 scopus 로고    scopus 로고
    • Episodic-like memory in Ts65Dn, a mouse model of Down syndrome
    • DOI 10.1016/j.bbr.2007.09.015, PII S016643280700469X
    • Fernandez, F. and Garner, C.C. (2008). Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. Behav. Brain Res. 188, 233-237. (Pubitemid 351178776)
    • (2008) Behavioural Brain Research , vol.188 , Issue.1 , pp. 233-237
    • Fernandez, F.1    Garner, C.C.2
  • 98
  • 99
  • 101
    • 0031425147 scopus 로고    scopus 로고
    • Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: Focus on the roman rat lines
    • DOI 10.1023/A:1021400830503
    • Fernandez-Teruel, A., Escorihuela, R.M., Castellano, B., Gonzalez, B., and Tobena, A. (1997). Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: Focus on the Roman rat lines. Behav. Genet. 27, 513-526. (Pubitemid 28098959)
    • (1997) Behavior Genetics , vol.27 , Issue.6 , pp. 513-526
    • Fernandez-Teruel, A.1    Escorihuela, R.M.2    Castellano, B.3    Gonzalez, B.4    Tobena, A.5
  • 102
    • 0025296344 scopus 로고
    • Down's syndrome and Alzheimer's disease: Dendritic spine counts in the hippocampus
    • DOI 10.1007/BF00294247
    • Ferrer, I. and Gullotta, F. (1990). Down's syndrome and Alzheimer's disease: Dendritic spine counts in the hippocampus. Acta Neuropathol. 79, 680-685. (Pubitemid 20170346)
    • (1990) Acta Neuropathologica , vol.79 , Issue.6 , pp. 680-685
    • Ferrer, I.1    Gullotta, F.2
  • 103
    • 0027953818 scopus 로고
    • Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome)
    • Fiedler, J.L., Epstein, C.J., Rapoport, S.I., Caviedes, R., and Caviedes, P. (1994). Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). Brain Res. 658, 27-32. (Pubitemid 24291699)
    • (1994) Brain Research , vol.658 , Issue.1-2 , pp. 27-32
    • Fiedler, J.L.1    Epstein, C.J.2    Rapoport, S.I.3    Caviedes, R.4    Caviedes, P.5
  • 107
    • 0028856422 scopus 로고
    • A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
    • Fuentes, J.J., Pritchard, M.A., Planas, A.M., Bosch, A., Ferrer, I., and Estivill, X. (1995). A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum. Mol. Genet. 4, 1935-1944.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1935-1944
    • Fuentes, J.J.1    Pritchard, M.A.2    Planas, A.M.3    Bosch, A.4    Ferrer, I.5    Estivill, X.6
  • 110
    • 0031865781 scopus 로고    scopus 로고
    • Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice
    • DOI 10.1046/j.1460-9568.1998.00058.x
    • Gahtan, E., Auerbach, J.M., Groner, Y., and Segal, M. (1998). Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice. Eur. J. Neurosci. 10, 538-544. (Pubitemid 28325477)
    • (1998) European Journal of Neuroscience , vol.10 , Issue.2 , pp. 538-544
    • Gahtan, E.1    Auerbach, J.M.2    Groner, Y.3    Segal, M.4
  • 111
    • 64549126454 scopus 로고    scopus 로고
    • Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome
    • Galante, M., Jani, H., Vanes, L., Daniel, H., Fisher, E.M., Tybulewicz, V.L., Bliss, T.V., and Morice, E. (2009). Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum. Mol. Genet. 18, 1449-1463.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1449-1463
    • Galante, M.1    Jani, H.2    Vanes, L.3    Daniel, H.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7    Morice, E.8
  • 112
    • 0042025826 scopus 로고    scopus 로고
    • Understanding mental retardation in down's syndrome using trisomy 16 mouse models
    • DOI 10.1034/j.1601-183X.2003.00024.x
    • Galdzicki, Z. and Siarey, R.J. (2003). Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav. 2, 167-178. (Pubitemid 36898803)
    • (2003) Genes, Brain and Behavior , vol.2 , Issue.3 , pp. 167-178
    • Galdzicki, Z.1    Siarey, R.J.2
  • 113
    • 0019511599 scopus 로고
    • Pathology of the auditory system in autosomal trisomies with morphometric and quantitative study of the ventral cochlear nucleus
    • DOI 10.1016/0022-510X(81)90058-7
    • Gandolfi, A., Horoupian, D.S., and De Teresa, R.M. (1981). Pathology of the auditory system in autosomal trisomies with morphometric and quantitative study of the ventral cochlear nucleus. J. Neurol. Sci. 51, 43-50. (Pubitemid 11078502)
    • (1981) Journal of the Neurological Sciences , vol.51 , Issue.1 , pp. 43-50
    • Gandolfi, A.1    Horoupian, D.S.2    De Teresa, R.M.3
  • 114
    • 28544452525 scopus 로고    scopus 로고
    • Oxidative stress and hematologic and biochemical parameters in individuals with down syndrome
    • Garcez, M.E., Peres, W., and Salvador, M. (2005). Oxidative stress and hematologic and biochemical parameters in individuals with Down syndrome. Mayo Clin. P. 80, 1607-1611. (Pubitemid 41747063)
    • (2005) Mayo Clinic Proceedings , vol.80 , Issue.12 , pp. 1607-1611
    • Garcez, M.E.1    Peres, W.2    Salvador, M.3
  • 115
    • 0036023971 scopus 로고    scopus 로고
    • A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
    • Geling, A., Steiner, H., Willem, M., Bally-Cuif, L., and Haass, C. (2002). A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep. 3, 688-694.
    • (2002) EMBO Rep. , vol.3 , pp. 688-694
    • Geling, A.1    Steiner, H.2    Willem, M.3    Bally-Cuif, L.4    Haass, C.5
  • 116
    • 0029266133 scopus 로고
    • Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta
    • Gerlai, R. and Roder, J. (1995). Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta. J. Psychiatry Neurosci. 20, 105-112.
    • (1995) J. Psychiatry Neurosci. , vol.20 , pp. 105-112
    • Gerlai, R.1    Roder, J.2
  • 117
    • 77955637621 scopus 로고    scopus 로고
    • APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation
    • Ghosal, K., Stathopoulos, A., and Pimplikar, S.W. (2010). APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS One 5, e11866.
    • (2010) PLoS One , vol.5
    • Ghosal, K.1    Stathopoulos, A.2    Pimplikar, S.W.3
  • 118
    • 0023190338 scopus 로고
    • Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue
    • Godridge, H., Reynolds, G.P., Czudek, C., Calcutt, N.A., and Benton, M. (1987). Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue. J. Neurol. Neurosurg. Psychiatry 50, 775-778. (Pubitemid 17076293)
    • (1987) Journal of Neurology Neurosurgery and Psychiatry , vol.50 , Issue.6 , pp. 775-778
    • Godridge, H.1    Reynolds, G.P.2    Czudek, C.3
  • 119
  • 121
    • 57649116085 scopus 로고    scopus 로고
    • NAP and D-SAL: Neuroprotection against the beta amyloid peptide 1-42
    • Gozes, I., Divinski, I., and Piltzer, I. (2008). NAP and D-SAL: Neuroprotection against the beta amyloid peptide (1-42). BMC Neurosci. 9 (Suppl. 3), S3.
    • (2008) BMC Neurosci. , vol.9 , Issue.SUPPL. 3
    • Gozes, I.1    Divinski, I.2    Piltzer, I.3
  • 122
    • 0034097607 scopus 로고    scopus 로고
    • Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of down's syndrome
    • DOI 10.1006/exnr.1999.7289
    • Granholm, A.C., Sanders, L.A., and Crnic, L.S. (2000). Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp. Neurol. 161, 647-663. (Pubitemid 30137022)
    • (2000) Experimental Neurology , vol.161 , Issue.2 , pp. 647-663
    • Granholm, A.-C.E.1    Sanders, L.A.2    Crnic, L.S.3
  • 124
    • 0345874735 scopus 로고    scopus 로고
    • Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of down syndrome
    • DOI 10.1002/hipo.10130
    • Granholm, A.C., Sanders, L., Seo, H., Lin, L., Ford, K., and Isacson, O. (2003). Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus 13, 905-914. (Pubitemid 38100740)
    • (2003) Hippocampus , vol.13 , Issue.8 , pp. 905-914
    • Granholm, A.-C.1    Sanders, L.2    Seo, H.3    Lin, L.4    Ford, K.5    Isacson, O.6
  • 125
    • 0015816889 scopus 로고
    • Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat
    • Greenough, W.T., Volkmar, F.R., and Juraska, J.M. (1973). Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat. Exp. Neurol. 41, 371-378.
    • (1973) Exp. Neurol. , vol.41 , pp. 371-378
    • Greenough, W.T.1    Volkmar, F.R.2    Juraska, J.M.3
  • 126
    • 0022395267 scopus 로고
    • Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex
    • DOI 10.1016/S0163-1047(85)90310-3
    • Greenough, W.T., Larson, J.R., and Withers, G.S. (1985). Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex. Behav. Neural Biol. 44, 301-314. (Pubitemid 16193388)
    • (1985) Behavioral and Neural Biology , vol.44 , Issue.2 , pp. 301-314
    • Greenough, W.T.1    Larson, J.R.2    Withers, G.S.3
  • 129
    • 0016745165 scopus 로고
    • Systematic approach to the study of trisomy in the mouse. II
    • Gropp, A., Kolbus, U., and Giers, D. (1975). Systematic approach to the study of trisomy in the mouse. II. Cytogenet. Cell Genet. 14, 42-62.
    • (1975) Cytogenet. Cell Genet. , vol.14 , pp. 42-62
    • Gropp, A.1    Kolbus, U.2    Giers, D.3
  • 131
    • 41149164894 scopus 로고    scopus 로고
    • Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome
    • DOI 10.1111/j.1750-3639.2007.00113.x
    • Guidi, S., Bonasoni, P., Ceccarelli, C., Santini, D., Gualtieri, F., Ciani, E., and Bartesaghi, R. (2008). Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome. Brain Pathol. 18, 180-197. (Pubitemid 351430398)
    • (2008) Brain Pathology , vol.18 , Issue.2 , pp. 180-197
    • Guidi, S.1    Bonasoni, P.2    Ceccarelli, C.3    Santini, D.4    Gualtieri, F.5    Ciani, E.6    Bartesaghi, R.7
  • 132
    • 79953113713 scopus 로고    scopus 로고
    • Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with Down syndrome
    • Guidi, S., Ciani, E., Bonasoni, P., Santini, D., and Bartesaghi, R. (2011a). Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with Down syndrome. Brain Pathol. 21, 361-373.
    • (2011) Brain Pathol. , vol.21 , pp. 361-373
    • Guidi, S.1    Ciani, E.2    Bonasoni, P.3    Santini, D.4    Bartesaghi, R.5
  • 133
    • 80051741673 scopus 로고    scopus 로고
    • Pharmacotherapy with fluoxetine rescues dendritic hypotrophy in the Ts65Dn mouse model for DS
    • Florence, Italy, July 14-18.
