RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-κB signaling via its novel chaperoning function

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Lim, Keo Heun ^a   Kim, Kyun Hwan ^b,c   Choi, Seong Il ^a   Park, Eun Sook ^b   Park, Seung Hwa ^b   Ryu, Kisun ^a   Park, Yong Kwang ^b   Kwon, So Young ^b   Yang, Sung Il ^b,c   Lee, Han Chu ^d   Sung, In Kyung ^b   Seong, Baik L ^a  

^a Yonsei University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Konkuk University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEPATITIS B VIRUS X PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RIBOSOMAL PROTEIN S3A; RIBOSOME PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; RPS3A PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE SILENCING; GENOME ANALYSIS; GENOTYPE; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS CARCINOGENESIS; BIOSYNTHESIS; CELL STRAIN HEPG2; FLUORESCENCE MICROSCOPY; GENETICS; HEPATITIS B; HOST PATHOGEN INTERACTION; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; VIROLOGY; WESTERN BLOTTING;

HEPATITIS B VIRUS;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FEMALE; GREEN FLUORESCENT PROTEINS; HEP G2 CELLS; HEPATITIS B; HEPATITIS B VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MOLECULAR CHAPERONES; MUTATION; NF-KAPPA B; RIBOSOMAL PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 80051703434     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022258     Document Type: Article

References (47)

