Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 9, 2011, Pages 1219-1229

  Russo, Alessandra ^a   Cardile, Venera ^a   Caggia, Silvia ^a   Gunther, Germán ^b   Troncoso, Nicolas ^c   Garbarino, Juan ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF CHILE   (Chile)

^c Lo Vicuña and Cia ^*  (Chile)

^d DEPARTAMENTO DE FÍSICA   (Chile)

Author keywords

apoptosis; heat shock protein; melanoma cells; Peumus boldus; ultraviolet radiation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BOLDINE; CASPASE 3; CATECHIN; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; NITRIC OXIDE; PEUMUS BOLDUS EXTRACT; PLANT EXTRACT; PLASMID DNA; QUERCETIN; REACTIVE OXYGEN METABOLITE; RUTOSIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DNA PROBE; DRUG ISOLATION; DRUG POTENTIATION; DRUG TARGETING; ENZYME ASSAY; ENZYME RELEASE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VIVO STUDY; MELANOMA; MELANOMA CELL; OXIDATION REDUCTION REACTION; PEUMUS BOLDUS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIATION PROTECTION; SINGLE STRANDED DNA BREAK; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MELANOMA; NITRIC OXIDE; OXIDATION-REDUCTION; PEUMUS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLASMIDS; ULTRAVIOLET RAYS;

EID: 80051683413     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01320.x     Document Type: Article

References (31)

1. Fernández J, et al,. Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver. Phytother Res 2009; 23: 1024-1027.
2. O'Brien P, et al,. Boldine and its antioxidant or health-promoting properties. Chem Biol Interact 2006; 159: 1-17. (Pubitemid 41773627)
3. Gotteland M, et al,. Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers. Rev Med Chile 1995; 123: 955-960.
4. Schmeda-Hirschmann G, et al,. Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo"). Free Radical Res 2003; 37: 447-452. (Pubitemid 36240409)
5. Speisky H, et al,. Determination of boldine in plasma by high-performance liquid chromatography. J Chromatogr 1993; 612: 315-319. (Pubitemid 23067192)
6. Hidalgo ME, et al,. Boldine as a sunscreen, its photoprotector capacity against UVB radiation. Cosmetics Toiletries 1998; 113: 59-66.
7. Rancan F, et al,. Protection against UVB irradiation by natural filters extracted from lichens. J Photochem Photobiol 2002; 68: 133-139. (Pubitemid 35469832)
8. Russo A, et al,. Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. Cell Biol Toxicol 2000; 16: 91-98. (Pubitemid 30451544)
9. Pourzand C, Tyrrell RM,. Apoptosis, the role of oxidative stress and the example of solar UV radiation. Photochem Photobiol 1999; 70: 380-390. (Pubitemid 129555812)
10. de Gruijl FR,. Photocarcinogenesis: UVA vs UVB radiation. Skin Pharmacol Appl Skin Physiol 2002; 15: 316-320.
11. Gerhardt D, et al,. Boldine: a potential new antiproliferative drug against glioma cell lines. Invest New Drugs 2009; 27: 517-525.
12. Hung H,. Dietary quercetin inhibits proliferation of lung carcinoma cells. Forum Nutr 2007; 60: 146-157.
13. Bobe G, et al,. Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Cancer Epidemiol Biomarkers Prev 2008; 17: 553-562. (Pubitemid 351469204)
14. Garbarino J, et al,. Potential anticancer activity of extract from Peumus boldus leaves in human epithelial cancer cells. Nat Prod Commun 2008; 3: 2095-2098.
15. Russo A, et al,. Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells. Life Sci 2008; 83: 468-474.
16. Patury S, et al,. Pharmacological targeting of the Hsp70 chaperone. Curr Top Med Chem 2009; 9: 1337-1351.
17. Garrido C, et al,. Heat shock proteins 27 and 70 anti-apoptotic proteins with tumorigenic properties. Cell Cycle 2006; 5: 2592-2601. (Pubitemid 44785803)
18. Nagai N, et al,. Quercetin suppresses heat shock response by down regulation of HSF1. Biochem Biophys Res Commun 1995; 208: 1099-1105.
19. Amatore C, et al,. Angeli's salt (Na(2)N(2)O(3)) is a precursor of HNO and NO: a voltammetric study of the reactive intermediates released by Angeli's salt decomposition. ChemMedChem 2007; 2: 898-903.
20. 1. Food Chem Toxicol 2002; 40: 25-31. (Pubitemid 33132138)
21. Sekine T, et al,. Tumor-specific and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res 2007; 27: 133-143.
22. Bednarek I, et al,. Single-cell gel electrophoresis (comet assay) as a tool for apoptosis determination in tumor cell lines HL-60 and Jurkat cultures treated with anisomycin. Ann Acad Med 2006; 60: 278-284.
23. Godard T, et al,. Early detection of staurosporine-induced apoptosis by comet and annexin V assays. Histochem Cell Biol 1999; 112: 155-161. (Pubitemid 29421925)
24. Shi Y,. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 2002; 9: 459-470. (Pubitemid 34273778)
25. Russo PAJ, Halliday GM,. Inhibition of nitric oxide and reactive oxygen species production improves the ability of a sunscreen to protect from sunburn, immunosuppression and photocarcinogenesis. Br J Dermatol 2006; 155: 408-415. (Pubitemid 44050577)
26. Russo A, et al,. Nitric oxide and skin: effect of natural compounds. In:, Pandalai SG, ed. Recent Research Developments in Chemistry and Biology of Nitric Oxide. Kerala: Research Signpost, 2008: 149-179.
27. Russo A, et al,. Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines. Life Sci 2004; 76: 545-558. (Pubitemid 39535666)
28. Johnstone RW, et al,. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002; 108: 153-164. (Pubitemid 34161136)
29. Schulze-Osthoff K, et al,. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: evidence for the involvement of mitochondrial radical generation. J Biol Chem 1992; 267: 5317-5323.
30. Buttke TM, Sandstrom PA,. Oxidative stress as a mediator of apoptosis. Immunol Today 1994; 15: 7-10.
31. Loo G,. Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation. J Nutr Biochem 2003; 14: 64-73. (Pubitemid 36349516)