A retrospective analysis of the use of caspofungin in recipients of liver transplant with a modified high index of suspicion for fungal infection. A critical review of mortality, acute cellular rejection, infections, and changes in the liver function tests while on caspofungin

Clinical Transplantation

Volumn 25, Issue 4, 2011, Pages 569-575

  Doria, Cataldo ^a   Bodzin, Adam S ^a   Vaccino, Silvia ^a   Daskalakis, Constantine ^b   Krawitz, Steven ^c   Ramirez, Carlo B ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Antifungal; Invasive fungal infection; Liver transplantation

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; CLOTRIMAZOLE; FLUCONAZOLE; NYSTATIN;

ACUTE CELLULAR R; ACUTE GRAFT REJECTION; ACUTE KIDNEY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; ASCITES; BILE; BREATHING DISORDER; CANDIDA ALBICANS; CANDIDA GLABRATA; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; FEMALE; FUNGUS CULTURE; HUMAN; HYPOTHERMIA; LIVER FUNCTION; LIVER TOXICITY; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PYREXIA IDIOPATHICA; SEPSIS; VENTILATORY FAILURE;

ANTIFUNGAL AGENTS; ECHINOCANDINS; FEMALE; GRAFT REJECTION; HUMANS; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MYCOSES; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 80051703927     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01308.x     Document Type: Article

References (16)

1. Alexander BD. Prophylaxis of invasive mycoses in solid organ transplantation. Curr Opin Infect Dis 2002: 15: 583.
2. Singh N, Wagener MM, Cacciarelli TV, Levitsky J. Antifungal management practices in liver transplant recipients. Am J Transplant 2008: 8: 426.
3. Briegel J, Forst H, Spill B et al. Risk factors for systemic fungal infections in liver transplant recipients. Eur J Clin Microbioil Infect Dis 1995: 14: 375.
4. Gavalda J, Len O, San Juan R et al. Risk factors for invasive aspergillosis in solid-organ transplant recipients: a case-control study. Clin Infect Dis 2005: 41: 52.
5. Fortun J, Martin-Davila P, Moreno S et al. Risk factors for invasive aspergillosis in liver transplant recipients. Liver Transplant 2002: 8: 1065.
6. Paya CV. Prevention of fungal infection in transplantation. Transplant Infec Dis 2002: 4: 46.
7. Marino IR, Doria C, Scott VL et al. Efficacy and safety of basiliximab with a tacrolimus-based regimen in liver transplant recipients. Transplantation 2004: 78: 886.
8. Ascioglu S, Rex JH, De Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002: 34: 7.
9. Mohr J, Johnson M, Cooper T, Lewis JS, Ostrosky-Zeichner L. Current options in antifungal pharmacotherapy. Pharmacotherapy 2008: 28: 614.
10. Ostrosky-Zeichner L, Marr KA, Rex JH, Cohen SH. Amphotericin B: time for a new "gold standard." Clin Infect Dis 2003: 37: 415.
11. Fortún J, Martin-Dávila P, Montejo M et al. Prophylaxis with caspofungin in high-risk liver transplant recipients. Transplantation 2009: 87: 424.
12. Chiou CC, Groll AH, Walsh TJ. New drugs and novel targets for treatment of invasive fungal infections in patients with cancer. Oncologist 2000: 5: 120.
13. Kartsonis NA, Saah AJ, Joy Lipka C, Taylor AF, Sable CA. Salvage therapy with caspofungin for invasive aspergillosis: results from the caspofungin compassionate use study. J Infect 2005: 50: 196.
14. Groetzner J, Kaczmarek I, Wittwer T et al. Caspofungin as first-line therapy for the treatment of invasive aspergillosis after thoracic organ transplantation. J Heart Lung Transplant 2008: 27: 1.
15. Glasmacher A, Cornely OA, Orlopp K et al. Caspofungin treatment in severely ill, immunocompromised patients: a case-documentation study of 118 patients. J Antimicrob Chemother 2006: 57: 127.
16. United Network of Organ Sharing (UNOS) data request for MELD (Mean) score for organs: Kidney, Kidney/Pancreas, Liver, and Heart for Jefferson Hospital (PATJ), Region 2, and USA for 2005 to 2007.