    • Guidi, S., Stagni, F., Ragazzi, E., Bianchi, P., Ciani, E., and Bartesaghi, R. (2011b). Pharmacotherapy with fluoxetine rescues dendritic hypotrophy in the Ts65Dn mouse model for DS. 8th World Congress of IBRO, Florence, Italy, July 14-18, 2011.
    • (2011) 8th World Congress of IBRO
    • Guidi, S.1    Stagni, F.2    Ragazzi, E.3    Bianchi, P.4    Ciani, E.5    Bartesaghi, R.6
  • 134
    • 0033135902 scopus 로고    scopus 로고
    • Human minibrain homologue (MNBH/DYRK1): Characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome
    • DOI 10.1006/geno.1999.5775
    • Guimera, J., Casas, C., Estivill, X., and Pritchard, M. (1999). Human minibrain homologue (MNBH/DYRK1): Characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Genomics 57, 407-418. (Pubitemid 29239228)
    • (1999) Genomics , vol.57 , Issue.3 , pp. 407-418
    • Guimera, J.1    Casas, C.2    Estivill, X.3    Pritchard, M.4
  • 135
    • 0035233607 scopus 로고    scopus 로고
    • Antioxidant proteins in fetal brain: Superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome
    • Gulesserian, T., Engidawork, E., Fountoulakis, M., and Lubec, G. (2001). Antioxidant proteins in fetal brain: Superoxide dismutase- 1 (SOD-1) protein is not overexpressed in fetal Down syndrome. J. Neural. Transm. Suppl. 61, 71-84. (Pubitemid 38085073)
    • (2001) Journal of Neural Transmission, Supplement , Issue.61 , pp. 71-84
    • Gulesserian, T.1    Engidawork, E.2    Fountoulakis, M.3    Lubec, G.4
  • 136
    • 0036086620 scopus 로고    scopus 로고
    • Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain
    • DOI 10.1006/bbrc.2002.6389
    • Gulesserian, T., Kim, S.H., Fountoulakis, M., and Lubec, G. (2002). Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain. Biochem. Biophys. Res. Commun. 291, 62-67. (Pubitemid 34681138)
    • (2002) Biochemical and Biophysical Research Communications , vol.291 , Issue.1 , pp. 62-67
    • Gulesserian, T.1    Hwan Kim, S.2    Fountoulakis, M.3    Lubec, G.4
  • 138
    • 3242767625 scopus 로고    scopus 로고
    • Gait dynamics in trisomic mice: Quantitative neurological traits of Down syndrome
    • DOI 10.1016/j.physbeh.2004.04.006, PII S0031938404001283
    • Hampton, T.G., Stasko, M.R., Kale, A., Amende, I., and Costa, A.C. (2004). Gait dynamics in trisomic mice: Quantitative neurological traits of Down syndrome. Physiol. Behav. 82, 381-389. (Pubitemid 38981625)
    • (2004) Physiology and Behavior , vol.82 , Issue.2-3 , pp. 381-389
    • Hampton, T.G.1    Stasko, M.R.2    Kale, A.3    Amende, I.4    Costa, A.C.S.5
  • 139
    • 30144433373 scopus 로고    scopus 로고
    • Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: A model of Down syndrome
    • DOI 10.1002/cne.20844
    • Harashima, C., Jacobowitz, D.M., Witta, J., Borke, R.C., Best, T.K., Siarey, R.J., and Galdzicki, Z. (2006). Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: A model of Down syndrome. J. Comp. Neurol. 494, 815-833. (Pubitemid 43054228)
    • (2006) Journal of Comparative Neurology , vol.494 , Issue.5 , pp. 815-833
    • Harashima, C.1    Jacobowitz, D.M.2    Witta, J.3    Borke, R.C.4    Best, T.K.5    Siarey, R.J.6    Galdzicki, Z.7
  • 140
    • 1642268979 scopus 로고    scopus 로고
    • Functional and morphological alterations in compound transgenic mice overexpreszing Cu/Zn superoxide dismutaze and amyloid precursor protein
    • DOI 10.1111/j.1460-9568.2004.03188.x
    • Harris-Cerruti, C., Kamsler, A., Kaplan, B., Lamb, B., Segal, M., and Groner, Y. (2004). Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction]. Eur. J. Neurosci. 19, 1174-1190. (Pubitemid 38387195)
    • (2004) European Journal of Neuroscience , vol.19 , Issue.5 , pp. 1174-1190
    • Harris-Cerruti, C.1    Kamsler, A.2    Kaplan, B.3    Lamb, B.4    Segal, M.5    Groner, Y.6
  • 142
    • 0029813783 scopus 로고    scopus 로고
    • Consequences of trisomy 16 for mouse brain development: Corticogenesis in a model of Down syndrome
    • Haydar, T.F., Blue, M.E., Molliver, M.E., Krueger, B.K., and Yarowsky, P.J. (1996). Consequences of trisomy 16 for mouse brain development: Corticogenesis in a model of Down syndrome. J. Neurosci. 16, 6175-6182. (Pubitemid 26313992)
    • (1996) Journal of Neuroscience , vol.16 , Issue.19 , pp. 6175-6182
    • Haydar, T.F.1    Blue, M.E.2    Molliver, M.E.3    Krueger, B.K.4    Yarowsky, P.J.5
  • 143
    • 0034214395 scopus 로고    scopus 로고
    • Role of founder cell deficit delayed neuronogenesis in microencephaly of the trisomy 16 mouse
    • Haydar, T.F., Nowakowski, R.S., Yarowsky, P.J., and Krueger, B.K. (2000). Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J. Neurosci. 20, 4156-4164. (Pubitemid 30365686)
    • (2000) Journal of Neuroscience , vol.20 , Issue.11 , pp. 4156-4164
    • Haydar, T.F.1    Nowakowski, R.S.2    Yarowsky, P.J.3    Krueger, B.K.4
  • 144
    • 14644396515 scopus 로고    scopus 로고
    • Ets-2 promotes the activation of a mitochondrial death pathway in down's syndrome neurons
    • DOI 10.1523/JNEUROSCI.5107-04.2005
    • Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., and Busciglio, J. (2005). ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J. Neurosci. 25, 2295-2303. (Pubitemid 40322270)
    • (2005) Journal of Neuroscience , vol.25 , Issue.9 , pp. 2295-2303
    • Helguera, P.1    Pelsman, A.2    Pigino, G.3    Wolvetang, E.4    Head, E.5    Busciglio, J.6
  • 147
    • 9144267928 scopus 로고    scopus 로고
    • Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
    • DOI 10.1002/ana.20250
    • Hunter, C.L., Bachman, D., and Granholm, A.C. (2004). Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Ann. Neurol. 56, 675-688. (Pubitemid 39540748)
    • (2004) Annals of Neurology , vol.56 , Issue.5 , pp. 675-688
    • Hunter, C.L.1    Bachman, D.2    Granholm, A.-C.3
  • 148
    • 0032870743 scopus 로고    scopus 로고
    • Molecular mechanisms underlying mood stabilization in manic-depressive illness: The phenotype challenge
    • Ikonomov, O.C. and Manji, H.K. (1999). Molecular mechanisms underlying mood stabilization in manic-depressive illness: The phenotype challenge. Am. J. Psychiatry 156, 1506-1514. (Pubitemid 29459980)
    • (1999) American Journal of Psychiatry , vol.156 , Issue.10 , pp. 1506-1514
    • Ikonomov, O.C.1    Manji, H.K.2
  • 150
    • 0032420997 scopus 로고    scopus 로고
    • Cellular and molecular basis of estrogen's neuroprotection: Potential relevance for Alzheimer's disease
    • Inestrosa, N.C., Marzolo, M.P., and Bonnefont, A.B. (1998). Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease. Mol. Neurobiol. 17, 73-86. (Pubitemid 29030732)
    • (1998) Molecular Neurobiology , vol.17 , Issue.1-3 , pp. 73-86
    • Inestrosa, N.C.1    Marzolo, M.-P.2    Bonnefont, A.B.3
  • 151
    • 18244415365 scopus 로고    scopus 로고
    • Hippocampal volume and neuronal number in Ts65Dn mice: A murine model of Down syndrome
    • DOI 10.1016/S0304-3940(98)00641-7, PII S0304394098006417
    • Insausti, A.M., Megias, M., Crespo, D., Cruz-Orive, L.M., Dierssen, M., Vallina, I.F., Insausti, R., and Florez, J. (1998). Hippocampal volume and neuronal number in Ts65Dn mice: A murine model of Down syndrome. Neurosci. Lett. 253, 175-178. (Pubitemid 28442591)
    • (1998) Neuroscience Letters , vol.253 , Issue.3 , pp. 175-178
    • Insausti, A.M.1    Megias, M.2    Crespo, D.3    Cruz-Orive, L.M.4    Dierssen, M.5    Vallina, T.F.6    Insausti, R.7    Florez, J.8
  • 152
    • 33645237951 scopus 로고    scopus 로고
    • Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity
    • Isbrucker, R.A., Bausch, J., Edwards, J.A., and Wolz, E. (2006). Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity. Food Chem. Toxicol. 44, 626-635.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 626-635
    • Isbrucker, R.A.1    Bausch, J.2    Edwards, J.A.3    Wolz, E.4
  • 154
    • 77951096438 scopus 로고    scopus 로고
    • Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome
    • Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C.J., and Yamakawa, K. (2010). Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cereb. Cortex 20, 1131-1143.
    • (2010) Cereb. Cortex , vol.20 , pp. 1131-1143
    • Ishihara, K.1    Amano, K.2    Takaki, E.3    Shimohata, A.4    Sago, H.5    Epstein, C.J.6    Yamakawa, K.7
  • 156
    • 4444304016 scopus 로고    scopus 로고
    • β-Amyloid (1-42)-induced learning and memory deficits in mice: Involvement of oxidative burdens in the hippocampus and cerebral cortex
    • DOI 10.1016/j.bbr.2004.04.012, PII S0166432804001536
    • Jhoo, J.H., Kim, H.C., Nabeshima, T., Yamada, K., Shin, E.J., Jhoo, W.K., Kim, W., Kang, K.S., Jo, S.A., and Woo, J.I. (2004). Beta-amyloid (1-42)-induced learning and memory deficits in mice: Involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav. Brain Res. 155, 185-196. (Pubitemid 39208900)
    • (2004) Behavioural Brain Research , vol.155 , Issue.2 , pp. 185-196
    • Jhoo, J.H.1    Kim, H.-C.2    Nabeshima, T.3    Yamada, K.4    Shin, E.-J.5    Jhoo, W.-K.6    Kim, W.7    Kang, K.-S.8    Jo, S.A.9    Woo, J.I.10
  • 157
    • 0032401643 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress are significantly elevated in Down syndrome
    • DOI 10.1016/S0891-5849(98)00137-3, PII S0891584998001373
    • Jovanovic, S.V., Clements, D., and MacLeod, K. (1998). Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic. Biol. Med. 25, 1044-1048. (Pubitemid 28558330)
    • (1998) Free Radical Biology and Medicine , vol.25 , Issue.9 , pp. 1044-1048
    • Jovanovic, S.V.1    Clements, D.2    MacLeod, K.3
  • 158
    • 21544467552 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for patients with Alzheimer's disease: Systematic review of randomised clinical trials
    • Kaduszkiewicz, H., Zimmermann, T., Beck-Bornholdt, H.P., and van den Bussche, H. (2005). Cholinesterase inhibitors for patients with Alzheimer's disease: Systematic review of randomised clinical trials. BMJ 331, 321-327.
