Relationships between knee pain and osteoarthritis biomarkers based on systemic fluids and magnetic resonance imaging

Journal of Musculoskeletal Pain

Volumn 19, Issue 3, 2011, Pages 144-153

  Dam, Erik B ^a   Byrjalsen, Inger ^b   Arendt Nielsen, Lars ^c,d   Christiansen, Claus ^b,d   Karsdal, Morten A ^e  

^a Biomediq   (Denmark)

^b CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

^d C4Pain   (Denmark)

^e NORDIC BIOSCIENCE A S   (Denmark)

Author keywords

Biomarker; MRI; Osteoarthritis; Pain; UCTX II

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; CARBOXY TERMINAL TELOPEPTIDE TYPE 1; CARBOXY TERMINAL TELOPEPTIDE TYPE 2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CARTILAGE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; FEMUR; FOLLOW UP; HARDNESS; HUMAN; IMAGE ANALYSIS; JOINT CAVITY; KNEE PAIN; KNEE RADIOGRAPHY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; OSTEOARTHRITIS; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; THICKNESS; TIBIA; TISSUE STRUCTURE; VISUAL ANALOG SCALE;

EID: 80051677650     PISSN: 10582452     EISSN: 15407012     Source Type: Journal    
DOI: 10.3109/10582452.2011.582988     Document Type: Article

References (51)

