Cushing's Syndrome due to a Pancreatic neuroendocrine tumor metastatic to the ovaries: A clinicopathological description of a case

Endocrine Pathology

Volumn 22, Issue 2, 2011, Pages 118-124

  La Rosa, Stefano ^a   Marando, Alessandro ^b   Ghezzi, Fabio ^a   Colombo, Paolo ^c   Finzi, Giovanna ^b   Capella, Carlo ^a,b  

^a OSPEDALE DI CIRCOLO   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

ACTH; Cushing' syndrome; Ectopic secretion; Neuroendocrine tumor; Pancreas

Indexed keywords

CORTICOTROPIN; KETOCONAZOLE;

ABDOMINAL PAIN; ADULT; ARTICLE; CANCER INVASION; CASE REPORT; CUSHING SYNDROME; DEATH; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; JAUNDICE; LAPAROTOMY; LIVER NODULE; LYMPH NODE HYPERPLASIA; NEUROENDOCRINE TUMOR; OVARY METASTASIS; PANCREAS CARCINOMA; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; RADIODIAGNOSIS; SUPERIOR MESENTERIC VEIN; TUMOR DIFFERENTIATION; TUMOR VOLUME;

ACTH SYNDROME, ECTOPIC; ADULT; CARCINOMA, NEUROENDOCRINE; CUSHING SYNDROME; FATAL OUTCOME; FEMALE; HUMANS; HYSTERECTOMY; KETOCONAZOLE; LIVER NEOPLASMS; LYMPH NODES; OVARIAN NEOPLASMS; PANCREATIC NEOPLASMS;

EID: 80051704272     PISSN: 10463976     EISSN: 15590097     Source Type: Journal    
DOI: 10.1007/s12022-011-9153-z     Document Type: Article

References (26)

1. Cushing HW. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp 50:137-195, 1932.
2. Orth DN. Cushing's syndrome. N Engl J Med 332:791-803, 1995.
3. Aniszewski JP, Young WF, Thompson GB, Grant CS, van Heerden JA. Cushing syndrome due to ectopic adrenocorticotropic hormone secretion. World J Surg 25:934-940, 2001. (Pubitemid 32666396)
4. La Rosa S, Furlan D, Sessa F, Capella C. The endocrine pancreas. In: Lloyd RV, ed. Endocrine pathology. Differential diagnosis and molecular advances. 2nd ed. New York: Springer, 2010; 367-413.
5. Corrin B, Gilby ED, Jones NF, Patrik J. Oat cell carcinoma of the pancreas with ectopic ACTH secretion. Cancer 31:1523-1527, 1973.
6. Kitchens CS, Alexander RW. Cushing's syndrome secondary to a neuroendocrine tumor: relapse after bilateral adrenalectomy. Cancer 48:1873-1876, 1981. (Pubitemid 11022891)
7. Miehle K, Tannapfel A, Lamesch P, Borte G, Schnker E, Kluge K, et al. Pancreatic neuroendocrine tumor with ectopic adrenocorticotropin production upon second recurrence. J Clin Endocrinol Metab 89:3731-3736, 2004. (Pubitemid 39071464)
8. Solcia E, Klöppel G, Capella C. Tumors of the endocrine pancreas. In Rosai J, Sobin LH eds. Tumors of the pancreas. Atlas of tumor pathology. 3rd ed. Washington, DC: Armed Forces Institute of Pathology, 1997; 145-209.
9. Öberg KC, Wells K, Seraj IM, Garberoglio CA, Akin MRA. ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing's syndrome. Int J Gynecol Pathol 21:276-280, 2002. (Pubitemid 34680346)
10. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique. J Histochem Cytochem 25:577-589, 1981.
11. Soga J, Tazawa K. Pathologic analysis of carcinoids. Histologic revaluation of 62 cases. Cancer 28:990-998, 1971.
12. Rawlinson DG. Electron microscopy of an ACTH-secreting islet cell carcinoma. Cancer 31:1015-1019, 1973.
13. Robboy SJ, Scully RE, Norris HJ. Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer 33:798-811, 1974.
14. Moore RG, Chung M, Granai CO, Gajewski W, Steinhoff MM. Incidence of metastasis to the ovaries from nongenital tract primary tumors. Gynecol Oncol 93:87-91, 2004. (Pubitemid 38429553)
15. Young RH. From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 14:149-177, 2007. (Pubitemid 46661558)
16. Weitberg AB, Weitzman SA. Metastatic islet cell carcinoma: a potentially treatable cause of "carcinoma of unknown origin". CA Cancer J Clin 33:167-171, 1983. (Pubitemid 13103374)
17. La Rosa S, Klersy C, Uccella S, Dainese L, Albarello L, Sonzogni A, et al. Improved histologic and clinico-pathologic criteria for prognostic evaluation of pancreatic endocrine tumors. Hum Pathol 40:30-40, 2009.
18. Neta-Maier RT, Nieuwlaat WA, Sweep CGJ, Wesseling P, Massager L, Hermus ARM. Virilization due to ovarian androgen hypersecretion in a patient with ectopic adrenocorticotrophic hormone secretion by a carcinoid tumour: case report. Human Reprod 21:2601-2605, 2006. (Pubitemid 44542151)
19. Parson V, Rigby B. Cushing's syndrome associated with adenocarcinoma of the ovary. Lancet ii:992-994, 1958.
20. Crawford SM, Pyrah RD, Ismail SM. Cushing's syndrome associated with recurrent endometrioid adenocarcinoma of the ovary. J Clin Pathol 47:766-768, 1994.
21. Obertzova M, Andreeva M, Zacharieva S, Ivanova R, Dashev G. Ectopic ACTH-syndrome due to ovarian carcinoma. Exp Clin Endocrinol Diabetes 105:363-365, 1997. (Pubitemid 27523693)
22. Suzuki T, Ino K, Kikkawa F, Shibata K, Kajiyama H, Morita T, et al. Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis. Gynecol Oncol 90:662-666, 2003.
23. Kasperlik-Zaluska AA, Sikorowa L, Ploch E, Soszy?ski P, Jeske W, Migdalska B, et al. Ectopic ACTH syndrome due to bilateral ovarian androblastoma with double, gynandroblastic differentiation in one ovary. Eur J Obstet Gynecol Reprod Biol 52:223-228, 1993. (Pubitemid 24028518)
24. Sworczak K, Blaut K, Malecha M, Lewczuk A. Ectopic ACTH syndrome associated with ovarian steroid-cell tumor. J Endocrinol Invest 25:369-372, 2002. (Pubitemid 34436134)
25. Sporrong B, Falkmer S, Robboy SJ, Alumets J, Håkanson R, Ljungberg O, et al. Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer 49:68-74, 1982. (Pubitemid 12196138)
26. Sclaghecke R, Kreuzpaintner G, Bürrig KF, Juli E, Kley HK. Cushing's syndrome due to ACTH-production of an ovarian carcinoid. Klin Wochenschr 67:640-644, 1989. (Pubitemid 19158738)