    • (2005) BMJ , vol.331 , pp. 321-327
    • Kaduszkiewicz, H.1    Zimmermann, T.2    Beck-Bornholdt, H.P.3    Van Den Bussche, H.4
  • 160
    • 0032125464 scopus 로고    scopus 로고
    • Event-related brain potentials during an extended visual recognition memory task depict delayed development of cerebral inhibitory processes among 6-month-old infants with Down syndrome
    • DOI 10.1016/S0167-8760(98)00015-4, PII S0167876098000154
    • Karrer, J.H., Karrer, R., Bloom, D., Chaney, L., and Davis, R. (1998). Event-related brain potentials during an extended visual recognition memory task depict delayed development of cerebral inhibitory processes among 6-month-old infants with Down syndrome. Int. J. Psychophysiol. 29, 167-200. (Pubitemid 28306604)
    • (1998) International Journal of Psychophysiology , vol.29 , Issue.2 , pp. 167-200
    • Karrer, J.H.1    Karrer, R.2    Bloom, D.3    Chaney, L.4    Davis, R.5
  • 161
    • 70350534843 scopus 로고    scopus 로고
    • Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
    • Katoh, Y. and Katoh, M. (2009). Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr. Mol. Med. 9, 873-886.
    • (2009) Curr. Mol. Med. , vol.9 , pp. 873-886
    • Katoh, Y.1    Katoh, M.2
  • 162
    • 0034675224 scopus 로고    scopus 로고
    • Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease
    • Kim, S.H., Yoo, B.C., Broers, J.L., Cairns, N., and Lubec, G. (2000). Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease. Biochem. Biophys. Res. Commun. 276, 329-334.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 329-334
    • Kim, S.H.1    Yoo, B.C.2    Broers, J.L.3    Cairns, N.4    Lubec, G.5
  • 163
    • 79952573396 scopus 로고    scopus 로고
    • Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis
    • Kim, Y., Park, J., Song, W.J., and Chang, S. (2010). Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis. Neurosignals 18, 164-172.
    • (2010) Neurosignals , vol.18 , pp. 164-172
    • Kim, Y.1    Park, J.2    Song, W.J.3    Chang, S.4
  • 165
    • 0030271334 scopus 로고    scopus 로고
    • Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice
    • DOI 10.1016/0031-9384(96)00218-1
    • Klein, S.L., Kriegsfeld, L.J., Hairston, J.E., Rau, V., Nelson, R.J., and Yarowsky, P.J. (1996). Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol. Behav. 60, 1159-1164. (Pubitemid 26336736)
    • (1996) Physiology and Behavior , vol.60 , Issue.4 , pp. 1159-1164
    • Klein, S.L.1    Kriegsfeld, L.J.2    Hairston, J.E.3    Rau, V.4    Nelson, R.J.5    Yarowsky, P.J.6
  • 166
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of down syndrome
    • DOI 10.1523/JNEUROSCI.1766-04.2004
    • Kleschevnikov, A.M., Belichenko, P.V., Villar, A.J., Epstein, C.J., Malenka, R.C., and Mobley, W.C. (2004). Hippocampal longterm potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 24, 8153-8160. (Pubitemid 39280835)
    • (2004) Journal of Neuroscience , vol.24 , Issue.37 , pp. 8153-8160
    • Kleschevnicov, A.M.1    Belichenko, P.V.2    Villar, A.J.3    Epstein, C.J.4    Malenka, R.C.5    Mobley, W.C.6
  • 167
    • 0026458310 scopus 로고
    • Magnetic resonance imaging evaluation of delayed myelination in Down syndrome: A case report and review of the literature
    • Koo, B.K., Blaser, S., Harwood-Nash, D., Becker, L.E., and Murphy, E.G. (1992). Magnetic resonance imaging evaluation of delayed myelination in Down syndrome: A case report and review of the literature. J. Child Neurol. 7, 417-421.
    • (1992) J. Child Neurol. , vol.7 , pp. 417-421
    • Koo, B.K.1    Blaser, S.2    Harwood-Nash, D.3    Becker, L.E.4    Murphy, E.G.5
  • 169
    • 0033970177 scopus 로고    scopus 로고
    • Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice
    • DOI 10.1016/S0006-8993(00)01984-3, PII S0006899300019843
    • Kurt, M.A., Davies, D.C., Kidd, M., Dierssen, M., and Florez, J. (2000). Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res. 858, 191-197. (Pubitemid 30105799)
    • (2000) Brain Research , vol.858 , Issue.1 , pp. 191-197
    • Ayberk Kurt, M.1    Ceri Davies, D.2    Kidd, M.3    Dierssen, M.4    Florez, J.5
  • 170
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • DOI 10.1016/j.brainres.2004.06.075, PII S0006899304010807
    • Kurt, M.A., Kafa, M.I., Dierssen, M., and Davies, D.C. (2004). Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res. 1022, 101-109. (Pubitemid 39194990)
    • (2004) Brain Research , vol.1022 , Issue.1-2 , pp. 101-109
    • Ayberk Kurt, M.1    Ilker Kafa, M.2    Dierssen, M.3    Ceri Davies, D.4
  • 171
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • DOI 10.1038/nn983
    • Lai, K., Kaspar, B.K., Gage, F.H., and Schaffer, D.V. (2003). Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat. Neurosci. 6, 21-27. (Pubitemid 36026328)
    • (2003) Nature Neuroscience , vol.6 , Issue.1 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 173
    • 34447331007 scopus 로고    scopus 로고
    • Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities
    • DOI 10.1093/hmg/ddm086
    • Li, Z., Yu, T., Morishima, M., Pao, A., LaDuca, J., Conroy, J., Nowak, N., Matsui, S., Shiraishi, I., and Yu, Y.E. (2007). Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum. Mol. Genet. 16, 1359-1366. (Pubitemid 47055132)
    • (2007) Human Molecular Genetics , vol.16 , Issue.11 , pp. 1359-1366
    • Li, Z.1    Yu, T.2    Morishima, M.3    Pao, A.4    LaDuca, J.5    Conroy, J.6    Nowak, N.7    Matsui, S.-I.8    Shiraishi, I.9    Yu, Y.E.10
  • 174
    • 0028236667 scopus 로고
    • 2+- dependent phosphatase
    • DOI 10.1038/369235a0
    • Lieberman, D.N. and Mody, I. (1994). Regulation of NMDA channel function by endogenous Ca(2+ )-dependent phosphatase. Nature 369, 235-239. (Pubitemid 24154801)
    • (1994) Nature , vol.369 , Issue.6477 , pp. 235-239
    • Lieberman, D.N.1    Mody, I.2
  • 175
    • 62049085639 scopus 로고    scopus 로고
    • Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model
    • Lockrow, J., Prakasam, A., Huang, P., Bimonte-Nelson, H., Sambamurti, K., and Granholm, A.C. (2009). Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp. Neurol. 216, 278-289.
    • (2009) Exp. Neurol. , vol.216 , pp. 278-289
    • Lockrow, J.1    Prakasam, A.2    Huang, P.3    Bimonte-Nelson, H.4    Sambamurti, K.5    Granholm, A.C.6
  • 176
    • 79955723158 scopus 로고    scopus 로고
    • Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome
    • Lockrow, J., Boger, H., Bimonte-Nelson, H., and Granholm, A.C. (2011a). Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behav. Brain Res. 221, 610-622.
    • (2011) Behav. Brain Res. , vol.221 , pp. 610-622
    • Lockrow, J.1    Boger, H.2    Bimonte-Nelson, H.3    Granholm, A.C.4
  • 177
    • 79951897216 scopus 로고    scopus 로고
    • A Noradrenergic Lesion Exacerbates Neurodegeneration in a Down Syndrome Mouse Model
    • Lockrow, J., Boger, H., Gerhardt, G., Bachman, D., and Granholm, A.C. (2011b). A Noradrenergic Lesion Exacerbates Neurodegeneration in a Down Syndrome Mouse Model. J. Alzheimers Dis. 23, 471-489.
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 471-489
    • Lockrow, J.1    Boger, H.2    Gerhardt, G.3    Bachman, D.4    Granholm, A.C.5
  • 178
    • 33746585652 scopus 로고    scopus 로고
    • Hippocampal hypocellularity in the Ts65Dn mouse originates early in development
    • DOI 10.1016/j.brainres.2006.05.022, PII S0006899306013977
    • Lorenzi, H.A. and Reeves, R.H. (2006). Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res. 1104, 153-159. (Pubitemid 44148518)
    • (2006) Brain Research , vol.1104 , Issue.1 , pp. 153-159
    • Lorenzi, H.A.1    Reeves, R.H.2
  • 179
    • 31444447881 scopus 로고    scopus 로고
    • Notch signalling in vertebrate neural development
    • DOI 10.1038/nrn1847, PII NRN1847
    • Louvi, A. and Artavanis-Tsakonas, S. (2006). Notch signalling in vertebrate neural development. Nat. Rev. Neurosci. 7, 93-102. (Pubitemid 43151596)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.2 , pp. 93-102
    • Louvi, A.1    Artavanis-Tsakonas, S.2
  • 181
    • 0039357820 scopus 로고    scopus 로고
    • + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons
    • DOI 10.1016/S0896-6273(00)80381-5
    • Luscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C., and Nicoll, R.A. (1997). G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19, 687-695. (Pubitemid 27430754)
    • (1997) Neuron , vol.19 , Issue.3 , pp. 687-695
    • Luscher, C.1    Jan, L.Y.2    Stoffel, M.3    Malenka, R.C.4    Nicoll, R.A.5
  • 182
    • 0018639015 scopus 로고
    • Assessment of the quality of sitting and gait patterns in children with Down's syndrome
    • Lydic, J. (1979). Assessment of the quality of sitting and gait patterns in children with Down's syndrome. Phys. Ther. 12, 1489-1494. (Pubitemid 10169537)
    • (1979) Physical Therapy , vol.59 , Issue.12 , pp. 1489-1494
    • Lydic, J.S.1    Steele, C.2
  • 183
    • 3543097554 scopus 로고    scopus 로고
    • Gene expression from the aneuploid chromosome in a trisomy mouse model of Down syndrome
    • DOI 10.1101/gr.2090904
    • Lyle, R., Gehrig, C., Neergaard-Henrichsen, C., Deutsch, S., and Antonarakis, S.E. (2004). Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res. 14, 1268-1274. (Pubitemid 39029223)
    • (2004) Genome Research , vol.14 , Issue.7 , pp. 1268-1274
    • Lyle, R.1    Gehrig, C.2    Neergaard-Henrichsen, C.3    Deutsch, S.4    Antonarakis, S.E.5
  • 184
    • 62849113692 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21
    • Lyle, R., Bena, F., Gagos, S., Gehrig, C., Lopez, G., Schinzel, A., Lespinasse, J., Bottani, A., Dahoun, S., Taine, L., et al. (2009). Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. Eur. J. Hum. Genet. 17, 454-466.
