Efficacy of Chinese herbal medicine Mailuo Shutong Granule and Hirudoid cream for chronic venous disorder-induced pigmentation in lower extremities: A prospective, randomized controlled trial

Journal of Chinese Integrative Medicine

Volumn 9, Issue 8, 2011, Pages 866-870

  Wei, Xiao Long ^a   Feng, Rui ^a   Zhao, Zhi Qing ^a   Jing, Zai Ping ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chinese herbal; Drugs; Hirudoid; Hyperpigmentation; Prospective study; Randomized controlled trial; Skin pigmentation; Venous insufficiency

Indexed keywords

HERBACEOUS AGENT; HIRUDOID;

ARTICLE; CHINESE MEDICINE; CHRONIC VEIN INSUFFICIENCY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CREAM; DRUG EFFICACY; DRUG GRANULE; HERBAL MEDICINE; HUMAN; HYPERPIGMENTATION; MAILUO SHUTONG; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; CHRONIC DISEASE; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; PHYTOTHERAPY; PIGMENTATION DISORDERS; PROSPECTIVE STUDIES; VENOUS INSUFFICIENCY;

EID: 80051722686     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20110808     Document Type: Article

References (21)

1. Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2005; 111(18): 2398-2409.
2. Barron GS, Jacob SE, Kirsner RS. Dermatologie complications of chronic venous disease: medical management and beyond. Ann Vase Surg. 2007; 21(5): 652-662.
3. Neglen P; Writing Group II of the Pacific Vascular Symposium 6, Eklöf B, Kulwicki A, Davies A, Deschamps T, Garcia M, Gloviczki P, Labropoulos N, Nicolaides A, Partsch H, Perrin M, Rabe E, Wittens C. Prevention and treatment of venous ulcers in primary chronic venous insufficiency. J Vase Surg. 2010; 52 (5 Suppl): 15S-20S.
4. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Rapid relief of signs/ symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006; 57 (5): 569-576.
5. Ghauri AS, Nyamekye IK. Leg ulceration: the importance of treating the underlying pathophysiology. Phlebology. 2010; 25 (Suppl 1): 42-51.
6. Allen L. Assessment and management of patients with varicose veins. Nurs Stand. 2009; 23(23): 49-57.
7. Finlayson K, Edwards H, Courtney M. The impact of psychosocial factors on adherence to compression therapy to prevent recurrence of venous leg ulcers. J Clin Nurs. 2010; 19(9-10): 1289-1297.
8. Rutherford RB, Padberg FT Jr, Comerota AJ, Kistner RL, Meissner MH, Moneta GL. Venous severity scoring: An adjunct to venous outcome assessment. J Vase Surg. 2000; 31(6): 1307-1312.
9. Meissner MH, Natiello C, Nicholls SC. Performance characteristics of the venous clinical severity score. J Vase Surg. 2002; 36(5): 889-895.
10. Bergan JJ, Pascarella L, Schmid-Schönbein GW. Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension. J Vase Surg. 2008; 47 (1): 183-192.
11. Jünger M, Steins A, Hahn M, Häfner HM. Microcir- culatory dysfunction in chronic venous insufficiency (CVI). Microcirculation. 2000; 7(6 Pt 2): S3-S12.
12. Tian N, Li YZ, Liu YY. Research on the microcirculation of blood-stasis syndrome. Zhongguo Zhong Xi Yi Jie HeZaZhi. 2001; 21(4): 248-251. Chinese. (Chinese Source) 2001; 21(4): 248-251.
13. Wang YN, Dai X, Liu M, Zhang M. Distribution rules of syndrome essential in lower extremity deep venous thrombosis. Zhongguo Zhong Xi Yi Jie He Wai Ke Za Zhi. 2010; 16(4): 409-411. Chinese with abstract in English (Chinese Source). 2010; 16(4): 409-411.
14. Wang HZ. Clinical observation of Chinese medicine treatment of deep vein thrombosis. Zhong Yi Xue Bao. 2010; 25(5): 979-980. Chinese with abstract in English. (Chinese Source) 2010; 25(5): 979-980.
15. Hou LC, Song W. Treatment with Mailuo Shutong for deep venous thrombosis in lower extremity: a report of 354 cases. Liaoning Zhong Yi Za Zhi. 2004; 31(8): 674. Chinese. (Chinese Source) 2004; 31(8): 674.
16. Kumokawa T, Hirata K, Sato K, Kano S. Dermal absorption of mucopolysaccharide polysulfate (heparinoid) in human and minipig. Arzneimittelforschung. 2011; 61 (2): 85-91.
17. Elling H. Immunofluorescence demonstration of transdermal deposition of mucopolysaccharides into the skin. Arzne- imittelforschung. 1987; 37(7): 816-818.
18. Kuisma I, Tamelander G. Mucopolysaccharide polysul- phate cream in the prevention of pressure sores - a double blind study. Ann Clin Res. 1987; 19(6): 374-377.
19. Bergqvist D, Brunkwall J, Jensen N, Persson NH. Treatment of superficial thrombophlebitis. A comparative trial between placebo, Hirudoid cream and piroxicam gel. Ann Chir Gynaecol. 1990; 79(2): 92-96.
20. Tang HL, Zhai SD. Hirudoid for microcirculation disorder: a systematic review. Zhongguo Xun Zheng Yi Xue Za Zhi. 2010; 10(8): 946-951. Chinese with abstract in English.(Chinese Source) 2010; 10(8): 946-951.
21. Vecchio C, Frisinghelli A. Topically applied heparins for the treatment of vascular disorders: a comprehensive review. Clin Drug Investig. 2008; 28(10): 603-614.