1. Hunter DJ, McDougall JJ, Keefe FJ: The symptoms of osteoar-thritis and the genesis of pain. Rheum Dis Clin North Am 34: 623-643, 2008.
2. Read SJ, Dray A: Osteoarthritic pain: A review of current, theoretical and emerging therapeutics. Expert Opin Investig Drugs 17: 619-640, 2008. (Pubitemid 351858385)
3. Bove SE, Flatters SJ, Inglis JJ, Mantyh PW: New advances in musculoskeletal pain. Brain Res Rev 60: 187-201, 2009.
4. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romund-stad L, Hals EK, Kvarstein G, Stubhaug A: Assessment of pain. Br J Anaesth 101: 17-24, 2008. (Pubitemid 351881909)
5. Laine L, White WB, Rostom A, Hochberg M: COX-2 selective inhibitors in the treatment of osteoarthritis. Semin Arthritis Rheum 38: 165-187, 2008.
6. Arendt-Nielsen L, Graven-Nielsen T: Muscle pain: Sensory implications and interaction with motor control. Clin J Pain 24: 291-298, 2008. (Pubitemid 351572784)
7. Creamer P: Osteoarthritis pain and its treatment. Curr Opin Rheumatol 12: 450-455, 2000.
8. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T: Sensitization in patients with painful knee osteoarthritis. Pain 149: 573-581, 2010.
9. Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L: Osteoar-thritis and its association with muscle hyperalgesia: An experimental controlled study. Pain 93: 107-114, 2001. (Pubitemid 32568395)
10. Harden RN, Bruehl S, Stanos S, Brander V, Chung OY, Saltz S, Adams A, Stulberg SD: Prospective examination of pain-related and psychological predictors of CRPS-like phenomena following total knee arthroplasty: A preliminary study. Pain 106: 393-400, 2003. (Pubitemid 37505887)
11. Nie H, Graven-Nielsen T, Arendt-Nielsen L: Spatial and temporal summation of pain evoked by mechanical pressure stimulation. Eur J Pain 13: 592-599, 2009.
12. Abramson SB, Attur M, Yazici Y: Prospects for disease modification in osteoarthritis. Nat Clin Pract Rheumatol 2: 304-312, 2006. (Pubitemid 43842259)
13. Ragab Y, Emad Y, Abou-Zeid A: Bone marrow edema syndromes of the hip: MRI features in different hip disorders. Clin Rheumatol 27: 475-482, 2008. (Pubitemid 351404303)
14. Kellgren JH, Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16: 494-501, 1957.
15. Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, Klickstein L, Aggarwal P, Nemirovskiy O, Byrjalsen I, Qvist P, Bay-Jensen AC, Dam EB, Madsen SH, Christiansen C: Biochemical markers and the FDA critical path: How bio-markers may contribute to the understanding of pathophysiol-ogy and provide unique and necessary tools for drug development. Biomarkers 14: 181-202, 2009.
16. Saftig P, Hunziker E, Wehmeyer O, Jones S, Boyde A, Rommers-kirch W, Moritz JD, Schu P, von Figura K: Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci USA 95: 13453-13458, 1998. (Pubitemid 28522993)
17. Ravn P, Hosking D, Thompson D, Cizza G, Wasnich RD, McClung M, Yates AJ, Bjarnason NH, Christiansen C: Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study. J Clin Endocrinol Metab 84: 2363-2368, 1999.
18. Schaller S, Henriksen K, Hoegh-Andersen P, Sondergaard BC, Sumer EU, Tanko LB, Qvist P, Karsdal MA: In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: How biomarkers can assist? Assay Drug Dev Technol 3: 553-580, 2005. (Pubitemid 41824373)
19. Sondergaard BC, Henriksen K, Wulf H, Oestergaard S, Schurigt U, Brauer R, Danielsen I, Christiansen C, Qvist P, Karsdal MA: Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartilage 14: 738-748, 2006. (Pubitemid 43986357)
20. Dam EB, Byrjalsen I, Karsdal MA, Qvist P, Christiansen C: Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI. Osteo-arthritis Cartilage 17: 384-389, 2009.
21. Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duister-maat JJ, Garnero P, Hellio Le Graverand MP, DeGroot J, Slag-boom PE: Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: The GARP study. Ann Rheum Dis 65: 360-365, 2006. (Pubitemid 43268226)
22. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF: The prevalence of knee osteoarthritis in the elderly. The Fra-mingham Osteoarthritis Study. Arthritis Rheum 30: 914-918, 1987. (Pubitemid 17140857)
23. Lethbridge-Cejku M, Scott WW, Reichle R, Ettinger WH, Zon-derman A, Costa P, Plato CC, Tobin JD, Hochberg MC: Association of radiographic features of osteoarthritis of the knee with knee pain: Data from the Baltimore Longitudinal Study of Aging. Arthritis Care Res 8: 182-188, 1995.
24. Eckstein F, Burstein D, Link TM: Quantitative MRI of cartilage and bone: Degenerative changes in osteoarthritis. NMR Biomed 19: 822-854, 2006. (Pubitemid 44811544)
25. Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, Rosenquist C, Qvist P: Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 29: 209-215, 2001. (Pubitemid 32823562)
26. Rosenquist C, Fledelius C, Christgau S, Pedersen BJ, Bonde M, Qvist P, Christiansen C: Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Clin Chem 44: 2281-2289, 1998. (Pubitemid 28511750)