    • (2009) Eur. J. Hum. Genet. , vol.17 , pp. 454-466
    • Lyle, R.1    Bena, F.2    Gagos, S.3    Gehrig, C.4    Lopez, G.5    Schinzel, A.6    Lespinasse, J.7    Bottani, A.8    Dahoun, S.9    Taine, L.10
  • 185
    • 27744485503 scopus 로고    scopus 로고
    • Antidepressant action: To the nucleus and beyond
    • DOI 10.1016/j.tips.2005.10.005, PII S0165614705002701
    • Malberg, J.E. and Blendy, J.A. (2005). Antidepressant action: To the nucleus and beyond. Trends Pharmacol. Sci. 26, 631-638. (Pubitemid 41636308)
    • (2005) Trends in Pharmacological Sciences , vol.26 , Issue.12 , pp. 631-638
    • Malberg, J.E.1    Blendy, J.A.2
  • 186
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg, J.E., Eisch, A.J., Nestler, E.J., and Duman, R.S. (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110. (Pubitemid 32042912)
    • (2000) Journal of Neuroscience , vol.20 , Issue.24 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 187
    • 0021814284 scopus 로고
    • Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age
    • Mann, D.M., Yates, P.O., Marcyniuk, B., and Ravindra, C.R. (1985). Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J. Ment. Defic. Res. 29 (Pt 2), 125-135. (Pubitemid 15029018)
    • (1985) Journal of Mental Deficiency Research , vol.29 , Issue.2 , pp. 125-135
    • Mann, D.M.A.1    Yates, P.O.2    Marcyniuk, B.3
  • 188
    • 0242690133 scopus 로고    scopus 로고
    • Calcineurin in memory and bidirectional plasticity
    • DOI 10.1016/j.bbrc.2003.10.046
    • Mansuy, I.M. (2003). Calcineurin in memory and bidirectional plasticity. Biochem. Biophys. Res. Commun. 311, 1195-1208. (Pubitemid 37393442)
    • (2003) Biochemical and Biophysical Research Communications , vol.311 , Issue.4 , pp. 1195-1208
    • Mansuy, I.M.1
  • 189
    • 0037403505 scopus 로고    scopus 로고
    • Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain
    • DOI 10.1016/S0888-7543(03)00035-1
    • Mao, R., Zielke, C.L., Zielke, H.R., and Pevsner, J. (2003). Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain. Genomics 81, 457-467. (Pubitemid 36437522)
    • (2003) Genomics , vol.81 , Issue.5 , pp. 457-467
    • Mao, R.1    Zielke, C.L.2    Zielke, H.R.3    Pevsner, J.4
  • 190
    • 0017234871 scopus 로고
    • Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study
    • Marin-Padilla, M. (1976). Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study. J. Comp. Neurol. 167, 63-81.
    • (1976) J. Comp. Neurol. , vol.167 , pp. 63-81
    • Marin-Padilla, M.1
  • 191
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • DOI 10.1016/S0166-4328(02)00026-8, PII S0166432802000268
    • Martinez-Cue, C., Baamonde, C., Lumbreras, M., Paz, J., Davisson, M.T., Schmidt, C., Dierssen, M., and Florez, J. (2002). Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav. Brain Res. 134, 185-200. (Pubitemid 34912698)
    • (2002) Behavioural Brain Research , vol.134 , Issue.1-2 , pp. 185-200
    • Martinez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3    Paz, J.4    Davisson, M.T.5    Schmidt, C.6    Dierssen, M.7    Florez, J.8
  • 192
    • 23744473479 scopus 로고    scopus 로고
    • Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome
    • DOI 10.1016/j.bbr.2005.04.016, PII S0166432805001853
    • Martinez-Cue, C., Rueda, N., Garcia, E., Davisson, M.T., Schmidt, C., and Florez, J. (2005). Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav. Brain Res. 163, 174-185. (Pubitemid 41138051)
    • (2005) Behavioural Brain Research , vol.163 , Issue.2 , pp. 174-185
    • Martinez-Cue, C.1    Rueda, N.2    Garcia, E.3    Davisson, M.T.4    Schmidt, C.5    Florez, J.6
  • 193
    • 0026766860 scopus 로고
    • The nerve growth factor family of receptors
    • Meakin, S.O. and Shooter, E.M. (1992). The nerve growth factor family of receptors. Trends Neurosci. 15, 323-331.
    • (1992) Trends Neurosci. , vol.15 , pp. 323-331
    • Meakin, S.O.1    Shooter, E.M.2
  • 194
    • 0026561025 scopus 로고
    • The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
    • Meakin, S.O., Suter, U., Drinkwater, C.C., Welcher, A.A., and Shooter, E.M. (1992). The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc. Natl. Acad. Sci. USA 89, 2374-2378.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2374-2378
    • Meakin, S.O.1    Suter, U.2    Drinkwater, C.C.3    Welcher, A.A.4    Shooter, E.M.5
  • 195
    • 0030709340 scopus 로고    scopus 로고
    • Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice
    • Megias, M., Verduga, R., Dierssen, M., Florez, J., Insausti, R., and Crespo, D. (1997). Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport 8, 3475-3478. (Pubitemid 27497467)
    • (1997) NeuroReport , vol.8 , Issue.16 , pp. 3475-3478
    • Megias, M.1    Verduga, R.2    Dierssen, M.3    Florez, J.4    Insausti, R.5    Crespo, D.6
  • 196
    • 0027154265 scopus 로고
    • Developmental changes of S-100 protein and glial fibrillary acidic protein in the brain in Down syndrome
    • DOI 10.1006/exnr.1993.1052
    • Mito, T. and Becker, L.E. (1993). Developmental changes of S-100 protein and glial fibrillary acidic protein in the brain in Down syndrome. Exp. Neurol. 120, 170-176. (Pubitemid 23165012)
    • (1993) Experimental Neurology , vol.120 , Issue.2 , pp. 170-176
    • Mito, T.1    Becker, L.E.2
  • 202
    • 0036855511 scopus 로고    scopus 로고
    • The effects of piracetam on cognitive performance in a mouse model of Down's syndrome
    • DOI 10.1016/S0031-9384(02)00873-9, PII S0031938402008739
    • Moran, T.H., Capone, G.T., Knipp, S., Davisson, M.T., Reeves, R.H., and Gearhart, J.D. (2002). The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol. Behav. 77, 403-409. (Pubitemid 35373895)
    • (2002) Physiology and Behavior , vol.77 , Issue.2-3 , pp. 403-409
    • Moran, T.H.1    Capone, G.T.2    Knipp, S.3    Davisson, M.T.4    Reeves, R.H.5    Gearhart, J.D.6
  • 203
    • 47549096987 scopus 로고    scopus 로고
    • Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tcl mouse model of down syndrome
    • DOI 10.1101/lm.969608
    • Morice, E., Andreae, L.C., Cooke, S.F., Vanes, L., Fisher, E.M., Tybulewicz, V.L., and Bliss, T.V. (2008). Preservation of longterm memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn. Mem. 15, 492-500. (Pubitemid 352008671)
    • (2008) Learning and Memory , vol.15 , Issue.7 , pp. 492-500
    • Morice, E.1    Andreae, L.C.2    Cooke, S.F.3    Vanes, L.4    Fisher, E.M.C.5    Tybulewicz, V.L.J.6    Bliss, T.V.P.7
  • 204
    • 0034716909 scopus 로고    scopus 로고
    • Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
    • Morrison, S.J., Perez, S.E., Qiao, Z., Verdi, J.M., Hicks, C., Weinmaster, G., and Anderson, D.J. (2000). Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell 101, 499-510.
    • (2000) Cell , vol.101 , pp. 499-510
    • Morrison, S.J.1    Perez, S.E.2    Qiao, Z.3    Verdi, J.M.4    Hicks, C.5    Weinmaster, G.6    Anderson, D.J.7
  • 205
    • 70350075694 scopus 로고    scopus 로고
    • Neuroscience: Alzheimer's disease
    • Mucke, L. (2009). Neuroscience: Alzheimer's disease. Nature 461, 895-897.
    • (2009) Nature , vol.461 , pp. 895-897
    • Mucke, L.1
  • 206
    • 48349085043 scopus 로고    scopus 로고
    • The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    • Muller, T., Meyer, H.E., Egensperger, R., and Marcus, K. (2008). The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog. Neurobiol. 85, 393-406.
    • (2008) Prog. Neurobiol. , vol.85 , pp. 393-406
    • Muller, T.1    Meyer, H.E.2    Egensperger, R.3    Marcus, K.4
  • 207
    • 1842816475 scopus 로고    scopus 로고
    • A distinct role for norepinephrine in memory retrieval
    • DOI 10.1016/S0092-8674(04)00259-4, PII S0092867404002594
    • Murchison, C.F., Zhang, X.Y., Zhang, W.P., Ouyang, M., Lee, A., and Thomas, S.A. (2004). A distinct role for norepinephrine in memory retrieval. Cell 117, 131-143. (Pubitemid 38469904)
    • (2004) Cell , vol.117 , Issue.1 , pp. 131-143
    • Murchison, C.F.1    Zhang, X.-Y.2    Zhang, W.-P.3    Ouyang, M.4    Lee, A.5    Thomas, S.A.6
  • 208
    • 0042025827 scopus 로고    scopus 로고
    • Down's syndrome: A genetic disorder in biobehavioral perspective
    • DOI 10.1034/j.1601-183X.2003.00026.x
    • Nadel, L. (2003). Down's syndrome: A genetic disorder in biobehavioral perspective. Genes Brain Behav. 2, 156-166. (Pubitemid 36898802)
    • (2003) Genes, Brain and Behavior , vol.2 , Issue.3 , pp. 156-166
    • Nadel, L.1
  • 209
    • 0031471277 scopus 로고    scopus 로고
    • Apoptosis-related protein expression in the hippocampus in Alzheimer's disease
    • DOI 10.1016/S0197-4580(97)00157-7, PII S0197458097001577
    • Nagy, Z.S. and Esiri, M.M. (1997). Apoptosis-related protein expression in the hippocampus in Alzheimer's disease. Neurobiol. Aging 18, 565-571. (Pubitemid 28046409)
    • (1997) Neurobiology of Aging , vol.18 , Issue.6 , pp. 565-571
    • Nagy, Z.1    Esiri, M.M.2
  • 212
    • 0033001624 scopus 로고    scopus 로고
    • On the occurrence of neuronal sprouting in the frontal cortex of a patient with Down's syndrome
    • DOI 10.1007/s004010050959
    • Ohara, S., Tsukada, M., and Ikeda, S. (1999). On the occurrence of neuronal sprouting in the frontal cortex of a patient with Down's syndrome. Acta Neuropathol. 97, 85-90. (Pubitemid 29132650)
    • (1999) Acta Neuropathologica , vol.97 , Issue.1 , pp. 85-90
    • Ohara, S.1    Tsukada, M.2    Ikeda, S.-I.3
  • 213
    • 7444231620 scopus 로고    scopus 로고
    • A chromosome 21 critical region does not cause specific down syndrome phenotypes
    • DOI 10.1126/science.1098992
    • Olson, L.E., Richtsmeier, J.T., Leszl, J., and Reeves, R.H. (2004a). A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science 306, 687-690. (Pubitemid 39440917)
    • (2004) Science , vol.306 , Issue.5696 , pp. 687-690
    • Olson, L.E.1    Richtsmeier, J.T.2    Leszl, J.3    Reeves, R.H.4
  • 214
    • 3042612213 scopus 로고    scopus 로고
    • Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes
    • DOI 10.1002/dvdy.20079
    • Olson, L.E., Roper, R.J., Baxter, L.L., Carlson, E.J., Epstein, C.J., and Reeves, R.H. (2004b). Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev. Dyn. 230, 581-589. (Pubitemid 38802484)
    • (2004) Developmental Dynamics , vol.230 , Issue.3 , pp. 581-589
    • Olson, L.E.1    Roper, R.J.2    Baxter, L.L.3    Carlson, E.J.4    Epstein, C.J.5    Reeves, R.H.6
  • 217
    • 34548669115 scopus 로고    scopus 로고
    • Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome
    • DOI 10.1016/j.mcn.2007.07.007, PII S1044743107001698
    • Park, J., Yang, E.J., Yoon, J.H., and Chung, K.C. (2007). Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Mol. Cell Neurosci. 36, 270-279. (Pubitemid 47418617)
    • (2007) Molecular and Cellular Neuroscience , vol.36 , Issue.2 , pp. 270-279
    • Park, J.1    Yang, E.J.2    Yoon, J.H.3    Chung, K.C.4
  • 218
    • 77957807271 scopus 로고    scopus 로고
    • Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells
    • Park, J., Oh, Y., Yoo, L., Jung, M.S., Song, W.J., Lee, S.H., Seo, H., and Chung, K.C. (2010). Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 285, 31895-31906.
