-
1
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
DOI 10.1038/34201
-
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH Jr, de Sauvage FJ (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391:90-2 (Pubitemid 28079221)
-
(1998)
Nature
, vol.391
, Issue.6662
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.-M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.-W.8
Hynes, M.9
Goddard, A.10
Rosenthal, A.11
Epstein Jr., E.H.12
De Sauvage, F.J.13
-
2
-
-
0033590605
-
A frequent activated smoothened mutation in sporadic basal cell carcinomas
-
DOI 10.1038/sj.onc.1202360
-
Lam CW, Xie J, To KF, Ng HK, Lee KC, Yuen NW, Lim PL, Chan LY, Tong SF, McCormick F (1999) A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 18:833-6 (Pubitemid 29080343)
-
(1999)
Oncogene
, vol.18
, Issue.3
, pp. 833-836
-
-
Lam, C.-W.1
Xie, J.2
To, K.-F.3
Ng, H.-K.4
Lee, K.-C.5
Yuen, N.W.-F.6
Lim, P.-L.7
Chan, L.Y.-S.8
Tong, S.-F.9
McCormick, F.10
-
3
-
-
1842335673
-
Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin
-
Kallassy M, Toftgard R, Ueda M, Nakazawa K, Vorechovsky I, Yamasaki H, Nakazawa H (1997) Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. Cancer Res 57:4731-5 (Pubitemid 27468977)
-
(1997)
Cancer Research
, vol.57
, Issue.21
, pp. 4731-4735
-
-
Kallassy, M.1
Toftgard, R.2
Ueda, M.3
Nakazawa, K.4
Vorechovsky, I.5
Yamasaki, H.6
Nakazawa, H.7
-
4
-
-
4143097168
-
Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia
-
DOI 10.1002/path.1591
-
Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ (2004) Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 203:909-17 (Pubitemid 39089279)
-
(2004)
Journal of Pathology
, vol.203
, Issue.4
, pp. 909-917
-
-
Oniscu, A.1
James, R.M.2
Morris, R.G.3
Bader, S.4
Malcomson, R.D.G.5
Harrison, D.J.6
-
5
-
-
33745713280
-
Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia
-
DOI 10.1097/01.mpa.0000222319.59360.21, PII 0000667620060700000006
-
Shao J, Zhang L, Gao J, Li Z, Chen Z (2006) Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. Pancreas 33:38-44 (Pubitemid 43995338)
-
(2006)
Pancreas
, vol.33
, Issue.1
, pp. 38-44
-
-
Shao, J.1
Zhang, L.2
Gao, J.3
Li, Z.4
Chen, Z.5
-
6
-
-
25144461600
-
Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms
-
Martin ST, Sato N, Dhara S, Chang R, Hustinx SR, Abe T, Maitra A, Goggins M (2005) Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther 4:728-33 (Pubitemid 41351171)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.7
, pp. 728-733
-
-
Martin, S.T.1
Sato, N.2
Dhara, S.3
Chang, R.4
Hustinx, S.R.5
Abe, T.6
Maitra, A.7
Goggins, M.8
-
7
-
-
35349020543
-
Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer
-
DOI 10.1002/path.2216
-
Taniguchi H, Yamamoto H, Akutsu N, Nosho K, Adachi Y, Imai K, Shinomura Y (2007) Transcriptional silencing of hedgehoginteracting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer. J Pathol 213:131-9 (Pubitemid 47612235)
-
(2007)
Journal of Pathology
, vol.213
, Issue.2
, pp. 131-139
-
-
Taniguchi, H.1
Yamamoto, H.2
Akutsu, N.3
Nosho, K.4
Adachi, Y.5
Imai, K.6
Shinomura, Y.7
-
8
-
-
52449129646
-
Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma
-
Tada M, Kanai F, Tanaka Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Muroyama R, Fukai K, Imazeki F, Kawabe T, Yokosuka O, Omata M (2008) Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma. Clin Cancer Res 14:3768-76
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3768-3776