1. Branda M, Wands JR, (2006) Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology 43: 891-902.
2. Kremsdorf D, Soussan P, Paterlini-Brechot P, Brechot C, (2006) Hepatitis B virus-related human carcinogenesis. Oncogene 25: 3823-3833.
3. Bouchard MJ, Schneider RJ, (2004) The enigmatic X gene of hepatitis B virus. J Virol 78: 12725-12734.
4. Tang H, Oishi N, Kaneko S, Murakami S, (2006) Molecular functions and biological roles of hepatitis B virus X protein. Cancer Sci 97: 977-983.
5. Wang WL, London WT, Lega L, Feitelson MA, (1991) HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology 14: 29-37.
6. Benn J, Su F, Doria M, Schneider RJ, (1996) Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal Mitogen-Activated Protein kinases. J Vriol 70: 4978-4985.
7. Karin M, (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436.
8. Lucito R, Schneider RJ, (1992) Hepatitis B virus protein activates transcription factor NF-κB without requirement for protein kinase C. J Virol 66: 983-991.
9. Wang T, Wang Y, Wu MC, Guan XY, Yin ZF, (2004) Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma. World J Gastroenterol 10: 356-360.
10. Waris G, Huh KW, Siddiqui A, (2001) Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 21: 7721-7730.
11. Yun C, Um HR, Jin YH, Wang JH, Lee MO, et al. (2002) NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. Cancer Lett 184: 97-104.
12. Iizuka N, Oka M, Yamada-Okabe H, Mori N, Tamesa T, et al. (2002) Comparison of gene expression profiles between hepatitis B virus- and Hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res 62: 3939-3944.
13. Kim MY, Park E, Park JH, Park DH, Moon WS, et al. (2001) Expression profile of nine novel genes differentially expressed in hepatitis B virus-associated hepatocellular carcinomas. Oncogene 20: 4568-4575.
14. Kim JH, You KR, Kim IH, Cho BH, Kim CY, et al. (2004) Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. Hepatology 39: 129-138.
15. Takagi M, Absalon MJ, McLure KG, Kastan MB, (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and Nucleodin. Cell 123: 49-53.
16. Lutsch G, Stahl J, Kärgel HJ, Noll F, Bielka H, (1990) Immunoelectron microscopic studies on the location of ribosomal proteins on the surface of the 40S ribosomal subunit from rat liver. Eur J Cell Biol 51: 140-150.
17. Kashuba E, Yurchenko M, Szirak K, Stahl J, Klein G, et al. (2005) Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein. Exp Cell Res 303: 47-55.
18. Kho CJ, Wang Y, Zarbl H, (1996) Effect of decreased fte-1 gene expression on protein synthesis, cell growth, and transformation. Cell Growth Differ 7: 1157-1166.
19. Kho CJ, Zarbl H, (1992) Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria. Proc Natl Acad Sci U S A 89: 2200-2204.
20. Shuda M, Kondoh N, Tanaka K, Ryo A, Wakatsuki T, et al. (2000) Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Anticancer Res 20: 2489-2494.
21. Musholt TJ, Goodfellow PJ, Scheumann GF, Pichlmayr R, Wells SA Jr, et al. (1997) Differential display in primary and metastatic medullary thyroid carcinoma. J Surg Res 69: 94-100.
22. Pogue-geile K, Geiser JR, Shu M, Miller C, Wool IG, et al. (1991) Ribosomal protein Genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol 11: 3842-3849.
23. Slizhikova DK, Vinogradova TV, Sverdlov ED, (2005) The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer. Bioorg Khim 31: 195-199.
24. Starkey CR, Levy LS, (1995) Identification of differentially expressed genes in T-lymphoid malignancies in an animal model system. Int J Cancer 62: 325-331.
25. Tarantul VZ, Nikolaev AI, Martynenko A, Hannig H, Hunsmann G, et al. (2000) Differential gene expression in B-cell non-Hodgkin's lymphoma of SIV-infected monkey. AIDS Res Hum Retroviruses 16: 173-179.
26. Naora H, (1999) Involvement of ribosomal proteins in regulating cell growth and apoptosis: translational modulation or recruitment for extraribosomal activity? Immunol Cell Biol 77: 197-205.
27. Naora H, Takai I, Adachi M, Naora H, (1998) Altered cellular responses by varying expression of a ribosomal protein gene: sequential coordination of enhancement and suppression of ribosomal protein S3a gene expression induces apoptosis. J Cell Biol 141: 741-753.
28. Naora H, Nishida T, Shindo Y, Adachi M, Naora H, (1996) Constitutuvely enhanced nbl expression is associated with the induction of internucleosomal DNA cleavage by Actinomycin D. Biochem Biophys Res Commun 224: 258-264.
29. Song D, Sakamoto S, Taniguchi T, (2002) Inhibition of Poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a. Biochemistry 41: 929-934.
30. Cui K, Coutts M, Stahl J, Sytkowski AJ, (2000) Novel interaction between the transcription factor chop(GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis. J Biol Chem 275: 7591-7596.
31. Henkler F, Hoare J, Waseem N, Goldin RD, McGarvey MJ, et al. (2001) Intracellular localization of the hepatitis B virus HBx protein. J Gen Virol 82: 871-882.
32. Kim KH, Seong BL, (2003) Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 22: 2104-2116.
33. Song CZ, Bai ZL, Song CC, Wang QW, (2003) Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis. World J Gastroenterol 9: 1521-1524.
34. Urban S, Hildt E, Eckerskorn C, Sirma H, Kekule A, et al. (1997) Isolation and molecular characterization of hepatitis B virsus X-protein from a baculovirus expression system. Hepatology 26: 1045-1053.
35. Jameel S, Siddiqui A, Maguire HF, Rao KV, (1990) Hepatitis B virus X protein produced in Escherichia coli is biologically functional. J Virol 64: 3963-3966.
36. Liu D, Zou L, Li W, Wang L, Wu Y, (2009) High-level expression and large-scale preparation of soluble HBx antigen from Escherichia coli. Biotechnol Appl Biochem 54: 141-147.
37. Marczinovits I, Somogyi C, Patthy A, Nemeth P, Molnar J, (1997) An alternative purification protocol for producing hepatitis B Virus X antigen on a preparative scale in Escherichia coli. J Biotechnol 56: 81-88.
38. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR, (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 31: 164-172.
39. Tsutsumi S, Neckers L, (2007) Extracellular heat shock protein 90: A role for a molecule chaperone in cell motility and cancer metstasis. Cancer Sci 98: 1536-1539.
40. Whitesell L, Lindquist SL, (2005) HSP90 and the chaperoning of cancer. Nat Rev Cancer 5: 761-772.
41. Kovacs D, Rakacs M, Agoston B, Lenkey K, Semrad K, et al. (2009) Janus chaperones: Assistance of both RNA- and protein-folding by ribosomal proteins. FEBS Lett 583: 88-92.
42. Kabir MA, Sherman F, (2008) Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae. FEMS Yeast Res 8: 1236-1244.
43. Choi SI, Ryu K, Seong BL, (2009) RNA-mediated chaperone type for de novo protein folding. RNA Biol 6: 21-24.
44. Kim HK, Choi SI, Seong BL, (2010) 5S rRNA-assisted DnaK refolding. Biochem Biophys Res Commun 391: 1177-1181.
45. Choi SI, Han KS, Kim CW, Ryu K, Kim BH, et al. (2008) Protein solubility and folding enhancement by interaction with RNA. PLoS One 3: e2677.
46. Kim CW, Han KS, Ryu KS, Kim BH, Kim KH, et al. (2007) N-terminal domains of native multidomain proteins have the potential to assist de novo folding of their downstream domains in vivo by acting as solubility enhancers. Protein Sci 16: 635-643.
47. Trepel J, Mollapour M, Giaccone G, Neckers L, (2010) Targeting the dynamic HSP90 compelex in cancer. Nat Rev Cancer 10: 537-549.