    • (2010) J. Biol. Chem. , vol.285 , pp. 31895-31906
    • Park, J.1    Oh, Y.2    Yoo, L.3    Jung, M.S.4    Song, W.J.5    Lee, S.H.6    Seo, H.7    Chung, K.C.8
  • 223
    • 77952240568 scopus 로고    scopus 로고
    • Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome
    • Perez-Cremades, D., Hernandez, S., Blasco-Ibanez, J.M., Crespo, C., Nacher, J., and Varea, E. (2010). Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome. J. Neural Transm. 117, 445-455.
    • (2010) J. Neural Transm. , vol.117 , pp. 445-455
    • Perez-Cremades, D.1    Hernandez, S.2    Blasco-Ibanez, J.M.3    Crespo, C.4    Nacher, J.5    Varea, E.6
  • 224
    • 2542612948 scopus 로고    scopus 로고
    • Learning from NMDA receptor trafficking: Clues to the development and maturation of glutamatergic synapses
    • DOI 10.1159/000077524
    • Perez-Otano, I. and Ehlers, M.D. (2004). Learning from NMDA receptor trafficking: Clues to the development and maturation of glutamatergic synapses. Neurosignals 13, 175-189. (Pubitemid 38698090)
    • (2004) NeuroSignals , vol.13 , Issue.4 , pp. 175-189
    • Perez-Otano, I.1    Ehlers, M.D.2
  • 225
    • 0026635574 scopus 로고
    • Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
    • Phillips, R.G. and LeDoux, J.E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274-285.
    • (1992) Behav. Neurosci. , vol.106 , pp. 274-285
    • Phillips, R.G.1    LeDoux, J.E.2
  • 226
  • 227
    • 1542509945 scopus 로고    scopus 로고
    • Cytoskeleton derangement in brain of patients with Down Syndrome, Alzheimer's disease and Pick's disease
    • Pollak, D., Cairns, N., and Lubec, G. (2003). Cytoskeleton derangement in brain of patients with Down syndrome, Alzheimer's disease and Pick's disease. J. Neural. Transm. Suppl. 67, 149-158. (Pubitemid 38339930)
    • (2003) Journal of Neural Transmission, Supplement , Issue.67 , pp. 149-158
    • Pollak, D.1    Cairns, N.2    Lubec, G.3
  • 228
    • 51249103592 scopus 로고    scopus 로고
    • Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn
    • Pollonini, G., Gao, V., Rabe, A., Palminiello, S., Albertini, G., and Alberini, C.M. (2008). Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 156, 99-106.
    • (2008) Neuroscience , vol.156 , pp. 99-106
    • Pollonini, G.1    Gao, V.2    Rabe, A.3    Palminiello, S.4    Albertini, G.5    Alberini, C.M.6
  • 229
    • 79953134025 scopus 로고    scopus 로고
    • Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome
    • Popov, V.I., Kleschevnikov, A.M., Klimenko, O.A., Stewart, M.G., and Belichenko, P.V. (2011). Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome. J. Comp. Neurol. 519, 1338-1354.
    • (2011) J. Comp. Neurol. , vol.519 , pp. 1338-1354
    • Popov, V.I.1    Kleschevnikov, A.M.2    Klimenko, O.A.3    Stewart, M.G.4    Belichenko, P.V.5
  • 230
    • 34447306022 scopus 로고    scopus 로고
    • RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: A potential pathogenic process in neurodegeneration
    • DOI 10.1093/hmg/ddm049
    • Porta, S., Serra, S.A., Huch, M., Valverde, M.A., Llorens, F., Estivill, X., Arbones, M.L., and Marti, E. (2007). RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: A potential pathogenic process in neurodegeneration. Hum. Mol. Genet. 16, 1039-1050. (Pubitemid 47062725)
    • (2007) Human Molecular Genetics , vol.16 , Issue.9 , pp. 1039-1050
    • Porta, S.1    Serra, S.A.2    Huch, M.3    Valverde, M.A.4    Llorens, F.5    Estivill, X.6    Arbones, M.L.7    Marti, E.8
  • 231
    • 0030762882 scopus 로고    scopus 로고
    • The growth of non-pyramidal neurons in the primary motor cortex of man: A Golgi study
    • Prinz, M., Prinz, B., and Schulz, E. (1997). The growth of nonpyramidal neurons in the primary motor cortex of man: A Golgi study. Histol. Histopathol. 12, 895-900. (Pubitemid 27410444)
    • (1997) Histology and Histopathology , vol.12 , Issue.4 , pp. 895-900
    • Prinz, M.1    Prinz, B.2    Schulz, E.3
  • 232
    • 0018328365 scopus 로고
    • Pathobiology of cortical neurons in metabolic and unclassified amentias
    • Purpura, D.P. (1979). Pathobiology of cortical neurons in metabolic and unclassified amentias. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 57, 43-68.
    • (1979) Res. Publ. Assoc. Res. Nerv. Ment. Dis. , vol.57 , pp. 43-68
    • Purpura, D.P.1
  • 233
    • 42249107309 scopus 로고    scopus 로고
    • Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways
    • DOI 10.1016/j.ejpn.2007.08.010, PII S1090379807001535
    • Rachidi, M. and Lopes, C. (2008). Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways. Eur. J. Paediatr. Neurol. 12, 168-182. (Pubitemid 351545848)
    • (2008) European Journal of Paediatric Neurology , vol.12 , Issue.3 , pp. 168-182
    • Rachidi, M.1    Lopes, C.2
  • 236
    • 18644384781 scopus 로고    scopus 로고
    • Trophic actions of GABA on neuronal development
    • DOI 10.1016/j.tins.2005.03.010, PII S0166223605000834
    • Represa, A. and Ben-Ari, Y. (2005). Trophic actions of GABA on neuronal development. Trends Neurosci. 28, 278-283. (Pubitemid 40775771)
    • (2005) Trends in Neurosciences , vol.28 , Issue.6 SPEC. ISS. , pp. 278-283
    • Represa, A.1    Ben-Ari, Y.2
  • 237
    • 0033980511 scopus 로고    scopus 로고
    • Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice
    • DOI 10.1002/(SICI)1097-0177(200002)217:2<137::AID-DVDY1>3.0.CO;2-N
    • Richtsmeier, J.T., Baxter, L.L., and Reeves, R.H. (2000). Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev. Dyn. 217, 137-145. (Pubitemid 30080493)
    • (2000) Developmental Dynamics , vol.217 , Issue.2 , pp. 137-145
    • Richtsmeier, J.T.1    Baxter, L.L.2    Reeves, R.H.3
  • 238
    • 0030942897 scopus 로고    scopus 로고
    • Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome
    • DOI 10.1016/S0024-3205(97)00067-2, PII S0024320597000672
    • Risser, D., Lubec, G., Cairns, N., and Herrera-Marschitz, M. (1997). Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci. 60, 1231-1237. (Pubitemid 27191762)
    • (1997) Life Sciences , vol.60 , Issue.15 , pp. 1231-1237
    • Risser, D.1    Lubec, G.2    Cairns, N.3    Herrera-Marschitz, M.4
  • 239
    • 33750898266 scopus 로고    scopus 로고
    • A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex
    • DOI 10.1016/j.neuroscience.2006.09.003, PII S0306452206011936
    • Robertson, R.T., Baratta, J., Yu, J., and Guthrie, K.M. (2006). A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience 143, 523-539. (Pubitemid 44724938)
    • (2006) Neuroscience , vol.143 , Issue.2 , pp. 523-539
    • Robertson, R.T.1    Baratta, J.2    Yu, J.3    Guthrie, K.M.4
  • 240
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • DOI 10.1016/S0140-6736(03)12987-X
    • Roizen, N.J. and Patterson, D. (2003). Down's syndrome. Lancet 361, 1281-1289. (Pubitemid 36428586)
    • (2003) Lancet , vol.361 , Issue.9365 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 242
    • 0021276604 scopus 로고
    • Down's syndrome: Is there a decreased population of neurons?
    • Ross, M.H., Galaburda, A.M., and Kemper, T.L. (1984). Down's syndrome: Is there a decreased population of neurons? Neurology 34, 909-916. (Pubitemid 14076456)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 909-916
    • Ross, M.H.1    Galaburda, A.M.2    Kemper, T.L.3
  • 243
    • 39149111255 scopus 로고    scopus 로고
    • Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome
    • Rueda, N., Florez, J., and Martinez-Cue, C. (2008a). Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci. Lett. 433, 22-27.
    • (2008) Neurosci. Lett. , vol.433 , pp. 22-27
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 244
    • 39149135216 scopus 로고    scopus 로고
    • Effects of chronic administration of SGS-111 during adulthood and during the pre-and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome
    • Rueda, N., Florez, J., and Martinez-Cue, C. (2008b). Effects of chronic administration of SGS-111 during adulthood and during the pre-and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav. Brain Res. 188, 355-367.
