A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein

Journal of General Virology

Volumn 92, Issue 9, 2011, Pages 2153-2159

  Ren, Junping ^a   Liu, Tianshuang ^a   Pang, Lan ^a   Li, Kui ^b   Garofalo, Roberto P ^a   Casola, Antonella ^a   Bao, Xiaoyong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 3; NONSTRUCTURAL PROTEIN 1;

ARTICLE; DIMERIZATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

CELL LINE; EPITHELIAL CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; PROTEIN BINDING; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

HUMAN RESPIRATORY SYNCYTIAL VIRUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A; RICE STRIPE VIRUS;

EID: 80051706667     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.032987-0     Document Type: Article

References (29)

1. Bao, X., Kolli, D., Liu, T., Shan, Y., Garofalo, R. P. & Casola, A. (2008a). Human metapneumovirus small hydrophobic protein inhibits NF-kB transcriptional activity. J Virol 82, 8224-8229.
2. Bao, X., Liu, T., Shan, Y., Li, K., Garofalo, R. P. & Casola, A. (2008b). Human metapneumovirus glycoprotein G inhibits innate immune responses. PLoS Pathog 4, e1000077.
3. Barnes, B., Lubyova, B. & Pitha, P. M. (2002). On the role of IRF in host defense. J Interferon Cytokine Res 22, 59-71.
4. Barro, M. & Patton, J. T. (2005). Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. Proc Natl Acad Sci U S A 102, 4114-4119.
5. Casola, A., Burger, N., Liu, T., Jamaluddin, M., Brasier, A. R. & Garofalo, R. P. (2001). Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. Role in viral-induced interferon regulatory factor activation. J Biol Chem 276, 19715-19722.
6. Collins, P. L. & Murphy, B. R. (2005). New generation live vaccines against human respiratory syncytial virus designed by reverse genetics. Proc Am Thorac Soc 2, 166-173.
7. Dragan, A. I., Hargreaves, V. V., Makeyeva, E. N. & Privalov, P. L. (2007). Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding. Nucleic Acids Res 35, 3525-3534.
8. Ehrhardt, C., Kardinal, C., Wurzer, W. J., Wolff, T., von Eichel- Streiber, C., Pleschka, S., Planz, O. & Ludwig, S. (2004). Rac1 and PAK1 are upstream of IKK-e and TBK-1 in the viral activation of interferon regulatory factor-3. FEBS Lett 567, 230-238.
9. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M. & Maniatis, T. (2003). IKKe and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4, 491-496.
10. Guerrero-Plata, A., Casola, A., Suarez, G., Yu, X., Spetch, L., Peeples, M. E. & Garofalo, R. P. (2006). Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am J Respir Cell Mol Biol 34, 320-329.
11. Hall, C. B. (2001). Respiratory syncytial virus and parainfluenza virus. N Engl J Med 344, 1917-1928.
12. Hiscott, J. (2007). Triggering the innate antiviral response through IRF-3 activation. J Biol Chem 282, 15325-15329.
13. Hwang, S., Kim, K. S., Flano, E., Wu, T. T., Tong, L. M., Park, A. N., Song, M. J., Sanchez, D. J., O'Connell, R. M. & other authors (2009). Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell HostMicrobe 5, 166-178.
14. Jin, H., Zhou, H., Cheng, X., Tang, R., Munoz, M. & Nguyen, N. (2000). Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo. Virology 273, 210-218.
15. Kawai, T. & Akira, S. (2008). Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 1143, 1-20.
16. Lefort, S., Soucy-Faulkner, A., Grandvaux, N. & Flamand, L. (2007). Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. J Virol 81, 10950-10960.
17. Lin, R., Heylbroeck, C., Pitha, P. M. & Hiscott, J. (1998). Virusdependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasomemediated degradation. Mol Cell Biol 18, 2986-2996.
18. Lin, R., Genin, P., Mamane, Y., Sgarbanti, M., Battistini, A., Harrington, W. J., Jr, Barber, G. N. & Hiscott, J. (2001). HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene 20, 800-811.
19. Ling, Z., Tran, K. C. & Teng, M. N. (2009). Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. J Virol 83, 3734-3742.
20. Liu, P., Jamaluddin, M., Li, K., Garofalo, R. P., Casola, A. & Brasier, A. R. (2007). Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J Virol 81, 1401-1411.
21. Munday, D. C., Emmott, E., Surtees, R., Lardeau, C. H., Wu, W., Duprex, W. P., Dove, B. K., Barr, J. N. & Hiscox, J. A. (2010). Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus. Mol Cell Proteomics 9, 2438-2459.
22. Servant, M. J., ten Oever, B., LePage, C., Conti, L., Gessani, S., Julkunen, I., Lin, R. & Hiscott, J. (2001). Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J Biol Chem 276, 355-363.
23. Spann, K. M., Tran, K. C., Chi, B., Rabin, R. L. & Collins, P. L. (2004). Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages. J Virol 78, 4363-4369.
24. Spann, K. M., Tran, K. C. & Collins, P. L. (2005). Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kB, and proinflammatory cytokines. J Virol 79, 5353-5362.
25. Suhara, W., Yoneyama, M., Kitabayashi, I. & Fujita, T. (2002). Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem 277, 22304-22313.
26. Swedan, S., Musiyenko, A. & Barik, S. (2009). Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways. J Virol 83, 9682-9693.
27. Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. (2001). IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19, 623-655.
28. Teng, M. N. & Collins, P. L. (1999). Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein. J Virol 73, 466-473.
29. Wagoner, J., Austin, M., Green, J., Imaizumi, T., Casola, A., Brasier, A., Khabar, K. S., Wakita, T., Gale, M., Jr & Polyak, S. J. (2007). Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection. J Virol 81, 309-318.