-
-
Tada, M.1
Kanai, F.2
Tanaka, Y.3
Tateishi, K.4
Ohta, M.5
Asaoka, Y.6
Seto, M.7
Muroyama, R.8
Fukai, K.9
Imazeki, F.10
Kawabe, T.11
Yokosuka, O.12
Omata, M.13
-
9
-
-
31744451535
-
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway
-
DOI 10.1016/j.devcel.2005.12.013, PII S1534580706000050
-
Svard J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergstrom A, Ericson J, Toftgard R, Teglund S (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10:187-97 (Pubitemid 43174952)
-
(2006)
Developmental Cell
, vol.10
, Issue.2
, pp. 187-197
-
-
Svard, J.1
Henricson, K.H.2
Persson-Lek, M.3
Rozell, B.4
Lauth, M.5
Bergstrom, A.6
Ericson, J.7
Toftgard, R.8
Teglund, S.9
-
10
-
-
65649084121
-
Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice
-
Svard J, Rozell B, Toftgard R, Teglund S (2009) Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. Mol Carcinog 48:408-19
-
(2009)
Mol Carcinog
, vol.48
, pp. 408-419
-
-
Svard, J.1
Rozell, B.2
Toftgard, R.3
Teglund, S.4
-
11
-
-
13644261744
-
Activation of the hedgehog pathway in advanced prostate cancer
-
Sheng T, Li C, Zhang X, Chi S, He N, Chen K, McCormick F, Gatalica Z, Xie J (2004) Activation of the hedgehog pathway in advanced prostate cancer. Mol Cancer 3:29
-
(2004)
Mol Cancer
, vol.3
, pp. 29
-
-
Sheng, T.1
Li, C.2
Zhang, X.3
Chi, S.4
He, N.5
Chen, K.6
McCormick, F.7
Gatalica, Z.8
Xie, J.9
-
12
-
-
33745606922
-
Activation of the hedgehog pathway in a subset of lung cancers
-
DOI 10.1016/j.canlet.2005.11.036, PII S0304383505010451
-
Chi S, Huang S, Li C, Zhang X, He N, Bhutani MS, Jones D, Castro CY, Logrono R, Haque A, Zwischenberger J, Tyring SK, Zhang H, Xie J (2006) Activation of the hedgehog pathway in a subset of lung cancers. Cancer Lett 244:53-60 (Pubitemid 44485862)
-
(2006)
Cancer Letters
, vol.244
, Issue.1
, pp. 53-60
-
-
Chi, S.1
Huang, S.2
Li, C.3
Zhang, X.4
He, N.5
Bhutani, M.S.6
Jones, D.7
Castro, C.Y.8
Logrono, R.9
Haque, A.10
Zwischenberger, J.11
Tyring, S.K.12
Zhang, H.13
Xie, J.14
-
13
-
-
19944433687
-
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
-
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G (2005) Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol 152:43-51
-
(2005)
Br J Dermatol
, vol.152
, pp. 43-51
-
-
Reifenberger, J.1
Wolter, M.2
Knobbe, C.B.3
Kohler, B.4
Schonicke, A.5
Scharwachter, C.6
Kumar, K.7
Blaschke, B.8
Ruzicka, T.9
Reifenberger, G.10
-
14
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM, Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka JT, Hogg D (2002) Mutations in SUFU predispose to medulloblastoma. Nat Genet 31:306-10
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
Hui, C.C.4
Mainprize, T.G.5
Zhang, X.6
Agatep, R.7
Chiappa, S.8
Gao, L.9
Lowrance, A.10
Hao, A.11
Goldstein, A.M.12
Stavrou, T.13
Scherer, S.W.14
Dura, W.T.15
Wainwright, B.16
Squire, J.A.17
Rutka, J.T.18
Hogg, D.19
-
15
-
-
36849065315
-
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
-
DOI 10.1016/j.cell.2007.11.025, PII S009286740701522X
-
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-203 (Pubitemid 350235027)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
Hu, Y.11
Tan, Z.12
Stokes, M.13
Sullivan, L.14
Mitchell, J.15
Wetzel, R.16
MacNeill, J.17
Ren, J.M.18
Yuan, J.19
Bakalarski, C.E.20
Villen, J.21
Kornhauser, J.M.22
Smith, B.23
Li, D.24
Zhou, X.25
Gygi, S.P.26
Gu, T.-L.27
Polakiewicz, R.D.28
Rush, J.29
Comb, M.J.30
more..