    • (2008) Behav. Brain Res. , vol.188 , pp. 355-367
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 246
    • 39749196069 scopus 로고    scopus 로고
    • Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: Evidence for a functional link between Down syndrome and Alzheimer's disease
    • DOI 10.1111/j.1471-4159.2007.05075.x
    • Ryoo, S.R., Cho, H.J., Lee, H.W., Jeong, H.K., Radnaabazar, C., Kim, Y.S., Kim, M.J., Son, M.Y., Seo, H., Chung, S.H., et al. (2008). Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: Evidence for a functional link between Down syndrome and Alzheimer's disease. J. Neurochem. 104, 1333-1344. (Pubitemid 351293338)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.5 , pp. 1333-1344
    • Ryoo, S.-R.1    Cho, H.-J.2    Lee, H.-W.3    Jeong, H.K.4    Radnaabazar, C.5    Kim, Y.-S.6    Kim, M.-J.7    Son, M.-Y.8    Seo, H.9    Chung, S.-H.10    Song, W.-J.11
  • 248
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago, H., Carlson, E.J., Smith, D.J., Rubin, E.M., Crnic, L.S., Huang, T.T., and Epstein, C.J. (2000). Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 48, 606-613.
    • (2000) Pediatr. Res. , vol.48 , pp. 606-613
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3    Rubin, E.M.4    Crnic, L.S.5    Huang, T.T.6    Epstein, C.J.7
  • 249
    • 34147140845 scopus 로고    scopus 로고
    • Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation
    • DOI 10.1385/JMN:30:3:329, PII JMN303329
    • Sahir, N., Brenneman, D.E., and Hill, J.M. (2006). Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation. J. Mol. Neurosci. 30, 329-340. (Pubitemid 46568351)
    • (2006) Journal of Molecular Neuroscience , vol.30 , Issue.3 , pp. 329-340
    • Sahir, N.1    Brenneman, D.E.2    Hill, J.M.3
  • 250
    • 13944257674 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    • DOI 10.1523/JNEUROSCI.3741-04.2005
    • Sairanen, M., Lucas, G., Ernfors, P., Castren, M., and Castren, E. (2005). Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J. Neurosci. 25, 1089-1094. (Pubitemid 40268949)
    • (2005) Journal of Neuroscience , vol.25 , Issue.5 , pp. 1089-1094
    • Sairanen, M.1    Lucas, G.2    Ernfors, P.3    Castren, M.4    Castren, E.5
  • 254
    • 0030811487 scopus 로고    scopus 로고
    • Aberrant expression of bcl-2 gene family in Down's syndrome brains
    • DOI 10.1016/S0169-328X(97)00078-8, PII S0169328X97000788
    • Sawa, A., Oyama, F., Cairns, N.J., Amano, N., and Matsushita, M. (1997). Aberrant expression of bcl-2 gene family in Down's syndrome brains. Brain Res. Mol. Brain Res. 48, 53-59. (Pubitemid 27298128)
    • (1997) Molecular Brain Research , vol.48 , Issue.1 , pp. 53-59
    • Sawa, A.1    Oyama, F.2    Cairns, N.J.3    Amano, N.4    Matsushita, M.5
  • 255
    • 0023395215 scopus 로고
    • Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages
    • Schapiro, M.B., Creasey, H., Schwartz, M., Haxby, J.V., White, B., Moore, A., and Rapoport, S.I. (1987). Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages. Neurology 37, 1424-1427.
    • (1987) Neurology , vol.37 , pp. 1424-1427
    • Schapiro, M.B.1    Creasey, H.2    Schwartz, M.3    Haxby, J.V.4    White, B.5    Moore, A.6    Rapoport, S.I.7
  • 256
    • 0026699998 scopus 로고
    • Comparative coherence studies in healthy volunteers and Down's syndrome patients from childhood to adult age. Electroencephalogr
    • Schmid, R.G., Tirsch, W.S., Rappelsberger, P., Weinmann, H.M., and Poppl, S.J. (1992). Comparative coherence studies in healthy volunteers and Down's syndrome patients from childhood to adult age. Electroencephalogr. Clin. Neurophysiol. 83, 112-123.
    • (1992) Clin. Neurophysiol. , vol.83 , pp. 112-123
    • Schmid, R.G.1    Tirsch, W.S.2    Rappelsberger, P.3    Weinmann, H.M.4    Poppl, S.J.5
  • 257
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • DOI 10.1172/JCI200114002
    • Schmidt, A.M., Yan, S.D., Yan, S.F., and Stern, D.M. (2001). The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J. Clin. Invest. 108, 949-955. (Pubitemid 32946067)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.7 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 258
    • 0025071591 scopus 로고
    • Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months
    • Schmidt-Sidor, B., Wisniewski, K.E., Shepard, T.H., and Sersen, E.A. (1990). Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months. Clin. Neuropathol. 9, 181-190. (Pubitemid 20287898)
    • (1990) Clinical Neuropathology , vol.9 , Issue.4 , pp. 181-190
    • Schmidt-Sidor, B.1    Wisniewski, K.E.2    Shepard, T.H.3    Sersen, E.A.4
  • 259
    • 0032529841 scopus 로고    scopus 로고
    • 2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: A model of Down's syndrome
    • Schuchmann, S., Muller, W., and Heinemann, U. (1998). Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: A model of Down's syndrome. J. Neurosci. 18, 7216-7231. (Pubitemid 28425808)
    • (1998) Journal of Neuroscience , vol.18 , Issue.18 , pp. 7216-7231
    • Schuchmann, S.1    Muller, W.2    Heinemann, U.3
  • 260
    • 0026706872 scopus 로고
    • Neurohistological findings in the parietal cortex of children with chromosome aberrations
    • Schulz, E. and Scholz, B. (1992). Neurohistological findings in the parietal cortex of children with chromosome aberrations. J. Hirnforsch. 33, 37-62.
    • (1992) J. Hirnforsch. , vol.33 , pp. 37-62
    • Schulz, E.1    Scholz, B.2
  • 261
    • 0032918137 scopus 로고    scopus 로고
    • Caspases as treatment targets in stroke and neurodegenerative diseases
    • DOI 10.1002/1531-8249(199904)45:4<421::AID-ANA2>3.0.CO;2-Q
    • Schulz, J.B., Weller, M., and Moskowitz, M.A. (1999). Caspases as treatment targets in stroke and neurodegenerative diseases. Ann. Neurol. 45, 421-429. (Pubitemid 29165807)
    • (1999) Annals of Neurology , vol.45 , Issue.4 , pp. 421-429
    • Schulz, J.B.1    Weller, M.2    Moskowitz, M.A.3
  • 262
    • 66449131559 scopus 로고    scopus 로고
    • Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling
    • Schwartz, N., Schohl, A., and Ruthazer, E.S. (2009). Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling. Neuron 62, 655-669.
    • (2009) Neuron , vol.62 , pp. 655-669
    • Schwartz, N.1    Schohl, A.2    Ruthazer, E.S.3
  • 263
    • 0033593483 scopus 로고    scopus 로고
    • Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome
    • DOI 10.1016/S0304-3940(98)00945-8, PII S0304394098009458
    • Seidl, R., Fang-Kircher, S., Bidmon, B., Cairns, N., and Lubec, G. (1999). Apoptosis-associated proteins p53 and APO-1/ Fas (CD95) in brains of adult patients with Down syndrome. Neurosci. Lett. 260, 9-12. (Pubitemid 29066889)
    • (1999) Neuroscience Letters , vol.260 , Issue.1 , pp. 9-12
    • Seidl, R.1    Fang-Kircher, S.2    Bidmon, B.3    Cairns, N.4    Lubec, G.5
  • 264
    • 0034684619 scopus 로고    scopus 로고
    • Ets target genes: Past, present and future
    • DOI 10.1038/sj.onc.1204034
    • Sementchenko, V.I. and Watson, D.K. (2000). Ets target genes: Past, present and future. Oncogene 19, 6533-6548. (Pubitemid 32108443)
    • (2000) Oncogene , vol.19 , Issue.55 , pp. 6533-6548
    • Sementchenko, V.I.1    Watson, D.K.2
  • 265
    • 18244388693 scopus 로고    scopus 로고
    • Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    • DOI 10.1016/j.expneurol.2004.11.017
    • Seo, H. and Isacson, O. (2005). Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp. Neurol. 193, 469-480. (Pubitemid 40626769)
    • (2005) Experimental Neurology , vol.193 , Issue.2 , pp. 469-480
    • Seo, H.1    Isacson, O.2
  • 266
    • 0018775545 scopus 로고
    • Fatty acid composition of lipids of human brain myelin and synaptosomes: Changes in phenylketonuria and Down's syndrome
    • DOI 10.1016/0020-711X(79)90002-8
    • Shah, S.N. (1979). Fatty acid composition of lipids of human brain myelin and synaptosomes: Changes in phenylketonuria and Down's syndrome. Int. J. Biochem. 10, 477-482. (Pubitemid 9203531)
    • (1979) International Journal of Biochemistry , vol.10 , Issue.6 , pp. 477-482
    • Shah, S.N.1
  • 267
    • 33751184222 scopus 로고    scopus 로고
    • Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique
    • Shankaran, M., King, C., Lee, J., Busch, R., Wolff, M., and Hellerstein, M.K. (2006). Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique. J. Pharmacol. Exp. Ther. 319, 1172-1181.
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 1172-1181
    • Shankaran, M.1    King, C.2    Lee, J.3    Busch, R.4    Wolff, M.5    Hellerstein, M.K.6
  • 268
    • 0031045614 scopus 로고    scopus 로고
    • Whither Down syndrome critical regions?
    • DOI 10.1007/s004390050383
    • Shapiro, B.L. (1997). Whither Down syndrome critical regions? Hum. Genet. 99, 421-423. (Pubitemid 27095809)
    • (1997) Human Genetics , vol.99 , Issue.3 , pp. 421-423
    • Shapiro, B.L.1
  • 269
    • 4043140665 scopus 로고    scopus 로고
    • Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: An immunohistochemical study of MAP-2, drebrin and GAP-43
    • DOI 10.1016/j.brainres.2004.05.100, PII S000689930400839X
    • Shapiro, L.A. and Whitaker-Azmitia, P.M. (2004). Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: An immunohistochemical study of MAP-2, drebrin and GAP-43. Brain Res. 1019, 39-46. (Pubitemid 39078608)
    • (2004) Brain Research , vol.1019 , Issue.1-2 , pp. 39-46
    • Shapiro, L.A.1    Whitaker-Azmitia, P.M.2
  • 270
    • 79956146841 scopus 로고    scopus 로고
    • Alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
    • Shichiri, M., Yoshida, Y., Ishida, N., Hagihara, Y., Iwahashi, H., Tamai, H., and Niki, E. (2011). alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome. Free. Radic. Biol. Med. 15, 1801-1811.
