Evaluation of two automated chemiluminescence immunoassays, the LIAISON Treponema Screen and the ARCHITECT Syphilis TP, and the Treponema pallidum particle agglutination test for laboratory diagnosis of syphilis

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 8, 2011, Pages 1375-1377

  Wellinghausen, Nele ^a   Dietenberger, Hanna ^a  

^a Dr Gaertner and Kolleagues Laboratory   (Germany)

Author keywords

chemiluminescence immunoassays (CLIA); serology; syphilis; Treponema pallidum particle agglutination (TPPA)

Indexed keywords

AGGLUTINATION TEST; ARTICLE; AUTOANALYSIS; CHEMOLUMINESCENCE; DIAGNOSTIC TEST ACCURACY STUDY; FALSE POSITIVE RESULT; HUMAN; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; PREGNANCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SYPHILIS; TREPONEMA PALLIDUM; TREPONEMA PALLIDUM HEMAGGLUTINATION TEST;

AGGLUTINATION TESTS; ANTIBODIES, BACTERIAL; AUTOMATION; FEMALE; HUMANS; IMMUNOASSAY; LABORATORIES; LUMINESCENT MEASUREMENTS; MALE; PREGNANCY; PROSPECTIVE STUDIES; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; SYPHILIS; TREPONEMA PALLIDUM;

TREPONEMA; TREPONEMA PALLIDUM;

EID: 80051719690     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.643     Document Type: Article

References (15)

1. Centers for Disease Control and Prevention. 2009. Sexually transmitted disease surveillance. U.S. Department of Health and Human Services, Atlanta, GA, 2010.
2. Marcus U, Hamouda O. Syphilis in Germany, 2004: Diagnoses increasing, particularly in smaller cities and rural areas. Euro Surveill 2005;10:E050728.
3. Peeling RW, Mabey DC. Syphilis. Nat Rev Microbiol 2004;2: 448-9.
4. Egglestone SI, Turner AJ. Serological diagnosis of syphilis. PHLS Syphilis Serology Working Group. Commun Dis Public Health 2000;3:158-62.
5. Hagedorn H.-J. MiQ 16. Syphilis. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. 2001.
6. Sena AC, White BL, Sparling PF. Novel Treponema pallidum serologic tests: A paradigm shift in syphilis screening for the 21st century. Clin Infect Dis 2010;51:700-8.
7. Schofer H, Brockmeyer NH, Hagedorn HJ, Hamouda O, Handrick W, Krause W, et al. wSyphilis. Guideline of the German Sexually Transmitted Diseases Society of diagnosis and therapy of syphilisx. J Dtsch Dermatol Ges 2006;4:160-77.
8. French P, Gomberg M, Janier M, Schmidt B, van Voorst Vader P, Young H. 2008 European Guidelines on the Management of Syphilis. Int J STD AIDS 2009;20:300-9.
9. Knight CS, Crum MA, Hardy RW. Evaluation of the LIAISON chemiluminescence immunoassay for diagnosis of syphilis. Clin Vaccine Immunol 2007;14:710-3. (Pubitemid 47104757)
10. Marangoni A, Sambri V, Accardo S, Cavrini F, D'Antuono A, Moroni A, et al. Evaluation of LIAISON Treponema screen, a novel recombinant antigen-based chemiluminescence immunoassay for laboratory diagnosis of syphilis. Clin Diagn Lab Immunol 2005;12:1231-4. (Pubitemid 41475833)
11. Yoshioka N, Deguchi M, Kagita M, Kita M, Watanabe M, Asari S, et al. Evaluation of a chemiluminescent microparticle immunoassay for determination of Treponema pallidum antibodies. Clin Lab 2007;53:597-603. (Pubitemid 351166426)
12. Marangoni A, Moroni A, Accardo S, Cevenini R. Laboratory diagnosis of syphilis with automated immunoassays. J Clin Lab Anal 2009;23:1-6.
13. Young H, Pryde J, Duncan L, Dave J. The Architect Syphilis assay for antibodies to Treponema pallidum: An automated screening assay with high sensitivity in primary syphilis. Sex Transm Infect 2009;85:19-23.
14. Gerber A, Krell S, Morenz J. Recombinant Treponema pallidum antigens in syphilis serology. Immunobiology 1996;196:535-49. (Pubitemid 27168446)
15. Peeling RW, Ye H. Diagnostic tools for preventing and managing maternal and congenital syphilis: An overview. Bull World Health Organ 2004;82:439-46. (Pubitemid 38828430)