-
16
-
-
33750203160
-
Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer
-
Taja-Chayeb L, Chavez-Blanco A, Martinez-Tlahuel J, Gonzalez-Fierro A, Candelaria M, Chanona-Vilchis J, Robles E, Duenas-Gonzalez A (2006) Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer. Cancer Cell Int 6:22
-
(2006)
Cancer Cell Int
, vol.6
, pp. 22
-
-
Taja-Chayeb, L.1
Chavez-Blanco, A.2
Martinez-Tlahuel, J.3
Gonzalez-Fierro, A.4
Candelaria, M.5
Chanona-Vilchis, J.6
Robles, E.7
Duenas-Gonzalez, A.8
-
17
-
-
29344456631
-
Overexpression of platelet-derived growth factor receptor α in endothelial cells of hepatocellular carcinoma associated with high metastatic potential
-
DOI 10.1158/1078-0432.CCR-05-0944
-
Zhang T, Sun HC, Xu Y, Zhang KZ, Wang L, Qin LX, Wu WZ, Liu YK, Ye SL, Tang ZY (2005) Overexpression of plateletderived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin Cancer Res 11:8557-63 (Pubitemid 43005900)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.24
, pp. 8557-8563
-
-
Zhang, T.1
Sun, H.-C.2
Xu, Y.3
Zhang, K.-Z.4
Wang, L.5
Qin, L.-X.6
Wu, W.-Z.7
Liu, Y.-K.8
Ye, S.-L.9
Tang, Z.-Y.10
-
18
-
-
33645506349
-
Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer
-
Matei D, Emerson RE, Lai YC, Baldridge LA, Rao J, Yiannoutsos C, Donner DD (2006) Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer. Oncogene 25:2060-9
-
(2006)
Oncogene
, vol.25
, pp. 2060-2069
-
-
Matei, D.1
Emerson, R.E.2
Lai, Y.C.3
Baldridge, L.A.4
Rao, J.5
Yiannoutsos, C.6
Donner, D.D.7
-
19
-
-
33745192635
-
Autocrine PDGFR signaling promotes mammary cancer metastasis
-
Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H, Grunert S (2006) Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 116:1561-70
-
(2006)
J Clin Invest
, vol.116
, pp. 1561-1570
-
-
Jechlinger, M.1
Sommer, A.2
Moriggl, R.3
Seither, P.4
Kraut, N.5
Capodiecci, P.6
Donovan, M.7
Cordon-Cardo, C.8
Beug, H.9
Grunert, S.10
-
20
-
-
11344264600
-
Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice
-
Lev DC, Kim SJ, Onn A, Stone V, Nam DH, Yazici S, Fidler IJ, Price JE (2005) Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice. Clin Cancer Res 11:306-14 (Pubitemid 40075809)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.1
, pp. 306-314
-
-
Lev, D.C.1
Sun, J.K.2
Onn, A.3
Stone, V.4
Nam, D.-H.5
Yazici, S.6
Fidler, I.J.7
Price, J.E.8
-
21
-
-
59649103684
-
The alpha-receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells
-
Russell MR, Jamieson WL, Dolloff NG, Fatatis A (2009) The alpha-receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells. Oncogene 28:412-21
-
(2009)
Oncogene
, vol.28
, pp. 412-421
-
-
Russell, M.R.1
Jamieson, W.L.2
Dolloff, N.G.3
Fatatis, A.4
-
22
-
-
40249117273
-
PDGFRa/β expression correlates with the metastatic behavior of human colorectal cancer: A possible rationale for a molecular targeting strategy
-
Wehler TC, Frerichs K, Graf C, Drescher D, Schimanski K, Biesterfeld S, Berger MR, Kanzler S, Junginger T, Galle PR, Moehler M, Gockel I, Schimanski CC (2008) PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. Oncol Rep 19:697-704 (Pubitemid 351330438)
-
(2008)
Oncology Reports
, vol.19
, Issue.3
, pp. 697-704
-
-
Wehler, T.C.1
Frerichs, K.2
Graf, C.3
Drescher, D.4
Schimanski, K.5
Biesterfeld, S.6
Berger, M.R.7
Kanzler, S.8
Junginger, T.9
Galle, P.R.10
Moehler, M.11
Gockel, I.12
Schimanski, C.C.13
-
23
-
-
27944470037
-
Hedgehog signaling is activated in subsets of esophageal cancers
-
DOI 10.1002/ijc.21295