    • (2011) Free. Radic. Biol. Med. , vol.15 , pp. 1801-1811
    • Shichiri, M.1    Yoshida, Y.2    Ishida, N.3    Hagihara, Y.4    Iwahashi, H.5    Tamai, H.6    Niki, E.7
  • 271
    • 0037166050 scopus 로고    scopus 로고
    • Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome
    • DOI 10.1016/S0304-3940(02)00210-0, PII S0304394002002100
    • Shim, K.S. and Lubec, G. (2002). Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci. Lett. 324, 209-212. (Pubitemid 34493871)
    • (2002) Neuroscience Letters , vol.324 , Issue.3 , pp. 209-212
    • Shim, K.S.1    Lubec, G.2
  • 272
    • 3142746639 scopus 로고    scopus 로고
    • Derangement of hypothetical proteins in fetal down's syndrome brain
    • DOI 10.1023/B:NERE.0000023617.49590.19
    • Shin, J.H., Gulesserian, T., Weitzdoerfer, R., Fountoulakis, M., and Lubec, G. (2004). Derangement of hypothetical proteins in fetal Down's syndrome brain. Neurochem. Res. 29, 1307-1316. (Pubitemid 39023503)
    • (2004) Neurochemical Research , vol.29 , Issue.6 , pp. 1307-1316
    • Shin, J.-H.1    Gulesserian, T.2    Weitzdoerfer, R.3    Fountoulakis, M.4    Lubec, G.5
  • 273
    • 71949111113 scopus 로고    scopus 로고
    • Prevalence of Down syndrome among children and adolescents in 10 regions of the United States
    • Shin, M., Besser, L.M., Kucik, J.E., Lu, C., Siffel, C., and Correa, A. (2009). Prevalence of Down syndrome among children and adolescents in 10 regions of the United States. Pediatrics 124, 1565-1571.
    • (2009) Pediatrics , vol.124 , pp. 1565-1571
    • Shin, M.1    Besser, L.M.2    Kucik, J.E.3    Lu, C.4    Siffel, C.5    Correa, A.6
  • 275
    • 21344435258 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome
    • DOI 10.1016/j.neuropharm.2005.02.012, PII S0028390805000833
    • Siarey, R.J., Villar, A.J., Epstein, C.J., and Galdzicki, Z. (2005). Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology 49, 122-128. (Pubitemid 40910022)
    • (2005) Neuropharmacology , vol.49 , Issue.1 , pp. 122-128
    • Siarey, R.J.1    Villar, A.J.2    Epstein, C.J.3    Galdzicki, Z.4
  • 277
    • 0015846291 scopus 로고
    • Neuronal migration, with special reference to developing human brain: A review
    • Sidman, R.L. and Rakic, P. (1973). Neuronal migration, with special reference to developing human brain: A review. Brain Res. 62, 1-35.
    • (1973) Brain Res. , vol.62 , pp. 1-35
    • Sidman, R.L.1    Rakic, P.2
  • 278
    • 0029075809 scopus 로고
    • Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2
    • Smith, D.J., Zhu, Y., Zhang, J., Cheng, J.F., and Rubin, E.M. (1995). Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics 27, 425-434.
    • (1995) Genomics , vol.27 , pp. 425-434
    • Smith, D.J.1    Zhu, Y.2    Zhang, J.3    Cheng, J.F.4    Rubin, E.M.5
  • 280
    • 0034941330 scopus 로고    scopus 로고
    • Nerve growth factor signaling, neuroprotection, and neural repair
    • DOI 10.1146/annurev.neuro.24.1.1217
    • Sofroniew, M.V., Howe, C.L., and Mobley, W.C. (2001). Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281. (Pubitemid 32695259)
    • (2001) Annual Review of Neuroscience , vol.24 , pp. 1217-1281
    • Sofroniew, M.V.1    Howe, C.L.2    Mobley, W.C.3
  • 283
    • 0032747486 scopus 로고    scopus 로고
    • Activation of caspase- 3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
    • Stadelmann, C., Deckwerth, T.L., Srinivasan, A., Bancher, C., Bruck, W., Jellinger, K., and Lassmann, H. (1999). Activation of caspase- 3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am. J. Pathol. 155, 1459-1466.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1459-1466
    • Stadelmann, C.1    Deckwerth, T.L.2    Srinivasan, A.3    Bancher, C.4    Bruck, W.5    Jellinger, K.6    Lassmann, H.7
  • 284
    • 4043159976 scopus 로고    scopus 로고
    • Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome
    • DOI 10.1016/j.bbr.2004.01.012, PII S0166432804000166
    • Stasko, M.R. and Costa, A.C. (2004). Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behav. Brain Res. 154, 1-17. (Pubitemid 39070448)
    • (2004) Behavioural Brain Research , vol.154 , Issue.1 , pp. 1-17
    • Stasko, M.R.1    Costa, A.C.S.2
  • 285
    • 33947227299 scopus 로고    scopus 로고
    • Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome
    • DOI 10.1007/s10519-006-9119-y
    • Stewart, L.S. (2007). Chronobiometry of Behavioral Activity in the Ts65Dn Model of Down Syndrome. Behav. Genet. 37, 388-398. (Pubitemid 46425331)
    • (2007) Behavior Genetics , vol.37 , Issue.2 , pp. 388-398
    • Stewart, L.S.1    Persinger, M.A.2    Cortez, M.A.3    Snead III, O.C.4
  • 286
    • 0035490566 scopus 로고    scopus 로고
    • Down syndrome phonology: Developmental patterns and intervention strategies
    • Stoel Gammon, C. (2001). Down syndrome phonology: Developmental patterns and intervention strategies. Downs Syndr. Res. Pract. 7, 93-100.
    • (2001) Downs Syndr. Res. Pract. , vol.7 , pp. 93-100
    • Stoel Gammon, C.1
  • 287
    • 39449092446 scopus 로고    scopus 로고
    • Cerebellum morphogenesis: The foliation pattern is orchestrated by multi-cellular anchoring centers
    • Sudarov, A. and Joyner, A.L. (2007). Cerebellum morphogenesis: The foliation pattern is orchestrated by multi-cellular anchoring centers. Neural. Dev. 2, 26.
    • (2007) Neural. Dev. , vol.2 , pp. 26
    • Sudarov, A.1    Joyner, A.L.2
  • 288
    • 0018964370 scopus 로고
    • Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. A quantitative Golgi study
    • DOI 10.1007/BF00688755
    • Suetsugu, M. and Mehraein, P. (1980). Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. A quantitative Golgi study. Acta Neuropathol. 50, 207-210. (Pubitemid 10030034)
    • (1980) Acta Neuropathologica , vol.50 , Issue.3 , pp. 207-210
    • Suetsugu, M.1    Mehraein, P.2
  • 290
    • 0022613253 scopus 로고
    • The anterior commissure in Down's syndrome
    • Sylvester, P.E. (1986). The anterior commissure in Down's syndrome. J. Ment. Defic. Res. 30 (Pt 1), 19-26. (Pubitemid 16142019)
    • (1986) Journal of Mental Deficiency Research , vol.30 , Issue.1 , pp. 19-26
    • Sylvester, P.E.1
  • 291
    • 0019419703 scopus 로고
    • Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome. A quantitative and qualitative Golgi study
    • DOI 10.1016/0006-8993(81)90314-0
    • Takashima, S., Becker, L.E., Armstrong, D.L., and Chan, F. (1981). Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study. Brain Res. 225, 1-21. (Pubitemid 11026571)
    • (1981) Brain Research , vol.225 , Issue.1 , pp. 1-21
    • Takashima, S.1    Becker, L.E.2    Armstrong, D.L.3    Chan, F.W.4
  • 293
    • 0028361046 scopus 로고
    • Dendritic and histochemical development and ageing in patients with Down's syndrome
    • Takashima, S., Iida, K., Mito, T., and Arima, M. (1994). Dendritic and histochemical development and ageing in patients with Down's syndrome. J. Intellect. Disabil. Res. 38 (Pt 3), 265-273. (Pubitemid 24168352)
    • (1994) Journal of Intellectual Disability Research , vol.38 , Issue.3 , pp. 265-273
    • Takashima, S.1    Iida, K.2    Mito, T.3    Arima, M.4
  • 296
    • 77950350271 scopus 로고    scopus 로고
    • Memantine: A review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias
    • Thomas, S.J. and Grossberg, G.T. (2009). Memantine: A review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias. Clin. Interv. Aging 4, 367-377.
    • (2009) Clin. Interv. Aging , vol.4 , pp. 367-377
    • Thomas, S.J.1    Grossberg, G.T.2
  • 297
    • 77955844840 scopus 로고    scopus 로고
    • Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations
    • Toiber, D., Azkona, G., Ben-Ari, S., Toran, N., Soreq, H., and Dierssen, M. (2010). Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol. Dis. 40, 348-359.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 348-359
    • Toiber, D.1    Azkona, G.2    Ben-Ari, S.3    Toran, N.4    Soreq, H.5    Dierssen, M.6
  • 301
    • 33745035951 scopus 로고    scopus 로고
    • Motor development and neuropsychological patterns in persons with Down syndrome
    • DOI 10.1007/s10519-006-9057-8
    • Vicari, S. (2006). Motor development and neuropsychological patterns in persons with Down syndrome. Behav. Genet. 36, 355-364. (Pubitemid 43876775)
    • (2006) Behavior Genetics , vol.36 , Issue.3 , pp. 355-364
    • Vicari, S.1
  • 302
    • 0033990963 scopus 로고    scopus 로고
    • Implicit and explicit memory: A functional dissociation in persons with Down syndrome
    • Vicari, S., Bellucci, S., and Carlesimo, G.A. (2000). Implicit and explicit memory: A functional dissociation in persons with Down syndrome. Neuropsychologia 38, 240-251.
    • (2000) Neuropsychologia , vol.38 , pp. 240-251
    • Vicari, S.1    Bellucci, S.2    Carlesimo, G.A.3
  • 303
    • 18944397794 scopus 로고    scopus 로고
    • 16)65Dn and mouse Chromosome 12
    • DOI 10.1007/s00335-004-2428-7
    • Villar, A.J., Belichenko, P.V., Gillespie, A.M., Kozy, H.M., Mobley, W.C., and Epstein, C.J. (2005). Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm. Genome 16, 79-90. (Pubitemid 40895684)
    • (2005) Mammalian Genome , vol.16 , Issue.2 , pp. 79-90
    • Villar, A.J.1    Belichenko, P.V.2    Gillespie, A.M.3    Kozy, H.M.4    Mobley, W.C.5    Epstein, C.J.6
  • 304
    • 64249116198 scopus 로고    scopus 로고
    • Prenatal NAP+ SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors
    • Vink, J., Incerti, M., Toso, L., Roberson, R., Abebe, D., and Spong, C.Y. (2009). Prenatal NAP+ SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors. Am. J. Obstet. Gynecol. 200, 524 e521-524.
    • (2009) Am. J. Obstet. Gynecol. , vol.200 , Issue.524
    • Vink, J.1    Incerti, M.2    Toso, L.3    Roberson, R.4    Abebe, D.5    Spong, C.Y.6
  • 306
    • 0036329013 scopus 로고    scopus 로고
    • Perinatal growth of prefrontal layer III pyramids in down syndrome
    • DOI 10.1016/S0887-8994(02)00380-6, PII S0887899402003806
    • Vuksic, M., Petanjek, Z., Rasin, M.R., and Kostovic, I. (2002). Perinatal growth of prefrontal layer III pyramids in Down syndrome. Pediatr. Neurol. 27, 36-38. (Pubitemid 34823589)
    • (2002) Pediatric Neurology , vol.27 , Issue.1 , pp. 36-38
    • Vuksic, M.1    Petanjek, Z.2    Rasin, M.R.3    Kostovic, I.4
  • 307
    • 0026594076 scopus 로고
    • Callosal morphology concurs with neurobehavioral and neuropathological findings in two neurodevelopmental disorders
    • Wang, P.P., Doherty, S., Hesselink, J.R., and Bellugi, U. (1992). Callosal morphology concurs with neurobehavioral and neuropathological findings in two neurodevelopmental disorders. Arch. Neurol. 49, 407-411.