27. Peterfy C, Li J, Zaim S, Duryea J, Lynch JA, Miaux Y, yu W, Genant HK: Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radio-graphic joint-space width in the knee: Test-retest reproducibil-ity. Skeletal Radiol 32: 128-132, 2003. (Pubitemid 36818111)
28. Folkesson J, Dam EB, Olsen OF, Pettersen PC, Christiansen C: Segmenting articular cartilage automatically using a voxel classification approach. IEEE Trans Med Imaging 26: 106-115, 2007. (Pubitemid 46096355)
29. Qazi AA, Folkesson J, Pettersen PC, Karsdal MA, Christiansen C, Dam EB: Separation of healthy and early osteoarthritis by automatic quantification of cartilage homogeneity. Osteoar-thritis Cartilage 15: 1199-1206, 2007. (Pubitemid 47387047)
30. Folkesson J, Dam EB, Olsen OF, Karsdal MA, Pettersen PC, Christiansen C: Automatic quantification of local and global articular cartilage surface curvature: Biomarkers for osteoar-thritis? Magn Reson Med 59: 1340-1346, 2008. (Pubitemid 351813263)
31. Dam EB, Fletcher PT, Pizer SM: Automatic shape modeling based on principal geodesic analysis bootstrapping. Med Image Anal 12: 136-151, 2008.
32. Dam EB, Folkesson J, Pettersen PC, Christiansen C: Automatic Cartilage Thickness Quantification Using a Statistical Shape Model, MICCAI Joint Disease Workshop, http://www.diku.dk/∼erikdam/JOINT/Doc/MICCAI06-JointWorkshop.pdf, 42-49, 2006.
33. Dam EB, Folkesson J, Pettersen PC, Christiansen C: Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading. Osteoarthritis Cartilage 15: 808-818, 2007. (Pubitemid 46888161)
34. DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver-operating characteristic curves: A nonparametric approach. Biometrics 44: 837-845, 1988.
35. Ratcliffe SJ, Shults J: GEEQBOX: A MATLAB toolbox for generalized estimating equations and quasi-least squares. J Stat Softw 25: 1-14, 2008.
36. Szebenyi B, Hollander AP, Dieppe P, Quilty B, Duddy J, Clarke S, Kirwan JR: Associations between pain, function, and radio-graphic features in osteoarthritis of the knee. Arthritis Rheum 54: 230-235, 2006. (Pubitemid 43122206)
37. Cicuttini FM, Baker J, Hart DJ, Spector TD: Association of pain with radiological changes in different compartments and views of the knee joint. Osteoarthritis Cartilage 4: 143-147, 1996. (Pubitemid 26226438)
38. McCrae F, Shouls J, Dieppe P, Watt I: Scintigraphic assessment of osteoarthritis of the knee joint. Ann Rheum Dis 51: 938-942, 1992.
39. Creamer P, Lethbridge-Cejku M, Hochberg MC: Determinants of pain severity in knee osteoarthritis: Effect of demographic and psychosocial variables using 3 pain measures. J Rheumatol 26: 1785-1792, 1999. (Pubitemid 29367321)
40. Bingham COIII, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF: Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: Results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 54: 3494-3507, 2006. (Pubitemid 44737161)
41. Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, Kazis L, Gale DR: The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 134: 541-549, 2001. (Pubitemid 32245315)
42. Sowers MF, Hayes C, Jamadar D, Capul D, Lachance L, Jan-nausch M, Welch G: Magnetic resonance-detected subchondral bone marrow and cartilage defect characteristics associated with pain and X-ray-defined knee osteoarthritis. Osteoarthritis Cartilage 11: 387-393, 2003. (Pubitemid 36722652)
43. Hunter DJ, March L, Sambrook PN: The association of cartilage volume with knee pain. Osteoarthritis Cartilage 11: 725-729, 2003. (Pubitemid 37184490)
44. Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, Tannenbaum H, Meyer JM, Beary JF, Cline GA, Pelletier JP: Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: Correlation with clinical symptoms and radiographic changes. Arthritis Res Ther 8: R21, 2006.
45. Wluka AE, Wolfe R, Stuckey S, Cicuttini FM: How does tibial cartilage volume relate to symptoms in subjects with knee osteo-arthritis? Ann Rheum Dis 63: 264-268, 2004. (Pubitemid 38250668)
46. Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, Majum-dar S: Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226: 373-381, 2003. (Pubitemid 36313421)
47. Kornaat PR, Bloem JL, Ceulemans RY, Riyazi N, Rosendaal FR, Nelissen RG, Carter WO, Hellio Le Graverand MP, Kloppen-burg M: Osteoarthritis of the knee: Association between clinical features and MR imaging findings. Radiology 239: 811-817, 2006. (Pubitemid 43830617)
48. Garnero P, Mazieres B, Gueguen A, Abbal M, Berdah L, Le-quesne M, Nguyen M, Salles JP, Vignon E, Dougados M: Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: The ECHO-DIAH cohort. J Rheumatol 32: 697-703, 2005. (Pubitemid 40524704)
49. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E: Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: Relations with disease activity and joint damage. Ann Rheum Dis 60: 619-626, 2001. (Pubitemid 32493990)
50. Felson DT: The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 17: 624-628, 2005.
51. Arendt-Nielsen L, Hoeck HC, Karsdal MA, Christiansen C: Role of calcitonin in management of musculoskeletal pain. Rheuma-tol Rep 1: 39-42, 2009.