-
Ma X, Sheng T, Zhang Y, Zhang X, He J, Huang S, Chen K, Sultz J, Adegboyega PA, Zhang H, Xie J (2006) Hedgehog signaling is activated in subsets of esophageal cancers. Int J Cancer 118:139-48 (Pubitemid 41681590)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.1
, pp. 139-148
-
-
Ma, X.1
Sheng, T.2
Zhang, Y.3
Zhang, X.4
He, J.5
Huang, S.6
Chen, K.7
Sultz, J.8
Adegboyega, P.A.9
Zhang, H.10
Xie, J.11
-
24
-
-
4043129541
-
Pathology of upper gastrointestinal malignancies
-
DOI 10.1053/j.seminoncol.2004.04.020, PII S0093775404002416
-
Sarbia M, Becker KF, Hofler H (2004) Pathology of upper gastrointestinal malignancies. Semin Oncol 31:465-75 (Pubitemid 39070266)
-
(2004)
Seminars in Oncology
, vol.31
, Issue.4
, pp. 465-475
-
-
Sarbia, M.1
Becker, K.F.2
Hofler, H.3
-
25
-
-
0035001278
-
Activation of expression of hedgehog target genes in basal cell carcinomas
-
DOI 10.1046/j.1523-1747.2001.01315.x
-
Bonifas JM, Pennypacker S, Chuang PT, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH Jr (2001) Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol 116:739-42 (Pubitemid 32467653)
-
(2001)
Journal of Investigative Dermatology
, vol.116
, Issue.5
, pp. 739-742
-
-
Bonifas, J.M.1
Pennypacker, S.2
Chuang, P.-T.3
McMahon, A.P.4
Williams, M.5
Rosenthal, A.6
De Sauvage, F.J.7
Epstein Jr., E.H.8
-
26
-
-
0035979147
-
A role of PDGFRα in basal cell carcinoma proliferation
-
DOI 10.1073/pnas.151173398
-
Xie J, Aszterbaum M, Zhang X, Bonifas JM, Zachary C, Epstein E, McCormick F (2001) A role of PDGFRalpha in basal cell carcinoma proliferation. Proc Natl Acad Sci USA 98:9255-9 (Pubitemid 32743903)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.16
, pp. 9255-9259
-
-
Xie, J.1
Aszterbaum, M.2
Zhang, X.3
Bonifas, J.M.4
Zachary, C.5
Epstein, E.6
McCormick, F.7
-
27
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
DOI 10.1200/JCO.2003.04.190
-
Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA (2003) Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21:4342-9 (Pubitemid 46621810)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.23
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
Blanke, C.D.4
Von Mehren, M.5
Joensuu, H.6
McGreevey, L.S.7
Chen, C.-J.8
Van Den Abbeele, A.D.9
Druker, B.J.10
Kiese, B.11
Eisenberg, B.12
Roberts, P.J.13
Singer, S.14
Fletcher, C.D.M.15
Silberman, S.16
Dimitrijevic, S.17
Fletcher, J.A.18
-
28
-
-
31744450041
-
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
-
DOI 10.1111/j.1432-0436.2005.00042.x
-
Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M, Hui CC (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73:397-405 (Pubitemid 43922158)
-
(2005)
Differentiation
, vol.73
, Issue.8
, pp. 397-405
-
-
Barnfield, P.C.1
Zhang, X.2
Thanabalasingham, V.3
Yoshida, M.4
Hui, C.-C.5
-
29
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
DOI 10.1038/nature02962
-
Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431:707-12 (Pubitemid 39382619)
-
(2004)
Nature
, vol.431
, Issue.7009
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
30
-
-
77952337262
-
Indentification of signature genes for detecting hedgehog signaling activation in gastric cancer
-
Yang L, Huang SH, Bian YH, Ma XL, Zhang HW, Xie JW (2010) Indentification of signature genes for detecting hedgehog signaling activation in gastric cancer. Mol Med Rep 3:473-478
-
(2010)
Mol Med Rep
, vol.3
, pp. 473-478
-
-
Yang, L.1
Huang, S.H.2
Bian, Y.H.3
Ma, X.L.4
Zhang, H.W.5
Xie, J.W.6
|