    • (1992) Arch. Neurol. , vol.49 , pp. 407-411
    • Wang, P.P.1    Doherty, S.2    Hesselink, J.R.3    Bellugi, U.4
  • 308
    • 38949158786 scopus 로고    scopus 로고
    • Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
    • DOI 10.1523/JNEUROSCI.3632-07.2008
    • Wang, J.W., David, D.J., Monckton, J.E., Battaglia, F., and Hen, R. (2008). Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J. Neurosci. 28, 1374-1384. (Pubitemid 351231535)
    • (2008) Journal of Neuroscience , vol.28 , Issue.6 , pp. 1374-1384
    • Wang, J.-W.1    David, D.J.2    Monckton, J.E.3    Battaglia, F.4    Hen, R.5
  • 310
    • 0025876197 scopus 로고
    • Down syndrome: MR quantification of brain structures and comparison with normal control subjects
    • Weis, S., Weber, G., Neuhold, A., and Rett, A. (1991). Down syndrome: MR quantification of brain structures and comparison with normal control subjects. AJNR Am. J. Neuroradiol. 12, 1207-1211.
    • (1991) AJNR Am. J. Neuroradiol. , vol.12 , pp. 1207-1211
    • Weis, S.1    Weber, G.2    Neuhold, A.3    Rett, A.4
  • 311
    • 0035226716 scopus 로고    scopus 로고
    • Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure
    • Weitzdoerfer, R., Dierssen, M., Fountoulakis, M., and Lubec, G. (2001). Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. J. Neural. Transm. Suppl. 61, 59-70. (Pubitemid 38085072)
    • (2001) Journal of Neural Transmission, Supplement , Issue.61 , pp. 59-70
    • Weitzdoerfer, R.1    Dierssen, M.2    Fountoulakis, M.3    Lubec, G.4
  • 312
    • 0036288814 scopus 로고    scopus 로고
    • Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain
    • DOI 10.1016/S0006-291X(02)00291-7, PII S0006291X02002917
    • Weitzdoerfer, R., Fountoulakis, M., and Lubec, G. (2002). Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain. Biochem. Biophys. Res. Commun. 293, 836-841. (Pubitemid 34687264)
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , Issue.2 , pp. 836-841
    • Weitzdoerfer, R.1    Fountoulakis, M.2    Lubec, G.3
  • 313
    • 0034683183 scopus 로고    scopus 로고
    • Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons
    • DOI 10.1016/S0014-2999(00)00523-9, PII S0014299900005239
    • Wenk, G.L., McGann, K., Mencarelli, A., Hauss-Wegrzyniak, B., Del Soldato, P., and Fiorucci, S. (2000). Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. Eur. J. Pharmacol. 402, 77-85. (Pubitemid 30625313)
    • (2000) European Journal of Pharmacology , vol.402 , Issue.1-2 , pp. 77-85
    • Wenk, G.L.1    McGann, K.2    Mencarelli, A.3    Hauss-Wegrzyniak, B.4    Del Soldato, P.5    Fiorucci, S.6
  • 314
    • 39449117350 scopus 로고    scopus 로고
    • Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
    • DOI 10.1038/sj.mp.4002093, PII 4002093
    • Wexler, E.M., Geschwind, D.H., and Palmer, T.D. (2008). Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Mol. Psychiatry 13, 285-292. (Pubitemid 351272655)
    • (2008) Molecular Psychiatry , vol.13 , Issue.3 , pp. 285-292
    • Wexler, E.M.1    Geschwind, D.H.2    Palmer, T.D.3
  • 315
    • 0035891882 scopus 로고    scopus 로고
    • Serotonin and brain development: Role in human developmental diseases
    • DOI 10.1016/S0361-9230(01)00615-3, PII S0361923001006153
    • Whitaker-Azmitia, P.M. (2001). Serotonin and brain development: Role in human developmental diseases. Brain Res. Bull. 56, 479-485. (Pubitemid 34031783)
    • (2001) Brain Research Bulletin , vol.56 , Issue.5 , pp. 479-485
    • Whitaker-Azmitia, P.M.1
  • 316
    • 0141758248 scopus 로고    scopus 로고
    • A voxel-based morphometric study of nondemented adults with Down Syndrome
    • DOI 10.1016/S1053-8119(03)00273-8
    • White, N.S., Alkire, M.T., and Haier, R.J. (2003). A voxel-based morphometric study of nondemented adults with Down Syndrome. Neuroimage 20, 393-403. (Pubitemid 37188527)
    • (2003) NeuroImage , vol.20 , Issue.1 , pp. 393-403
    • White, N.S.1    Alkire, M.T.2    Haier, R.J.3
  • 317
    • 36849085926 scopus 로고    scopus 로고
    • Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development
    • DOI 10.1542/peds.2006-3448
    • Whittle, N., Sartori, S.B., Dierssen, M., Lubec, G., and Singewald, N. (2007). Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics 120, e1465-1471. (Pubitemid 350223666)
    • (2007) Pediatrics , vol.120 , Issue.6
    • Whittle, N.1    Sartori, S.B.2    Dierssen, M.3    Lubec, G.4    Singewald, N.5
  • 318
    • 24644479070 scopus 로고    scopus 로고
    • Piracetam: A review of pharmacological properties and clinical uses
    • Winblad, B. (2005). Piracetam: A review of pharmacological properties and clinical uses. CNS Drug Rev. 11, 169-182. (Pubitemid 41278980)
    • (2005) CNS Drug Reviews , vol.11 , Issue.2 , pp. 169-182
    • Winblad, B.1
  • 319
    • 0033956698 scopus 로고    scopus 로고
    • Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: Usefulness as combined US markers
    • Winter, T.C., Ostrovsky, A.A., Komarniski, C.A., and Uhrich, S.B. (2000). Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: Usefulness as combined US markers. Radiology 214, 533-538. (Pubitemid 30077715)
    • (2000) Radiology , vol.214 , Issue.2 , pp. 533-538
    • Winter, T.C.1    Ostrovsky, A.A.2    Komamiski, C.A.3    Uhrich, S.B.4
  • 320
    • 0018075465 scopus 로고
    • Precocious aging and dementia in patients with Down's syndrome
    • Wisniewski, K., Howe, J., Williams, D.G., and Wisniewski, H.M. (1978). Precocious aging and dementia in patients with Down's syndrome. Biol. Psychiatry 13, 619-627. (Pubitemid 9041470)
    • (1978) Biological Psychiatry , vol.13 , Issue.5 , pp. 619-627
    • Wisniewski, K.1    Howe, J.2    Williams, D.G.3    Wisniewski, H.M.4
  • 321
    • 0025668992 scopus 로고
    • Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis
    • Wisniewski, K.E. (1990). Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. Am. J. Med. Genet. Suppl. 7, 274-281.
    • (1990) Am. J. Med. Genet. Suppl. , vol.7 , pp. 274-281
    • Wisniewski, K.E.1
  • 322
    • 0024411610 scopus 로고
    • Postnatal delay of myelin formation in brains from Down syndrome infants and children
    • Wisniewski, K.E. and Schmidt-Sidor, B. (1989). Postnatal delay of myelin formation in brains from Down syndrome infants and children. Clin. Neuropathol. 8, 55-62. (Pubitemid 19169365)
    • (1989) Clinical Neuropathology , vol.8 , Issue.2 , pp. 55-62
    • Wisniewski, K.E.1    Schmidt-Sidor, B.2
  • 323
    • 0021827420 scopus 로고
    • Alzheimer's disease in Down's syndrome: Clinicopathologic studies
    • Wisniewski, K.E., Dalton, A.J., McLachlan, C., Wen, G.Y., and Wisniewski, H.M. (1985a). Alzheimer's disease in Down's syndrome: Clinicopathologic studies. Neurology 35, 957-961. (Pubitemid 15026265)
    • (1985) Neurology , vol.35 , Issue.7 , pp. 957-961
    • Wisniewski, K.E.1    Dalton, A.J.2    McLachlan, C.3
  • 324
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • DOI 10.1002/ana.410170310
    • Wisniewski, K.E., Wisniewski, H.M., and Wen, G.Y. (1985b). Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17, 278-282. (Pubitemid 15136603)
    • (1985) Annals of Neurology , vol.17 , Issue.3 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 325
  • 326
    • 41049093658 scopus 로고    scopus 로고
    • Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate
    • DOI 10.1007/s11064-007-9494-7
    • Xie, W., Ramakrishna, N., Wieraszko, A., and Hwang, Y.W. (2008). Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate. Neurochem. Res. 33, 776-783. (Pubitemid 351423141)
    • (2008) Neurochemical Research , vol.33 , Issue.5 , pp. 776-783
    • Xie, W.1    Ramakrishna, N.2    Wieraszko, A.3    Hwang, Y.-W.4
  • 327
    • 77949678789 scopus 로고    scopus 로고
    • Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells
    • Yabut, O., Domogauer, J., and D'Arcangelo, G. (2010). Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. J. Neurosci. 30, 4004-4014.
    • (2010) J. Neurosci. , vol.30 , pp. 4004-4014
    • Yabut, O.1    Domogauer, J.2    D'Arcangelo, G.3
  • 328
    • 0035955696 scopus 로고    scopus 로고
    • Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells
    • Yang, E.J., Ahn, Y.S., and Chung, K.C. (2001). Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells. J. Biol. Chem. 276, 39819-39824.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39819-39824
    • Yang, E.J.1    Ahn, Y.S.2    Chung, K.C.3
  • 329
  • 330
    • 8144224974 scopus 로고    scopus 로고
    • G93A G1H transgenic mouse model of amyotrophic lateral sclerosis
    • DOI 10.1111/j.1460-9568.2004.03648.x
    • Zang, D.W., Yang, Q., Wang, H.X., Egan, G., Lopes, E.C., and Cheema, S.S. (2004). Magnetic resonance imaging reveals neuronal degeneration in the brainstem of the superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis. Eur. J. Neurosci. 20, 1745-1751. (Pubitemid 39471567)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.7 , pp. 1745-1751
    • Zang, D.W.1    Yang, Q.2    Wang, H.X.3    Egan, G.4    Lopes, E.C.5    Cheema, S.S.6
  • 331
    • 0035977139 scopus 로고    scopus 로고
    • Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory
    • DOI 10.1016/S0092-8674(01)00585-2
    • Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B.D., Miyakawa, T., Bear, M.F., and Tonegawa, S. (2001). Forebrainspecific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell 107, 617-629. (Pubitemid 34014863)
    • (2001) Cell , vol.107 , Issue.5 , pp. 617-629
    • Zeng, H.1    Chattarji, S.2    Barbarosie, M.3    Rondi-Reig, L.4    Philpot, B.D.5    Miyakawa, T.6    Bear, M.F.7    Tonegawa, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.